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Programmable time-domain digital-coding metasurface for non-linear harmonic manipulation and new wireless communication systems

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National Science Review 2019年第2期6卷 231-238页

作者： Jie zhao Xi yang Jun yan Dai Qiang cheng Xiang li Ning hua Qi Jun Chen Ke Guo Dong bai Shuo liu Shi jin Andrea Alù Tie Jun Cui State Key Laboratory of Millimeter Waves Southeast University Jiangsu Cyber-Space Science & Technology Co. Ltd Physics Program The Graduate Center City University of New York National Mobile Communication Research Laboratory Southeast University Synergetic Innovation Center of Wireless Communication Technology Southeast University Department of Electrical Engineering City College of New York Photonics Initiative Advanced Science Research Center City University of New York

Optical non-linear phenomena are typically observed in natural materials interacting with light at high intensities, and they benefit a diverse range of applications from communication to sensing. However,controlling harmonic conversion with high efficiency and flexibility remains a major issue in modern optical and radio-frequency systems. Here, we introduce a dynamic time-domain digital-coding metasurface that enables efficient manipulation of spectral harmonic distribution. By dynamically modulating the local phase of the surface reflectivity, we achieve accurate control of different harmonics in a highly programmable and dynamic fashion, enabling unusual responses, such as velocity illusion. As a relevant application, we propose and realize a novel architecture for wireless communication systems based on the time-domain digital-coding metasurface, which largely simplifies the architecture of modern communication systems, at the same time yielding excellent performance for real-time signal transmission. The presented work, from new concept to new system, opens new pathways in the application of metamaterials to practical technology.

关键词： metasurface time-domain digital coding non-linear harmonics control new architecture of communication

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Feasibility of hyperspectral analysis for discrimination of rabbit liver VX2 tumor

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World Journal of Gastrointestinal Oncology 2019年第1期11卷 1-8页

作者： Feng Duan jing yuan Xuan liu li Cui yan-hua bai Xiao-Hui li huang-rong Xu Chen-yang liu Wei-Xing yu Department of Interventional Radiology the General Hospital of Chinese People's Liberation Army Department of Pathology the General Hospital of Chinese People's Liberation Army Key Laboratory of Spectral Imaging Technology of Chinese Academy of Sciences Xi'an Institute of Optics and Precision Mechanics Chinese Academy of Sciences

BACKGROUND Hepatocellular carcinoma is one of the most common malignant tumors worldwide. Currently, the most accurate diagnosis imaging modality for hepatocellular carcinoma is enhanced magnetic resonance imaging. However, it is still difficult to distinguish cirrhosis lesions, and novel diagnosis modalities are still *** To investigate the feasibility of hyperspectral analysis for discrimination of rabbit liver VX2 *** In this study, a rabbit liver VX2 tumor model was established. After laparotomy,under direct view, VX2 tumor tissue and normal liver tissue were subjected to hyperspectral *** The spectral signature of the liver tumor was clearly distinguishable from that of the normal tissue, simply from the original spectral curves. Specifically, two absorption peaks at 600-900 nm wavelength in normal tissue disappeared but a new reflection peak appeared in the tumor. The average optical reflection at the whole waveband of 400-1800 nm in liver tumor was higher than that of the normal *** Hyperspectral analysis can differentiate rabbit VX2 tumors. Further research will continue to perform hyperspectral imaging to obtain more information for differentiation of liver cancer from normal tissue.

关键词： Hyperspectral analysis VX2 tumor liver cancer Diagnosis Animal experiment

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Association between Selenium in Soil and Diabetes in Chinese Residents Aged 35–74 Years:Results from the 2010 National Survey of Chronic Diseases and Behavioral Risk Factors Surveillance

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Biomedical and Environmental Sciences 2020年第4期33卷 260-268页

