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Comparative effectiveness of first-line therapies for eradication of antibiotic-resistant Helicobacter pylori strains:A network metaanalysis

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World Journal of Clinical Cases 2022年第35期10卷 12959-12970页

作者： Shu-Peng Zou Qian cheng cheng-yang feng Chan Xu Ming-Hui Sun Department of Pharmacy Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430000Hubei ProvinceChina

BACKGROUND As a first-line treatment regimen for Helicobacter pylori(***)infection,antibiotic therapy is widely used ***,the question of increasing antibiotic resistance must be *** this issue,we need to find ways to reduce drug *** study examined all currently available first-line regimens and compared them with standard triple treatment through a network meta-analysis of randomized controlled trials(RCTs).AIM To compare first-line treatment regimens for eradication of antibiotic-resistant *** *** To compare the effectiveness of the first-line regimens for treating *** infection,a Bayesian network meta-analysis was applied to process data extracted from *** plausible ranking for each regimen was assessed by the surface under the cumulative ranking curve(SUCRA).In addition,we conducted a relevant search by reference citation *** Twenty-five RCTs involving 12029 participants[including 1602 infected with clarithromycin(CAM)-resistant strains and 1716 infected with metronidazole(MNZ)-resistant strains]were included,in which a total of seven regimens were used for *** *** results showed that dual therapy containing a high-dose proton pump inhibitor(HDDT)[odds ratio(OR):4.20,95%confidence interval(CI):2.29-8.13]was superior to other therapies for all patients,including those with CAM/MNZ-resistant *** *** the comparative effectiveness ranking,for CAM-resistant ***,HDDT(OR:96.80,95%CI:22.46-521.9)had the best results,whereas standard triple therapy ranked last(SUCRA:98.7%vs 0.3%).In the subgroup of high cure rates(≥90%),HDDT was also generally better than other *** For the eradication of CAM-and MNZ-resistant *** strains,HDDT exhibited considerable *** studies of CAM-resistant *** were based on small samples due to a lack of antibiotic sensitivity tests in many RCTs,but the results showed that all patients,including

关键词： Helicobacter pylori Clarithromycin resistance First-line therapy Proton pump inhibitors

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DNA Damage,Apoptosis and C-myc,C-fos,and C-jun Overexpression Induced by Selenium in Rat Hepatocytes

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Biomedical and Environmental Sciences 2006年第3期19卷 197-204页

作者： RI-AN YU cheng-feng yang XUE-MIN CHEN Department of Occupational and Environmental Health MOE Key Laboratory of Environment and Health School of Public Health Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 Hubei China

Objective To study the effects of selenium on DNA damage, apoptosis and c-myc, c-fos, and c-jun expression in rat hepatocytes. Methods Sodium selenite at the doses of 5, 10, and 20 μmol/kg was given to rats by i.p. and there were 5 male SD rats in each group. Hepatocellular DNA damage was detected by single cell gel electrophoresis （or comet assay）. Hepatocellular apoptosis was determined by TUNEL （TdT-mediated dUTP nick end labelling） and flow cytometry. C-myc, c-fos, and c-jun expression in rat bepatocytes were assayed by Northern dot hybridization. C-myc, c-fos, and c-jun protein were detected by immunohistochemical method. Results At the doses of 5, 10, and 20μmol/kg, DNA damage was induced by sodium selenite in rat hepatocytes and the rates of comet cells were 34.40%, 74.80%, and 91.40% respectively. Results also showed an obvious dose-response relationship between the rates of comet cells and the doses of sodium selenite （r=0.9501, P〈0.01）. Sodium selenite at the doses of 5, 10, and 20μmol/kg caused c-myc, c-fos, and c-jun overexpression obviously. The positive brown-yellow signal for proteins of c-myc, c-fos, and c-jun was mainly located in the cytoplasm of bepatocytes with immunohistocbemical method. TUNEL-positive cells were detected in selenium-treated rat livers. Apoptotic rates （%） of selenium-treated liver cells at the doses of 5, 10, and 20 μmol/kg were （3.72±1.76）, （5.82±1.42）, and （11.76±1.87） respectively, being much higher than those in the control. Besides an obvious dose-response relationship between apoptotic rates and the doses of sodium selenite （r=0.9897, P〈0.01）, these results displayed a close relationship between DNA damage rates and apoptotic rates, and the relative coefficient was 0.9021, P〈0.01. Conclusion Selenium at 5-20μmol/kg can induce DNA damage, apoptosis, and overexpression of c-myc, c-fos, and c-jun in rat hepatocytes.

