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FSD1 inhibits glioblastoma diffuse infiltration through restriction of HDAC6-mediated microtubule deacetylation

Science China Life Sciences 2025年

作者： Dake Xiao Haowen Ran Lishu Chen Yuanyuan Li Yan Cai Songyang zhang Qinghui Qi Huiran Wu cheng zhang Shuailiang Cao Lanjuan Mi Haohao Huang Ji Qi Qiuying Han Haiqing Tu Huiyan Li Tao Zhou Fangye Li Ailing Li Jianghong Man Nanhu Laboratory National Center of Biomedical Analysis School of Traditional Chinese Medicine Capital Medical University Department of Neurosurgery General Hospital of Central Theater Command of Chinese PLA School of Life and Health Sciences Huzhou College Department of Neurosurgery Beijing Fengtai Hospital Department of Neurosurgery First Medical Center of PLA General Hospital

The infiltration of glioblastoma multiforme(GBM) is predominantly characterized by diffuse spread, contributing significantly to therapy resistance and recurrence of GBM. In this study, we reveal that microtubule deacetylation, mediated through the downregulation of fibronectin type III and SPRY domain-containing 1(FSD1), plays a pivotal role in promoting GBM diffuse infiltration. FSD1 directly interacts with histone deacetylase 6(HDAC6) at its second catalytic domain, thereby impeding its deacetylase activity on α-tubulin and preventing microtubule deacetylation and depolymerization. This inhibitory interaction is disrupted upon phosphorylation of FSD1 at its Ser317 and Ser324 residues by activated CDK5, leading to FSD1 dissociation from microtubules and facilitating HDAC6-mediated α-tubulin deacetylation. Furthermore, increased expression of FSD1 or interference with FSD1 phosphorylation reduces microtubule deacetylation, suppresses invasion of GBM stem cells, and ultimately mitigates tumor infiltration in orthotopic GBM xenografts. Importantly, GBM tissues exhibit diminished levels of FSD1 expression, correlating with microtubule deacetylation and unfavorable clinical outcomes in GBM patients. These findings elucidate the mechanistic involvement of microtubule deacetylation in driving GBM cell invasion and offer potential avenues for managing GBM infiltration.

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Analyzing the Urban Hierarchical Structure Based on Multiple Indicators of Economy and Industry: An Econometric Study in China

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Computer Modeling in Engineering & Sciences 2022年第6期131卷 1831-1855页

作者： Jing cheng yang Xie Jie zhang School of Architecture Tsinghua UniversityBeijing100084China Beijing Tsinghua Tongheng Urban Planning&Design Institute Beijing100085China

For a city,analyzing its advantages,disadvantages and the level of economic development in a country is important,especially for the cities in China developing at flying *** corresponding literatures for the cities in China have not considered the indicators of economy and industry in *** this paper,based on multiple indicators of economy and industry,the urban hierarchical structure of 285 cities above the prefecture level in China is *** indicators from the economy,industry,infrastructure,medical care,population,education,culture,and employment levels are selected to establish a new indicator system for analyzing urban hierarchical *** factor analysis method is used to investigate the relationship between the variables of selected indicators and obtain the score of each common factor and comprehensive scores and rankings for 285 cities above the prefecture level in *** to the comprehensive scores,285 cities above the prefecture level are clustered into 15 levels by using K-means clustering ***,the hierarchical structure system of the cities above the prefecture level in China is obtained and corresponding policy implications are *** results and implications can not only be applied to the urban planning and development in China but also offer a reference on other developing *** methodologies used in this paper can also be applied to study the urban hierarchical structure in other countries.

