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Detoxification strategy of Microcystis aeruginosa to the toxicity of Cd(Ⅱ):role of EPS in alleviating toxicity

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Journal of Oceanology and Limnology 2024年第3期42卷 802-815页

作者： Xingye HAN Fangyuan LIU Yibo ZHANG Kai cheng Heyun WANG Hongmei ge Innovation Demonstration Base of Ecological Environment geotechnical and Ecological Restoration of Rivers and Lakes School of Civil EngineeringArchitecture and EnvironmentHubei University of TechnologyWuhan 430068China School of Environmental Science and Engineering Huazhong University of Science and TechnologyWuhan 430074China National Engineering Research Center of Advanced Technology and Equipment for Water Environment Pollution Monitoring Wuhan 430068China

Although many studies have found that cadmium(Cd)can be toxic to microalgae,only a few reports focused on the role of extracellular polymeric substances(EPS)in Cd(Ⅱ)*** biochemical and physiological endpoints of Microcystis aeruginosa,including the composition and functional groups of soluble EPS(SL-EPS),loosely bound EPS(LB-EPS),and tightly bound EPS(TB-EPS),were detected to elucidate the toxicity and detoxification mechanisms of Cd(Ⅱ)for *** and physiological assays on *** showed that the 0.25-mg/L Cd(Ⅱ)resulted in a larger inhibition on growth and F_(v)/F_(m).Nevertheless,Cd(Ⅱ)significantly induced much higher contents of superoxide dismutase(SOD),intracellular microcystin LR(MC-LR),extracellular MC-LR,and *** electron microscopy with energy dispersive X-ray spectroscopy confirmed that Cd(Ⅱ)was absorbed into the EPS *** transform infrared spectrum analysis revealed that the functional groups bound with Cd(Ⅱ)of algae biomass,SL-EPS,LB-EPS,and TB-EPS were somewhat *** C=O/C=N groups ofδ-lactam or protein were their prominent functional groups,suggesting that amide or proteins in the EPS played a key role in the adsorption in Cd(Ⅱ).The concentration of 0.25 mg/L of Cd(Ⅱ)may change the chemical structure of EPS by altering the production of protein-like substances containing *** study indicated that *** could detoxify Cd(Ⅱ)stress via induction of antioxidant capacity(higher SOD activity and MC synthesis),EPS production,and modification in chemical structure of EPS.

关键词： Microcystis aeruginosa cadmium extracellular polymeric substances(EPS) microcystin detoxification

A Study on the Assessment and Integration of Multi-Source Evapotranspiration Products over the Tibetan Plateau

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Advances in Atmospheric Sciences 2024年第3期41卷 435-448页

作者： Ming cheng Lei ZHONG Yaoming MA Han MA Yaoxin CHANG Peizhen LI Meilin cheng Xian WANG Nan ge School of Earth and Space Sciences University of Science and Technology of ChinaHefei 230026China CAS Center for Excellence in Comparative Planetology Hefei 230026China Jiangsu Collaborative Innovation Center for Climate Change Nanjing 210023China Frontiers Science Center for Planetary Exploration and Emerging Technologies University of Science and Technology of ChinaHefei 230026China Land-Atmosphere Interaction and its Climatic Effects Group State Key Laboratory of Tibetan Plateau Earth SystemResources and Environment(TPESRE)Institute of Tibetan Plateau ResearchChinese Academy of SciencesBeijing 100101China College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijing 100049China College of Atmospheric Science Lanzhou UniversityLanzhou 730000China National Observation and Research Station for Qomolongma Special Atmospheric Processes and Environmental Changes Dingri 858200China Kathmandu Center of Research and Education Chinese Academy of SciencesBeijing 100101China China-Pakistan Joint Research Center on Earth Sciences Chinese Academy of SciencesIslamabad 45320Pakistan