关键词： Selenium DNA damage Apoptosis C-myc C-fos C-jun

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Reconstruction of a muon bundle in the JUNO central detector

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Nuclear Science and Techniques 2022年第5期33卷 78-90页

作者： cheng-feng yang Yong-Bo Huang Ji-Lei Xu Di-Ru Wu Yong-Peng Zhang Wu-Ming Luo Miao He Guo-Ming Chen Si-Yuan Zhang School of Physical Science and Technology Guangxi UniversityNanning 530004China Institute of High Energy Physics Beijing 100049China University of Chinese Academy of Sciences Beijing 100049China

The Jiangmen Underground Neutrino Observatory(JUNO)is a multi-purpose neutrino *** of the main goals is to determine the neutrino mass ordering by precisely measuring the energy spectrum of reactor *** the detection of reactor antineutrinos,cosmogenic backgrounds,such as^(9)Li/^(8)He and fast neutrons induced by cosmic muons,should be rejected carefully by applying muon veto cuts,which require good muon track *** a 20-kton liquid scintillator detector,the simulation shows the proportion of muon bundles(muon multiplicity≥2)to be approximately 8%in JUNO,whereas its reconstruction has been rarely discussed in previous *** study proposes an efficient algorithm for muon track reconstruction based on the charge response of a photomultiplier tube *** is the first reconstruction of muon bundles in a large-volume liquid scintillator *** addition,the algorithm shows good performance and potential for reconstruction for both a single muon and double muons(muon multiplicity=2).The spatial resolution of a single-muon reconstruction was20 cm,and the angular resolution was 0.5°.For doublemuon reconstruction,the spatial and angular resolutions could be 30 cm and 1.0°,***,this paper also discusses muon classification and the veto strategy.

关键词： JUNO Liquid scintillatordetector Muon reconstruction Muon bundle Veto strategy

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Localizing base stations with measured data:a concatenated image-based deep learning approach

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Science China(Information Sciences) 2025年

作者： yang CHEN Ziyuan LIU feng JIANG Hong SHEN Wei XU Mengyu LI Ritao cheng National Mobile Communications Research Laboratory Southeast University China Mobile Group Design Institute Co. Ltd.

Localization has become an indispensable function of modern cellular communication systems[1]. In a cloud radio access network （C-RAN）, the remote radio head （RRH） is the actual signal transmitter, whose location ...

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Wireless Regional Area Networks and Cognitive Radio 2

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ZTE Communications 2006年第3期4卷 56-60页

作者： Tian feng, cheng Shilun, yang Zhen(Communication Engineering Institute, Nanjing University of Posts and Telecommunications, Nanjing 210003, China)

IEEE has set up in October 2004 the IEEE802.22 Working Group-Wireless Regional Area Network (WRAN) Task Force to work out air interface standard based on Cognitive Radio (CR) technologies. The standard includes Physical Layer (PHY) and Media Access Control (MAC), utilizig the vacant spectrum bands already allocated to broadcast TV without interference.. The WRAN employs CR technologies to sense and estimate the television signals and use the technologies of dynamic spectrum management to find and then allocate vacant spectrums. The CR technologies are representing one of the major trends for future wireless communications. This article on WRANs and CR technologies will be divided into two issues. In this issue, WRANs and IEEE 802.22, CR technologies are introduced. And the second part in the next issue will analyze the applications of CR technologies.

关键词： Radio IEEE ZTE Wireless Regional Area Networks and Cognitive Radio 2 WRAN

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干细胞介导的酶前药策略与肿瘤靶向治疗研究进展

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中华肿瘤防治杂志 2018年第2期25卷 146-150页

作者：冯承阳刘东张程亮华中科技大学同济医学院附属同济医院药学部湖北武汉430030

目的传统化疗在杀灭肿瘤细胞的同时也给患者机体带来了较大的毒副作用,严重影响患者生活质量。近年来,人们利用干细胞定向肿瘤迁移特性将其作为细胞载体,配合酶前药体系共同杀灭肿瘤细胞实现了较好的效果,本文综述了近年来干细胞介导的... 详细信息

