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Embolization combined with endoscopic variceal ligation for the treatment of esophagogastric variceal bleeding in patients with cirrhosis

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Chinese Medical Journal 2007年第1期120卷 36-40页

作者： HUANG Liu-ye CUI Jun WU cheng-rong LIU yun-xiang Department of Gastroenterology Yuhuangding Hospital MedicalCollege of Qingdao University Yantai 264000 China

Background Esophagogastric variceal bleeding caused by cirrhosis is a kind of emergent condition in the clinic. This study was conducted to explore the therapeutic effect and superiority of embolization of gastric fundus vadces combined with endoscopic variceal ligation （EVL） of esophageal varices for the treatment of patients with esophagogastric variceal bleeding caused by cirrhosis. Methods Totally 172 patients were diagnosed by endoscopic examination within 24 hours of hospitalization with active gastric fundus variceal bleeding and grade II above esophageal varices caused by cirrhosis. Other causes leading to upper digestive tract bleeding were excluded. Patients were randomly divided into a control group （n=82） and a therapy group （n=-90） following a random number table method. For the former, embolization for gastric fundus varices was performed, then an EVL for esophageal varices was performed 2 months later. For the therapy group, embolization for gastric fundus varices and EVL for esophageal varices were performed at the same time. Results The rate of emergency hemostasis in the therapy group was 100.0%, higher than that in the control group （87.8%, P〈0.05）. The rate of early rebleeding in the therapy group was 6.7% while the rate in the control group was 23.6% （P〈0.05）. No complications related to treatment occurred in both groups. Conclusion Embolization for gastric fundus varices combined with EVL for esophageal varices is a safe and effective method for the treatment of patients with esophagogastric variceal bleeding caused by cirrhosis.

关键词： esophagogastric varices embolization endoscopic variceal ligation cirrhosis

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Narrow-band imaging in the diagnosis of early esophageal cancer and precancerous lesions

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Chinese Medical Journal 2009年第7期122卷 776-780页

作者： HUANG Liu-ye CUI Jun WU cheng-rong LIU yun-xiang XU Ning Department of Gastroenterology Yantai Yuhuangding HospitalAffiliated to Medical College of Qingdao University YantaiShandong 264000 China

Background In the recent years, the incidence of esophageal cancer in China has increased. The key point for raising the survival rate is the diagnosis and treatment at an early stage. Narrow-band imaging （NBI） can enhance the contrast of the mucous membrane of the esophagus without staining. This study aimed to explore the value of NBI in the diagnosis of early esophageal cancer and precancerous lesions. Methods The esophagus was examined with ordinary endoscopy and NBI endoscopy. Pit patterns and blood capillary forms were examined with routine magnifying endoscopy and NBI endoscopy. Finally, a 1.2% Lugoul＇s iodine solution was used to stain the esophageal mucosal surface and a biopsy was taken at all the sites where NBI or iodine staining was positive. NBI and iodine staining scales were compared with pathologic diagnosis, which was considered as the gold standard. Results A total of 90 cases （138 lesions in total） were diagnosed as early esophageal cancer or precancerous lesions; 104 lesions （75.4%） were detected with ordinary endoscopy, 120 lesions （87.0%） were detected with NBI endoscopy, and 138 lesions （100%） were detected with iodine staining. The lesion detection rate of NBI was significantly lower than that of iodine staining （X2=17.176, P 〈0.01）. However, there was no significant difference between NBI and iodine staining for the diagnosis of high grade intraepithelial neoplasia （X2=1.362, P 〉0.05）, while the detection rate of NBI was significantly lower than that of iodine staining for the diagnosis of low grade intraepithelial neoplasia （X2=13.388, P 〈0.01）. The pit pattern and blood capillary form of early esophageal cancer and precancerous lesions could be demonstrated clearer with NBI than with ordinary endoscopy. Conclusions NBI can enhance the contrast of the mucous membrane of the esophagus without staining. The combination of NBI and iodine staining can raise the diagnostic rate of early esophageal cancer and precancerous lesions.

