检索结果-南通市图书馆

The ferroptosis activity is associated with neurological recovery following chronic compressive spinal cord injury

Neural Regeneration Research 2023年第11期18卷 2482-2488页

作者： Zhengran yu Xing cheng Wenxu Pan cheng yu Yang Duan Department of Spine Surgery Orthopedics Center of Guangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhouGuangdong ProvinceChina Department of Spine Surgery The First Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong ProvinceChina Department of Gastroenterology Guangzhou Women and Children’s Medical CenterJinan UniversityGuangzhouGuangdong ProvinceChina Department of Spine Surgery Zhujiang HospitalSouthern Medical UniversityGuangzhouGuangdong ProvinceChina

Chronic compressive spinal cord injury in compressive cervical myelopathy conditions can lead to rapid neurological deterioration in the early phase,followed by partial self-recovery,and ultimately an equilibrium state of neurological *** is a crucial pathological process in many neurodegenerative diseases;however,its role in chro nic compressive spinal cord injury remains *** this study,we established a chronic compressive spinal cord injury rat model,which displayed its most severe behavioral and electrophysiological dysfunction at 4 wee ks and partial recovery at 8 weeks after *** RNA sequencing data identified enriched functional pathways,including ferroptosis,presynapse,and postsynaptic membrane activity at both 4 and 8 wee ks following chro nic compressive spinal co rd *** nsmission electron microscopy and malondialdehyde quantification assay confirmed that ferroptosis activity peaked at 4 weeks and was attenuated at 8 weeks after chronic *** ptosis activity was negatively correlated with behavioral ***,quantitative polymerase chain reaction,and western blotting showed that expression of the anti-ferroptosis molecules,glutathione peroxidase 4(GPX4) and MAF BZIP transcription factor G(MafG),in neuro ns was suppressed at 4 weeks and upregulated at 8 weeks following spinal co rd *** was a positive correlation between the expression of these two molecules,suggesting that they may work together to contribute to functional recovery following chronic compressive spinal cord *** conclusion,our study determined the genome-wide expression profile and fe rroptosis activity of a consistently compressed spinal cord at different time *** results showed that anti-fe rroptosis genes,specifically GPX4 and MafG,may be involved in spontaneous neurological recovery at 8 weeks of chronic compressive spinal cord *** findings contribute to a better understanding of t

关键词： chronic spinal cord compression compressive cervical myelopathy ferroptosis genome-wide transcriptome glutathione peroxidase 4(GPX4) MAF BZIP transcription factor G(MafG) neurological function

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

T lymphocytes and aortic aneurysms

引用

Science China(Life Sciences) 2014年第8期57卷 795-801页

作者： lv Bing-Jie LI JingYong cheng Xiang Laboratory of Cardiovascular Immunology Institute of CardiologyUnion HospitalTongji Medical CollegeHuazhong University of Science and Technology Laboratory of Biological Targeted Therapy of Ministry of Education

Aortic aneurysms are common and life threatening problems with high rates of *** initiation and progression of aneurysms are characterized by extensive extracellular matrix degradation and immune cells invasion within arterial *** the pathogenesis of all aneurysms,inflammation and immune cells play a significant *** T cells are abundant in aneurysm tissue,their functions in initiation and propagation of aneurysms remain *** review summarizes the current state of knowledge of T lymphocytes on this disease and focuses on potential mechanisms of specific T cell responses.

关键词： T cells cytokines aortic aneurysms inflammation pathogenesis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

引用

Frontiers of Information Technology & Electronic Engineering 2017年第6期18卷 796-807页

作者： Zhen-hua yuAN Chen CHEN Xiang cheng Guo-cheng lv Liu-qing YANG Ye JIN State Key Laboratory of Advanced Optical Communication Systems and Networks Peking University Department of Electrical & Computer Engineering Colorado State University

