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Triamcinolone as an adjunct to the combination of anti-VEGF for the management of diabetic macular edema

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International Journal of Ophthalmology(English edition) 2021年第6期14卷 869-874页

作者： Ying-Ying Yu Yong cheng Li-Bin Chang Hui-Ka Xia xiao-Xin Li Department of Ophthalmology Peking University People’s HospitalEye diseases and Optometry InstituteBeijing Key Laboratory of Diagnosis and Therapy of Retinal and Choroid DiseasesCollege of OptometryPeking University Health Science CenterBeijing 100044China Department of Ophthalmology Beijing Jingmei Group General HospitalBeijing 102300China Department of Ophthalmology Hebei General HospitalShijiazhuang 050051Hebei ProvinceChina Xiamen Eye Center of Xiamen University Xiamen 361003Fujian ProvinceChina

AIM:To assess the efficacy of intravitreal triamcinolone(IVTA)as an adjunct to the combination of anti-vascular endothelial growth factor(VEGF)for the management of diabetic macular edema(DME).METHODS:A total of 51 patients with visual disabilities causing by DME from two sites were retrospectively collected and assigned to two groups according to the therapeutic method:intravitreal conbercept(IVC)combined with focal laser(24 eyes)and IVC combined with focal laser and IVTA(27 eyes).Best-corrected visual acuity(BCVA),the required number of IVCs,central retinal thickness(CRT),the mean costs of treatment burden and safety were compared over 12 ***:From baseline to month 1 through month 12,IVC combined with focal laser and IVTA improved the mean average change in BCVA superior to IVC combined with focal laser(+5.20 vs+2.71 letters).At month 12,20.83%of the IVC combined with focal laser and 37.04%of IVC combined with focal laser and IVTA arms gained more than 10 BCVA *** the period,the mean CRT decreased significantly in the IVC combined with focal laser and IVTA arm(-245.9μm)compared to the IVC combined with focal laser arm(-98.45μm).The average of 6.45 and 1.25 conbercept injections performed in the IVC combined with focal laser and IVC combined with focal laser and IVTA arms,*** mean cost of treatment burden for 12 mo was$6247.44±4069.18 in the IVC combined with focal laser arm and$1679.19±542.73 in the IVC combined with focal laser and IVTA arm,with a statistically significant *** from occasional minor subconjunctival hemorrhage,no other significant ocular adverse events(AEs)were observed in either group during the 12-month ***:It is effective and cost-effective to treat DME by utilizing triamcinolone as an adjunct to the combination of anti-VEGF.

关键词： diabetic macular edema intravitreal triamcinolone anti-vascular endothelial growth factor

Asymmetric Deoxygenative Cyanation of Benzyl Alcohols Enabled by Synergistic Photoredox and Copper Catalysis

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Chinese Journal of Chemistry 2020年第12期38卷 1671-1675页

作者： Hong-Wei Chen Fu-Dong Lu Ying cheng Yue Jia Liang-Qiu Lu Wen-Jing xiao CCNJ-uOttow Joint Research Cente Key laboratory of Pesticide and Chemical BiologyMinistry of EducationCollege of Chemistry Central ChinaNormal University152 Luoyu RoadWuhanHubei 430079China State Key Laboratory of Organometalic Chemistry Shanghai lnstitute of Organic Chemistry345 Lingling RoadShanghai20032China

of main observation and conclusion An enantioselective deoxygenative cyanation of benzyl alcohols was accomplished for the first time through the synergistic photoredox and copper *** reaction features the use of organic photosensitizer and low-cost 3d metal catalyst,simple and safe operations,and extremely mild conditions.A variety of chiral benzyl nitriles were produced in generally good yields and high level of enantiocontrols from readily available feedstocks(22 examples,up to 93%yield and 92%ee).

