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PCAF-mediated acetylation of METTL3 impairs mRNA translation efficiency in response to oxidative stress

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Science China(Life Sciences) 2024年第10期67卷 2157-2168页

作者： cheng Liu Miao Yu Mengyuan Wang siyuan Yang Yenan Fu Lei Zhang Chaoyang Zhu Hongquan Zhang Program for Cancer and Cell Biology Department of Human AnatomyHistology and EmbryologySchool of Basic Medical SciencesPeking University International Cancer Instituteand State Key Laboratory of Molecular OncologyPeking University Health Science CenterBeijing 100191China Department of General Surgery and Urological Surgery Huaihe HospitalHenan UniversityKaifeng 100084China Department of Human Anatomy Histologyand EmbryologyShenzhen University School of MedicineShenzhen 518055China

METTL3 methylates RNA and regulates the fate of mRNA through its methyltransferase ***3 enhances RNA translation independently of its catalytic ***,the underlying mechanism is still ***,we report that METTL3 is both interacted with and acetylated at lysine 177 by the acetyltransferase PCAF and deacetylated by *** the methyltransferase activity nor the stability of METTL3 is affected by its acetylation at ***,acetylation of METTL3 blocks its interaction with EIF3H,a subunit of the translation initiation factor,thereby reducing mRNA translation ***,acetylation of METTL3 responds to oxidative ***,oxidative stress enhances the interaction of PCAF with METTL3,increases METTL3 acetylation,and suppresses the interaction of METTL3 with EIF3H,thereby decreasing the translation efficiency of ribosomes and inhibiting cell ***,we suggest a mechanism by which oxidative stress regulates RNA translation efficiency by the modulation of METTL3 acetylation mediated by PCAF.

关键词： METTL3 acetylation PCAF m^(6)A oxidative stress translation SIRT3

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HUNK inhibits cargo uptake and lysosomal traffic in the caveolar pathway via the AGAP3/ARF6

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Science Bulletin 2024年第2期69卷 173-178页

作者： siyuan Jiang Xiaoqi Han Tihui Liu Ying He Zidong Zhao Tongfeng Liu Shuwen cheng Jihang Zhang Liqiang Duan Yajuan Liu Tianyou cheng Yong Liu Qinong Ye Shan Gao Zhongda Hospital Medical SchoolAdvanced Institute for Life and HealthSoutheast UniversityNanjing 20096China Medical School of Guizhou University Guiyang 550025China Shanxi Academy of Advanced Research and Innovation Taiyuan 030032China Zhongda Hospital School of Life Sciences and TechnologyAdvanced Institute for Life and HealthSoutheast UniversityNanjing 210096China Nanjing University Medical School Nanjing 210046China Hubei Key Laboratory of Cell Homeostasis College of Life SciencesTaiKang Center for Life and Medical SciencesWuhan UniversityWuhan 430072China Department of Medical Molecular Biology Beijing Institute of BiotechnologyCollaborative Innovation Center for Cancer MedicineBeijing 100850China

Endocytosis is a crucial cellular process that takes up cargos by enclosing them in membrane-bound vesicles,and transports cargos to different parts of the cell,such as the lysosomes[1].Endocytosis is classified into several mechanistically and morphologically pathways,including clathrin-mediated endocytosis(CME)and caveolae-mediated endocytosis(CavME)[1,2].

关键词： endocytosis cargo uptake

Experimental research on thermal transport properties of crystallized palladium-based alloys

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Frontiers in Energy 2018年第1期12卷 121-126页

作者： siyuan cheng Xuguo SHI Weigang MA Xing ZHANG Guanglai LIU Mingxiang PAN Weihua WANG Key Laboratory for Thermal Science and Power Engineering of Ministryof Education Department of Engineering Mechanics TsinghuaUniversity Beijing 100084 China Institute of Physics Chinese Academy of Sciences Beijing 100190China

