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Transcatheter mitral valve implantation using a novel system:preclinical results

Journal of Geriatric Cardiology 2020年第9期17卷 566-573页

作者： Jia-You TANG Lin-He LU Yang liu Lan-Lan LI Yan-Yan MA Shi-Qiang YU jin-cheng liu Jian YANG Department of Cardiovascular Surgery the First Affiliated Hospital of Air Force Military Medical UniversityXi’anChina

Background This preclinical study in sheep sought to demonstrate the initial safety and feasibility of a novel transcatheter mitral valve system(Mi-thos valve)composed of a self-expanding frame and a bovine pericardial tissue *** The valve was implanted in 26 sheep using a transapical approach for short-and long-term *** technical feasibility,safety,durability,and valve function were evaluated during and 6 months after the procedure using intracardiac and transthoracic echocardiography,multisliced computed tomography,histological analysis,and electron *** The success rate of valve implantation was 100%,and the immediate survival rate after surgery was 84%.Five animals died within 90 min after the development of the prosthetic valve due to an acute left ventricular outflow tract obstruction(n=2)and sudden intraoperative ventricular fibrillation(n=3).Twelve animals died within 1 month due to acute left heart ***(n=5)and moderate(n=2)paravalvular leakage occurred in seven animals,and two moderate PVL animals died of chronic heart failure within three *** imaging studies of the remaining seven animals showed excellent function and alignment of the valves,with no coronary artery obstruction,no left ventricular outflow tract obstruction,no severe transvalvular gradients and no paravalvular *** evaluation demonstrated stable,secure positioning of the valve,with full endothelialization of the valve leaflets without injury to the ventricular or atrial *** and electron microscopic examinations at six months showed no obvious macro-or microcalcification in the *** Preclinical studies indicate that transcatheter implantation of the Mi-thos valve is technically safe and *** durability,functionality,and lack of leaflet calcification were all verified in animal *** information from these preclinical studies will be applied to patient select

关键词： Mitral regurgitation Mitral valve implantation Preclinical study Transapical Transcatheter

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Oxidation behavior of low-grade vanadiferous titanomagnetite concentrate with high titanium

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Journal of Iron and Steel Research International 2024年第2期31卷 329-341页

作者： jin-sheng liu Zhen-xing Xing Gong-jin cheng Xue-yong Ding Xiang-xin Xue School of Metallurgy Northeastern UniversityShenyang110819LiaoningChina Liaoning Key Laboratory of Recycling Science for Metallurgical Resources Shenyang110819LiaoningChina Innovation Research Institute of Vanadium and Titanium Resource Industry Technology Northeastern UniversityShenyang110819LiaoningChina

In order to clarify the oxidation mechanisms and make better use of the low-grade vanadiferous titanomagnetite concentrate with high titanium(LVTC),the oxidation behavior of LVTC was *** results showed that oxidation degree was achieved within 90 min when temperature was not lower than 700°C,and the main phases of the oxidized LVTC consisted of Fe9TiO15,Fe2O3,CaSiTiO5 and a small amount of *** temperature is favorable to the formation of *** surface of LVTC gradually becomes rough,with fine particles of needle-like and granular shape appearing on the surface,which finally turn from laminar to creamy,spread out,and are interspersed with many tiny *** phase oxidation paths in LVTC were as follows:(1)Fe2.75Ti0.25O4→Fe9TiO15+Fe2O3;(2)Fe2.75Ti0.25O4→Fe2O3+FeTiO3→Fe2TiO5;(3)FeTiO3→Fe2O3+Fe2Ti3O9→*** is predominantly mesoporous whether oxidized or not,with the pores mainly distributed in the range of 2–40 nm,and the specific surface area of LVTC decreases significantly with increasing temperature.