Evapotranspiration(ET)is a crucial variable in the terrestrial water,carbon,and energy *** present,a large number of multi source ET products *** to sparse observations,however,great challenges exist in the evaluation and integration of ET products in remote and complex areas such as the Tibetan Plateau(TP).In this paper,the applicability of the multiple collocation(MC)method over the TP is evaluated for the first time,and the uncertainty of multisource ET products(based on reanalysis,remote sensing,and land surface models)is further analyzed,which provides a theoretical basis for ET data *** results show that 1)ET uncertainties quantified via the MC method are lower in RS-based ET products(5.95 vs.7.06 mm month^(-1))than in LSM ET products(10.22 vs.17.97 mm month^(-1))and reanalysis ET estimates(7.27 vs.12.26 mm month-1).2)A multisource evapotranspiration(MET)dataset is generated at a monthly temporal scale with a spatial resolution of 0.25°across the TP during *** has better performance than any individual product.3)Based on the fusion product,the total ET amount over the TP and its patterns of spatiotemporal variability are clearly *** annual total ET over the entire TP is approximately 380.60 ***,an increasing trend of 1.59±0.85 mm yr^(-1)over the TP is shown during *** study provides a basis for future studies on water and energy cycles and water resource management over the TP and surrounding regions.

关键词： evapotranspiration data fusion multiple collocation the Tibetan Plateau

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程少丹治疗难治性膝骨关节炎经验

中国中医骨伤科杂志 2024年第7期32卷 82-84页

作者：熊子超彭思琛葛程张洋王世辉高韵文庞海莉刘璐丁云媃程少丹上海中医药大学附属光华医院上海200052 上海中医药大学上海201203 上海市长宁区程少丹名中医工作室上海200052 上海市中医药研究院中西医结合关节炎研究所上海200052

程少丹认为难治性膝骨关节炎核心病机在于肾阳不足,推动无力,导致水液内停,宗筋瘛疭为患。治疗关键在于温阳利水,形成针药结合的温阳利水治法。针具继承上海伤科八大家之陆氏伤科银质针及芒针,针法强调辨证取穴、粗针重刺、长针深刺,温... 详细信息

程少丹认为难治性膝骨关节炎核心病机在于肾阳不足,推动无力,导致水液内停,宗筋瘛疭为患。治疗关键在于温阳利水,形成针药结合的温阳利水治法。针具继承上海伤科八大家之陆氏伤科银质针及芒针,针法强调辨证取穴、粗针重刺、长针深刺,温针灸助阳,泻机关之水;遣方用药主以调身通痹方及温肾通痹方随证加减。

关键词：难治性膝骨关节炎证治临床经验肾阳不足水液内停温阳利水

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小型化冷阴极触发管的研究

真空电子技术 2024年第3期 85-90页

作者：田伟静史中正张欣王霄姜鹏吴平孙承革张明中国电子科技集团公司第十二研究所北京100015 空装驻北京地区第七军代表室北京100080

冷阴极触发管是电子引信系统中的关键器件,具有开关电流大、使用电压范围宽、温度范围宽、可靠性高、抗干扰性强等特点。针对电子引信系统小型化、集成化、低成本、高可靠发展的需要,本文开展小型化冷阴极触发管的研究,设计并制得样管... 详细信息

冷阴极触发管是电子引信系统中的关键器件,具有开关电流大、使用电压范围宽、温度范围宽、可靠性高、抗干扰性强等特点。针对电子引信系统小型化、集成化、低成本、高可靠发展的需要,本文开展小型化冷阴极触发管的研究,设计并制得样管。通过仿真,给出静电场分布情况。对样管进行电参数和可靠性能测试,结果表明,其工作电压范围为1.2~1.8 kV,且可通过对工作寿命、振动、高低温工作和贮存、冲击等可靠性试验考核,主要参数基本满足现代电子引信的使用需求。

关键词：引信冷阴极触发管低成本小型化

A comparison of statistical learning of naturalistic textures between DCNNs and the human visual hierarchy

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Science China Technological Sciences 2024年第8期67卷 2310-2318页

