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Intravenous tirofiban therapy for patients with capsular warning syndrome

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Stroke & Vascular Neurology 2019年第1期4卷 22-27页

作者： Wei Li Ya Wu Xiao-Shu Li cheng-chun liu Shu-Han Huang chun-Rong Liang Huan Wang Li-Li Zhang Zhi-Qiang Xu Yan-Jiang Wang Meng Zhang Department of Neurology Daping Hospital&Research Institute of SurgeryThe Army Military Medical UniversityChongqingChina

Background Capsular warning syndrome(CWS)is defined as recurrent episodes of transient ischaemic attacks≥3 times during a short time *** is no effective therapy to stop these ***,herein,report our experience of using intravenous tirofiban to treat *** All patients with CWS in our hospital from January 2013 to September 2017 were *** in tirofiban group(T-group)were treated by intravenous tirofiban at 0.4μg/kg/min for 30 min followed by 0.1-0.15μg/kg/min *** treatments(non-T-group)included thrombolytic,oral antiplatelet agents and *** haemorrhage(ICH),systematic bleeding,new attacks after treatment,National Institutes of Health Stroke Scale(NIHSS)scores at 24 hours and modified Rankin Scales(mRSs)at 3 months were *** statistics were used for *** Of 23 patients qualified(15 in T-group,8 in non-T-group),the duration of symptoms ranged from 2 to 100 min before *** treatment,in T-group,four patients(26.7%)had recurrent attacks,and NIHSS scores were 0 in 11 patients(73.3%)at 24 *** patients reached a favourable outcome(mRS≤2) at 3 *** non-T-group,five patients(62.5%)had new *** scores were 0 in two patients(25%)at 24 *** 3 months,seven patients(87.5%)reached a favourable *** ICH nor systematic bleeding or thrombocytopaenia occurred in both groups of *** Intravenous tirofiban can be a potentially effective and safe therapy to stop early symptomatic fluctuations and shorten the duration of functional deficits in patients with CWS.

关键词： patients Intravenous intravenous

Distribution, characteristics, metallogenic processes and prospecting potential of terrestrial brine-type lithium deposits in the world and lithium demand situation

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China Geology 2025年第1期8卷 1-25页

作者： Dian-he liu cheng-lin liu chun-lian Wang Xiao-can Yu MNR Key Laboratory of Metallogeny and Mineral Assessment Institute of Mineral ResourcesChinese Academy of Geological SciencesBeijing 100037China Peking University School of Earth and Space SciencesBeijing 100871China School of Earth Resources China University of Geosciences(Wuhan)Wuhan 430074China Institute of Geology Chinese Academy of Geological SciencesBeijing 100037China

In response to the rise of the energy storage industries such as new energy vehicles and the wide application of lithium in various fields worldwide,the global demand for lithium resources has been in explosive *** order to further comprehensively understand the global supply and demand pattern,development and utilization status,genesis of ore deposits and other characteristics of lithium resources,based on the achievements of many researchers at home and abroad,this paper systematically summarized the lithium supply and demand situation,resource endowment,deposit classification and distribution,typical geological characteristics,metallogenic factors and metallogenic regularity of terrestrial brine-type lithium deposits which are the main types of development and utilization all over the *** review shows that brine-type lithium resource and(or)reserves in the plateau salt lakes are huge and play an important *** addition,the mineralization potential of the underground brine-type lithium deposit is broad *** potential resources of underground brines are enormous,and the geothermal spring water type is also worthy of *** lithium deposits are mainly controlled by the subduction and collision of regional plate tectonics,arid climate and provenance *** of the scientific research on underground brines in the future is expected to provide another significant support for the global demand for lithium resources.

关键词： Brine in plateau salt lake Underground brine Geothermal spring brine Terrestrial brine classification Lithium migration mechanism Brine genesis Mineral exploration engineering Lithium enrich mechanism

Enhancing the photocatalytic efficiency by the molecular modification effect derived from pollutant adsorption on highly crystalline BiOBr

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Journal of Environmental Sciences 2025年第2期148卷 263-273页

作者： Yang Jin Tongyin liu Yanpeng Mao Fan Li chun Hu National Engineering Laboratory for Reducing Emissions from Coal Combustion Engineering Research Center of Environmental Thermal Technology of Ministry of EducationShandong Key Laboratory of Energy Carbon Reduction and Resource UtilizationSchool of Energy and Power EngineeringShandong UniversityJinan 250061China Beijing Enterprises Water GroupInvestment Limited Beijing 100102China Institute of Environmental Research at Greater Bay Key Laboratory for Water Quality and Conservation of the Pearl River DeltaMinistry of EducationGuangzhou UniversityGuangzhou 510006China Key Laboratory of Drinking Water Science and Technology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China