关键词： Low-grade vanadiferous titanomagnetite concentrate Oxidation degree Phase transformation Micromorphology Oxidation path Pore structure

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Simultaneous dual-region two-photon imaging of biological dynamics spanning over 9 mm in vivo

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Photonics Research 2024年第3期12卷 456-464页

作者： CHI liu cheng jin JUNHAO DENG JUNHAO LIANG LIcheng ZHANG LINGJIE KONG State Key Laboratory of Precision Measurement Technology and Instruments Department of Precision InstrumentTsinghua UniversityBeijing 100084China School of Life Sciences Tsinghua UniversityBeijing 100084China Senior Department of Orthopedics The Fourth Medical Center of Chinese PLA General HospitalBeijing 100853China IDG/McGovern Institute for Brain Research Tsinghua UniversityBeijing 100084China

Biodynamical processes,especially in system biology,that occur far apart in space may be highly *** study such biodynamics,simultaneous imaging over a large span at high spatio-temporal resolutions is highly *** example,large-scale recording of neural network activities over various brain regions is indispensable in ***,limited by the field-of-view(FoV)of conventional microscopes,simultaneous recording of laterally distant regions at high spatio-temporal resolutions is highly ***,we propose to extend the distance of simultaneous recording regions with a custom micro-mirror unit,taking advantage of the long working distance of the objective and spatio-temporal *** demonstrate simultaneous dual-region two-photon imaging,spanning as large as 9 mm,which is 4 times larger than the nominal FoV of the *** verify the system performance in in vivo imaging of neural activities and vascular dilations,simultaneously,at two regions in mouse brains as well as in spinal cords,*** adoption of our proposed scheme will promote the study of systematic biology,such as system neuroscience and system immunology.

关键词： recording vivo dynamics

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Interface Design Strategy for GNS/AZ91 Composites with Semi-Coherent Structure

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Acta Metallurgica Sinica(English Letters) 2024年第3期37卷 467-483页

作者： jing-Peng Xiong Yi-Qi Zeng jin-Long liu Wei-cheng Wang Lan Luo Yong liu Key Laboratory of Lightweight and High Strength Structural Materials of Jiangxi Province School of Advanced ManufacturingNanchang UniversityNanchang 330031China School of Physics and Materials Science Nanchang UniversityNanchang 330031China

The interfacial structure plays an important role in the mechanical properties of magnesium matrix composite(MMCs)reinforced with graphene nanosheet(GNS)due to their poor wettability with the Mg *** interface design strategy was proposed to form the semi-coherent interfacial structure with superior bonding *** lattice mismatch and interfacial bonding strength between Mg/rare earth oxide/carbon were utilized as key characteristics to evaluate the interfacial *** oxide(La2O3)was selected as the intermediate candidate due to its low lattice mismatch and high interfacial bonding *** identify the interfacial structure of Mg/La2O3/graphene,first-principles calculations were conducted to calculate the ideal work of separation and electronic structure of the *** demonstrated the presence of strong ionic and covalent interactions at the interface,which theoretically verified the strong interfacial bonding strength among Mg/La2O3/graphene *** experimentally validate the interface strength,MMCs with the interface structure of Mg/La2O3/GNS were *** formation of in-situ La2O3 led to the successful attainment of semi-coherent structures between Mg/La2O3 and La2O3/GNS,resulting in high strength and good ductility of the ***,this work proposes a new approach to interface design in MMCs with an enhancement of mechanical properties.