关键词： redox benzyl alcohols

Effects of individual shock wave therapy vs celecoxib on hip pain caused by femoral head necrosis

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World Journal of Clinical Cases 2023年第9期11卷 1974-1984页

作者： Jun-Yu Zhu Jun Yan Jian xiao Hai-guang Jia Hao-Jun Liang Geng-Yan Xing Orthopedic Department The Third Medical Center of Chinese People’s Liberation Army General HospitalThe Armed Police Clinical CollegeAnhui Medical UniversityHefei 230022Anhui ProvinceChina Orthopedic Department The Third Medical Center of Chinese People’s Liberation Army General HospitalBeijing 100039China

BACKGROUND Celecoxib has been used to treat hip discomfort and functional difficulties associated with osteonecrosis of the femoral head(ONFH),although significant adverse reactions often follow long-term *** shock wave therapy(ESWT)can delay the progression of ONFH,alleviate the pain and functional limitations it causes,and avoid the adverse effects of *** To investigate the effects of individual ESWT,a treatment alternative to the use of celecoxib,in alleviating pain and dysfunction caused by *** This was a randomized,controlled,double-blinded,non-inferiority *** examined 80 patients for eligibility in this study;8 patients were excluded based on inclusion and exclusion criteria.A total of 72 subjects with ONFH were randomly assigned to group A(n=36;celecoxib+alendronate+sham-placebo shock wave)or group B(n=36;individual focused shock wave[ESWT based on magnetic resonance imaging three-dimensional(MRI-3D)reconstruction]+alendronate).The outcomes were assessed at baseline,at the end of treatment,and at an 8-wk *** primary outcome measure was treatment efficiency after 2 wk of intervention using the Harris hip score(HHS)(improvement of 10 points or more from the baseline was deemed sufficient).Secondary outcome measures were post-treatment HHS,visual analog scale(VAS),and Western Ontario and McMaster Universities Osteoarthritis Index(WOMAC)*** After treatment,the pain treatment efficiency of group B was greater than that of group A(69%vs 51%;95%CI:4.56%to 40.56%),with non-inferiority thresholds of-4.56%and-10%,***,the HHS,WOMAC,and VAS scores in group B dramatically improved during the follow-up period as compared to those in group A(P<0.001).After therapy,the VAS and WOMAC in group A were significantly improved from the 2nd to 8th wk(P<0.001),although HHS was only significantly altered at the 2 wk point(P<0.001).On the 1st d and 2nd wk after treatment,HHS and VAS scores were different

关键词： Extracorporeal shockwave therapy Osteonecrosis of femoral head Pain Magnetic resonance imaging three-dimensional reconstruction Celecoxib

Synthesis, crystal structure and thermal analysis of tetraiodo-4,4'-bi-1,2,4-triazole

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Chinese Chemical Letters 2013年第9期24卷 786-788页

作者： Lei Li Yu Chi xiao-Yu Zhang guang-Quan Zhang Yong Zhang Ting-Xing Zhao Ming Huang Hong-Bo Li School of Materials Science and Engineering Southwest University of Science and Technology Institute of Chemical Materials CAEP

Tetraiodo-4,4＇-bi-l,2,4-triazole （1） was synthesized from a reaction of iodine monochloride witb 4,4＇ bi- 1,2,4-triazole （2）, which was prepared by a transamination reaction between 4-amine-1,2,4-triazole and N,N-dimethylformamide azine dihydrochloride （3） obtained via a Vilsmeier reaction. The title compound was extensively characterized by melting point, elemental analysis, 1R, HRMS and single crystal X-ray diffraction. The single crystal X-ray structural analysis reveals that compound 1 exhibits a stable conformation with the two triazole rings being perpendicular to minimize three-dimensional steric hindrance and stacking through aromatic zr. analysis from TGA and DSC indicates that resnectivelv. Jr packing interactions between molecules. The therma compound I decomposes at 275.40 ℃ and 338.35 C

关键词： Tetraiodo-4 4'-bi- 1 2 4-triazole Synthesis Crystal structure Thermal stability