The adsorption of pollutants can not only promote the direct surface reaction,but also modify the catalyst itself to improve its photoelectric characteristics,which is rarely studied for water treatment with inorganic photocatalyst.A highly crystalline BiOBr(c-BiOBr)was synthesized by a two-step preparation *** to the calcination,the highly crystalline enhanced the interface interaction between pollutant and *** complex of organic pollutant and[Bi_(2)O_(2)]^(2+)could promote the active electron transfer from the adsorbed pollutant to c-BiOBr for the direct pollutant degradation by holes(h^(+)).Moreover,the pollutant adsorption actually modified c-BiOBr and promoted more unpaired electrons,which would coupling with the photoexcitation to promote generate more O_(2)^(•-).The molecular modification effect derived from pollutant adsorption significantly improved the removal of *** work strongly deepens the understanding of the molecularmodification effect from the pollutant adsorption and develops a novel and efficient approach for water treatment.

关键词： Highly crystalline BiOBr Pollutant adsorption Molecular modification Photocatalysis Water treatment

Mode-switching cooperative defense strategy for the orbit pursuit-evasion-defense game

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Defence Technology(防务技术) 2025年第2期44卷 272-286页

作者： Yongshang Wei Tianxi liu cheng Wei School of Aerospace Harbin Institute of TechnologyHarbin150000China

This paper presents a mode-switching collaborative defense strategy for spacecraft pursuit-evasiondefense *** these scenarios,the pursuer tries to avoid the defender while capturing the evader,while the evader and defender form an alliance to prevent the pursuer from achieving its ***,the behavioral modes of the pursuer,including attack and avoidance modes,were established using differential game *** modes are then recognized by an interactive multiple model-matching algorithm(IMM),that uses several smooth variable structure filters to match the modes of the pursuer and update their probabilities in real *** on the linear-quadratic optimization theory,combined with the results of strategy identification,a two-way cooperative optimal strategy for the defender and evader is proposed,where the evader aids the defender to intercept the pursuer by performing luring *** results show that the interactive multi-model algorithm based on several smooth variable structure filters perform well in the strategy identification of the pursuer,and the cooperative defense strategy based on strategy identification has good interception performance when facing pursuers,who are able to flexibly adjust their game objectives.

关键词： Cooperative policy Differential games Orbit pursuit-evasion-defense game Mod recognition

Three-dimensional fracture of UO_(2)ceramic pellets by phase field modeling

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Science China(Physics,Mechanics & Astronomy) 2025年第1期68卷 165-176页

作者： Wei Xiong Xuan Ye Hongzhang cheng Xiaoming liu Institute of Nuclear and New Energy Technology Collaborative Innovation Center of Advanced Nuclear Energy TechnologyKey Laboratory of Advanced Reactor Engineering and Safety of Ministry of EducationTsinghua UniversityBeijing 100084China State Key Laboratory of Nonlinear Mechanics Institute of MechanicsChinese Academy of SciencesBeijing 100190China School of Engineering Science University of Chinese Academy of SciencesBeijing 100049China

Fracture is the primary failure type for the UO_(2)ceramic pellets,which are operated under irradiation and thermal processes,and physically confined by the *** this work,by combining closely coupled physical processes of heat conduction,heat transfer,and mechanical deformation with the cohesive phase field framework,we proposed a high-precision modeling of quasistatic cracking of three-dimensional(3D)UO_(2)ceramic fuel pellets under high temperature and *** simulation results agree well with the experimental results,indicating that the proposed method has the potential to capture 3D crack modes in the interested time ***,we studied the relation of the 3D fracture patterns of fuel pellets with the peak power *** was found that the power level plays a critical role in determining the competition between radial and circumferential cracks,as well as transverse penetrating cracks.

关键词： phase field method nuclear fuel pellet coupled thermo-mechanical model thermal fracture

Theoretical calculation on degradation mechanism of novel copolyesters under CALB enzyme

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Journal of Environmental Sciences 2025年第3期149卷 242-253页

作者： Yuanyang Ren Zhiwen cheng Luwei cheng Yawei liu Mingyue Li Tao Yuan Zhemin Shen School of Environmental Science and Engineering Shanghai Jiao Tong UniversityShanghai 200240China State Environmental Protection Key Laboratory of Environmental Health Impact Assessment of Emerging Contaminants Shanghai 200240China Shanghai Institute of Pollution Control and Ecological Security Shanghai 200092China

Poly(butylene succinate-co-furandicarboxylate)(PBSF)and poly(butylene adipateco-furandicarboxylate)(PBAF)are novel furandicarboxylic acid-based biodegradable copolyesters with great potential to replace fossil-derived terephthalic acid-based copolyesters such as poly(butylene succinate-co-terephthalate)(PBST)and poly(butylene adipate-co-terephthalate)(PBAT).In this study,quantum chemistry techniques after molecular dynamics simulations are employed to investigate the degradationmechanism of PBSF and PBAF catalyzed by Candida antarctica lipase B(CALB).Computational analysis indicates that the catalytic reaction follows a four-step mechanism resembling the ping-pong bibi mechanism,with the initial two steps being acylation reactions and the subsequent two being hydrolysis ***,the first step of the hydrolysis is identified as the rate-determining ***,by introducing single-point mutations to expand the substrate entrance tunnel,the catalytic distance of the first acylation step ***,energy barrier of the rate-determining step is decreased in the PBSF system by site-directed mutations on key residues increasing hydrophobicity of the enzyme’s active *** study unprecedently show the substrate binding pocket and hydrophobicity of the enzyme’s active site have the potential to be engineered to enhance the degradation of copolyesters catalyzed by CALB.

