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SCancerRNA:Expression at the Single-cell Level and Interaction Resource of Non-coding RNA Biomarkers for Cancers

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Genomics, Proteomics & Bioinformatics 2024年第3期22卷 125-131页

作者： Hongzhe Guo Liyuan Zhang Xinran Cui liang cheng Tianyi Zhao Yadong Wang Faculty of Computing Harbin Institute of TechnologyHarbin 150001China College of Bioinformatics Science and Technology Harbin Medical UniversityHarbin 150001China School of Medicine and Health Harbin Institute of TechnologyHarbin 150001China

Non-coding RNAs(ncRNAs)participate in multiple biological processes associated with cancers as tumor suppressors or oncogenic *** to their high stability in plasma,urine,and many other fluids,ncRNAs have the potential to serve as key biomarkers for early diagnosis and screening of *** cancer progression,tumor heterogeneity plays a crucial role,and it is particularly important to understand the gene expression patterns of individual *** the development of single-cell RNA sequencing(scRNA-seq)technologies,uncovering gene expression in different cell types for human cancers has become feasible by profiling transcriptomes at the cellular ***,a well-organized and comprehensive online resource that provides access to the expression of genes corresponding to ncRNA biomarkers in different cell types at the single-cell level is not available ***,we developed the SCancerRNA database to summarize experimentally supported data on long ncRNA,microRNA,PIWI-interacting RNA,small nucleolar RNA,and circular RNA biomarkers,as well as data on their differential expression at the cellular ***,we collected biological functions and clinical applications of biomarkers to facilitate the application of ncRNA biomarkers to cancer diagnosis,as well as the monitoring of progression and targeted *** also allows users to explore interaction networks of different types of ncRNAs,and build computational models in the *** is freely accessible at http://***/BioMarker.

关键词： Non-coding RNA Biomarker Cancer Single cell Interaction network

Positive Interactions： Crucial Organizers in a Plant Community

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Journal of Integrative Plant Biology 2006年第2期48卷 128-136页

作者： Dong-liang cheng Gen-Xuan Wang Bao-Ming Chen Xiao-Ping Wei Key Laboratory of Arid and Grassland Agroecology at Lanzhou University Ministry of Education Lanzhou 730000 China College of Life Sciences Zhejiang University Hangzhou 310027 China

For more than a century, ecologists have concentrated on competition as a crucial process for community organization. However, more recent experimental investigations have uncovered the striking Influence of positive Interactions on the organization of plant communities. Complex combinations of competition and positive interactions operating simultaneously among plant species seem to be widespread In nature. In the present paper, we reviewed the mechanism and ecological importance of positive Interactions In plant communities, emphasizing the certainties and uncertainties that have made It an attractive area of research. Positive Interactions, or facilitation, occur when one species enhances the survival, growth, or richness of another. The Importance of facilitation in plant organization increases with ablotlc stress and the relative Importance of competition decreases. Only by combining plant interactions and the many fields of biology can we fully understand how and when the positive Interactions occur.

关键词： competition environmental gradient facilitation plant community plant-plant communications positive interactions.

Experimental Investigation on the Pressure Propagation Mechanism of Tight Reservoirs

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Fluid Dynamics & Materials Processing 2020年第3期16卷 425-440页

作者： Jing Sun Dehua Liu Xiang Zhu Wenjun Huang liang cheng Yangtze University Petroleum Engineering CollegeWuhanChina Hubei Cooperative Innovation Center of Unconventional Oil and Gas WuhanChina Hubei Shale Gas Development Engineering Technology Research Center WuhanChina

Low permeability tight sandstone reservoirs have a high filtrational resistance and a very low fluid flow *** a result,the propagation speed of the formation pressure is low and fluid flow behaves as a non-Darcy flow,which typically displays a highly non-linear *** this paper,the characteristics and mechanism of pressure propagation in this kind of reservoir are revealed through a laboratory pressure propagation experiment and through data from an actual tight reservoir *** main performance mechanism is as follows:A new pressure cage concept is proposed based on the pressure variation characteristics of the laboratory *** are two methods of energy propagation in the actual water injection process:one is that energy is transmitted to the deep reservoir by the fluid flowing through the reservoir,and the other is that energy is transmitted by the elasticity of the *** one injection well model and one production well model,the pressure distribution curve between the injection and production wells,as calculated by the theoretical method,has three section types,and they show an oblique“S”shape with a straight middle ***,the actual pressure distribution curve is nonlinear,with an obvious pressure advance at the *** the injection pressure increases to a certain level,the curve shape is an oblique and reversed“S”*** on the research,this paper explains the deep-seated reasons for the difference in pressure distribution and proposes that it is an effective way to develop low permeability tight reservoirs using the water injection supplement energy method.