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高速铁路接触网吊弦拉扭多工况耦合力学性能

计算机仿真 2024年第8期41卷 155-160页

作者：吕笑文刘叶诚谭海恒徐志彪五邑大学轨道交通学院广东江门529000

吊弦是电气化铁路接触网的重要组成部件,随着列车的不断提速,对高速铁路接触网吊弦提出了更高的要求。针对吊弦在拉-扭耦合应力下的服役工况,采用有限元仿真软件对其进行拉-扭多工况耦合模拟。仿真结果表明:纯扭转载荷作用下吊弦的轴向... 详细信息

吊弦是电气化铁路接触网的重要组成部件,随着列车的不断提速,对高速铁路接触网吊弦提出了更高的要求。针对吊弦在拉-扭耦合应力下的服役工况,采用有限元仿真软件对其进行拉-扭多工况耦合模拟。仿真结果表明:纯扭转载荷作用下吊弦的轴向位移及扭转角度与扭转载荷近似呈线性正相关,沿吊弦丝线截面圆周方向,等效应力呈层状分布;拉-扭耦合应力下,其扭转角随载荷的增大而增大,但应力分布无明显规律。特别地,当耦合电流作用时,拉-扭载荷作用下,吊弦丝线的局部应力显著增大,抗变形能力降低。

关键词：吊弦数值模拟力学性能拉扭耦合载流

SYNTHESIS OF POLY(VINYL ACETATE)-INTERCALATED GRAPHITE OXIDE BY AN IN SITU INTERCALATIVE POLYMERIZATION

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Chinese Journal of Polymer Science 2000年第5期18卷 413-418页

作者： Ping-gui Liu Peng xiao Min xiao Ke-cheng Gong Beijing Institute of Aeronautical Materials, Beijing 100095, China Polymer Structure & Modification Lab, South China University of Technology, guangzhou 510640, China 北京航空材料研究院北京华南理工大学广东广州

Graphite oxide, a pseudo-two-dimensional solid in bulk form, was synthesized from natural graphite powder by oxidization with KMnO4 in concentrated H2SO4. The poly(vinyl acetate)-intercalated graphite oxide nano-composite was prepared by an in situ intercalative polymerization reaction, in which n-octanol-graphite oxide intercalation compounds were first obtained, vinyl acetate monomer was then dispersed into the interlayer of modified graphite oxide, followed by thermal polymerization of the monomer. It was experimentally shown that the c-axis space of poly(vinyl acetate)-intercalated graphite oxide was increased to 0.115 nm, which suggested there existed a monolayer of poly(vinyl acetate) chain between the layers of graphite oxide. The nanocomposite was also characterized with thermal analysis and FT-IR spectrometry.

关键词： graphite oxide poly(vinyl acetate) intercalate

The Current Status and Challenges Regarding Tuberculosis Infection Control in Health Care Facilities in China

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Biomedical and Environmental Sciences 2015年第11期28卷 848-854页

作者： ZHAO Fei cheng Jun cheng Shi Ming ZHANG Hui ZHAO Yan Lin ZHANG Can You HU Dong Mei FAN Hai Ying HUANG Fei QU Yan HE guang Xue WANG Li Xia National Center for Tuberculosis Control and Prevention Chinese Center for Disease Control and Prevention Science and Technology Department Chinese Center for Disease Control and Prevention

Health care facilities are a high-risk environment for generating and spreading respiratory infectious diseases such as tuberculosis （TB）. The TB prevention and treatment staff in health care facilities are responsi... 详细信息

关键词： TB The Current Status and Challenges Regarding Tuberculosis Infection Control in Health Care Facilities in China

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酸化与富磷影响农田土壤硅的移动性

中国土壤与肥料 2024年第1期 51-59页

作者：张庚金贾露露索猛利吴建富郑继成颜晓魏宗强曾庆阳江西农业大学国土资源与环境学院江西南昌330045 海南省三亚市南繁科学技术研究院海南三亚572022

硅是水稻等禾本科作物生长发育不可或缺的营养元素,pH影响着土壤中硅的有效性和形态转化,而土壤磷与硅之间存在明显的竞争吸附效应。以常年水稻-瓜/菜轮作农田土壤为研究对象,进行等摩尔硅磷竞争吸附试验、土壤培养试验和硅分组试验,模... 详细信息

