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Esophageal granular cell tumors:Report of 9 cases and a literature review

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World Journal of Gastroenterology 2012年第47期18卷 7118-7121页

作者： Guo-Qiang xu Hong-Tan Chen cheng-fu xu Xiao-Dong Teng Department of Gastroenterology the First Affiliated HospitalCollege of MedicineZhejiang University Department of Pathology the First Affiliated HospitalCollege of MedicineZhejiang University

Esophageal granular cell tumors(GCTs) are rare tumors of the *** evaluated the clinical and pathologic features of 9 esophageal GCT patients(5 men and 4 women) from our institute and reviewed the related disease *** age ranged from 25 to 53 years(mean:41 years).All the patients were asymptomatic or presented with non-specific *** GCTs occurred in the distal esophagus and were less than 6 mm in *** analysis showed that the average gray-scale endoscopic ultrasound images of esophageal GCTs were greater than that of esophageal *** patients were treated by endoscopic resection,and 1 patient underwent surgical *** post-therapy recurrence or metastasis developed during follow-up(mean:36.4 mo,range:1-72 mo).

关键词： Esophageal granular cell tumor Endoscopic ultrasonography Computer images analysis

Pre-MASLD:Should it be defined separately?

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Hepatobiliary & Pancreatic Diseases International 2024年第1期23卷 1-3页

作者： Hang-Kai Huang You-Ming Li cheng-fu xu Department of Gastroenterology Zhejiang Provincial Clinical Research Center for Digestive Diseasesthe First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China

Nonalcoholic fatty liver disease(NAFLD)is one of the most common chronic liver diseases,yet it has not received sufficient attention[1].Over the past two decades,the overall global prevalence of NAFLD has risen from 25%to 37%[2].The disease burden of NAFLD is fueled by the epidemic of obesity and diabetes[3].It is estimated that more than half of patients with diabetes have NAFLD.

关键词： NAFLD liver diseases

Association of the frequency of peripheral natural killer T cells with nonalcoholic fatty liver disease

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World Journal of Gastroenterology 2007年第33期13卷 4504-4508页

作者： cheng-fu xu Chao-Hui Yu You-Ming Li Lei xu Juan Du Zhe Shen Department of Gastroenterology The First Affiliated Hospital of Zhejiang University School of Medicine Hangzhou 310003 Zhejiang Province China

AIM: To investigate whether changes in the frequencyof peripheral natural killer T (NKT) cells were correlatedwith liver disease in patients who had metabolicpredispositions to nonalcoholic fatty liver disease(NAFLD).METHODS: Peripheral blood samples were obtainedfrom 60 Chinese NAFLD patients and 60 age and gendermatched healthy controls. The frequency of peripheralNKT cells was detected by flow cytometry. Clinical andlaboratory data were collected for further analysis. RESULTS: NAFLD patients had a lower frequencyof peripheral NKT cells than healthy controls (1.21%± 0.06% vs 1.62% ± 0.07%, P furtheranalysis revealed that the frequency of peripheralNKT cells was negatively correlated with body massindex, waist circumference and serum levels of alanineaminotransferase. Logistic regression analysis revealedthat elevated body mass index [hazard ratio (HR):2.991], aspartate aminotransferase levels (HR: 1.148)and fasting blood sugar (HR: 3.133) increased the riskof NAFLD, whereas an elevated frequency of peripheralNKT cells (HR: 0.107) decreased the risk. CONCLUSION: Changes in the frequency of peripheralNKT cells were correlated with NAFLD and a decreasedfrequency of peripheral NKT cells was a risk factor forNAFLD.

关键词： Nonalcoholic fatty liver disease Natural killer T cells Flow cytometry Risk factor

Inflammatory bowel disease unclassified

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2011年第4期12卷 280-286页

作者： Ning ZHOU Wei-xing CHEN Shao-hua CHEN cheng-fu xu You-ming LI Department of Gastroenterology the First Affiliated Hospital College of Medicine Zhejiang University Hangzhou 310003 China