关键词： Interface design strategy Magnesium matrix composite Graphene nanosheets Semi-coherent interface Mechanical properties

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Preventive effects of Bifidobacterium lactis Probio-M8 on ovalbumin-induced food allergy in mice

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Food Science and Human Wellness 2024年第4期13卷 2346-2352页

作者： Jialu Shi Yan Xu cheng liu Shizhi Wang jin Wang Vijaya Raghavan Key Laboratory of Environmental Medicine and Engineering Ministry of Educationand Department of Nutrition and Food HygieneSchool of Public HealthSoutheast UniversityNanjing 210009China Department of Bioresource Engineering Faculty of Agricultural and Environmental SciencesMcGill UniversitySainte-Anne-de-BellevueQC H9X3V9Canada

Food allergy is a significant public health concern *** probiotics have been found to enhance food allergy by regulating immune-microbe interactions in animal models and ***,the effects of Bifidobacterium lactis Probio-M8 on food allergy have not been thoroughly *** present study examined the anti-allergic properties of Probio-M8,particularly in relation to immune response and gut microbiota *** demonstrate that oral administration of Probio-M8 effectively mitigated the allergy symptoms triggered by ovalbumin(OVA)by ameliorating the morphological damage in the jejunum,reducing OVA-specific IgE and histamine levels in the serum,and suppressing Th2 cytokines(interleukin(IL)4 and IL-13)while increasing Th1 cytokines(interferon(IFN)γ)and regulatory T(Treg)cytokines(IL-10 and transforming growth factor(TGF)β1)in the culture supernatants of splenic ***,Probio-M8 effectively altered the diversity and composition of gut microbiota,particularly the relative abundances of Akkermansia_muciniphila in OVA-induced *** to the OVA group,the Probio-M8 group showed a decrease in the relative abundance of Akkermansia_*** conclusion,Probio-M8 demonstrates the potential to alleviate food allergy by regulating the Th1/Th2 response and modulating gut microbiota,thereby offering a novel therapeutic strategy for patients with food allergy.

关键词： Food allergy Bifidobacterium lactis Probio-M8 T cell immune response Gut microbiota

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Sodium Leak Channel in Glutamatergic Neurons of the Lateral Parabrachial Nucleus Helps to Maintain Respiratory Frequency Under Sevoflurane Anesthesia

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Neuroscience Bulletin 2024年第8期40卷 1127-1140页

作者： Lin Wu Donghang Zhang Yujie Wu jin liu jingyao Jiang cheng Zhou Department of Anesthesiology West China HospitalSichuan UniversityChengdu 610041China Laboratory of Anesthesia and Critical Care Medicine National-Local Joint Engineering Research Centre of Translational Medicine of AnesthesiologyWest China HospitalSichuan UniversityChengdu 610041China

The lateral parabrachial nucleus(PBL)is implicated in the regulation of respiratory *** leak channel(NALCN)mutations disrupt the respiratory rhythm and influence anesthetic sensitivity in both rodents and ***,we investigated whether the NALCN in PBL glutamatergic neurons maintains respiratory function under general *** results showed that chemogenetic activation of PBL glutamatergic neurons increased the respiratory frequency(RF)in mice;whereas chemogenetic inhibition suppressed *** knockdown in PBL glutamatergic neurons but not GABAergic neurons significantly reduced RF under physiological conditions and caused more respiratory suppression under sevoflurane *** knockdown in PBL glutamatergic neurons did not further exacerbate the respiratory suppression induced by propofol or *** sevoflurane anesthesia,painful stimuli rapidly increased the RF,which was not affected by NALCN knockdown in PBL glutamatergic *** study suggested that the NALCN is a key ion channel in PBL glutamatergic neurons that maintains respiratory frequency under volatile anesthetic sevoflurane but not intravenous anesthetic propofol.

关键词： Glutamatergic neurons Lateral parabrachial nucleus NALCN Respiration General anesthesia

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Enhancing blocking temperature using inverse hydrogen bonds for non-radical bridged dimeric Dy(Ⅲ) single-molecule magnets

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Science China Chemistry 2024年第10期67卷 3328-3338页

作者： Peng-Bo jin Qian-cheng Luo Ye-Ye liu Yan-Zhen Zheng Frontier Institute of Science and Technology State Key Laboratory of Electrical Insulation and Power EquipmentMOE Key Laboratory for Nonequilibrium Synthesis and Modulation of Condensed MatterXi'an Key Laboratory of Electronic Devices and Material Chemistry and School of ChemistryXi'an Jiaotong University