作者： WANG Qi Qi yu Shi cheng XU cheng Dong liu Jian Jun li yuan Qiu ZHANG Man Hui long Xiao Juan liu yun Ning BI yu Fang zhao Wen hua YAO Hong yan Chinese Center for Disease Control and Prevention Beijing 102206China State Key Laboratory of Resources and Environmental Information System Institute of Geographic Sciences and Natural Resources ResearchChinese Academy of SciencesBeijing 100101China Peking University Third Hospital Beijing 100191China National Center for Chronic and Non communicable Disease Control and Prevention Chinese Center for Disease Control and PreventionBeijing 100050China Shanghai National Clinical Research Center for Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic DiseasesRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China National Institute for Nutrition and Health Chinese Center for Disease Control and PreventionBeijing 100050China

Objective To explore the association between soil selenium levels and the risk of diabetes in Chinese adults aged 35–74 *** Data for this study were derived from the China Chronic Diseases and Behavioral Risk Factors Surveillance 2010 *** concentrations in soil were obtained from the Atlas of Soil Environmental Background Values in China.A two-level binary logistic regression model was used to determine the association between soil selenium concentrations and the risk of diabetes,with participants nested within districts/*** A total of 69,332 participants aged 35–74 years,from 158 districts/counties were included in the *** of selenium in soil varied greatly across the 158 districts/counties,with a median concentration of 0.219 mg/kg(IQR:0.185–0.248).The results showed that both Quartile 1(0.119–0.185 mg/kg)and Quartile 4(0.249–0.344 mg/kg)groups were positively associated with diabetes compared to a soil selenium concentration of 0.186–0.219 mg/kg(Quartile 2),crude odds ratios(ORs)(95%CI)were 1.227(1.003–1.502)and 1.280(1.048–1.563).The P values were 0.045 and 0.013,for Quartile 1 and Quartile 4 groups,*** adjusting for all confounding factors of interest,the Quartile 1 group became non-significant,and the Quartile 4 group had an adjusted OR(95%CI)of 1.203(1.018–1.421)relative to the reference group(Quartile 2),the P values was *** significant results were seen for the Quartile 3 group(0.220–0.248 mg/kg)compared to the reference *** Excessive selenium concentrations in soil could increase the risk of diabetes among Chinese adults aged 35–74 years.

关键词： Selenium Diabetes Odds ratio Behavioral risk factors Survey

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Identification of active compound combination contributing to anti-inflammatory activity of Xiao-cheng-Qi Decoction via human intestinal bacterial metabolism

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Chinese Journal of Natural Medicines 2018年第7期16卷 513-524页

作者： liu Xing-yan li li li Xue-Qing yu Bo-yang liu Ji-hua Jiangsu Key Laboratory of TCM Evaluation and Translational Research China Pharmaceutical University State Key Laboratory of Natural Medicines China Pharmaceutical University

Human intestinal bacteria play an important role in the metabolism of herbal medicines, leading to the variations in their pharmacological profile. The present study aimed to investigate the metabolism of Xiao-cheng-Qi decoction(XCQD) by human intestinal bacteria and to discover active component combination(ACC) contributing to the anti-inflammatory activity of XCQD. The water extract of XCQD was anaerobically incubated with human intestinal bacteria suspensions for 48 h at 37 °C. A liquid chromatography-hybrid quadrupole time-of-flight mass spectrometry(LC-Q-TOF/MS) method was performed for identification of the metabolites. In addition, the anti-inflammatory effects of XCQD and biotransformed XCQD(XCQD-BT) were evaluated in vitro with cytokines in RAW264.7 cells induced by lipopolysaccharide(LPS). A total of 51 compounds were identified in XCQD and XCQD-BT. Among them, 20 metabolites were proven to be transformed by human intestinal bacteria. Significantly, a combination of 14 compounds was identified as ACC from XCQD-BT, which was as effective as XCQD in cell models of inflammation. In conclusion, this study provided an applicable method, based on intestinal bacterial metabolism, for identifying combinatory compounds responsible for a certain pharmacological activity of herbal medicines.