关键词： Low permeability tight reservoir pressure propagation pressure cage formation energy

A SIMPLE FINITE ELEMENT METHOD FOR THE REISSNER-MINDLIN PLATE

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Journal of Computational Mathematics 1994年第1期12卷 46-54页

作者： cheng Xiao-liang (Department of Mathematics, Hangzhou University, Hangzhou, Zhejiang, China) HANGZHOU UNIV DEPT MATHHANGZHOUPEOPLES R CHINA

A simple finite element method for the Reissner-Mindlin plate model in the primitive variables is presented and analyzed. The method uses conforming linear finite elements for both the transverse displacement and rotation. It is proved that the method converges with optimal order uniformly with respect to *** is simpler and more economical than the Arnold-Falk element[1].

关键词： Math A SIMPLE FINITE ELEMENT METHOD FOR THE REISSNER-MINDLIN PLATE IV

Online Condition Monitoring of Gripper Cylinder in TBM Based on EMD Method

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Chinese Journal of Mechanical Engineering 2017年第6期30卷 1325-1337页

作者： Lin Li Jian-Feng Tao Hai-Dong Yu Yi-Xiang Huang cheng-liang Liu State Key Laboratory of Mechanical System and Vibration Shanghai Jiao Tong University Shanghai 200240 China Shanghai Key Laboratory of Digital Manufacture for Thin-walled Structures Shanghai 200240 China

The gripper cylinder that provides braced force for Tunnel Boring Machine （TBM） might fail due to severe vibration when the TBM excavates in the tunnel. Early fault diagnosis of the gripper cylinder is important for the safety and efficiency of the whole tunneling project. In this paper, an online condition monitoring system based on the Empirical Mode Decomposition （EMD） method is estab- lished for fault diagnosis of the gripper cylinder while TBM is working. Firstly, the lumped mass parameter model of the gripper cylinder is established considering the influence of the variable stiffness at the rock interface, the equivalent stiffness of the oil, the seals, and the copper guide sleeve. The dynamic performance of the gripper cylinder is investigated to provide basis for its health condition evaluation. Then, the EMD method is applied to identify the characteristic frequencies of the gripper cylinder for fault diagnosis and a field test is used to verify the accuracy of the EMD method for detection of the characteristic frequencies. Furthermore, the contact stiff- ness at the interface between the barrel and the rod is calculated with Hertz theory and the relationship between the natural frequency and the stiffness varying with the health condition of the cylinder is simulated based on the dynamic model. The simulation shows that the character- istic frequencies decrease with the increasing clearance between the barrel and the rod, thus the defects could be indicated by monitoring the natural frequency. Finally, a health condition management system of the gripper cylin- der based on the vibration signal and the EMD method is established, which could ensure the safety of TBM.

关键词： Fault diagnosis - Empirical modedecomposition (EMD) Condition Monitoring - Grippercylinder TBM

Erratum to: Mineralized manganese dioxide channel as the stent coating for in situ precise tumor navigation

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Nano Research 2021年第7期14卷 2464-2466页

作者： Junyuan Xiao Yiran Zhang Tonglei Fang Tianwen Yuan Qinghua Tian Jingjing Liu Yingsheng cheng Yueqi Zhu liang cheng Wenguo Cui Department of Radiology Shanghai Jiao Tong University Affiliated Sixth People’s HospitalNo.600Yishan RoadShanghai 200233China Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases Shanghai Institute of Traumatology and OrthopaedicsRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China Institute of Functional Nano&Soft Materials(FUNSOM) Jiangsu Key Laboratory of Carbon-based Functional Materials and DevicesSoochow UniversitySuzhou 215123China Depatment of Interventional Oncology Dahua HospitalXuhui DistrictShanghai 200237China

The article “Mineralized manganese dioxide channel as the stent coating for in situ precise tumor navigation” was erroneously originally published electronically on the publisher’s internet portal (currently Spring... 详细信息

关键词： Nanotechnology Materials Science general Atomic/Molecular Structure and Spectra Condensed Matter Physics Biotechnology Biomedicine general

Sub-pixel change detection for urban land-cover analysis via multi-temporal remote sensing images

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Geo-Spatial Information Science 2014年第1期17卷 26-38页

作者： Peijun DU Sicong LIU Pei LIU Kun TAN liang cheng Key Laboratory for Satellite Mapping Technology and Application of National Administration of Surveying Mapping and GeoinformationNanjing UniversityNanjing CityJiangsu ProvinceP.R.China Department of Information Engineering and Computer Science University of TrentoTrentoItaly Jiangsu Provincial Key Laboratory for Resources and Environment Information Engineering China University of Mining and TechnologyXuzhouJiangsu ProvinceP.R.China