关键词： esophageal neoplasms endoscopy narrow-band imaging

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Effects of Buyang Huanwu Decoction on antioxidant and drug-metabolizing enzymes in rat liver

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Chinese Journal of Natural Medicines 2014年第6期12卷 449-454页

作者： FAN Xing-Hua SHI Wei-Zhou cheng yun-xiang YANG Xiu-Fen Department of Pharmacology College of Pharmacy Guangxi University of Chinese Medicine Department of pharmacy Liuzhou Worker's Hospital

AIM: To study the effect of Buyang Huanwu Decoction(BYHWD) on the antioxidant enzymes and drug-metabolizing enzymes in rat liver. METHOD: Following treatment of rats with BYHWD at 6.42, 12.83, or 25.66 g·kg–1 per day for 15 days, microsomes and cytosols isolated from the liver tissues were prepared by differential centrifugation according to standard procedures. The activities of the antioxidant enzymes and cytochrome b5, NADPH-cytochrome P450 reductase, CYP3 A, CYP2E1, UGT, and GST of the rat livers were determined by UV-Vis spectrophotometer. RESULTS: The activities of ALT, AST, antioxidant enzymes, and the Hepatosomatic Index in serum were not significantly affected. In cytosols, the activity of CAT was significantly increased at the dosage of 12.83 g·kg–1, and all the other antioxidant activities and MDA levels were not affected by this treatment. BYHWD had no effect on cytochrome b5, NADPH-cytochrome P450 reductase, CYP3 A, and UGT. At the highest dose(25.66 g·kg–1), the activity of CYP2E1 was significantly inhibited, and the activities of GST and the level of GSH were increased. CONCLUSION: BYHWD is safe for the liver, and has the functions of detoxification and antioxidant. Patients should be cautioned about the herb-drug interaction of BYHWD and CYP2E1 substrates.

关键词： Buyang Huanwu Decoction Antioxidant Drug-metabolizing enzymes

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对“应用平面杆系有限元法程序分析连续弯箱梁桥”一文的补充

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公路 2005年第2期50卷 1-7页

作者：程翔云湖南大学土木工程学院长沙市410082

文中补充了两项内容:(1)验证了应用平面杆系有限元法程序也能分析混合型(抗扭支座与点铰支座兼有)连续弯箱梁桥的截面内力;(2)找到了另一种更简便的方法来计算该类桥型中两个特殊截面(跨中和中支点截面)的内力。

关键词：箱梁桥平面杆系桥型铰支座有限元法截面内力连续计算补充中和

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基于阈值处理的TD-SCDMA下行多用户信道估计方法

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电子学报 2012年第9期40卷 1904-1908页

作者：赵德香马秀荣白媛程云翔天津理工大学计算机与通信工程学院薄膜电子与通信器件天津市重点实验室天津300384

阈值后处理是针对TD-SCDMA系统中B Steiner信道估计器受加性噪声影响而提出的一种去噪方法,该方法误滤除信息径,保留噪声径.本文提出一种基于阈值处理的多用户信道估计方法,它基于某一下行用户会收到所有其它下行用户的训练序列这一特性... 详细信息

阈值后处理是针对TD-SCDMA系统中B Steiner信道估计器受加性噪声影响而提出的一种去噪方法,该方法误滤除信息径,保留噪声径.本文提出一种基于阈值处理的多用户信道估计方法,它基于某一下行用户会收到所有其它下行用户的训练序列这一特性,设定一个值,与各用户幅度加权值比较,去掉信噪比很小的用户对应的信道估计窗,将其余用户的信道估计窗进行平均,然后将平均后的结果再进行阈值后处理,抑制由噪声贡献的信道响应.仿真结果表明,提出的方法与直接进行阈值后处理法在同一误码率下,所需平均信噪比（SNR）降低1~4dB;在SNR低于5dB时,与复杂度高的加权合并法具有相同的误码率.

关键词： TD-SCDMA BSteiner估计器信道估计信道估计窗平均阈值后处理

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非等长桩群桩基础的等代计算模型

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公路 2010年第12期55卷 1-5页

作者：程翔云湖南大学土木工程学院长沙市410082

非等长桩群桩基础的变形性能,可以用在顶端设置一个水平刚臂和一个水平弹簧支承的悬臂立柱来模拟。通过算例的分析结果表明,这种等代计算模型不仅具有较高的精度,而且大大地简化了超静定桥梁结构的上、下部结构整体分析。

关键词：群桩基础刚臂弹簧支承弹性中心偏心距非等长桩

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飞燕式钢管混凝土拱桥的计算图式

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公路 2005年第11期50卷 21-24页

作者：程翔云湖南大学土木工程学院长沙市410082

结合桥梁的受力特点和施工方法,提出了飞燕式钢管混凝土拱桥在不同阶段的计算图式和拱肋等代截面的计算公式。这些对于设计人员来说是有参考意义的。

关键词：飞燕式钢管混凝土等代截面自锚式拱桥计算图式中承式拱桥

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后张连续预应力筋锚固损失精确计算

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湖南大学学报（自然科学版） 2008年第9期35卷 15-18页

