检索结果-南通市图书馆

Fatty metamorphosis of the liver in patients with breast cancer:Possible associated factors

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2003年第7期9卷 1618-1620页

作者： cheng-hsin chu Shee-Chan Lin Shou-chuan Shih Chin-Roa Kao Sun-Yen Chou Division of Gastroenterology Department of Internal MedicineMackay Memorial HospitalTaipeiTaiwanChina

AIM: To investigate the relationship between breast cancer and fatty liver in Chinese ***: The study group consisted of 217 patients with newly diagnosed breast cancers and the control group of 182 subjects undergoing routine health examination in the same hospital. All subjects were female and the groups were matched for date of study. Ultrasound scanning was performed by the same operator using a 3.5 mHz *** of the liver was diagnosed based on the criteria of Saverymuttu et al. Clinical variables were statistically ***: Fatty liver was diagnosed in 98 patients of the study group and 37 patients of the control group, a significant difference was found in incidence (98/217, 45.2 % and 37/182, 20.3 %; P＜0.0001). On univariate analysis, fatty liver in breast cancer patients was associated with overweight,hyperlipidemia, and hepatitis. On multivariate analysis in the same patients, obesity and hyperlipidemia were significantly associated with fatty ***: The cause of fatty liver in women with breast cancer may be multifactorial. The present study confirms its link with overweight and hyperlipidemia.

关键词：乳腺癌脂肪肝相关性超重高血脂

Eosinophilic gastroenteritis: Clinical experience with 15 patients

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2003年第12期9卷 2813-2816页

作者： Ming-Jen Chen cheng-hsin chu Shee-Chan Lin Shou-chuan Shih Tsang-En Wang Division of Gastroenterology Department of Internal MedicineMackay Memorial HospitalMackay Junior College of NursingTaipeiTaiwanChina

AIM: To evaluate the clinic features of eosinophilicgastroenteritis and to examine the diagnosis, treatment,long-term outcome of this ***: Charts with a diagnosis of eosinophilicgastroenteritis from 1984 to 2002 at Mackay Memorial Hospital were reviewed retrospectively. There were 15 patients diagnosed with eosinophilic gastroenteritis. The diagnosis was established in 13 by histologic evaluation of endoscopic biopsy or operative specimen and in 2 by radiologic imaging and the presence of eosinophilic ***: All the patients had gastrointestinal symptoms and 12 (80 %) had hypereosinophilia (absolute eosinophil count 1 008 to 31 360/cm3). The most common symptoms were abdominal pain and diarrhea. Five of the 15 patients had a history of allergy. Seven patients had involvement of the mucosa, 2 of muscularis, and 6 of subserosa. One with a history of seafood allergy was successfully treated with an elimination diet. Another patient improved spontaneously after fasted for several days. The remaining 13 patients were treated with oral prednisolone, 10 to 40 mg/day initially,which was then tapered. The symptoms in all the patients subsided within two weeks. Eleven of the 15 patients were followed up for more than 12 months (12 to 104 months,mean 48.7), of whom 5 had relapses after discontinuing steroids (13 episodes). Two of these patients required longterm maintenance oral prednisolone (5 to 10 mg/day).CONCLUSION: Eosinophilic gastroenteritis is a rare condition of unclear etiology characterized by relapses and remissions. Short courses of corticosteroids are the mainstay of treatment, although some patients with relapsing disease require long-term low-dose steroids.

关键词：嗜曙红粒细胞增多性肠胃炎临床特点预后诊断药物疗法氢化泼尼松

Outcome of simple use of mechanical lithotripsy of difficult common bile duct stones

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2005年第4期11卷 593-596页

作者： Wen-Hsiung Chang cheng-hsin chu Tsang-En Wang Ming-Jen Chen Ching-chung Lin Division of Gastroenterology Department of Internal Medicine Mackay Memorial HospitalMackay MedicineNursing and Management college TaipeiTaiwan

