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Serological prevalence and risk factor analysis of hepatitis G virus infection in Hubei Province of China

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World Journal of Gastroenterology 2000年第4期6卷 585-587页

作者： De Ying Tian Dao Feng Yang Ning Shao Xia Zheng Gang Zhang Hong Bo Lei yuan cheng huang Department of Infectious Diseases Tongji HospitalTongji Medical UniversityWuhan 430030Hubei ProvinceChina Unit of National Genetic Engineering Xiamen UniversityXiamen 361005Fujian ProvinceChina

Hepatitis G virus (HGV),also known as GB virus C, is a recently cloned virus which may be associated with human non A-E hepatitis[1，2] It is parenterally transmitted and usually coinfected or superinfected with hepatitis B or hepatitis C virus[3-5]. Some investigations have been reported on the seroprevalence and molecular prevalence of HGV infection in different areas and different population[6-15]. Current infection of HGV is diagnosed by detection of HGV RNA, and past infection with HGV is detectable by testing anti-HGV envelope protein (E2)[16-17]. To investigate the prevalence of HGV in Hubei Province, a central area of the People's Republic of China, ELISA and RT-PCR were employed to detect serum anti-HGV and HGV RNA in 1516 patients who were divided into 16 groups.

关键词： hepatitis G virus enzyme linked immunoabsorbent assay risk factors polymerase chain reaction prevalence transcription genetic

Ten-year Time-trend Analysis of Dyslipidemia Among Adults in Wuhan

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Current Medical Science 2022年第5期42卷 1099-1105页

作者： Man ZHANG Zheng-ce WAN Yong-man LV yuan-cheng huang Liu HU Hui XU Xiao-mei LEI Health Management Center Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China

Objective Dyslipidemia is associated with an increased risk of cardiovascular disease,the major cause of death in an aging *** study aimed to estimate the prevalence of dyslipidemia for the past decade among adults in Wuhan,*** We performed a serial cross-sectional study that recruited 705219 adults from the Health Management Center of Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology from 2010 to *** diagnosis of dyslipidemia was based on the 2016 Chinese Guidelines for the Management of Dyslipidemia in *** effects and random effects models were applied to adjust the confounding variables(gender and age).Results The overall prevalence of dyslipidemia was 33.1%(46.2%in men and 14.7%in women)in *** prevalence of dyslipidemia was significantly increased over 10 years[from 28.6%(95%CI:28.2%–29.1%)in 2010 to 32.8%(95%CI:32.6%–33.1%)in 2019;.P<0.001],especially for hypo-high-density lipoprotein cholesterolemia[from 18.4%(95%CI:18.0%–18.8%)in 2010 to 24.5%(95%CI:24.3%–24.7%)in 2019;P<0.001].In 2019,the prevalence of dyslipidemia was higher in participants with comorbidities,including overweight/obesity,hypertension,diabetes,hyperuricemia,or chronic kidney disease,and dyslipidemia was the most significant among participants aged 30–39 *** This study demonstrated that dyslipidemia is on the rise in men,and more emphasis should be provided for the screening of dyslipidemia in young males for the primary prevention of cardiovascular and renal diseases.

关键词： dyslipidemia prevalence man cardiovascular disease

Carbohydrate-associated epitope-based anti-cancer drugs and vaccines

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Advances in Bioscience and Biotechnology 2013年第9期4卷 18-23页

作者： Gregory Lee cheng-yuan huang Song-Nan Chow Chin-Hsiang Chien Department of Obstetrics/Gynecology National Taiwan University Hospital Taipei Chinese Taipei Institute of Biochemistry and Molecular Biology National Yang Ming University Taipei Chinese Taipei UBC Center for Reproductive Health University of British Columbia Vancouver Canada Vancouver BioTech Ltd. Vancouver Canada