Objective:Inflammatory bowel diseases (IBDs) are idiopathic,chronic,and inflammatory intestinal *** two main types,ulcerative colitis (UC) and Crohn's disease (CD),sometimes mimic each other and are not readily *** purpose of this study was to present a series of hospitalized cases,which could not initially be classified as a subtype of IBD,and to try to note roles of the terms indeterminate colitis (IC) and inflammatory bowel disease unclassified (IBDU) when such a dilemma ***:Medical records of 477 patients hospitalized due to IBD,during the period of January 2002 to April 2009,were retrospectively studied in the present *** available previous biopsies from endoscopies of these patients were ***:Twenty-seven of 477 IBD patients (5.7%) had been initially diagnosed as having *** them,23 received colonoscopy and histological examinations in our hospital.A total of 90% (9/10) and 66.7% (4/6) of patients,respectively,had a positive finding via wireless capsule endoscopy (CE) and double-balloon enteroscopy (DBE).The barium-swallow or small bowel follow-through (SBFT) was performed on 11 *** changes were observed under computer tomographic (CT) scanning in 89.5% (17/19) of *** treatment strategies were employed for all ***:Our data indicate that IBDU accounts for 5.7% of initial diagnoses of *** definition of IBDU is valuable in clinical *** those who had no clear clinical,endoscopic,histological,or other features affording a diagnosis of either UC or CD,IBDU could be used parenthetically.

关键词： Inflammatory bowel disease unclassified Ulcerative colitis Crohn’s disease Subtype Diagnosis

Olfactomedin-4 in digestive diseases: A mini-review

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World Journal of Gastroenterology 2018年第17期24卷 1881-1887页

作者： Xin-Yu Wang Sheng-Hui Chen Ya-Nan Zhang cheng-fu xu Department of Gastro-enterology the First Affiliated Hospital College of Medicine Zhejiang University Department of Geriatrics Zhejiang Provincial People’s Hospital Department of Gastroenterology Key Laboratory of Precision Diagnosis and Treatment for Hepatobiliary and Pancreatic Tumor of Zhejiang Province the First Affiliated Hospital College of Medicine Zhejiang University

Olfactomedin-4(OLFM4, GW112, h GC-1) is a glycoprotein belonging to the olfactomedin family. The expression of OLFM4 is strong in the small intestine, colon and prostate, and moderate in the stomach and bone marrow. Previous studies have revealed that OLFM4 is closely associated with many digestive diseases. Up-regulation of OLFM4 has been detected in the Helicobacter pylori(H. pylori)-infected gastric mucosa, inflammatory bowel disease tissue and gastrointestinal malignancies, including gastric cancer, colorectal cancer, pancreatic cancer and gallbladder cancer. Downregulation of OLFM4 has also been detected in some cases, such as in poorly differentiated, advancedstage and metastatic tumors. Studies using OLFM4-deficient mouse models have revealed that OLFM4 acts as a negative regulator of H. pylori-specific immune responses and plays an important role in mucosal defense in inflammatory bowel disease. Patients with OLFM4-positive gastric cancer or colorectal cancer have a better survival rate than OLFM4-negative patients. However, the prognosis is worse in pancreatic cancer patients with high levels of expression of OLFM4. The NF-κB, Notch and Wnt signaling pathways are involved in the regulation of OLFM4 expression in digestive diseases, and its role in pathogenesis is associated with anti-inflammation, apoptosis, cell adhesion and proliferation. OLFM4 may serve as a potential specific diagnostic marker and a therapeutic target in digestive diseases. further studies are required to explore the clinical value of OLFM4.

关键词： Olfactomedin-4 Inflammation Cancer Helicobacter pylori infection

Risk factors for alcohol-related liver injury in the island population of China: A population-based case-control study

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World Journal of Gastroenterology 2008年第14期14卷 2255-2261页

作者： Zhe Shen You-Ming Li Chao-Hui Yu Yi Shen Lei xu cheng-fu xu Jin-Jin Chen Hua Ye Gen-Yun xu Department of Gastroenterology The First Affiliated Hospital Medicine School Zhejiang University Hangzhou 310003 Zhejiang Province China Department of Statistics Medicine School Zhejiang University Hangzhou 310000 Zhejiang Province China Department of Clinical Laboratory The First Affiliated Hospital Medicine School Zhejiang University Hangzhou 310003 Zhejiang Province China