关键词： Xiao-cheng-Qi decoction Human intestinal bacteria Metabolism Anti-inflammatory LC-Q-TOF/MS

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高寒沙化草地自然演替恢复下土壤有机碳矿化及其温度敏感性研究

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草地学报 2024年第9期32卷 2686-2694页

作者：李瑶吴菁菁吴忠玉修粤吴承静弓晋超赵佳芮李琳琳余水泉孙飞达马周文刘琳周冀琼李宏林白彦福四川农业大学草业科技学院四川成都611130 四川省若尔盖县科学技术和农业畜牧局四川若尔盖624500 青海大学省部共建三江源生态与高原农牧业国家重点实验室青海西宁810016

青藏高原东缘草地沙化态势严重,开展草地沙化退化与自然恢复土壤有机碳矿化及其温度敏感性(Temperature Sensitivity,Q_(10))对比研究,可为草原碳库管理提供理论支撑。本试验在若尔盖县分别选取典型沙化草地和长期自然恢复(10年)沙化草... 详细信息

青藏高原东缘草地沙化态势严重,开展草地沙化退化与自然恢复土壤有机碳矿化及其温度敏感性(Temperature Sensitivity,Q_(10))对比研究,可为草原碳库管理提供理论支撑。本试验在若尔盖县分别选取典型沙化草地和长期自然恢复(10年)沙化草地,采集表层0~10 cm和底层20~30 cm土壤样品带回室内进行控温(5℃,15℃和25℃)矿化培养实验。结果表明:与沙化草地相比,自然恢复途径下土壤有机碳(Soil organic carbon,SOC)的矿化速率降低了40%,土壤有机碳储量提高了2.23~2.57倍,SOC分解的温度敏感性由0.55~1.57增加到0.80~2.73,且底层土壤Q_(10)显著高于表层土壤。两种草地土壤有机碳累积矿化量与土壤初始SOC含量呈极显著的负相关关系,且底层土壤SOC矿化速率均显著高于表层土壤。未来气候变暖影响下自然恢复沙化地底层SOC矿化分解成为碳源的风险更高,应重点加强其草地深层土壤碳库的管理和调控措施。

关键词：高寒沙化草地自然恢复土壤有机碳温度敏感性

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Estimation Study of New Cancer Cases and Deaths in Wuwei, Hexi Corridor Region, China, 2018

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Biomedical and Environmental Sciences 2017年第11期30卷 829-833页

作者： CAO Bo yu li cheng yun XU Feng Lan liu Xiao Qin yanG yan Xu li jing GAO Cai yun rong You Ming li rong cheng li Ya li ZHENG Shan bai Ya Na YE yan cheng Institute of Epidemiology and Statistics School of Public Health Center for Cancer Prevent and Treatment Lanzhou University Department of Cancer Epidemiology Wuwei Cancer Registry Gansu Wuwei Tumor Hospital

Population-based cancer registration data were collected to estimate the cancer incidence and mortality in Wuwei, Hexi Corridor Region, China in 2018. We used the 2011-2013 data to predict the number of new cases and deaths in 2018 and the 2003-2013 data to analyze trends in cancer incidence and mortality. The goal is to enable cancer prevention and control directions. Our results indicated that stomach cancer is the most common cancer. For all cancers combined, the incidence and mortality rates showed significantly increasing trends（＋2.63% per year; P 〈 0.05 and ＋1.9% per year; P 〈 0.05）. This study revealed a significant cancer burden among the population of this area. Cancer screening and prevention should be performed after an epidemiological study of the cause of the cancer is completed.

关键词： Estimation Study of New Cancer Hexi Corridor Region

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Metal-free phthalocyanine single crystal： Solvothermal synthesis and near-infrared electroluminescence

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Chinese Chemical Letters 2016年第5期27卷 764-768页

作者： Qing-long bai Chun-hua Zhang Juan-Juan Song jing-Hai liu yan-Chun Feng li-Mei Duan Chuan-Hui cheng Inner Mongolia Key Lab of Chemistry of Natural Products and Synthesis of Functional Molecules College of Chemistry and Chemical Engineering Inner Mongolia University for Nationalities Tongliao 028000 China School of Physics and Optoelectronics Technology Dalian University of Technology Dalian 116024 China