AIM: The usual bile duct stone may be removed by means of Dormia basket or balloon catheter, and results are quite good. However, the degree of difficulty is increased when stones are larger. Studies on the subject reported many cases where mechanical lithotripsy is combined with a second technique, e.g. electrohydraulic lithotripsy (EHL), where stones are crushed using baby-mother scope electric shock. The extracorporeal shock-wave lithotripsy (ESWL) or laser lithotripsy also yields an excellent success rate of greater than 90%. However, the equipment for these techniques are very expensive; hence we opted for the simple mechanical lithotripsy and evaluated its performance. METHODS: During the period from August 1996 to December 2002, Mackay Memorial Hospital treated 304 patients suffering from difficult bile duct stones (stone>1.5 cm or stones that could not be removed by the ordinary Dormia basket or balloon catheter). These patients underwent endoscopic papillotomy (EPT) procedure, and stones were removed by means of the Olympus BML-4Q lithotripsy. A follow-up was conducted on the post-treatment conditions and complications of the patients. RESULTS: Out of the 304 patients, bile duct stones were successfully removed from 272 patients, a success rate of about 90%. The procedure failed in 32 patients, for whom surgery was needed. Out of the 272 successfully treated patients, 8 developed cholangitis, 21 developed pancreatitis, and 10 patients had delayed bleeding, and no patient died. Among these 272 successful removal cases, successful bile duct stone removal was achieved after the first lithotripsy in 211 patients, whereas 61 patients underwent multiple sessions of lithotripsy. As for the 61 patients that underwent multiple sessions of mechanical lithotripsy, 6 (9.8%) had post-procedure cholangitis, 12 (19.6%) had pancreatitis, and 9 patients (14.7%) had delayed bleeding. Compared with the 211 patients undergoing a single session of mechanical lithotripsy, 3 (1.4

关键词： Common bile duct stones Mechanical lithotripsy

Analysis of clinical manifestations of symptomatic acquired jejunoileal d i verticil la r disease

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2005年第35期11卷 5557-5560页

作者： Chia-Yuan Liu Wen-Hsiung Chang Shee-Chan Lin cheng-hsin chu Tsang-En Wang Shou-chuan Shih Division of Gastroenterology Department of Internal Medicine Mackay Memorial Hospital Taipei Taiwan China Department of Medical Research Mackay Memorial Hospital Taipei Taiwan China Division of Gastroenterology Department of Internal Medicine Mackay Memorial Hospital Taipei Taiwan China Division of Gastroenterology Department of Internal Medicine Mackay Memorial Hospital Taipei Taiwan China Mackay Medicine Nursing and Management College Taipei Taiwan China

AIM: To analyze systematically our experience over 22 years with symptomatic acquired diverticular disease of the jejunum and ileum, exploring the clinical manifestations and diagnosis of this rare but life-threatening ***: The medical records of patients with surgically confirmed symptomatic jejunoileal diverticular disease were retrospectively reviewed. Data collected included demographic data, laboratory results, clinical course (acute or chronic), preoperative diagnosis, and operative findings. Inclusion criteria were as follows: (1) surgical confirmation of jejunoileal diverticular disease and (2)exclusion of congenital diverticula (e.g. Meckel's diverticulum).RESULTS: From January 1982 to July 2004, 28 patients with a total of 29 operations met the study criteria. The male:female ratio was 14:14, and the mean age was 62.6±3.5 years. The most common manifestation was abdominal pain. In nearly half of the patients, the symptoms were chronic. Two patients died after surgery. Only four cases were correctly diagnosed prior to surgery, three by small bowel ***: Symptomatic acquired small bowel diverticular disease is difficult to diagnose. It should be considered in older patients with unexplained chronic abdominal symptoms. A small bowel series may be helpful in diagnosing this potentially life-threatening disease.

关键词： Acquired Symptomatic Jejunoileal Diverticulardisease

Acute transient hepatocellular injury in cholelithiasis and cholecystitis without evidence of choledocholithiasis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2009年第30期15卷 3788-3792页

作者： Chen-Wang Chang Wen-Hsiung Chang Ching-chung Lin cheng-hsin chu Tsang-En Wang Shou-chuan Shih Wen-Hsiung Chang Ching-Chung Lin Cheng-Hsin Chu Tsang-En Wang Division of Gastroenterology Department of Intemal Medicine Mackay Memorial Hospital Mackay Medicine Nursing and Management College Taipei 10449 Taiwan China Division of Gastroenterology Department of Internal Medicine Health Evaluation Center Mackay Memorial Hospital Mackay Medicine Nursing and Management College Taipei 10449 Taiwan China