Conventional change detection approaches are mainly based on per-pixel processing,which ignore the sub-pixel spectral variation resulted from spectral *** for medium-resolution remote sensing images used in urban landcover change monitoring,land use/cover components within a single pixel are usually complicated and heterogeneous due to the limitation of the spatial ***,traditional hard detection methods based on pure pixel assumption may lead to a high level of omission and commission errors inevitably,degrading the overall accuracy of change *** order to address this issue and find a possible way to exploit the spectral variation in a sub-pixel level,a novel change detection scheme is designed based on the spectral mixture analysis and decision-level *** spectral mixture model is selected for spectral unmixing,and change detection is implemented in a sub-pixel level by investigating the inner-pixel subtle changes and combining multiple composition *** proposed method is tested on multi-temporal Landsat Thematic Mapper and China–Brazil Earth Resources Satellite remote sensing images for the land-cover change detection over urban *** effectiveness of the proposed approach is confirmed in terms of several accuracy indices in contrast with two pixel-based change detection methods(*** vector analysis and principal component analysis-based method).In particular,the proposed sub-pixel change detection approach not only provides the binary change information,but also obtains the characterization about change direction and intensity,which greatly extends the semantic meaning of the detected change targets.

关键词： change detection sub-pixel level processing multi-temporal images spectral mixture model back propagation neural network remote sensing

An experimental study on horizontal well waterflooding in the Cretaceous porous carbonate reservoir of Oman

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Energy Geoscience 2024年第3期5卷 85-92页

作者： Jie Chen liang cheng Song Jin Yongli Wang Leiting Shi Geological Exploration and Development Research Institute Chuanqing Drilling Engineering Company LimitedCNPCChengdu 610051China International Nature Gas Technology Support Center CNPCChengdu 610051China Oman Project Company CNPCBeijing 100034China State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation Southwest Petroleum UniversityChengdu 610500China

Porous carbonate reservoirs,prevalent in the Middle East,are lithologically dominated by bioclastic limestones,exhibiting high porosity,low permeability,intricate pore structure,and strong *** through horizontal wells is commonly used for exploiting these ***,challenges persist,such as significant uncertainty and complex operational procedures regarding adjustment effects during the *** USH reservoir of the Cretaceous D oilfield,Oman exemplifies typical porous carbonate *** initially underwent depletion drive using vertical wells,followed by horizontal well waterflooding in the late ***,the oilfield is confronted with substantial developmental challenges,involving the understanding of residual oil distribution,effective water cut control,and sustaining oil production since it has entered the late development *** a microscopic visualization displacement system equipped with electrodes,this study elucidated the waterflooding mechanisms and residual oil distribution in the late-stage development of the USH *** results reveal that the reservoir's vertical stacking patterns act as the main factor affecting the horizontal well waterflooding *** water flow channels emerge under varying reservoir stacking patterns,with post-waterflooding residual oil predominantly distributed at the reservoir's top and *** oil recovery can be enhanced by adjusting the waterflooding's flow line and *** findings of this study will provide theoretical insights of waterflooding mechanisms and injection-production adjustments for exploiting other porous carbonate reservoirs in the Middle East through horizontal wells.

关键词： Porous carbonate reservoir Horizontal well waterflooding Microscopic visualization Three-dimensional physical model Waterflooding characteristics

Highly-Sensitive Multiplexed in vivo Imaging Using PEGylated Upconversion Nanoparticles

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Nano Research 2010年第10期3卷 722-732页

作者： liang cheng Kai Yang Shuai Zhang Mingwang Shao Shuittong Lee Zhuang Liu Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices Institute of Functional Nano and Soft MaterialsSoochow UniversitySuzhouJiangsu 215123China Center of Super-Diamond and Advanced Films(COSDAF)and Department of Physics and Materials Science City University of Hong KongHong KongChina

Lanthanide-based upconversion nanoparticles(UCNPs)have been widely explored in various fields,including optical imaging,in recent *** earlier work has shown that UCNPs with different lanthanide(Ln3+)dopants exhibit various colors,multicolor-especially in vivo multiplexed biomedical imaging-using UCNPs has rarely been *** this work,we synthesize a series of UCNPs with different emission colors and functionalize them with an amphiphilic polymer to confer water *** in vivo upconversion luminescence(UCL)imaging is demonstrated by imaging subcutaneously injected UCNPs and applied in multiplexed in vivo lymph node *** also use UCNPs for multicolor cancer cell labeling and realize in vivo cell tracking by UCL ***,for the first time we compare the in vivo imaging sensitivity of quantum dot(QD)-based fluorescence imaging and UCNP-based UCL imaging side by side,and find the in vivo detection limit of UCNPs to be at least one order of magnitude lower than that of QDs in our current non-optimized imaging *** data suggest that,by virtue of their unique optical properties,UCNPs have great potential for use in highly-sensitive multiplexed biomedical imaging.

关键词： Upconversion nanoparticles multicolor imaging lymphatic mapping cell tracking sensitive imaging