This article is focused on secure relay beamformer design with a correlated channel model in the relay-eavesdropper network. In this network, a single-antenna source-destination pair transmits secure information with the help of an amplify-and-forward (AF) relay equipped with multiple antennas, and the legitimate and eavesdropping channels are correlated. The relay cannot obtain the instantaneous channel state information (CSI) of the eavesdropper, and has only the knowledge of correlation information between the legitimate and eavesdropping channels. Depending on this information, we derive the conditional distribution of the eavesdropping channel. Two beamformers at the relay are studied for the approximate ergodic secrecy rate:(1) the generalized match-andforward (GMF) beamformer to maximize the legitimate channel rate, and (2) the general-rank beamformer (GRBF).In addition, one lower-bound-maximizing (LBM) beamformer at the relay is discussed for maximizing the lower bound of the ergodic secrecy rate. We find that the GMF beamformer is the optimal rank-one beamformer, that the GRBF is the iteratively optimal beamformer, and that the performance of the LBM beamformer for the ergodic secrecy rate gets close to that of the GRBF for the approximate secrecy rate. It can also be observed that when the relay has lower power or the channel gain of the second hop is low, the performance of the GMF beamformer surpasses that of the GRBF. Numerical results are presented to illustrate the beamformers' performance.

关键词： Physical layer security Relay beamforming Correlated channels Ergodic secrecy rate

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

NUMERICAL SI MULATION OF MOVING SCOUR BOUNDARY AND TURBULENCE FLOWAROUND SUBMARINE PIPELINES

引用

Journal of Hydrodynamics 2005年第4期17卷 404-411页

作者： LI yu-cheng LU Lin State Key Laboratory of Coastal and Offshore Engineering Dalian University of Technology Dalian 116024 China

A two dimensional vertical mathematical model is proposed in this paper for simulating the equilibrium profile of local scour around submarine pipelines. The current model is composed of a new k-ε turbulence model, fitting moving boundary with pre-meshed grid lines and incipient criterion of shear stress for sediments. Employing the proposed model, an instance is carried out numerically and compared with experiments. The calculation results agree well with the experiments. It shows that the improved two equation turbulence model, adopted in this paper is appropriate to simulating the turbulent flow ficld around submarine pipelines, fitting moving boundary with pre-mcshed grid lines method is efficient for moving boundary problems in a multiply connected domain and the stability evaluation method for seabed with critical shear stress based on log-wall law is a reliable choice.

关键词： numerical simulation submarine pipeline local scour moving boundary turbulence model

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Early prediction and prevention of infected pancreatic necrosis

引用

World Journal of Gastroenterology 2024年第9期30卷 1005-1010页

作者： cheng lv Zi-Xiong Zhang Lu Ke Department of Critical Care Medicine Jinling HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjing 210000Jiangsu ProvinceChina Research Institute of Critical Care Medicine and Emergency Rescue Nanjing UniversityNanjing 210000Jiangsu ProvinceChina

Approximately 20%-30%of patients with acute necrotizing pancreatitis develop infected pancreatic necrosis(IPN),a highly morbid and potentially lethal *** identification of patients at high risk of IPN may facilitate appropriate preventive measures to improve clinical *** the past two decades,several markers and predictive tools have been proposed and evaluated for this *** biomarkers like C-reactive protein,procalcitonin,lymphocyte count,interleukin-6,and interleukin-8,and newly developed biomarkers like angiopoietin-2 all showed significant association with *** the other hand,scoring systems like the Acute Physiology and Chronic Health Evaluation II and Pancreatitis Activity Scoring System have also been tested,and the results showed that they may provide better *** early prevention of IPN,several new therapies were tested,including early enteral nutrition,anti-biotics,probiotics,immune enhancement,etc.,but the results *** together,several evidence-supported predictive markers and scoring systems are readily available for predicting ***,effective treatments to reduce the incidence of IPN are still lacking apart from early enteral *** this editorial,we summarize evidence concerning early prediction and prevention of IPN,providing insights into future practice and study design.A more homo-geneous patient population with reliable risk-stratification tools may help find effective treatments to reduce the risk of IPN,thereby achieving individualized treatment.

