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The compound(E)-2-(3,4-dihydroxystyryl)-3-hydroxy-4H-pyran-4-one alleviates neuroinflammation and cognitive impairment in a mouse model of Alzheimer's disease

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Neural Regeneration Research 2025年第11期20卷 3330-3344页

作者： Xueyan Liu Wei Wu Xuejuan Li chengyan Wang Ke Chai Fanru Yuan Huijuan Zheng Yuxing Yao Chenlu Li Zu-cheng ye Daijun Zha Department of Medicinal Chemistry School of PharmacyFujian Medical UniversityFuzhouFujian ProvinceChina Fujian Provincial Key Laboratory of Brain Aging and Neurodegenerative Diseases School of Basic Medical SciencesFujian Medical UniversityFuzhouFujian ProvinceChina Institute of Laboratory Animal Center Fujian Medical UniversityFuzhouFujian ProvinceChina Department of Neurosurgery Neurosurgery Research InstituteThe First Affiliated HospitalFujian Medical UniversityFuzhouFujian ProvinceChina Department of Hyperbaric Oxygen National Regional Medical CenterBinhai Campus of the First Affiliated HospitalFujian Medical UniversityFuzhouFujian ProvinceChina

Previous studies have shown that the compound(E)-2-(3,4-dihydroxystyryl)-3-hydroxy-4H-pyran-4-one(D30),a pyromeconic acid derivative,possesses antioxidant and anti-inflammatory properties,inhibits amyloid-β aggregation,and alleviates scopolamine-induced cognitive impairment,similar to the phase Ⅲ clinical drug *** this study,we established a mouse model of Alzheimer's disease via intracerebroventricular injection of fibrillar amyloid-β to investigate the effect of D30 on fibrillar amyloid-β-induced *** results showed that D30 alleviated fibrillar amyloid-β-induced cognitive impairment,promoted fibrillar amyloid-β clearance from the hippocampus and cortex,suppressed oxidative stress,and inhibited activation of microglia and astrocytes.D30 also reversed the fibrillar amyloid-β-induced loss of dendritic spines and synaptic protein ***,we demonstrated that exogenous fibrillar amyloid-βintroduced by intracerebroventricular injection greatly increased galectin-3 expression levels in the brain,and this increase was blocked by *** the role of D30 in clearing amyloid-β,inhibiting neuroinflammation,protecting synapses,and improving cognition,this study highlights the potential of galectin-3 as a promising treatment target for patients with Alzheimer's disease.

关键词： Alzheimer's disease amyloid-β astrocyte cognitive impairment D30 dendritic spines galectin-3 microglia neuroinflammation neuron

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Gradient Estimates and Harnack Inequalities for Positive Solutions of ■ on Self-shrinkers

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Acta Mathematica Sinica,English Series 2019年第7期35卷 1217-1226页

作者： ye cheng ZHU Qing CHEN Department of Applied Mathematics Anhui University of Technology Maanshan 243002 P. R. China Department of Mathematics University of Science and Technology of China Hefei 230026 P. R. China

In this paper, we investigate the positive solutions of ■u =■υ/■t on self-shrinkers, then get some gradient estimates and Harnack inequalities for the positive solutions.

关键词： Harnack inequality self^shrinker ∞-Bakry-Emery Ricci tensor gradient estimate

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Large negative hyperpolariza-bilities (β) of the protonated Schiff bases of the azulenic retinal analogues

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Chinese Science Bulletin 2001年第10期46卷 831-835页

作者： Peng Wang cheng ye Center for Molecular Science Laboratory of Organic Solids Institute of Chemistry Chinese Academy of Sciences Beijing China

The molecular first hyperpolarizabilities (β) and electronic properties of some azulenic retinal analogues and their derivatives have been investigated theoretically by employing semiempirical approaches. The results indicate that the protonated Schiff bases (PSB) of the 2-substituted azulenic retinal analogues possess extremely large negative β values and very good transparency. These can be attributed to the large difference between the ground state dipole moment and the first excited state dipole moment according to the electronic property analysis. The characteristic blue-shifted absorption in polar solvents of the 2-substituted PSB chromophores can be well explained by the negative solva-tochromic effects. The largest calculated |μβ| value can reach the magnitude of 10-44 esu, which is close to the highest reported values of synthesized chromophores.