作者： LU Xincheng YUAN ZiQi ZHANG YiChi AI HaiLin cheng SiYuan ge YiRan FANG Fang CHEN NiHong Department of Psychological and Cognitive Sciences Tsinghua University Department of Computer Science and Technology Tsinghua University School of Psychological and Cognitive Sciences and Beijing Key Laboratory of Behavior and Mental Health Peking University Key Laboratory of Machine Perception (Ministry of Education) Peking University Peking-Tsinghua Center for Life Sciences Peking University IDG/McGovern Institute for Brain Research Peking University State Key Laboratory of Brain and Cognitive Science Institute of Psychology Chinese Academy of Sciences IDG/McGovern Institute for Brain Research Tsinghua University

The visual system continuously adapts to the statistical properties of the environment. Existing evidence shows a close resemblance between deep convolutional neural networks(CNNs) and primate visual stream in neural selectivity to naturalistic textures above the primary visual processing stage. This study delves into the mechanisms of perceptual learning in CNNs,focusing on how they assimilate the high-order statistics of natural textures. Our results show that a CNN model achieves a similar performance improvement as humans, as manifested in the learning pattern across different types of high-order image statistics. While L2 was the first stage exhibiting texture selectivity, we found that stages beyond L2 were critically involved in learning. The significant contribution of L4 to learning was manifested both in the modulations of texture-selective responses and in the consequences of training with frozen connection weights. Our findings highlight learning-dependent plasticity in the mid-to-high-level areas of the visual hierarchy. This research introduces an AI-inspired approach for studying learning-induced cortical plasticity, utilizing DCNNs as an experimental framework to formulate testable predictions for empirical brain studies.

关键词： CNN perceptual learning naturalistic texture psychophysics

Phase selection rule of high-entropy metallic glasses with different short-to-medium-range orders

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Rare Metals 2022年第6期41卷 2021-2027页

作者： Hui-Qiang Ying Si-Nan Liu Zhen-Duo Wu Wei-Xia Dong Jia-cheng ge Horst Hahn Virgil Provenzano Xun-Li Wang Si Lan School of Materials Science and Engineering Herbert Gleiter Institute of NanoscienceNanjing University of Science and TechnologyNanjing 210094China Center for Neutron Scattering and Applied Physics City University of Hong Kong Dongguan Research InstituteDongguan 523000China Department of Physics City University of Hong KongHong Kong 999077China Institute of Nanotechnology Karlsruhe Institute of Technology(KIT)Eggenstein-Leopoldshafen 76344Germany

When an equiatomic multi-component alloy is quenched from its molten state down to room temperature,either a solid solution crystalline alloy or a metallic glass is *** former is called a high-entropy alloy,whereas the latter is referred as a high-entropy metallic glass(HE-MG).In such multicomponent alloys,thermodynamic parame-ters,e.g.,the mixing entropy,the mixing enthalpy and other parameters such as atomic size mismatch,determine the resulting phases.

关键词： alloy entropy metallic

Anti-lymphangiogenesis for boosting drug accumulation in tumors

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Signal Transduction and Targeted Therapy 2024年第5期9卷 2161-2175页

作者： Chunling Wang Junchao Xu Xiaoyu cheng ge Sun Fenfen Li Guangjun Nie Yinlong Zhang CAS Key Laboratory for Biomedical Effects of Nanomaterials&Nanosafety CAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijing 100190China Sino-Danish College University of Chinese Academy of SciencesBeijing 100190China Sino-Danish Center for Education and Research Beijing 100190China Department of Bioengineering University of PennsylvaniaPhiladelphiaPA 19104USA School of Nanoscience and Engineering University of Chinese Academy of SciencesBeijing 100049China