Palladium-based alloy is a kind of material with a high glass forming ability and can be easily formed into an amorphous state. After an annealing process, it can also be maintained at a crystallized state. To study the thermal and electrical transport properties of crystallized palladium-based alloys, the steady-state T-type method, standard four-probe method, and AC heating-DC detecting T-type method were used to measure the thermal conductivity, electrical conductivity, and Seebeck coeffi- cient of crystallized Pd4oNiloCu3oP2o and Pd43Nilo- Cu27P2o alloys respectively. The results show that compared to amorphous samples, the thermal conductivity and electrical conductivity of crystallized palladium-based alloys are significantly higher, while the Seebeck coeffi- cient is lower. The ratio of crystallized and amorphous thermal conductivity is higher for Pd43Ni10Cu27P2o alloy fiber which has a higher glass forming ability, while the ratio of electronic thermal conductivity almost remains constant for both alloy fibers. The results also show that the slope of electrical resistivity to temperature is a function of elemental composition for crystallized quaternary palla- dium-based alloy fibers. The sensitivity of thermal conductivity and electrical conductivity to the composition is high, while the correlation between Seebeck coefficient and composition is relatively weak.

关键词： palladium-based alloy T-type method ther-mal conductivity electrical conductivity Seebeck coeffi-cient

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海岸线变化的单链曼延编号快速匹配方法

测绘学报 2022年第8期51卷 1817-1825页

作者：成思远张英翟亮中国测绘科学研究院自然资源调查监测研究中心北京100036 自然资源部测绘科学与地球空间信息技术重点实验室北京100036

受海岸带区域自然环境变迁与人类开发活动的综合影响,海岸线不断发生剧烈变化。发现海岸线变化并将变化前后的岸段进行匹配,对分析海岸线变化至关重要。针对传统空间分析工具难以直接确定不同时相变化岸段的对应关系的问题,本文引入单... 详细信息

受海岸带区域自然环境变迁与人类开发活动的综合影响,海岸线不断发生剧烈变化。发现海岸线变化并将变化前后的岸段进行匹配,对分析海岸线变化至关重要。针对传统空间分析工具难以直接确定不同时相变化岸段的对应关系的问题,本文引入单链曼延编号的思想对海岸线变化进行快速匹配,并按照“一对一”和“多对多”两种变化岸段匹配关系提出了位置变迁、类型转移、消失及新增等海岸线变化类型的判断公式,设计并实现了结合单链曼延编号的海岸线变化匹配与信息存储方法。试验证明,该方法能快速准确地实现海岸线变化匹配,并能很好地解决多对多变化岸段匹配的问题。

关键词：单链蔓延编号海岸线变化匹配方法变化类型

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Co-alteration of Myc and RTK-RAS pathways defines a liver-metastatic propensity and immune-cold subgroup of pancreatic adenocarcinoma

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Genes & Diseases 2024年第3期11卷 47-50页

作者： Yuyuan Zhang Ziyang Zu Hui Xu siyuan Weng Yuqing Ren Quan cheng Peng Luo Jian Zhang Zaoqu Liu Xinwei Han Department of Interventional Radiology The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan450052China Interventional Institute of Zhengzhou University ZhengzhouHenan450052China Interventional Treatment and Clinical Research Center of Henan Province ZhengzhouHenan 450052China Department of Hepatobiliary and Pancreatic Surgery The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan 450052China Department of Respiratory and Critical Care Medicine The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan450052China Department of Neurosurgery Xiangya HospitalCentral South UniversityChangshaHunan 410008China Department of Oncology Zhujiang HospitalSouthern Medical UniversityGuangzhouGuangdong 510280China

Co-altered pathways refer to the phenomenon where multiple biological pathways exhibit aberrant changes simultaneously within the same tumor *** phenomenon can facilitate a better understanding of the mechanism and evolution of tumors and serve as a biological marker for diagnosing,classifying,and treating tumors.1 However,the nature of alteration occurrence and the impact on pancreatic adenocarcinoma(PAAD)remain *** SELECT algorithm was originally designed to systematically assess the evolutionary dependencies and their impact between altered genes in cancer for anticipating drug resistance and proposing alternative ***,to better characterize the etiology of PAAD and develop an improved risk assessment strategy,2 by utilizing SELECT,we identified a co-altered pathway subgroup of PAAD that demonstrated an elevated risk for unfavorable prognosis,a propensity for liver metastasis,and an immunologically cold microenvironment.