AIM： To investigate acute transient hepatocellular injury in patients with cholelithiasis and cholecystitis but no evidence of choledocholithiasis.METHODS： The medical records of patients with cholelithiasis who underwent cholecystectomy between July 2003 and June 2007 were retrospectively reviewed. Imaging studies to detect common bile duct （CBD） stones were performed in 186 patients, who constituted the study population. Biochemical liver tests before and after surgery, and with the presence or absence of CBD stones were analyzed.RESULTS： In 96 patients with cholelithiasis and cholecystitis without evidence of CBD stones, 49 （51.0%） had an alanine aminotransferase level elevated to 2-3 times the upper limit of normal, and 40 （41.2%） had an elevated aspartate aminotransferase level. Similar manifestations of hepatocellular injury were, as would be expected, even more obvious in the 90 patients with CBD stones. These markers of hepatocellular injury resolved almost completely within 2 wk to 1 mo after cholecystectomy. Compared to 59 patients with histologically less severe cholecystitisin the group undergoing urgent surgery （total 74 patients）, the 15 patients with a gangrenous gallbladder had a higher mean level of total bilirubin （2.14 ± 1.27 mg/dL vs 2.66 ± 2.97 mg/dL, P 〈 0.001） and white cell count （9480 ± 4681/μL vs 12840 ± 5273/μL, P = 0.018）.CONCLUSION： Acute hepatocellular injury in cholelithiasis and cholecystitis without choledocholithiasis is mild and transient. Hyperbilirubinemia and leukocytosis may predict severe inflammatory changes in the gallbladder.

关键词： Acute transient hepatitis Cholelithiasis Cholecystitis Hyperbilirubinemia Leukocytosis

Concomitant hepatocellular adenoma and adenomatous hyperplasia in a patient without cirrhosis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2003年第3期9卷 627-630页

作者： chuan-Yuan Hsu cheng-hsin chu Shee-Chan Lin Fee-Shih Yang Tsen-Long Yang Kuo-Ming Chang Department of Hepatology & Gastroenterology Mackay Memorial HospitalTaipciTaiwanChina Department of Radiology Mackay Memorial HospitalTaipeiTaiwanChina Department of Surgery Mackay Memorial HospitalTaipeiTaiwanChina Department of Pathology Mackay Memorial HospitalTaipeiTaiwanChina

AIM: Hepatocelluar adenoma (HCA) and adenomatous hyperplasia (AH) are rare benign tumors of the liver. HCA is usually found in women who use oral contraceptives. AH usually occurs in patients with liver cirrhosis. Both tumors have potential for malignant ***: We described a male adult with chronic liver disease (CLD) who had been known to be a hepatitis B carrier (HBV) for years. He was found to have a spaceoccupying lesion with a suspicion of hepatocellular carcinoma (HCC) by abdominal ultrasonography. His α-fetoprotein (AFP)was normal. Angiographic findings were consistent with the diagnosis of HCC, he wished to avoid an operation, was treated with transcatheter hepatic arterial ***: He subsequently consented to surgery, and a right lobectomy was performed. The liver pathology disclosed HCA with nuclear dysplasia and post-embolization *** addition, there were multiple small foci of AH with nuclear dysplasia in the resected liver. Although he had some focal areas of cirrhosis-like change or post-embolization effect,the AH was associated only with normal liver ***: This case confirms that HCA and AH may resemble HCC on imaging studies, and that AH may occur in CLD in the absence of cirrhotic change.

关键词：肝细胞腺瘤腺瘤状增生肝硬化合并症乙型肝炎病毒

Clinical analysis of multiple primary malignancies in the digestive system: A hospital-based study

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2005年第27期11卷 4215-4219页

作者： Hui-Yun cheng cheng-hsin chu Wen-Hsiung Chang Tzu-Chi Hsu Shee-Chan Lin chuan-chuan Liu An-Ming Yang Shou-chuan Shih Shih Health Evaluation Center Mackay Memorial hospital TaipeiTaiwan China Department of Internal Medicine Mackay Memorial Hospital Taipei Taiwan China Department of Surgery Mackay Memorial HospitalTaipei Taiwan China Mackay Medicine Nursing and Management College Taipei Taiwan China

AIM： To analyze the characteristics of multiple primary malignancies （MPMs） of digestive system; including incidence, types of tumor combinations, time intervals between development of multiple tumors, clinical course,and prognostic factors affecting survival and ***： Data from a total of 129 patients treated from January 1991 to December 2000 for pathologically proved MPMs, including at least one originating from the digestive system, were reviewed ***： Among 129 patients, 120 （93.02%） had two primary cancers and 9 （6.98%） had three primary cancers. The major sites of MPMs of the digestive system were large intestine, stomach, and liver. Associated nondigestive cancers included 40 cases of gynecological cancers, of which 31 were carcinoma of cervix and 10 cases of genitourinary cancers, of which 5 were bladder cancers. Other cancers originated from the lung, breast,nasopharynx, larynx, thyroid, brain, muscle, and *** tract cancers, especially cervical, ovarian,bladder, and prostate cancers were the most commonlyassociated non-G! cancers, followed by cancer of the lung and breasts. Forty-three cases were synchronous, while the rest （86 cases） were metachronous cancers. Staging of MPMs and treatment regimes correlated with the prognosis between survival and non-survival ***： As advances in cancer therapy bring about a progressively larger percentage of long-term survivors, the proportion of patients with subsequent primary lesions will increase. Early diagnosis of these lesions, based on an awareness of the possibility of second and third cancers, and multidiscipiinary treatment strategies will substantially increase the survival of these patients.