A metal-flee purple H2Pc single crystal was synthesized by a facile solvothermal method, and its solubility and near-infrared （NIR） optical properties were also investigated due to its potential applications as a light-emitting layer for OLEDs. The H2Pc single crystal is insoluble in 1-chlorine naphthalene and other organic solvents. It gives a wide absorption in the range from 620 nm to 679 nm and a wide emission in near 922 nm. As an active light-emitting layer, H2Pc was employed to fabricate electroluminescent （EL） devices with a structure of ITO/NPB （30 nm）/Alq3：H2Pc （30 nm）/BCP （20 nm）/ Alq3 （20 nm）/Al. The emission center is at 936 nm when the H2Pc doping concentration is 20 wt%. The doping concentration strongly governs the emission intensity. When doping concentration decreases from 10 wt% to 1 wt%, the emission intensity remarkably fades, and simultaneously the emission center undergoes a blue shift.

关键词： Solvothermal synthesis H2Pc single crystal Optical properties Near-infrared Electroluminescence

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Improving Blood Monocyte Energy Metabolism Enhances Its Ability to Phagocytose Amyloid-βand Prevents Alzheimer’s Disease-Type Pathology and Cognitive Deficits

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Neuroscience Bulletin 2023年第12期39卷 1775-1788页

作者： Zhi-Hao liu yu-Di bai Zhong-yuan yu Hui-yun li Jie liu cheng-rong Tan Gui-hua Zeng yun-Feng Tu Pu-yang Sun yu-Juan Jia jin-Cai He yan-Jiang Wang Xian-Le Bu Department of Neurology The First Affiliated Hospital of Wenzhou Medical UniversityWenzhou325000China Department of Neurology and Centre for Clinical Neuroscience Daping HospitalThird Military Medical UniversityChongqing400042China Chongqing Key Laboratory of Ageing and Brain Diseases Chongqing400042China Institute of Brain and Intelligence Third Military Medical UniversityChongqing400042China State Key Laboratory of Trauma Burns and Combined InjuryThird Military Medical UniversityChongqing400042China Center for Excellence in Brain Science and Intelligence Technology Chinese Academy of SciencesShanghai201200China

Deficiencies in the clearance of peripheral amyloidβ(Aβ)play a crucial role in the progression of Alzheimer’s disease(AD).Previous studies have shown that the ability of blood monocytes to phagocytose Aβis decreased in ***,the exact mechanism of Aβclearance dysfunction in AD monocytes remains *** the present study,we found that blood monocytes in AD mice exhibited decreases in energy metabolism,which was accompanied by cellular senescence,a senescence-associated secretory phenotype,and dysfunctional phagocytosis of Aβ.Improving energy metabolism rejuvenated monocytes and enhanced their ability to phagocytose Aβin vivo and in ***,enhancing blood monocyte Aβphagocytosis by improving energy metabolism alleviated brain Aβdeposition and neuroinflammation and eventually improved cognitive function in AD *** study reveals a new mechanism of impaired Aβphagocytosis in monocytes and provides evidence that restoring their energy metabolism may be a novel therapeutic strategy for AD.

关键词： Alzheimer's disease Aβclearance Monocyte Phagocytosis Energy metabolism

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Modified constraint-induced movement therapy alters synaptic plasticity of rat contralateral hippocampus following middle cerebral artery occlusion

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Neural Regeneration Research 2020年第6期15卷 1045-1057页

作者： Bei-Yao Gao Dong-Sheng Xu Pei-Le liu Ce li liang Du yan hua Jian Hu Jia-yun Hou yu-long bai Department of Rehabilitation Medicine Huashan HospitalFudan UniversityShanghaiChina Rehabilitation Section Department of Spine SurgeryTongji Hospital of Tongji UniversityShanghaiChina Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration(Tongji University)Ministry of Education ShanghaiChina Zhongshan Hospital Institute of Clinical Science Fudan UniversityShanghaiChina