关键词： adenocarcinoma elevated alteration

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对心房颤动以外的快速性房性心律失常的认识

实用心电学杂志 2024年第2期33卷 158-165页

作者：廖欢燕程思源韩宇臣李琰李峰汪雪松牛海涛卢喜烈李自成姚焰郭军暨南大学附属第一医院心内科广东广州510630 深圳大微医疗科技开发有限公司广东广州518000 暨南大学实验动物中心广东广州510630 中国人民解放军总医院心内科北京100853 中国医学科学院阜外心血管病医院心律失常中心北京100037

过去临床普遍认为,房性早搏(简称房早)、房性心动过速(简称房速)等心房颤动(简称房颤)以外的快速性房性心律失常并无重要临床意义。但近年来,随着检测手段的不断发展,越来越多的临床研究发现,房早、房速等除房颤以外的心房异位活动与脑... 详细信息

过去临床普遍认为,房性早搏(简称房早)、房性心动过速(简称房速)等心房颤动(简称房颤)以外的快速性房性心律失常并无重要临床意义。但近年来,随着检测手段的不断发展,越来越多的临床研究发现,房早、房速等除房颤以外的心房异位活动与脑卒中的风险相关,并可能进一步导致死亡率升高。同时,此类房性心律失常的发生次数与房颤、缺血性脑卒中等不良事件发生率之间存在正相关,其机制可能与亚临床心房心肌病的介导作用有关。对该类心律失常的临床临界值和室上异位活动,目前仍无明确定义。因此,通过动态心电图等手段、遵循规范化流程,对房颤以外的快速性房性心律失常进行规律检测和处理至关重要。本文介绍此类房性心律失常与心源性脑卒中的关系,以及对此类心律失常的检测在心源性脑卒中评估中的作用。

关键词：房性早搏房性心动过速心房心肌病心源性脑卒中

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基于精细单元碳收支核算及变化分类方法

地球信息科学学报 2023年第3期25卷 468-478页

作者：封雅静翟亮桑会勇成思远中国测绘科学研究院自然资源调查监测研究中心北京100830 自然资源部测绘科学与地球空间信息技术重点实验室北京100830 首都师范大学资源环境与旅游学院北京100048

精确地核算碳收支是实现“双碳”目标的前提,通过开展统计单元的碳收支核算可为国土空间优化提供可靠的数据支撑。本文在地理国情监测数据的支持下,结合社会经济数据、人口数据和能源数据等提出了一种格网为统计单元的精确碳收支核算及... 详细信息

精确地核算碳收支是实现“双碳”目标的前提,通过开展统计单元的碳收支核算可为国土空间优化提供可靠的数据支撑。本文在地理国情监测数据的支持下,结合社会经济数据、人口数据和能源数据等提出了一种格网为统计单元的精确碳收支核算及变化分类方法。该方法先核算了土地利用与覆被各类型的固碳量和碳排放量并将其空间化,再据此核算选定分辨率的统计单元内碳收支量,后根据碳收支量及其在研究期的变化将统计单元划分为9类:汇提高区、汇稳定区、汇恶化区、平衡向好区、稳定区、平衡向差区、源好转区、源稳定区和源加剧区。以江苏省2015年和2019年的数据为例进行碳收支核算和公里格网统计分析,结果表明:2019年江苏省的碳收支量为344.21×106t,与2015年相比增加了4.24×106t,旱地和工矿用地分别为固碳量和碳排放量的主要来源;苏北和苏中碳收支为碳汇的区域远多于苏南,碳收支为碳源的区域在经济比较发达的中心城区呈现聚集分布;覆盖江苏省的格网被划分为5类,针对每一类典型区域提出了低碳发展的有关建议。和传统方法相比,本文方法在碳收支核算和碳收支变化分类方面的可行性与优越性,可为实现碳公平和协同减排提供技术支持。

关键词：地理国情监测固碳碳排放碳收支碳源碳汇碳收支变化分类格网

氧化石墨烯改性水泥基注浆材料的制备及力学性能研究

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功能材料 2023年第2期54卷 2153-2158页

作者：程思嫄陈代果古巍四川大学锦江学院四川眉山620860 西南科技大学土木工程与建筑学院四川绵阳621000 中国科学技术大学中国科学院材料力学行为和设计重点实验室合肥230026