Single-molecule magnets（SMMs） are a kind of nanosized magnetic materials that are capable of storing massive bytes of *** coupling the spin centers in a proper manner is a usual approach to promote the working temperature（or blocking temperature） for *** delocalized radicals have been widely employed to accomplish this ***,we show a new manner by using weak but multiple B–Hδ-···Dy3+inverse hydrogen bonding（IHB） interactions to control the magnetic couplings in a series of dimeric dysprosiacaborane *** approach leads to a record high TB100sof 10 K among non-radical bridged dimeric SMMs,which is mainly ascribed to strong ferromagnetic coupling(4.38 cm-1) and the proper alignment of the magnetic principle axes of the adjacent dysprosium（Ⅲ） *** verifying by theoretical calculations,these results demonstrate that IHB interactions can be used to construct strong axial ferromagnetic coupling and enhancing magnetic blocking temperature for SMMs.

关键词： single-molecule magnets carborane dysprosium ferromagnetic coupling inverse hydrogen bond

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Revolutionizing plasmonic platform via magnetic field-assisted confined ultrafast laser deposition of high-density,uniform,and ultrafine nanoparticle arrays

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International Journal of Extreme Manufacturing 2024年第3期6卷 428-438页

作者： jin Xu Lingfeng Wang Peilin Yang Haoqing Jiang Huai Zheng Licong An Xingtao liu Gary J cheng School of Industrial Engineering Purdue UniversityWest LafayetteIN 47906United States of America Institute of Technological Sciences Wuhan UniversityWuhanHubei 430072People’s Republic of China

The remarkable capabilities of 2D plasmonic surfaces in controlling optical waves havegarnered significant ***,the challenge of large-scale manufacturing of uniform,well-aligned,and tunable plasmonic surfaces has hindered their *** address this,we present a groundbreaking tunable plasmonic platform design achieved throughmagnetic field(MF)assisted ultrafast laser direct deposition in *** precise control of metal nanoparticles(NPs),with cobalt(Co)serving as the model material,employing an MF,and fine-tuning ultrafast laser parameters,we have effectively converted coarse and non-uniform NPs into densely packed,uniform,and ultrafine NPs(~3 nm).This revolutionary advancement results in the creation of customizable plasmonic‘hot spots,’which play a pivotal role insurface-enhanced Raman spectroscopy(SERS)*** profound impact of this designable plasmonic platform lies in its close association with plasmonic resonance and *** the plasmonic nanostructures resonate with incident light,they generate intense local electromagnetic fields,thus vastly increasing the Raman scattering *** enhancement leads to an outstanding 2–18 fold boost in SERS performance and unparalleled sensing sensitivity down to 10^(-10)***,the plasmonic platform also demonstratesrobustness,retaining its sensing capability even after undergoing 50 cycles of rinsing andre-loading of ***,this work adheres to green manufacturing standards,making it an efficient and environmentally friendly method for customizing plasmonic‘hot spots’inSERS *** study not only achieves the formation of high-density,uniform,and ultrafine NP arrays on a tunable plasmonic platform but also showcases the profound relation betweenplasmonic resonance and energy *** outstanding results observed in SERS sensors further emphasize the immense potential of this technology for energy-relatedapplications,including photocatalysis,ph

关键词： magnetic field manipulation laser deposition metasurface SERS

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Tumor necrosis factor-stimulated gene-6 ameliorates early brain injury after subarachnoid hemorrhage by suppressing NLRC4 inflammasome-mediated astrocyte pyroptosis

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Neural Regeneration Research 2024年第5期19卷 1064-1071页