Modified constraint-induced movement therapy is an effective treatment for neurological and motor impairments in patients with stroke by increasing the use of their affected limb and limiting the contralateral ***,the molecular mechanism underlying its efficacy remains *** this study,a middle cerebral artery occlusion(MCAO)rat model was produced by the suture *** received modified constraint-induced movement therapy 1 hour a day for 14 consecutive days,starting from the 7^th day after middle cerebral artery *** 1 of treatment lasted for 10 minutes at 2r/min,day 2 for 20 minutes at 2 r/min,and from day 3 onward for 20 minutes at 4 r/*** gait analysis,adhesive removal test,and Y-maze test were used to investigate motor function,sensory function as well as cognitive function in rodent animals from the 1st day before MCAO to the 21^st day after *** the 21^st day after MCAO,the neurotransmitter receptor-related genes from both contralateral and ipsilateral hippocampi were tested by micro-array and then verified by western blot *** glutamate related receptor was shown by transmission electron microscopy and the glutamate content was determined by high-performance liquid *** results of behavior tests showed that modified constraint-induced movement therapy promoted motor and sensory functional recovery in the middle cerebral artery-occluded rats,but had no effect on cognitive *** modified constraint-induced movement therapy upregulated the expression of glutamate ionotropic receptor AMPA type subunit 3(Gria3)in the hippocampus and downregulated the expression of the beta3-adrenergic receptor gene Adrb3 and arginine vasopressin receptor 1 A,Avprla in the middle cerebral artery-occluded *** the ipsilateral hippocampus,only Adra2 a was downregulated,and there was no significant change in *** electron microscopy revealed a denser distribution the more distribution of postsynaptic glu

关键词： brain-derived neurotrophic factor glutamate hippocampus m CIMT middle cerebral artery occlusion modified constraint-induced movement therapy α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid receptor

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STCF conceptual design report (Volume 1): Physics & detector

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Frontiers of physics 2024年第1期19卷 1-154页