关键词： Urban planning hierarchical structure prefecture-level city factor analysis method K-means clustering algorithm China

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Partition airflow varying features of chaos-theory-based coalmine ventilation system and related safety forecasting and forewarning system

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International Journal of Mining Science and Technology 2017年第2期27卷 269-275页

作者： zhang Xiaoqiang cheng Weimin zhang Qin yang Xinxiang Du Wenzhou Key Laboratory of Ministry of Education for Mine Disaster Prevention and Control Shandong University of Sdence and TechnologyQingdao 266590China College of Mining and Safety Engineering Shandong University of Science and Technology Qingdao 266590China

To realize real-time monitoring and short-term forecasting and forewarning of coalmine ventilation systems(CVS), in this paper, we first established a joint surface and underground CVS safety management system consisting of main ventilation fan, safety-partition linked passageways, and air-required locations. We then applied chaos theory to identify the air quantity and gas concentration of underground partition boundaries, and adopted a fixed data quantity, multi-step progressive, weighted first-order local-domain method to setup a chaos prediction model and a CVS safety forecasting and forewarning system formed by the normal change level, orange forewarning level, and red alarm level. We next conduct the on-field application of the system in a coalmine in Jining, Shandong, China. The results showed that (1) in the statistical scale of 5 min, the changes in both air quantity and gas concentration along CVS partition airflow boundaries were characteristic of chaos and could be used for short-term chaos prediction, and the latter was more chaotic than the former;(2) the setup chaos prediction model had a higher prediction precision and the established safety prediction system could not only predict the variation in CVS stability but also reflect the rationality of underground mining intensity. Thus, this CVS safety forecasting and forewarning system is of better application value.

关键词： Mine ventilation system Safety partition Reconstructed phase space Maximum Lyapunov exponent Chaos forecasting and forewarning

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Comparative experimental study on reactive crystallization of Ni(OH)2 in an airlift-loop reactor and a stirred reactor

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Chinese Journal of Chemical Engineering 2018年第1期26卷 196-206页

作者： Tianrong Cao Weipeng zhang Jingcai cheng Chao yang Key Laboratory of Green Process and Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China Nanjing fiuzhang Chemical Technology Co.Ltd. Nanjing 21180China University of Chinese Academy of Sciences Beijing 100049China

The objective of this work is to study the reactive crystallization in an airlift-loop reactor （ALR） using the precipitation of Ni（OH）2 as a model reaction. The growth of Ni（OH）2 particles in an ALR and a stirred tank was quantified by scanning electronic microscope （SEM）, X-ray diffraction （XRD）, laser particle analyzer, tap densitometer and optical microscope, and the growth process of Ni（OH）2 particles is analyzed. It is found that the Ni（OH）2 particles prepared in an ALR have a better sphericity than those in a stirred tank and the growth of Ni（OH）2 particle tap density mainly depends on the size of crystallites： the bigger the size of crystallites, the bigger the tap density is. Based on these, the growth process of Ni（OH）2 particles in ALR is elaborated. Crystallites precipitated from solution aggregate to form large particles with much void. These constituting crystallites continue to grow up, that takes up the void inside particles and makes the tap densitv increase.

关键词： Reactive crystallization Airlift-loop reactor Nickel hydroxide Aggregation

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Resilience-oriented Transmission Expansion Planning with Optimal Transmission Switching Under Typhoon Weather

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CSEE Journal of Power and Energy Systems 2024年第1期10卷 129-138页

作者： yang Yuan Heng zhang Haozhong cheng Zheng Wang Key Laboratory of Control of Power Transmission and Conversion Ministry of EducationElectrical Engineering DepartmentShanghai Jiao Tong UniversityShanghaiChina State Grid East China Branch ShanghaiChina

This paper presents resilience-oriented transmission expansion planning(RTEP)with optimal transmission switching(OTS)model under typhoon *** proposed model carefully considers the uncertainty of component vulnerability by constructing a typhoon-related box uncertainty set where component failure rate varies within a range closely related with typhoon ***,a min-max-min model is developed to enhance transmission network resilience,where the upper level minimizes transmission lines investment,the middle level searches for the probability distribution of failure status leading to max worst-case expected load-shedding(WCEL)under typhoon,and the lower level optimizes WCEL by economic dispatch(ED)and OTS.A nested decomposition algorithm based on benders decomposition is developed to solve the *** studies of modified IEEE 30-bus and 261-bus system of a Chinese region illustrate that:a)the proposed RTEP method can enhance resilience of transmission network with less investment than widely used RTEP method based on attacker and defender(DAD)model,b)the influence of OTS on RTEP is closely related with contingency severity and system scale and c)the RTEP model can be efficiently solved even in a large-scale system.