The inadequate tumor accumulation of anti-cancer agents is a major shortcoming of current therapeutic drugs and remains an even more significant concern in the clinical prospects for *** strategies aiming at regulating the intratumoral permeability of therapeutic drugs have been explored in preclinical studies,with a primary focus on vascular regulation and stromal ***,these methods may trigger or facilitate tumor metastasis as a ***,there is an urgent need for innovative strategies that boost intratumoral drug accumulation without compromising treatment *** another important factor affecting drug tumor accumulation besides vasculature and stroma,the impact of tumor-associated lymphatic vessels(LVs)has not been widely *** the current research,we verified that anlotinib,a tyrosine kinase inhibitor with anti-lymphangiogenesis activity,and SAR131675,a selective VEGFR-3 inhibitor,effectively decreased the density of tumor lymphatic vessels in mouse cancer models,further enhancing drug accumulation in tumor *** combining anlotinib with therapeutic drugs,including doxorubicin(Dox),liposomal doxorubicin(Lip-Dox),and anti-PD-L1 antibody,we observed improved anti-tumor efficacy in comparison with monotherapy ***,this strategy significantly reduced tumor metastasis and elicited stronger anti-tumor immune *** work describes a new,clinically transferrable approach to augmenting intratumoral drug accumulation,which shows great potential to address the current,unsatisfactory efficacies of therapeutic drugs without introducing metastatic risk.

关键词： drugs angiogenesis metastasis

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跟骨软骨母细胞瘤一例及文献复习

罕少疾病杂志 2024年第4期31卷 4-6页

作者：吴佳倩閤承治黎清波胡显锋杜艳华湖北省武汉市第四医院全科医学科湖北武汉430030 湖北省武汉市第三医院全科医学科湖北武汉430060 湖北省武汉市第四医院骨肿瘤与脊柱外科湖北武汉430030

目的通过报道一例影像学表现不典型,病理报告提示细胞丰富伴坏死的跟骨软骨母细胞瘤结合文献复习,探讨其误诊原因及是否为恶性软骨母细胞瘤可能。方法分析1例软骨母细胞瘤病理提示细胞丰富伴坏死的诊疗过程并结合相关文献进行分析。结... 详细信息

目的通过报道一例影像学表现不典型,病理报告提示细胞丰富伴坏死的跟骨软骨母细胞瘤结合文献复习,探讨其误诊原因及是否为恶性软骨母细胞瘤可能。方法分析1例软骨母细胞瘤病理提示细胞丰富伴坏死的诊疗过程并结合相关文献进行分析。结论本病例手术时可见肿瘤边界尚清楚,未突破骨皮质,肉眼未见明显坏死及变性组织,考虑其恶变及转移可能性极小。细胞坏死原因考虑可能是跟骨体积小,肿瘤细胞在有限空间增殖,导致其坏死。细胞丰富考虑肿瘤增殖迅速有一定侵袭周围组织及转移可能,经手术对瘤体完整切除,周围组织充分灭活及骨水泥填充后其可能性也极小。该患者经两年随访后肿瘤无复发转移,证明该治疗方法有效。且软骨母细胞瘤极少恶变,增殖丰富并不能证明其为恶性软骨母细胞瘤。

关键词：软骨母细胞瘤跟骨影像学表现不典型细胞丰富伴坏死。

Analysis of kinematic and singular configurations of an asymmetrical parallel mechanism

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Journal of China University of Mining and Technology 2008年第1期18卷 135-139页

作者： cheng Gang ge Shi-rong Institute of Reliability and Rescue Robotics China University of Mining ＆ Technology Xuzhou Jiangsu 221008 China

The forward kinematics and singularity configuration of an asymmetrical parallel mechanism with three translational degrees of freedom were analyzed. By establishing the position equations of the mechanism and obtaining the forward solutions, a better decoupling of the mechanism was proved. Based on the Jacobi velocity transfer matrix, the possible singularity configurations were studied and the methods avoiding these configurations discussed. Although improving the rigidity, the 4R structures in the mechanism also resulted in new singularity configurations. By analysis of a feasible instance, this kind of parallel mechanism can avoid all singularity configurations. Meanwhile, it was proved that the design of structure parameters and the choice of inputs range are important for rigidity and stability of parallel mechanisms.

关键词： Jacobi矩阵运动学机械装置机械设计