RP215 is one of the three thousand monoclonal antibodies (Mabs) which were generated against the OC-3-VGH ovarian cancer cell line. RP215 was shown to react with a carbohydrate-associated epitope located specifically on glycoproteins, known as CA215, from cancer cells. Further molecular analysis by matrix adsorption laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) revealed that CA215 consists mainly of immunoglobulin super-family (IgSF) proteins, including immunoglobulins, T-cell receptors, and cell adhesion molecules, as well as several other unrelated proteins. Peptide mappings and glycoanalysis were performed with CA215 and revealed high-mannose and complex bisecting structures with terminal sialic acid in N-glycans. As many as ten O-glycans, which are structurally similar to those of mucins, were also identified. In addition, two additional O-linked glycans were exclusively detected in cancerous immunoglobulins but not in normal B cell-derived immunoglobulins. Immunizations of mice with purified CA215 resulted in the predominant generation of RP215-related Mabs, indicating the immunodominance of this carbohydrate-associated epitope. Anti-idiotype (anti-id) Mabs of RP215, which were generated in the rat, were shown to contain the internal images of the carbohydrate-associated epitope. Following immunizations of these anti-id Mabs in mice, the resulting anti-anti-id (Ab3) responses in mice were found to be immunologically similar to that of RP215. Judging from these observations, anti-id Mabs, which carry the internal image of the RP215-specific epitope, may be suitable candidates for anticancer vaccine development in humans.

关键词： Anti-Cancer Drugs Anti-Cancer Vaccines Anti-Idiotype CA215 Carbohydrate-Associated Epitope Immunodominance RP215

Cerebral fat embolism following autologous fat injection in facial reconstruction:A case report

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World Journal of Clinical Cases 2025年第2期13卷 50-58页

作者： Xiu-Ying Chen Fa Shen Chang cheng Yu-Han Wang Wen-Chao cheng De-Zhi yuan Wen huang Department of Neurology Chongqing Emergency Medical CenterChongqing University Central HospitalChongqing 400000China Department of Neurology Xinqiao HospitalThe Army Medical University(Third Military Medical University)Chongqing 400000China

BACKGROUND Autologous fat injection in facial reconstruction is a common cosmetic *** cerebral fat embolism(CFE)as a complication is rare,it carries serious health *** SUMMARY We present a case of a 29-year-old female patient who developed acute CFE following facial fat filling *** the surgery,the patient experienced symptoms including headache,nausea,vomiting,and difficulty breathing,which was followed by neurological symptoms such as slurred speech and left-sided *** physical examination and auxiliary investigations,including blood tests,head and neck computed tomography angiography,and cranial magnetic resonance diffusion-weighted imaging,were performed upon *** clinical diagnosis was acute cerebral embolism following facial fat filling *** included measures to improve cerebral circulation,dehydration for intracranial pressure reduction,nutritional support,and rehabilitation therapy for left limb *** patient showed a significant improvement in symptoms after 2 weeks of *** recovered left limb muscle strength to grade 5,had clear speech,and experienced complete relief of *** Our case highlights the potential occurrence of severe complications in patients undergoing fat injection in facial *** prevent these complications,plastic surgeons should enhance their professional knowledge and skills.

关键词： Cerebral fat embolism Mechanical thrombectomy Thrombolysis Steroid therapy Symptomatic treatment Case report

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羧甲基糯玉米淀粉在分散印花中的应用

印染 2017年第6期43卷 32-35页

作者：霍倩谭艳君田呈呈黄媛媛产业用纺织品协同创新中心西安工程大学陕西西安710048 西安工程大学纺织与材料学院陕西西安710048

以糯玉米淀粉和氯乙酸为原料,乙醇和异丙醇为溶剂,制备羧甲基糯玉米淀粉。通过正交试验,优化了羧甲基糯玉米淀粉(CMS)的合成工艺,即:溶剂[V(乙醇)∶V(异丙醇)为1∶1]质量分数94%,35℃碱化处理90 min,55℃醚化处理4.5 h,n(氯乙酸)∶n(淀... 详细信息