作者： Mingxiang Ding Lei jin Boyang Wei Wenping cheng Wenchao liu Xifeng Li Chuanzhi Duan Neurosurgery Center Department of Cerebrovascular SurgeryThe National Key Clinical SpecialtyThe Engineering Technology Research Center of Education Ministry of China on Diagnosis and Treatment of Cerebrovascular DiseaseGuangdong Provincial Key Laboratory on Brain Function Repair and RegenerationThe Neurosurgery Institute of Guangdong ProvinceZhujiang HospitalSouthern Medical UniversityGuangzhouGuangdong ProvinceChina Department of Cerebrovascular Intervention Zhongshan City People’s HospitalZhongshanGuangdong ProvinceChina

Subarachnoid hemorrhage is associated with high morbidity and mortality and lacks effective *** is a crucial mechanism underlying early brain injury after subarachnoid *** studies have confirmed that tumor necrosis factor-stimulated gene-6(TSG-6)can exert a neuroprotective effect by suppressing oxidative stress and ***,no study to date has explored whether TSG-6 can alleviate pyroptosis in early brain injury after subarachnoid *** this study,a C57BL/6J mouse model of subarachnoid hemorrhage was established using the endovascular perforation *** results indicated that TSG-6 expression was predominantly detected in astrocytes,along with NLRC4 and gasdermin-D(GSDMD).The expression of NLRC4,GSDMD and its N-terminal domain(GSDMD-N),and cleaved caspase-1 was significantly enhanced after subarachnoid hemorrhage and accompanied by brain edema and neurological *** explore how TSG-6 affects pyroptosis during early brain injury after subarachnoid hemorrhage,recombinant human TSG-6 or a siRNA targeting TSG-6 was injected into the cerebral *** TSG-6 administration downregulated the expression of NLRC4 and pyroptosis-associated proteins and alleviated brain edema and neurological ***,TSG-6 knockdown further increased the expression of NLRC4,which was accompanied by more severe astrocyte *** summary,our study revealed that TSG-6 provides neuroprotection against early brain injury after subarachnoid hemorrhage by suppressing NLRC4 inflammasome activation-induced astrocyte pyroptosis.

关键词： astrocyte early brain injury inflammasome NLRC4 pyroptosis subarachnoid hemorrhage tumor necrosis factor-stimulated gene-6(TSG-6)

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Computational Prediction of Graphdiyne-Supported Three-Atom Single-Cluster Catalysts

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CCS Chemistry 2023年第1期5卷 152-163页

作者： jin-cheng liu Hai Xiao Xiao-Kun Zhao Nan-Nan Zhang Yuan liu Deng-Hui Xing Xiaohu Yu Han-Shi Hu Jun Li Department of Chemistry Key Laboratory of Organic Optoelectronics and Molecular Engineering of the Ministry of EducationTsinghua UniversityBeijing Department of Chemistry Southern University of Science and TechnologyShenzhenGuangdong Shaanxi Key Laboratory of Catalysis School of Chemical and Environment SciencesShaanxi University of TechnologyHanzhongShaanxi

While heterogeneous single-atom catalysts(SACs)have achieved great success in the past decade,their application is potentially limited by their simplistic single-atom active centers,which make single-cluster catalysts(SCCs)a natural extension in the domain of heterogeneous *** with precise numbers of atoms and structural configurations possess SAC merits,yet have greater potential for catalyzing complex reactions and/or bulky *** systematic quantum-chemical studies and computational screening,we report here the rational design of transition metal three-atom clusters anchored on graphdiyne(GDY)as a novel kind of stable SCC with great promise for efficient and atomically precise heterogenous *** investigating their structure and catalytic performance for the oxygen reduction reaction,the hydrogen evolution reaction,and the CO_(2)reduction reaction,we have provided theoretical guidelines for their potential applications as heterogeneous *** GDY-supported three-atom SCCs provide an ideal benchmark scaffold for rational design of atomically precise heterogeneous catalysts for industrially important chemical reactions.

关键词： single-cluster catalyst single-atom catalyst graphdiyne atomically precise heterogenous catalysis

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