关键词： Decomposition algorithm optimal transmission switching resilience transmission expansion planning uncertainty vulnerability

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An Efficient EH-WSN Energy Management Mechanism

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Tsinghua Science and Technology 2018年第4期23卷 406-418页

作者： yang zhang Hong Gao Siyao cheng Jianzhong Li Department of Computer Science and Technology Harbin Institute of Technology Harbin 150001 China Department of Key Laboratory of Mechatronics Heilongjiang University Harbin 150080China

An Energy-Harvesting Wireless Sensor Network （EH-WSN） depends on harvesting energy from the environment to prolong network lifetime. Subjected to limited energy in complex environments, an EH-WSN encounters difficulty when applied to real environments as the network efficiency is reduced. Existing EH-WSN studies are usually conducted in assumed conditions in which nodes are synchronized and the energy profile is knowable or calculable. In real environments, nodes may lose their synchronization due to lack of energy. Furthermore, energy harvesting is significantly affected by multiple factors, whereas the ideal hypothesis is difficult to achieve in reality. In this paper, we introduce a general Intermittent Energy-Aware （lEA） EH-WSN platform. For the first time, we adopted a double-stage capacitor structure to ensure node synchronization in situations without energy harvesting, and we used an integrator to achieve ultra-low power measurement. With regard to hardware and software, we provided an optimized energy management mechanism for intermittent functioning. This paper describes the overall design of the lEA platform, and elaborates the energy management mechanism from the aspects of energy management, energy measurement, and energy prediction. In addition, we achieved node synchronization in different time and energy environments, measured the energy in reality, and proposed the light weight energy calculation method based on measured solar energy. In real environments, experiments are performed to verify the high performance of lEA in terms of validity and reliability. The lEA platform is shown to have ultra-low power consumption and high accuracy for energy measurement and prediction.

关键词： energy harvesting WSN energy efficiency energy measurement synchronous wakeup

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A simulation study of mercury release fluxes from soils in wet–dry rotation environment

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Journal of Environmental Sciences 2014年第7期26卷 1445-1452页

作者： Peng Liang cheng zhang Yongkui yang Dingyong Wang College of Resources and Environment Southwest University School of Environmental and Resource Sciences Zhejiang A&F University Chongqing Key Laboratory of Soil Multi-scale Interfacial Process

A simulative mesocosm study was conducted to evaluate the influence of wet-dry rotation on mercury（Hg） flux from soil/water to air and the distribution of Hg species in water as well as Hg chemical fractions in soil. Three types of soil were employed including two kinds of paddy soil, Typic Purpli-Udic Cambosols（TPUC） and Xanthi-Udic Ferralosols（XUF）, as well as the Alluvial Soil（AS） from Three Gorge reservoir area in Chongqing, China. The results showed that Hg fluxes in wetting periods were significantly higher than that in drying periods. It might be due to the formation of a layer of stable air over the water surface in which some redox reactions promote evasion processes over the water surface. This result indicated that more Hg would be evaporated from the Three Gorge reservoir and paddy soil field during the flooding season. Hg fluxes were positively correlated with air temperature and solar irradiation, while negatively correlated with air humidity and the electronic conductivity of water. Hg fluxes from AS and TPUC were significantly higher than that from XUF, which might be due to the higher organic matter（OM） contents in XUF than TPUC and AS. The reduction processes of oxidized Hg were restrained due to the strong binding of Hg to OM, resulting in the decrease in Hg flux from the soil.