以糯玉米淀粉和氯乙酸为原料,乙醇和异丙醇为溶剂,制备羧甲基糯玉米淀粉。通过正交试验,优化了羧甲基糯玉米淀粉(CMS)的合成工艺,即:溶剂[V(乙醇)∶V(异丙醇)为1∶1]质量分数94%,35℃碱化处理90 min,55℃醚化处理4.5 h,n(氯乙酸)∶n(淀粉)为1.15∶1,n(NaOH)∶(淀粉)为2.55∶1。测试合成的羧甲基n糯玉米淀粉性能发现,糯玉米淀粉经羧甲基化后表面结构发生变化,形成膨胀黏结;红外光谱证实羧基基团引入到糯玉米淀粉。以合成的羧甲基糯玉米淀粉为印花糊料,与海藻酸钠(SA)糊料进行复配后用于分散染料印花,优化的印花工艺为:m(CMS)∶m(SA)为1∶1,195℃焙烘120 s。

关键词：分散染料印花羧甲基糯玉米淀粉取代度涤纶

Identifying the dynamic behaviors in complete reconstruction of Co-based complex precatalysts during electrocatalytic oxygen evolution

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Journal of Energy Chemistry 2025年第1期100卷 226-233页

作者： Jingfang Zhang Danyang Wu Linke Cai Youluan Lu Fanpeng cheng Lijuan Shi Qun Yi Yao Liu Yi huang Key Laboratory of Green Chemical Engineering Process of Ministry of Education Engineering Research Center of Phosphorus Resources Development and Utilization of Ministry of Education Hubei Key Laboratory of Novel Reactor and Green Chemical Technology School of Chemical Engineering & Pharmacy Wuhan Institute of Technology Key Laboratory of Pesticide & Chemical Biology of Ministry of Education Engineering Research Center of Photoenergy Utilization for Pollution Control and Carbon Reduction of Ministry of Education College of Chemistry Central China Normal University College of Materials Science and Engineering Fuzhou University

Transition metal-based nanomaterials have emerged as promising electrocatalysts for oxygen evolution reaction（OER）. Considerable research efforts have shown that self-reconstruction occurs on these nanomaterials under operating conditions of OER process. However, most of them undergo incomplete reconstruction with limited thickness of reconstruction layer, leading to low component utilization and arduous exploration of real catalytic mechanism. Herein, we identify the dynamic behaviors in complete reconstruction of Co-based complexes during OER. The hollow phytic acid（PA） cross-linked CoFe-based complex nanoboxes with porous nanowalls are designed because of their good electrolyte penetration and mass transport ability, in favor of the fast and complete reconstruction. A series of experiment characterizations demonstrate that the reconstruction process includes the fast substitution of PA by OH-to form Co（Fe）(OH)xand subsequent potential-driven oxidation to Co（Fe）OOH. The obtained CoFeOOH delivers a low overpotential of 290 mV at a current density of 10 mA cm-2and a long-term *** experiment results together with theory calculations reveal that the Fe incorporation can result in the electron rearrangement of reconstructed CoFeOOH and optimization of their electronic structure,accounting for the enhanced OER activity. The work provides new insights into complete reconstruction of metal-based complexes during OER and offers guidelines for rational design of high-performance electrocatalysts.

关键词： Complete reconstruction Co-based complex Precatalysts Oxygen evolution reaction

Relationship between longitudinal changes in lipid composition and ischemic stroke among hypertensive patients

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World Journal of Clinical Cases 2025年第4期13卷 18-27页

作者： cheng-cheng Wei Yu-Qing huang cheng-Hong Yu Department of Cardiology Tongxiang First People's HospitalTongxiang 314500Zhejiang ProvinceChina Department of Cardiology Guangdong Cardiovascular InstituteGuangzhou 510080Guangdong ProvinceChina