关键词： Multiple primary malignancies Digestive system

Ultrasonography of splenic abnormalities

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2005年第26期11卷 4061-4066页

作者： Ming-Jen Chen Ming-Jer Huang Wen-Hsiung Chang Tsang-En Wang Horng-Yuan Wang cheng-hsin chu Shee-Chan Lin Shou-chuan Shih Division of Gastroenterology Department of Internal Medicine Mackay Memorial Hospital Mackay Medicine Nursing and Management College Taipei Taiwan China Division of Hematology and Oncology Department of Internal Medicine Mackay Memorial Hospital Taipei Taiwan China

AIM: This report gives a comprehensive overview of ultrasonography of splenic abnormalities. Certain ultrasonic features are also discussed with pathologic ***: We review the typical ultrasonic characteristics of a wide range of splenic lesions, illustrating them with images obtained in our institution from 2000 to *** hundred and three patients (47 men, 56 women),with a mean age of 54 years (range 9-92 years), were found to have an abnormal ultrasonic pattern of ***: We describe the ultrasonic features of various splenic lesions such as accessory spleen, splenomegaly,cysts, cavernous hemangiomas, lymphomas, abscesses,metastatic tumors, splenic infarctions, hematomas, and rupture, based on traditional gray-scale and color Doppler ***: Ultrasound is a widely available, noninvasive,and useful means of diagnosing splenic abnormalities. A combination of ultrasonic characteristics and clinical data may provide an accurate diagnosis. If the US appearance alone is not enough, US may also be used to guide biopsy of suspicious lesions.

关键词： Ultrasonography Ultrasound Splenic abnormalities Spleen

Colchicine sensitizes human hepatocellular carcinoma cells to damages caused by radiation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2005年第27期11卷 4237-4240页

作者： Chia-Yuan Liu Hui-Fen Liao Shou-chuan Shih Shee-Chan Lin Wen-Hsiung Chang cheng-hsin chu Tsang-En Wang Yu-Jen Chen Division of Gastroenterology Department of Internal Medic-ine Mackay Memorial Hospital Taipei Taiwan China Department of Medical Research Mackay Memorial Hospital TaipeiTaiwan China Mackay Medicine Nursing and ManagementCollege Taipei Taiwan China Graduate Institute of Sports Coaching Science Chinese Culture University Taipei Taiwan China Department of Radiation Oncology Mackay Memorial Hospital Taipei Taiwan China Department of Molecular Biology and Biochemistry Nation~ Chayi Unversity Chiayi 300 Taiwan China

AIM： We studied the effect of colchicine combined with radiation on the survival of human hepatocellular carcinoma （HCC） HA22T/VGH ***： Twenty-four hours after treatment with 0-8 ng/mL colchicine, HA22T/VGH cells were irradiated at various doses （0, 1, 2, 4, and 8 Gy）. Colony assay was performed to assess the surviving cell fraction. Survival curves were fitted by using a linear-quadratic model to estimate the sensitizer enhancement ratio （SER）. Flow cytometry was used for cell cycle ***： Colchicine at lower concentrations （1 and 2 ng/mL） had obvious synergy with radiation to inhibit HCC cell growth, whereas higher concentrations （4 and 8 ng/mL） had only additive effect to radiation. Pretreatment with 1 and 2 ng/mL colchicine for 24-h enhanced cell killing by radiation with SERs of 1.21 and 1.53, respectively.G2/N arrest was only observed with higher colchicine doses （8 and 16 ng/mL） after 24-h treatment, this effect was neither seen with lower doses （1, 2, and 4 ng/mL）nor with any dose after only 1 h of ***： Our results suggest that colchicine has potential as an adjunct to radiotherapy for HCC *** doses of colchicine possess radiosensitizing effects via some mechanism other than G2/M arrest. Further study is necessary to elucidate the mechanism.

关键词： Colchicine Radiation sensitizer Hepatocellularcarcinoma