关键词： molecular first hyperpolarizability nonlinear optics azulene retinal derivatives theoretical calculation.

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Surface and Interface Engineering for Advanced Nanofiltration Membranes

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Chinese Journal of Polymer Science 2022年第2期40卷 124-137页

作者： Bian-Bian Guo cheng-ye Zhu Zhi-Kang Xu Ministry of Education Key Laboratory of Macromolecular Synthesis and FunctionalizationKey Laboratory of Adsorption and Separation Materials&Technologies of Zhejiang ProvinceDepartment of Polymer Science and EngineeringZhejiang UniversityHangzhou 310027China

Nanofiltration has been attracting great attention in alleviating the global water crisis because of its high efficiency,mild operation,and strong *** decades,it remains a challenge to break the upper limit of performance and establish the formation-structureproperty relationship for nanofiltration *** feature article summarizes our recent progress in the preparation of high-performance thin-film composite(TFC)nanofiltration membranes,focusing on the mussel-inspired deposition method and the optimized interfacial polymerization(IP).By accelerating the oxidation of polydopamine and equilibrating the rate of aggregation and deposition processes,the mussel-inspired deposition method realizes the rapid and uniform formation of selective coatings or *** deposition systems endow the selective layer with rich chemical structures and easy post-functionalization,highlighting its potential in water *** for optimizing the conventional IP,the rapid polycondensation of amine and acid chloride groups is slowed down to enable the controllability of IP at the water-organic *** homogeneity and integrity of the TFC membranes are improved by constructing a uniform reaction platform and introducing a viscous medium to control the amine diffusion,which facilitates the water permeability and promotes the separation *** have proposed a series of practical strategies for improving TFC membranes and might provide more inspiration for other nanofiltration techniques.

关键词： Nanofiltration Thin-film composite membranes Mussel-inspired deposition Interfacial polymerization

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Consensus of a two-agent opinion dynamical system with processing delay

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International Journal of Biomathematics 2018年第6期11卷 111-128页

作者： ye cheng Xiao Wang Bao Shi School of Basic Sciences for AviationNaval Aviation University Yantai 264001 P. R. China College of Science National University of Defense Technology Changsha 410073 P. R. China

A sufficient condition is obtained for a two-agent opinion dynamical system with pro-cessing delay to experience unconditional consensus. To this end, the dynamics proposed is transformed into a general class of delay differential equation and asymptotic stability of the origin is then analyzed. It is also shown that increasing delay can prolong the time needed for the system to realize consensus and even induce a Hopf bifurcation.

关键词： Opinion dynamical system consensus processing delay asymptotic stability Hopf bifurcation.

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Study on the long-term passive cooling extension of AP1000 reactor

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Nuclear Science and Techniques 2013年第4期24卷 68-74页

作者： ye cheng ZHENG Mingguang WANG Yong QIU Zhongming School of Nuclear Science and Engineering Shanghai Jiao Tong University Shanghai Nuclear Engineering Research and Design Institute Zhejiang University

The AP1000 with high safety is a generation III pressurized water reactor(PWR),its significant feature is passive safety ***,its passive cooling can only maintain for 72 h and requires additional support from inside or outside the *** solve this problem,this study utilized the WGOTHIC software to calculate and analyze the water inventory in the passive containment cooling water tank under different *** results show that when the cooling water inventory is 6553.78 m3,the AP1000 nuclear power plants can achieve long-term,completely passive cooling without any inside or outside the *** same outcomes occur when 65-mm-thick containment wall increases the design pressure rating to 0.6 MPa at the cooling water inventory of 5673 ***,the AP1000 shield building was accordingly *** ANSYS analysis of the structural stability of the shield building with a 6000 m3 cooling water inventory confirmed that the new design can meet the requirements of the seismic design and the safe residual heat removal requirements of a large-scale PWR.

关键词： AP1000 压水反应堆散热 ANSYS分析冷却水箱被动安全系统抗震设计结构稳定性

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On the Hosoya index of graphs

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Applied Mathematics(A Journal of Chinese Universities) 2010年第2期25卷 155-161页

作者： WANG Bo ye cheng-fu YAN Li-ying Department of Mathematics Qinghai Normal University Xining 810008 China Qinghai Communications Technical College Xining 810003 China.