关键词： Mercury Flux Dynamic flux chamber Wet-dry rotation

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Human-robot shared control system based on 3D point cloud and teleoperation

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Science China(Technological Sciences) 2023年第8期66卷 2406-2414页

作者： yang chenguang zhang Ying ZHAO GuanYi cheng Long School of Automation Science and Engineering South China University of TechnologyGuangzhou 510641China Institute of Automation Chinese Academy of SciencesBeijing 100190China

Owing to the constraints of unstructured environments,it is difficult to ensure safe,accurate,and smooth completion of tasks using autonomous ***,for small-batch and customized tasks,autonomous operation requires path planning for each task,thus reducing *** propose a human-robot shared control system based on a 3D point cloud and teleoperation for a robot to assist human operators in the performance of dangerous and cumbersome *** system leverages the operator’s skills and experience to deal with emergencies and perform online error *** this framework,a depth camera acquires the 3D point cloud of the target object to automatically adjust the end-effector *** operator controls the manipulator trajectory through a teleoperation *** force exerted by the manipulator on the object is automatically adjusted by the robot,thus reducing the workload for the operator and improving the efficiency of task *** addition,hybrid force/motion control is used to decouple teleoperation from force control to ensure that force and position regulation will not interfere with each *** proposed framework was validated using the ELITE robot to perform a force control scanning task.

关键词： teleoperation 3D point cloud human-robot shared control hybrid force/motion control

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数值模拟课程中培养学生创新能力的教学探索

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高等建筑教育 2017年第3期26卷 69-72页

作者：张如林程旭东杨文东张艳美中国石油大学(华东)储运与建筑工程学院山东青岛266580

数值模拟技术是土木工程专业学生开展学术研究的基本技能,通过开设数值模拟课程,在教学实践中提出"软件超市"的教学模式,满足了学生的多样化及个性化需求。以结构设计竞赛题目和工程案例为训练任务,锻炼学生团队协作能力,激发学生学习兴... 详细信息

数值模拟技术是土木工程专业学生开展学术研究的基本技能,通过开设数值模拟课程,在教学实践中提出"软件超市"的教学模式,满足了学生的多样化及个性化需求。以结构设计竞赛题目和工程案例为训练任务,锻炼学生团队协作能力,激发学生学习兴趣,培养学生创新意识和解决实际问题的能力。经过土木工程分析软件与应用课程的三年教学实践,教学效果良好,提高了学生的科研水平。

关键词：数值模拟软件超市课程改革创新能力

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高糖对大鼠膀胱平滑肌细胞中钙库操控的钙离子通道的影响

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现代泌尿外科杂志 2017年第10期22卷 779-783页

作者：杨天成杨森张晖赵长剑王东文山西医科大学第一临床医学院山西太原030001 山西医科大学第一医院泌尿外科山西太原030001 山西医科大学附属山西大医院乳腺外科山西太原030032

目的观察高糖对大鼠膀胱平滑肌细胞(BSMCs)中钙库操控的钙离子通道(SOCC)的影响。方法通过激光共聚焦显微镜观察记录高糖处理的BSMCs激动和抑制SOCC后细胞内相对荧光强度值,反映其钙离子浓度变化。通过RT-qPCR和Western blot检测SOCC相... 详细信息

目的观察高糖对大鼠膀胱平滑肌细胞(BSMCs)中钙库操控的钙离子通道(SOCC)的影响。方法通过激光共聚焦显微镜观察记录高糖处理的BSMCs激动和抑制SOCC后细胞内相对荧光强度值,反映其钙离子浓度变化。通过RT-qPCR和Western blot检测SOCC相关组成分子STIM1和Orai1在高糖处理的BSMCs中mRNA与蛋白的表达水平。结果高糖处理的BSMCs加入SOCC激动剂CPA后相对荧光强度显著增加,加入SOCC抑制剂SKF-96365后相对荧光强度显著降低。高糖能上调BSMCs中SOCC重要组成分子STIM1和Orai1的mRNA表达水平以及蛋白表达水平。结论高糖能促进大鼠BSMCs中SOCC的激活,使胞外Ca^(2+)内流,可能为糖尿病膀胱的病因学研究提供新的思路。

关键词：高糖钙库操控的钙离子通道膀胱平滑肌细胞糖尿病膀胱

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