目的传统化疗在杀灭肿瘤细胞的同时也给患者机体带来了较大的毒副作用,严重影响患者生活质量。近年来,人们利用干细胞定向肿瘤迁移特性将其作为细胞载体,配合酶前药体系共同杀灭肿瘤细胞实现了较好的效果,本文综述了近年来干细胞介导的酶前药策略在肿瘤靶向治疗中的发展现状。方法应用PubMed分别以"Stem cell,Enzyme,Prodrug,Tumor"等为关键词检索相关文献,检索时间为建库开始到2017-08,共检索到有关英文文献89篇,主要选取近10年文献纳入分析。检索CNKI、维普、万方等中文数据库未发现有关文献,故未纳入中文文献。纳入标准:(1)应用于肿瘤治疗的干细胞及酶前药体系;(2)干细胞介导的酶前药策略治疗肿瘤的原理;(3)干细胞介导酶前药体系治疗肿瘤的疗效与存在问题。依据纳入标准,符合分析的文献共有38篇。结果干细胞介导的酶前药策略治疗肿瘤的原理在于通过基因工程使干细胞携带抗肿瘤前药的代谢酶基因,干细胞进入体内后定向迁移至肿瘤部位并在肿瘤局部表达药物代谢酶,全身给予抗肿瘤前药后,肿瘤局部可以生成浓度高的细胞毒性代谢产物可起杀肿瘤细胞作用。此法不仅可以提高治疗效率还可以减少药物治疗带来的毒副作用。结论干细胞介导的酶前药策略为肿瘤靶向治疗提供了一种新方法,也是近年来肿瘤领域研究的热点之一。随着研究的深入,干细胞介导的酶前药体系将有望更好地应用到肿瘤靶向治疗中。

关键词：干细胞酶/前药肿瘤靶向治疗综述文献

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Characterization of Spatio-Temporal Radio Channel for Macrocellular Environments at 1.95 GHz

Characterization of Spatio-Temporal Radio Channel for Macroc...

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2002海峡两岸三地无线科技研讨会

作者： Yu-Jiun Ren, feng-cheng yang, Li-cheng Chiang, Tsung-Hsien yang, Jenn-Hwan Tarng Department of Communication Engineering, National Chiao Tung University, No. 1001, Dashiue Rd, Hsinchu, Taiwan, China

Spatio-temporal radio channel impulse response for macrocellular systems is measured in urban and suburban areas by using the RUSK vector channel sounder. TOAs (Time-of-Arrivals) and AOAs (Angle-of-Ar

关键词： spatio-temporal radio channel vector channel impulse response smart antennas radio channel characterization

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张永和实验建筑之解

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中外建筑 2007年第1期 69-70页

作者：陈凤阳北京交通大学建筑系

以建筑语言学的基本要素——句法规则解析张永和实验建筑的手法游戏,进而从宏观上解读其创作的后现代性反传统的文化意义,意在提醒建筑理论界对待当今国内一些热门建筑现象要持客观的态度。

关键词：张永和实验建筑建筑语言句法规则建构本体化

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Catalytic atroposelective synthesis of indolyl quinazolinones bearing N-N/C-C diaxes

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Science China Chemistry 2025年

作者： Ning-Yi Wang Shuo Gao Zhu-Di Shu Bei-Bei cheng Chun Ma Yu-Chen Zhang feng Shi Research Center of Chiral Functional Heterocycles School of Chemistry and Materials Science Jiangsu Normal University School of Petrochemical Engineering Changzhou University School of Chemistry and Chemical Engineering Henan Normal University

The first catalytic atroposelective synthesis of indole derivatives bearing N-N/C-C diaxes has been established by the strategy of de novo ring formation. By this strategy, various indolyl quinazolinones bearing vicinal N-N/C-C diaxes were synthesized in high yields with overall good diastereoselectivities and excellent enantioselectivities via chiral phosphoric acid-catalyzed onepot asymmetric formal (5+1) cycloaddition/oxidation reaction. Moreover, such indolyl quinazolinones bearing vicinal N-N/CC diaxes have good configurational stability and could be converted into new chiral ligands with applications in asymmetric catalysis. Therefore, this work not only offered a new member for the family of diaxial atropisomers, but also provided a powerful strategy for catalytic asymmetric synthesis of atropisomers bearing N-N/C-C diaxes.

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广义混合问题中的离散现象

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无锡轻工业学院学报 1983年第3期 1-13页

作者：成风旸蔡日增

本文对非主型方程Lpu=uxx-x2utt+put=0的广义混合问题的离散现象进行了讨论。文中证明了当p≠P3,7,11,…时,问題的解是存在唯一的;当p=3,7,11,…时,唯一性破坏了,存在性一般也不成立。或者更确切地说,只有在适当的相容条件下,问題的解... 详细信息

本文对非主型方程Lpu=uxx-x2utt+put=0的广义混合问题的离散现象进行了讨论。文中证明了当p≠P3,7,11,…时,问題的解是存在唯一的;当p=3,7,11,…时,唯一性破坏了,存在性一般也不成立。或者更确切地说,只有在适当的相容条件下,问題的解才是存在的。

关键词：离散现象方程唯一性非平凡解能量积分法存在性非零解定理定解问题极限函数零点点(数学) 存在唯一

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