关键词： Poly(butylene succinate-co-furandicarboxylate) Poly(butylene adipate-co-furandicarboxylate) Candida antarctica lipase B Degradation mechanism Site-directed mutations

Observation of topological charge transformations in acoustic vortex using passive periodic systems

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Science China(Physics,Mechanics & Astronomy) 2025年第1期68卷 136-143页

作者： Di-Chao Chen Xie liu Changqing Xu Da-Jian Wu Ying cheng Xiao-Jun liu School of Physics and Technology Nanjing Normal UniversityNanjing 210023China Key Laboratory of Modern Acoustics School of PhysicsNanjing UniversityNanjing 210093China

Vortex transmutation utilizes a periodic system,which not only enables the alteration of the topological charge(TC)of unstable input vortices but also facilitates their transformation into stable *** approach is crucial for investigating the characteristics of vortices in various wave ***,we achieve acoustic vortex TC transmutation by employing a welldesigned dual-structured plate external system(DPES).The interactions between the acoustic vortex and the finite-order discrete rotational symmetry lead to the transformation of its topological charge when complete rotational symmetry is broken to Nthorder discrete *** results experimentally demonstrate the acoustic vortex TC transmutation based on passive artificial structures,enabling numerous applications in particle manipulation and information multiplexing as well as advancing our understanding and control over free-space acoustic vortices.

关键词： acoustic vortex topological charge transformation artificial structure

Preparation of FeCoNi medium entropy alloy from Fe^(3+)-Co^(2+)-Ni^(2+)solution system

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 92-101页

作者： Zongyou cheng Qing Zhao Mengjie Tao Jijun Du Xingxi Huang chengjun liu Key Laboratory for Ecological Metallurgy of Multimetallic Mineral(Ministry of Education) Northeastern UniversityShenyang 110819China School of Metallurgy Northeastern UniversityShenyang 110819China Engineering Research Center of Frontier Technologies for Low-carbon Steelmaking(Ministry of Education) Shenyang 110819China

In recent years,medium entropy alloys have become a research hotspot due to their excellent physical and chemical *** controlling reasonable elemental composition and processing parameters,the medium entropy alloys can exhibit similar properties to high entropy alloys and have lower *** this paper,a FeCoNi medium entropy alloy precursor was prepared via sol-gel and coprecipitation methods,respectively,and FeCoNi medium entropy alloys were prepared by carbothermal and hydrogen *** phases and magnetic properties of FeCoNi medium entropy alloy were *** showed that FeCoNi medium entropy alloy was produced by carbothermal and hydrogen reduction at 1500℃.Some carbon was detected in the FeCoNi medium entropy alloy prepared by carbothermal *** alloy prepared by hydrogen reduction was uniform and showed a relatively high ***,the hydrogen reduction product exhibited better saturation magnetization and lower coercivity.

关键词： medium entropy alloy sol-gel co-precipitation carbothermal hydrogen reduction

Numerical simulation of microstructure and microporosity morphology in directional solidification of aluminum-copper alloys:Effect of copper content and withdrawal rate

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China Foundry 2025年第1期22卷 33-44页

作者： Wei Yuan Hai-dong Zhao Xu Shen chun Zou Yuan liu Qing-yan Xu National Engineering Research Center of Near-Net-Shape Forming for Metallic Materials South China University of TechnologyGuangzhou 510640China Key Laboratory for Advanced Materials Processing Technology(Ministry of Education) Tsinghua UniversityBeijing 100084China

Microporosity formed in the solidification process of Al alloys is detrimental to the alloy properties.A two-dimensional cellular automaton(CA)model was developed to simulate the microstructure and microporosity formation in Al-Cu alloys,considering variations in Cu content and solidification *** results indicate that the Cu content primarily influences the growth of *** validate the model,directional solidification experiments were conducted on Al-Cu alloys with varing Cu contents and withdrawal *** experimental results of dendrites and microporosity characteristics agree well with the predictions from the developed model,thus confirming the validity of the *** alloy’s liquidus temperature,dendrite morphology,and hydrogen saturation solubility arising from different Cu contents have significant effects on microporosity *** withdrawal rate primarily affects the nucleation of hydrogen microporosity by altering cooling rates and dendritic growth rates,resulting in different microporosity characteristics.

关键词： microporosity dendrites cellular automaton Al-Cu alloys directional solidification