作者：邵旭东夏红波程翔云湖南大学桥梁工程研究所湖南长沙410082

基于摩擦理论,建立了预应力筋微段平衡方程,利用变形协调条件,推导了桥梁工程中典型的五段式预应力筋的锚固损失解析解,将计算方法推广到n段混合线形的预应力筋,并给出了反摩擦影响长度等于预应力筋全长时锚固损失的计算公式,最后通过... 详细信息

基于摩擦理论,建立了预应力筋微段平衡方程,利用变形协调条件,推导了桥梁工程中典型的五段式预应力筋的锚固损失解析解,将计算方法推广到n段混合线形的预应力筋,并给出了反摩擦影响长度等于预应力筋全长时锚固损失的计算公式,最后通过算例将本文的计算方法与现行公路桥梁规范和铁路桥梁规范给出的方法进行了对比.结果表明,本文解析方法适用于弯曲角度较大或形状变化较大的预应力筋的锚固损失计算.

关键词：桥梁后张预应力筋锚固损失解析解规范

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Mitophagy in acute central nervous system injuries:regulatory mechanisms and therapeutic potentials

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Neural Regeneration Research 2025年第9期20卷 2437-2453页

作者： Siyi Xu Junqiu Jia Rui Mao xiang Cao yun Xu Department of Neurology Nanjing Drum Tower HospitalClinical College of Jiangsu UniversityNanjingJiangsu ProvinceChina Department of Neurology Nanjing Drum Tower HospitalChinese Academy of Medical Science&Peking Union Medical CollegeNanjingJiangsu ProvinceChina Department of Neurology Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjingJiangsu ProvinceChina State Key Laboratory of Pharmaceutical Biotechnology and Institute of Translational Medicine for Brain Critical Diseases Nanjing UniversityNanjingJiangsu ProvinceChina Jiangsu Key Laboratory for Molecular Medicine Medical School of Nanjing UniversityNanjingJiangsu ProvinceChina Nanjing Neurology Medical Center NanjingJiangsu ProvinceChina

Acute central nervous system injuries,including ischemic stro ke,intracerebral hemorrhage,subarachnoid hemorrhage,traumatic brain injury,and spinal co rd injury,are a major global health *** optimal therapies and improving the long-term neurological functions of patients with acute central nervous system injuries are urgent *** are susceptible to damage after acute central nervous system injury,and this leads to the release of toxic levels of reactive oxygen species,which induce cell ***,a selective form of autophagy,is crucial in eliminating redundant or damaged mitochondria during these *** evidence has highlighted the significant role of mitophagy in acute central nervous system *** this review,we provide a comprehensive overview of the process,classification,and related mechanisms of *** also highlight the recent developments in research into the role of mitophagy in various acute central nervous system injuries and drug therapies that regulate *** the final section of this review,we emphasize the potential for treating these disorders by focusing on mitophagy and suggest future research paths in this area.

关键词： autophagy intracerebral hemorrhage ischemic stroke mitochondria mitochondrial biogenesis mitochondrial quality control mitophagy spinal cord injury subarachnoid hemorrhage traumatic brain injury

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基于自适应小区选择的切换控制算法研究

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通信学报 2011年第9期32卷 9-17页

作者：马秀荣张会龙白媛程云翔天津理工大学计算机与通信工程学院通信器件教育部工程研究中心天津300384 天津理工大学薄膜电子与通信器件天津市重点实验室天津300384

针对现有切换控制算法的不足,提出了一种基于自适应小区选择的优先级信道预留切换算法。该算法在切换时根据各小区的负载情况,通过调整导频功率使小区间负载均衡,以系统效用最大化为目标,进行基于预留信道的优先级切换。系统效用通过多... 详细信息

针对现有切换控制算法的不足,提出了一种基于自适应小区选择的优先级信道预留切换算法。该算法在切换时根据各小区的负载情况,通过调整导频功率使小区间负载均衡,以系统效用最大化为目标,进行基于预留信道的优先级切换。系统效用通过多选择多维背包算法建模实现,预留信道的优先级切换通过马尔科夫排队模型实现。通过多选择多维背包建模、马尔科夫排队建模与实验仿真表明,该算法的性能在相邻小区间负载不均衡的情况下比目前切换控制所用的优先级信道预留切换算法明显提高。在负载不均衡度为6时,话音业务阻塞率与数据业务分组丢失率比目前算法分别降低0.2%和3%左右,数据分组平均最大等待时间比目前算法降低0.15s,系统小区平均吞吐量最大时升高80kbit/s/cell/MHz。

关键词：切换优先级阻塞率小区选择

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