作者： M.Achasov X.C.Ai L.P.An R.Aliberti Q.An X.Z.bai Y.bai O.Bakina A.Barnyakov V.Blinov V.Bobrovnikov D.Bodrov A.Bogomyagkov A.Bondar I.Boyko Z.H.Bu F.M.Cai H.Cai J.J.Cao Q.H.Cao X.Cao Z.Cao Q.Chang K.T.Chao D.Y.Chen H.Chen H.X.Chen J.F.Chen K.Chen L.L.Chen P.Chen S.L.Chen S.M.Chen S.Chen S.P.Chen W.Chen X.Chen X.F.Chen X.R.Chen Y.Chen Y.Q.Chen H.Y.cheng J.cheng S.cheng T.G.cheng J.P.Dai L.Y.Dai X.C.Dai D.Dedovich A.Denig I.Denisenko J.M.Dias D.Z.Ding L.Y.Dong W.H.Dong V.Druzhinin D.S.Du Y.J.Du Z.G.Du L.M.Duan D.Epifanov Y.L.Fan S.S.Fang Z.J.Fang G.Fedotovich C.Q.Feng X.Feng Y.T.Feng J.L.Fu J.Gao Y.N.Gao P.S.Ge C.Q.Geng L.S.Geng A.Gilman L.Gong T.Gong B.Gou W.Gradl J.L.Gu A.Guevara L.C.Gui A.Q.Guo F.K.Guo J.C.Guo J.Guo Y.P.Guo Z.H.Guo A.Guskov K.L.Han L.Han M.Han X.Q.Hao J.B.He S.Q.He X.G.He Y.L.He Z.B.He Z.X.Heng B.L.Hou T.J.Hou Y.R.Hou C.Y.Hu H.M.Hu K.Hu R.J.Hu W.H.Hu X.H.Hu Y.C.Hu J.hua G.S.huang J.S.huang M.huang Q.Y.huang W.Q.huang X.T.huang X.J.huang Y.B.huang Y.S.huang N.Hüsken V.Ivanov Q.P.Ji J.J.Jia S.Jia Z.K.Jia H.B.Jiang J.Jiang S.Z.Jiang J.B.Jiao Z.Jiao H.J.jing X.L.Kang X.S.Kang B.C.Ke M.Kenzie A.Khoukaz I.Koop E.Kravchenko A.Kuzmin Y.Lei E.Levichev C.H.li C.li D.Y.li F.li G.li G.li H.B.li H.li H.N.li H.J.li H.L.li J.M.li J.li L.li L.li L.Y.li N.li P.R.li R.H.li S.li T.li W.J.li X.li X.H.li X.Q.li X.H.li Y.li Y.Y.li Z.J.li H.liang J.H.liang Y.T.liang G.R.liao L.Z.liao Y.liao C.X.lin D.X.lin X.S.lin B.J.liu C.W.liu D.liu F.liu G.M.liu H.B.liu J.liu J.J.liu J.B.liu K.liu K.Y.liu K.liu L.liu Q.liu S.B.liu T.liu X.liu Y.W.liu Y.liu Y.L.liu Z.Q.liu Z.Y.liu Z.W.liu I.Logashenko Y.long C.G.Lu J.X.Lu N.Lu Q.F.Lü Y.Lu Y.Lu Z.Lu P.Lukin F.J.Luo T.Luo X.F.Luo Y.H.Luo H.J.Lyu X.R.Lyu J.P.Ma P.Ma Y.Ma Y.M.Ma F.Maas S.Malde D.Matvienko Z.X.Meng R.Mitchell A.Nefediev Y.Nefedov S.L.Olsen Q.Ouyang P.Pakhlov G.Pakhlova X.Pan Y.Pan E.Passemar Y.P.Pei H.P.Peng L.Peng X.Y.Peng X.J.Peng K.Peters S.Pivovarov E.Pyata B.B.Qi Y.Q.Qi W.B.Qian Y.Qian C.F.Qiao J.J.Qin J.J.Qin L.Q.Qin X.S.Qin T.L.Qiu J.Rademacker C.F.Redmer H.Y.Sang Anhui University Hefei 230039China Beihang University Beijing 100191China Budker Institute of Nuclear Physics Novosibirsk 630090Russia CAS Key Laboratory of Theoretical Physics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China Cavendish Laboratory University of CambridgeJJ Thomson AveCambridge CB30HEUnited Kingdom Central China Normal University Wuhan 430079China Central South University Changsha 410083China China University of Geosciences Wuhan 430074China China University of Mining and Technology Xuzhou 221116China École Polytechnique Fédérale de Lausanne(EPFL) LausanneSwitzerland Fudan University Shanghai 200433China Goethe University Frankfurt D-60325 Frankfurt am MainGermany Guangxi Normal University Guilin 541004China Guangxi Uninversity Nanning 530004China Hangzhou Institute for Advanced Study UCASHangzhou 310024China Hebei Normal University Shijiazhuang 050024China Hebei University Baoding 071002China Hefei University of Technology Hefei 230601China Helmholtz Institute Mainz Staudinger Weg 18D-55099 MainzGermany Henan Normal University Xinxiang 453007China Henan University Kaifeng 475004China High Energy Physics Center Chung-Ang UniversitySeoul 06974Korea Higher School of Economy 11 Pokrovsky Bulvar Moscow 109028Russia huangshan University Huangshan 245000China Hubei University of Automotive Technology Shiyan 442002China Hunan Normal University Changsha 410081China Hunan University of Science and Technology Xiangtan 411201China Hunan University Changsha 410082China Indiana University BloomingtonIndiana 47405USA Inner Mongolia University Hohhot 010021China Institute of Advanced Science Facilities Shenzhen 518107China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China Institute of Physics Academia SinicaTaipeiTaiwan 11529China Institute of Theoretical Physics Chinese Academy of SciencesBeijing 100190China Jilin University Changch

The superτ-charm facility(STCF)is an electron–positron collider proposed by the Chinese particle physics *** is designed to operate in a center-of-mass energy range from 2 to 7 GeV with a peak luminosity of 0.5×10^(35) cm^(–2)·s^(–1) or *** STCF will produce a data sample about a factor of 100 larger than that of the presentτ-charm factory—the BEPCII,providing a unique platform for exploring the asymmetry of matter-antimatter(charge-parity violation),in-depth studies of the internal structure of hadrons and the nature of non-perturbative strong interactions,as well as searching for exotic hadrons and physics beyond the Standard *** STCF project in China is under development with an extensive R&D *** document presents the physics opportunities at the STCF,describes conceptual designs of the STCF detector system,and discusses future plans for detector R&D and physics case studies.

关键词： electron–positron collider tau-charm region high luminosity STCF detector conceptual design

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