AIM:To investigate the association of alcohol dose, duration of drinking and obesity with abnormal alcohol-related liver injury indicators, the prevalence of alcohol-related liver injury in the island population of ***:Randomized multistage stratified cluster sampling from the island population of China was used in the population-based case-control study. Then interview, physical examination, laboratory assessments and ultrasonography were done. RESULTS:Daily alcohol intake ≥ 20 g, duration of drinking ≥ 5 years and obesity were closely related to alcohol-related liver injury (P < 0.05). The odds-ratio (OR) (95% CI) was 1.965 (1.122-3.442), 3.412 (1.789-6.507) and 1.887 (1.261-2.824), respectively. The prevalence rate of alcohol-related liver injury in ≥ 20 g daily alcohol intake group and < 20 g daily alcohol intake group was 37.14% and 12.06%, respectively. The prevalence rate of alcohol-related liver injury in ≥ 5 years drinking group and < 5 years drinking group was 34.44% and 8.53%, respectively. No significant dose-response relation was found between daily alcohol intake and abnormal alcohol-related liver injury indicators as well as between duration of drinking and abnormal alcohol-related liver injury indicators. There was no significant difference in the prevalence of alcohol-related liver injury between beer drinking group and yellow rice wine drinking group, hard liquor drinking group, multiple drinking ***:The risk threshold of daily alcohol intake is 20 g and duration of drinking inducing alcohol-related liver injury 5 years in the island population of China. Liver injury induced by obesity should be concerned.

关键词： Alcohol Liver injury Prevalence Case-control study Epidemiology

Association of caveolin-3 and cholecystokinin A receptor with cholesterol gallstone disease in mice

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World Journal of Gastroenterology 2014年第28期20卷 9513-9518页

作者： Guo-Qiang xu cheng-fu xu Hong-Tan Chen Shan Liu Xiao-Dong Teng Gen-Yun xu Chao-Hui Yu Department of Gastroenterology the First Affiliated HospitalCollege of MedicineZhejiang University Department of Pathology the First Affiliated HospitalCollege of MedicineZhejiang University Department of Laboratory Medicine the First Affiliated HospitalCollege of MedicineZhejiang University

AIM: To investigate the role of caveolin-3 (CAV3) and cholecystokinin A receptor (CCKAR) in cholesterol gallstone disease (CGD).

关键词： Cholesterol gallstone disease Caveolin-3 Cholecystokinin A receptor Lithogenic diet Mechanism

Association between serum alpha-fetoprotein levels and fatty liver disease: A cross-sectional study

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World Journal of Gastroenterology 2014年第33期20卷 11865-11870页

作者： Ping xu cheng-fu xu Xing-yong Wan Chao-hui yu Chao Shen Peng Chen Gen-yun xu You-ming Li Department of Gastroenterology the First Affiliated Hospital College of Medicine Zhejiang University International Health Care Center the First Affiliated Hospital College of Medicine Zhejiang University Department of Laboratory Medicine the First Affiliated Hospital College of Medicine Zhejiang University

AIM: To investigate the association between serum alpha-fetoprotein (AFP) levels and fatty liver disease (FLD) in a Chinese population.

关键词： Fatty liver Alpha-fetoprotein Association Obesity Risk factor

Role of endoplasmic reticulum stress in the pathogenesis of nonalcoholic fatty liver disease

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World Journal of Gastroenterology 2014年第7期20卷 1768-1776页

作者： xue-Qun Zhang cheng-fu xu Chao-Hui Yu Wei-Xing Chen You-Ming Li Department of Gastroenterology The First Affiliated HospitalCollege of MedicineZhejiang University

Nonalcoholic fatty liver disease(NAFLD)has emerged as a common public health problem in recent ***,the underlying mechanisms leading to the development of NAFLD are not fully *** endoplasmic reticulum(ER)stress response has recently been proposed to play a crucial role in both the development of steatosis and progression to nonalcoholic *** stress is activated to regulate protein synthesis and restore homeostatic equilibrium when the cell is stressed due to the accumulation of unfolded or misfolded ***,delayed or insufficient responses to ER stress may turn physiological mechanisms into pathological consequences,including fat accumulation,insulin resistance,inflammation,and apoptosis,all of which play important roles in the pathogenesis of ***,understanding the role of ER stress in the pathogenesis of NAFLD has become a topic of intense *** review highlights the recent findings linking ER stress signaling pathways to the pathogenesis of NAFLD.

关键词： Endoplasmic reticulum stress Unfolded protein response Nonalcoholic fatty liver disease Nonalcoholic steatohepatitis