关键词： Acute pancreatitis Infected pancreatic necrosis Biomarker Scoring system Nutrition therapy Selective digestive decontamination Probiotics Antibiotics Immune enhancement therapy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Extraction behaviours of titanium and other impurities in the decomposition process of ilmenite by highly concentrated KOH solution

引用

International Journal of Minerals,Metallurgy and Materials 2012年第1期19卷 9-14页

作者： yu-min Liu Hua lv Tao Qi Yi Zhang College of Chemistry and Environmental Science Henan Normal University Xinxiang 453007 China Institute of Process Engineering Chinese Academy of Sciences Beijing 100080 China

To effectively utilize ilmenite and recycle KOH solution, the extraction behaviours of titanium and other associated impurities in the decomposition process of ilmenite by highly concentrated KOH solution were studied. Experiments on the extraction behaviours of tita- nium as well as other associated impurities of ilmenite such as iron, silicon, calcium, and aluminium were carried out. The effects of various parameters, including reaction temperature, KOH concentration, reaction time, alkali-to-ore mass ratio, and particle size on the extraction rate of titanium and other impurities were examined. When the finely ground ore （58-75 ~tm） reacted with KOH solution （80wt%） in an al- kali-to-ore mass ratio of 7：1 at 260~C for 60 min, almost complete extraction of titanium was achieved, while the extraction rate of aluminium was 78% and that of other impurities was less than 22%. Moreover, high purity （98.2wt%） TiO2 with the anatase structure could be gained in the purification process.

关键词： ilmenite titanium dioxide potassium hydroxide leaching

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Bulging intervertebral disc:an asymptotic elasticity solution

引用

Acta Mechanica Sinica 2018年第6期34卷 1167-1173页

作者： yu-cheng Lo Liu Wang Orthopaedic Department Changhua Christian HospitalChanghuaChina Department of Aerospace Engineering and EngineeringMechanics Center for Mechanics of SolidsStructures andMaterialsUniversity of Texas at AustinAustinTX78712USA

A bulging intervertebral disc (IVD) occurs when pressure on a spinal disc damages the once healthy disc,causing it to compress or change its normal *** medicine,most attention has been paid clinically to diagnosis of and treatment for such problems,which little effect has been made to understand such issues from a mechanics perspective,i.e.,the bulging deformation of the soft IVD induced by excessive compressive *** report herein a simple elasticity solution to understand the bulging disc *** simplicity,the soft IVD is modeled as an incompressible circular composite layer consisting of an inner nucleus and outer annulus,sandwiched between two vertebral segments which are much stiffer than the IVD and can be treated as rigid *** adopting any assumptions regarding prescribed displacements or stresses,we obtained the stress and displacement fields within the composite layer when a certain compressive stain is applied via an asymptotic *** asymptotic approach is very simple and accurate enough for prediction of the bugling profile of the *** also performed finite-element modeling (FEM) to validate our solutions;the predicted stress and displacement fields inside the composite are in good agreement with the FEM results.

关键词： Bulging intervertebral disc (IVD) Elastic composite layer Asymptotic solution Finite element method

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Deciphering fungal metabolon coupling tandem inverse-electrondemand Diels-Alder reaction and semipinacol rearrangement for the biosynthesis of spiro polycyclic alkaloids

引用

Science China Chemistry 2025年第01期 288-296页

作者： Shuai Liu Wen-Qiang Xu Ying-Tong Di Man-cheng Tang Ding-Kang Chen Ming-Ming Cao Yao-Wen Chang Hong-yu Tang Chun-Mao yuan Jun-Bo Yang Zhi-Li Zuo Han Guo Zi-Fei Xu Ying Zeng yun-Dong Wu Xiao-Jiang Hao Key Laboratory of Phytochemistry and Natural Medicines (Chinese Academy of Sciences) Kunming Institute of Botany Chinese Academy of Sciences University of Chinese Academy of Sciences Lab of Computational Chemistry and Drug Design State Key Laboratory of Chemical Oncogenomics Peking University Shenzhen Graduate School Shenzhen Bay Laboratory State Key Laboratory of Microbial Metabolism School of Life Sciences & Biotechnology Shanghai Jiao Tong University State Key Laboratory of Functions and Applications of Medicinal Plants Guizhou Medical University Molecular Biology Experimental Center Germplasm Bank of Wild Species in Southwest China Kunming Institute of Botany Chinese Academy of Sciences yunnan Key Laboratory for Wild Plant Resources Kunming Institute of Botany Chinese Academy of Sciences Research Unit of Chemical Biology of Natural Anti-Virus Products Chinese Academy of Medical Sciences