硅是水稻等禾本科作物生长发育不可或缺的营养元素,pH影响着土壤中硅的有效性和形态转化,而土壤磷与硅之间存在明显的竞争吸附效应。以常年水稻-瓜/菜轮作农田土壤为研究对象,进行等摩尔硅磷竞争吸附试验、土壤培养试验和硅分组试验,模拟探究土壤酸化和磷富集对土壤硅的有效性及移动性的影响,以期为农田硅、磷养分管理提供一定的理论依据。结果表明,在pH 3.5~6.4范围内,同时加入等摩尔浓度的硅和磷时,磷的存在会抑制土壤吸附硅,使土壤对硅的吸附量降低78%~350%。土壤对硅的吸附小于对磷的吸附,磷的添加导致了土壤中硅的解吸。土壤酸化和磷添加均降低了土壤对硅的吸附,且在pH较高时添加磷对降低土壤吸硅的效果更为显著。土壤酸化降低了可移动态硅、吸附态硅、有机结合态硅和铁铝锰(氢)氧化物结合态硅的含量,但增加无定形态硅含量。与pH 6.4相比,酸化使可移动态硅和吸附态硅含量分别降低了22.47%~54.32%、10.72%~33.40%;磷添加使可移动态硅含量增加了4.07%~9.40%,吸附态硅含量降低了1.19%~3.53%。pH可调控土壤硅的溶解与吸附-解吸过程,从而影响土壤硅的移动性;磷富集促进土壤吸附态硅的解吸,进而增强土壤硅的移动性。

关键词：土壤酸化磷添加硅吸附特性硅形态硅移动性

Establishment of induced pluripotent stem cells from aged mice using bone marrow-derived myeloid cells

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分子细胞生物学报:英文版 2011年第2期3卷 91-98页

作者： Zhao cheng Sachiko Ito Naomi Nishio Hengyi xiao Rong Zhang Haruhiko Suzuki Yayoi Okawa Toyoaki Murohara Ken-ichi Isobe Department of Immunology Nagoya University Graduate School of Medicine65 Turumai-choShowa-kuNagoyaAichi 466-8520Japan Laboratory for Geriatrics State Key Laboratory of BiotherapySichuan UniversityChengdu 610041China Department of Functioning Activation National Institute for Longevity SciencesNational Center for Geriatrics GerontologyAichi 463-0003Japan Department of Cardiology Nagoya University Graduate School of Medicine65 Turumai-choShowa-kuNagoyaAichi 466-8520Japan

If induced pluripotent stem(iPS)cells are to be used to treat damaged tissues or repair organs in elderly patients,it will be necessary to establish iPS cells from their *** determine the feasibility of using this technology with elderly patients,we asked if it was indeed possible to establish iPS cells from the bone marrow(BM)of aged *** cells from aged C57BL/6 mice carrying the green fluorescence protein(GFP)gene were cultured with granulocyte macrophage-colony stimulating factor(GM-CSF)for 4 *** factors(Oct3/4,Sox2,Klf4 and c-Myc)were introduced into the BM-derived myeloid(BM-M)*** efficiency of generating iPS cells from aged BM cultured in GM-CSF was ***,we succeeded in obtaining BM-M-iPS cells from aged C57BL/6 mice,which carried *** BM-M-iPS cells expressed SSEA-1 and Pou5f1 and were positive for alkaline phosphatase *** iPS cells did make teratoma with three germ layers following injection into syngeneic C57BL/6 mice,and can be differentiated to three germ layers in *** co-culturing with OP9,the BM-M-iPS cells can be differentiated to the myeloid *** differentiated BM-M-iPS cells proliferated well in the presence of GM-CSF,and lost expression of Nanog and Pou5f1,at least in part,due to methylation of their *** the contrary,Tnf and Il1b gene expression was upregulated and their promoters were hypomethylated.

关键词： induced pluripotent stem cells aged mouse bone marrow myeloid cells gene expression methylation ChIP assay