Let G be a （molecular） graph. The Hosoya index Z（G） of G is defined as the number of subsets of the edge set E（G） in which no two edges are adjacent in G, i.e., Z（G） is the total number of matchings of G. In this paper, we determine all the connected graphs G with n ＋ 1 ≤ Z（G） ≤5n - 17 for n ≥ 19. As a byproduct, the graphs of n vertices with Hosoya index from the second smallest value to the twenty first smallest value are obtained for n ≥ 19.

关键词： Graph Hosoya index matching

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Effect of Addition of Polytetrafluoroethylene (PTFE) and Silicon Carbide (SiC) on Properties of Electroless Nickel Alloy Coatings

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材料热处理学报 2004年第05B期25卷 1102-1105页

作者： WUYu-cheng HUXiao-ye WANGWen.fang HUANGXin-min FacultyofMaterialsScienceandEngineering HefeiUniversityofTechnology230009HefeiP.R.China

Electroless nickel (copper)-phosphorus-silicon carbide (SiC)-polytetrafluoroethylene (PTFE) composite coatings were prepared by adding SiC and PTFE into electroless nickel (copper)-phosphorus alloy baths. The effects of addition of SiC and PTFE on depositing rate, microhardness, wear resistance and anti-friction of the resulted composite coatings were studied. The results indicated that electroless nickel (copper)-phosphorus alloy coatings were greatly improved in depositing rate, microhardness, wear resistance and antifriction by co-deposited proper amount of SiC and PTFE.

关键词：非电解淀积聚四氟乙烯碳化硅镍合金

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Early expression of surfactant proteins D in Fusarium solani infected rat cornea

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International Journal of Ophthalmology(English edition) 2012年第3期5卷 297-300页

作者： cheng-ye Che, Gui-Qiu Zhao Department of Ophthalmology the Affiliated Hospital of Qingdao University Qingdao 266003 Shandong Province China Binzhou Hubin Eye Hospital Binzhou 256600 Shandong Province China

AIM: To investigate the early expression of surfactant proteins D(SP-D) in Fusarium solani infected rat cornea. METHODS: Wistar rats were divided into group A, B and C randomly. The right eyes were chosen as the experiment one. Group A was control group. Group B was not inoculated with Fusarium solani. Group C was taken as fusarium solani keratitis model. Five rats in group B and C were executed randomly at 6, 12, 24, 48 and 96 hours respectively after the experimental model being established. The expression of SP-D was assessed through immunohistochemistry and reverse transcription polyrnerase chain reaction(RT-PCR). RESULTS: RT-PCR detected that the SP-D mRNA expression was low in the corneal of normal rats and group B. The expression of fungal infected cornea increased gradually and reached the peak at 24 hours in group C. The synchronous expression of group B and C were in significant difference (P<0.01). Immunohistochemisty discovered the protein of SP-D expression was increased gradually from 12 hours and reached the peak at 48 hours in group C. The synchronous expression of group B and C were also in significant difference (P<0.01). CONCLUSION: There exists SP-D in rat corneal tissue and the expression is significantly increased at the early period of fusarium solani infected cornea. SP-D may play a role in the early innate immunity response of the corneal resistance to Fusarium solani infection.

关键词： keratitis Fusarium solani surfactant protein D innate immune

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Redactable consortium blockchain with access control:Leveraging chameleon hash and multi-authority attribute-based encryption

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High-Confidence Computing 2024年第1期4卷 14-23页

作者： Yueyan Dong Yifang Li ye cheng Dongxiao Yu School of Computer Science and Technology Shandong UniversityQingdao 266237China

A redactable blockchain allows authorized individuals to remove or replace undesirable content,offering the ability to remove illegal or unwanted *** control is a mechanism that limits data visibility and ensures that only authorized users can decrypt and access encrypted information,playing a crucial role in addressing privacy concerns and securing the data stored on a *** and access control are both essential components when implementing a regulated consortium blockchain in real-world situations to ensure the secure sharing of data while removing undesirable *** propose a decentralized consortium blockchain system prototype that supports redactability and access *** the development of a prototype blockchain system,we investigate the feasibility of combining these approaches and demonstrate that it is possible to implement a redactable blockchain with access control in a consortium blockchain setting.

关键词： Regulation Chameleon hash Redactable blockchain Consortium blockchain

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