In the intricate process of natural product biosynthesis, a metabolon can enhance metabolic flux by associating sequential enzymes. A fungal metabolon, comprising of flavin-dependent monooxygenase Spe F and P450 monooxygenase Spe G, is identified in the biosynthesis of spiro polycyclic alkaloids(+)-notoamide B and its diastereomer(+)-versicolamide B. Using notoamide E as a substance, Spe F/Spe G metabolon can control the stereoselectivity of its 2,3-epoxidation, followed by hydrogen atom ion at C-17 to generate reactive epoxide tau-m A with dienyl iminium unit. Subsequently,(+)-notoamide B and(+)-versicolamide B are produced via tandem nonenzymatic inverse-electron-demand Diels-Alder reaction and semipinacol rearrangement. This provides the first example of metabolon in the biosynthesis of spiro-prenylated indole alkaloids.

关键词：

来源：

同方期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Recent advances in graphene oxide catalyzed organic transformations

引用

Chinese Chemical Letters 2022年第5期33卷 2354-2362页

作者： Fan Gao Shouren Zhang Qiyan lv Bing yu School of Biology College of ChemistryZhengzhou UniversityZhengzhou 450001China Henan Key Laboratory of Nanocomposites and Applications Institute of Nanostructured Functional MaterialsHuanghe Science and Technology CollegeZhengzhou 450006China

Graphene oxide(GO),as a metal-free and readily available carbocatalyst,has been extensively applied in catalytic organic *** minireview aims to give an overview of the progress on the application of native GO as a cat... 详细信息

关键词： Graphene oxide Metal-free Carbocatalyst Eco-friendly

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Lateral position intubation followed by endoscopic ultrasoundguided angiotherapy in acute esophageal variceal rupture: A case report

引用

World Journal of Clinical Cases 2021年第2期9卷 372-378页

作者： Ting-Ting Wen Zheng-lv Liu Min Zeng yu Zhang Bao-Li cheng Xiang-Ming Fang Department of Anesthesiology The First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310003Zhejiang ProvinceChina Department of Anesthesiology The Second Hospital of YinzhouNingbo 315100Zhejiang ProvinceChina

BACKGROUND Massive esophageal variceal bleeding can be catastrophic,leading to high morbidity and *** experiencing massive esophageal variceal bleeding are at high risk of aspiration and hemorrhagic shock in acute *** and bleeding control are the two essential steps for resuscitation of these *** SUMMARY A 47-year-old male patient was admitted to our hospital with upper digestive tract *** was diagnosed with alcohol-induced liver cirrhosis and consequent esophagogastric *** he did not show a good response to somatostatin and Sengstaken-Blakemore tube placement,the patient was scheduled for endoscopic angiotherapy under *** assessment showed an ASA physical status of III and Child-Pugh classification ***,massive hemorrhage occurred just after induction of *** by video-guided laryngoscopy in the lateral decubitus position was attempted twice and was *** that,an experienced endoscopic ultrasound(EUS)specialist performed angiotherapy and occluded the culprit *** ultra-thin gastroscope was then inserted into the endotracheal tube to extract the blood observed in the lobar *** patient suffered hemorrhagic shock with an estimated blood loss of 1500 mL in 20 min and remained in the intensive care unit for two *** patient was discharged from our hospital eight days later without major *** Intubation in the lateral decubitus position and EUS-guided treatment can be lifesaving procedures in patients with massive upper gastrointestinal hemorrhage.

关键词： Intubation in the lateral position Endoscopic ultrasound Esophageal varices Angiotherapy Ultra-thin gastroendoscope Case report

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：