BACKGROUND Dyslipidemia was strongly linked to stroke,however the relationship between dyslipidemia and its components and ischemic stroke remained *** To investigate the link between longitudinal changes in lipid profiles and dyslipidemia and ischemic stroke in a hypertensive *** Between 2013 and 2014,6094 hypertension individuals were included in this,and ischemic stroke cases were documented to the end of *** changes of lipid were stratified into four groups:(1)Normal was transformed into normal group;(2)Abnormal was transformed into normal group;(3)Normal was transformed into abnormal group;and(4)Abnormal was transformed into abnormal *** examine the link between longitudinal changes in dyslipidemia along with its components and the risk of ischemic stroke,we utilized multivariate Cox proportional hazards models with hazard ratio(HR)and 95%*** The average age of the participants was 62.32 years±13.00 years,with 329 women making up 54.0%of the *** the course of a mean follow-up of 4.8 years,143 ischemic strokes *** normal was transformed into normal group was used as a reference,after full adjustments,the HR for dyslipidemia and ischemic stroke among abnormal was transformed into normal group,normal was transformed into abnormal group and abnormal was transformed into abnormal Wei CC et *** changed and ischemic stroke WJCC https://*** 2 February 6,2025 Volume 13 Issue 4 group were 1.089(95%CI:0.598-1.982;P=0.779),2.369(95%CI:1.424-3.941;P<0.001)and 1.448(95%CI:1.002-2.298;P=0.047)(P for trend was 0.233),*** In individuals with hypertension,longitudinal shifts from normal to abnormal in dyslipidemia-particularly in total and low-density lipoprotein cholesterol-were significantly associated with the risk of ischemic stroke.

关键词： Longitudinal change Hypertension Dyslipidemia Lipid profile Ischemic stroke

Preparation of FeCoNi medium entropy alloy from Fe^(3+)-Co^(2+)-Ni^(2+)solution system

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 92-101页

作者： Zongyou cheng Qing Zhao Mengjie Tao Jijun Du Xingxi huang chengjun Liu Key Laboratory for Ecological Metallurgy of Multimetallic Mineral(Ministry of Education) Northeastern UniversityShenyang 110819China School of Metallurgy Northeastern UniversityShenyang 110819China Engineering Research Center of Frontier Technologies for Low-carbon Steelmaking(Ministry of Education) Shenyang 110819China

In recent years,medium entropy alloys have become a research hotspot due to their excellent physical and chemical *** controlling reasonable elemental composition and processing parameters,the medium entropy alloys can exhibit similar properties to high entropy alloys and have lower *** this paper,a FeCoNi medium entropy alloy precursor was prepared via sol-gel and coprecipitation methods,respectively,and FeCoNi medium entropy alloys were prepared by carbothermal and hydrogen *** phases and magnetic properties of FeCoNi medium entropy alloy were *** showed that FeCoNi medium entropy alloy was produced by carbothermal and hydrogen reduction at 1500℃.Some carbon was detected in the FeCoNi medium entropy alloy prepared by carbothermal *** alloy prepared by hydrogen reduction was uniform and showed a relatively high ***,the hydrogen reduction product exhibited better saturation magnetization and lower coercivity.

关键词： medium entropy alloy sol-gel co-precipitation carbothermal hydrogen reduction

Solar flare forecasting based on a Fusion Model

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Earth and Planetary Physics 2025年第1期9卷 171-181页

作者： YiYang Li ShiYong huang SiBo Xu ZhiGang yuan Kui Jiang QiYang Xiong RenTong Lin School of Earth and Space Science Technology Hubei Luojia LaboratoryWuhan UniversityWuhan 430072China

Solar flare prediction is an important subject in the field of space *** learning technology has greatly promoted the development of this *** this study,we propose a novel solar flare forecasting model integrating Deep Residual Network(ResNet)and Support Vector Machine(SVM)for both≥C-class(C,M,and X classes)and≥M-class(M and X classes)*** collected samples of magnetograms from May 1,2010 to September 13,2018 from Space-weather Helioseismic and Magnetic Imager(HMI)Active Region Patches and then used a cross-validation method to obtain seven independent data *** then utilized five metrics to evaluate our fusion model,based on intermediate-output extracted by ResNet and SVM using the Gaussian kernel *** results show that the primary metric true skill statistics(TSS)achieves a value of 0.708±0.027 for≥C-class prediction,and of 0.758±0.042 for≥M-class prediction;these values indicate that our approach performs significantly better than those of previous *** metrics of our fusion model’s performance on the seven datasets indicate that the model is quite stable and robust,suggesting that fusion models that integrate an excellent baseline network with SVM can achieve improved performance in solar flare ***,we also discuss the performance impact of architectural innovation in our fusion model.

关键词： solar flare pace weather deep learning Fusion Model