氧化石墨烯凭借较高的比表面积和独特的片层状结构,具有优异的理化性能。为获得高性能的水泥基注浆材料,通过引入不同掺杂量(0.00,0.02%,0.04%和0.06%(质量分数))的氧化石墨烯,制备了改性水泥基注浆材料。采用XRD、SEM、FT-IR和力学性... 详细信息

氧化石墨烯凭借较高的比表面积和独特的片层状结构,具有优异的理化性能。为获得高性能的水泥基注浆材料,通过引入不同掺杂量(0.00,0.02%,0.04%和0.06%(质量分数))的氧化石墨烯,制备了改性水泥基注浆材料。采用XRD、SEM、FT-IR和力学性能测试等分析了氧化石墨烯的掺杂量对改性水泥基注浆材料晶体结构、力学性能和自收缩性能的影响。结果表明:氧化石墨烯的掺杂加速了水化反应的进行,提高了Ca(OH)_(2)的生成速率,同时减小了裂纹数量,增加了结构致密性;当氧化石墨烯的掺杂量为0.04%(质量分数)时,28 d的抗压强度、抗折强度和劈裂抗拉强度均达到了最大值,分别为59.80,14.70和1.89 MPa;所有注浆材料在水化前期收缩较快,20 h后收缩量进入了“平台期”,随着氧化石墨烯掺杂量的增加,改性注浆材料的自收缩性能抑制效果先增大后减小,当氧化石墨烯的掺杂量为0.04%(质量分数)时,改性注浆材料的自收缩量最小。

关键词：氧化石墨烯注浆材料力学性能形貌结构自收缩性能

Strong nonlinear optical processes with extraordinary polarization anisotropy in inversionsymmetry broken two-dimensional PdPSe

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Light(Science & Applications) 2024年第8期13卷 1524-1533页

作者： Song Zhu Ruihuan Duan Xiaodong Xu Fangyuan Sun Wenduo Chen Fakun Wang siyuan Li Ming Ye Xin Zhou Jinluo cheng Yao Wu Houkun Liang Junichiro Kono Xingji Li Zheng Liu Qi Jie Wang School of Electrical and Electronic Engineering Nanyang Technological University639798 SingaporeSingapore School of Material Science and Engineering Nanyang Technological University639798 SingaporeSingapore CINTRA CNRS/NTU/THALES UMI 3288Research Techno PlazaNanyang Technological University637371 SingaporeSingapore School of Materials Science and Engineering Harbin Institute of Technology150001 HarbinChina Department of Chemistry National University of Singapore117543 SingaporeSingapore GPL Photonics Lab State Key Laboratory of Applied OpticsChangchun Institute of OpticsFine Mechanics and PhysicsChinese Academy of Sciences130033 ChangchunChina School of Electronics and Information Engineering Sichuan University610064 ChengduSichuanChina School of Physical and Mathematical Sciences Nanyang Technological University637371 SingaporeSingapore Departments of Electrical and Computer Engineering Physics and Astronomyand Materials Science and NanoEngineeringRice UniversityHoustonTXUSA

Nonlinear optical activities,especially second harmonic generation(SHG),are key phenomena in inversion-symmetrybroken two-dimensional(2D)transition metal dichalcogenides(TMDCs).On the other hand,anisotropic nonlinear optical processes are important for unique applications in nano-nonlinear photonic devices with polarization functions,having become one of focused research topics in the field of nonlinear ***,the strong nonlinearity and strong optical anisotropy do not exist simultaneously in common 2D ***,we demonstrate strong secondorder and third-order susceptibilities of 64 pm/V and 6.2×10^(-19)m^(2)/V^(2),respectively,in the even-layer PdPSe,which has not been discovered in other common TMDCs(e.g.,MoS2).Strikingly,it also simultaneously exhibited strong SHG anisotropy with an anisotropic ratio of~45,which is the largest reported among all 2D materials to date,to the best of our *** addition,the SHG anisotropy ratio can be harnessed from 0.12 to 45(375 times)by varying the excitation wavelength due to the dispersion ofχ^(2)*** an illustrative example,we further demonstrate polarized SHG imaging for potential applications in crystal orientation identification and polarization-dependent spatial *** findings in 2D PdPSe are promising for nonlinear nanophotonic and optoelectronic applications.

关键词： materials. anisotropy nonlinear