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天然日光辐照下河口区CDOM的光化学降解

环境科学 2008年第6期29卷 1463-1468页

作者：郭卫东程远月厦门大学海洋与环境学院厦门361005

2005年5月初和5月末,对经0.2μm滤膜过滤的九龙江口低盐度水样进行了2次每天6h、为期1周的天然日光辐照实验,研究有色溶解有机物（CDOM）的荧光与吸收性质的光化学降解特征.结果表明,CDOM的类腐殖质荧光（λEx/λEm=350/450nm）、类色... 详细信息

2005年5月初和5月末,对经0.2μm滤膜过滤的九龙江口低盐度水样进行了2次每天6h、为期1周的天然日光辐照实验,研究有色溶解有机物（CDOM）的荧光与吸收性质的光化学降解特征.结果表明,CDOM的类腐殖质荧光（λEx/λEm=350/450nm）、类色氨酸荧光（λEx/λEm=225/350 nm）以及吸收系数在初夏短期日光辐照下均发生明显的光化学降解,其降解过程符合一级动力学方程,相应计算出类腐殖质和类色氨酸荧光以及吸收系数a（280）的半衰期分别为3.5-5.1 d、3.0-4.5 d及6.3 d.吸收损失光谱研究表明,对CDOM光降解起主要作用的是太阳辐射的紫外波段.照射42 h后,类腐殖质荧光的损失（70%）远高于吸收系数a（280）的损失（约40%）,表明CDOM荧光团比发色团更易被光漂白,但两者之间仍保持良好的正相关性.与对照组相比,CDOM经日光辐照后其A250/A350比值增大,表明光化学降解可使其平均分子粒径变小.结果表明,CDOM在入海后可通过光降解作用在近海海域发生转化及清除,光降解是陆源CDOM入海后的一个重要归宿.

关键词：有色溶解有机物光降解光漂白荧光吸收九龙江口

Endostar combined with chemotherapy for treatment of metastatic colorectal and gastric cancer： a pilot study

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Chinese Medical Journal 2011年第24期124卷 4299-4303页

作者： ZHOU Jian-feng BAI Chun-mei WANG Yu-zhou LI Xiao-yuan cheng yue-juan CHEN Shu-chang Department of Medical Oncology Peking Union Medical CollegeHospital Chinese Academy of Medical Sciences and Peking UnionMedical College Beijing 100730 China

Background Antiangiogenesis is a promising field of cancer therapy. Endostar, a novel recombinant human endostatin, is one of the few approved drugs acting as angiogenesis inhibitors of cancer in China. However, there are few clinical studies about Endostar in gastrointestinal cancer. This pilot study aimed to evaluate the efficacy and safety of the combination of Endostar and chemotherapy in patients with metastatic colorectal and gastric cancers. Methods From March 2007 to October 2009, 23 patients were enrolled. Patients received Endostar intravenously at a dose of 15 mg daily from day 1 to 14 and day 1 to 7 when combined with 3- and 2-week chemotherapy regimens, respectively, which were determined according to patients＇ previous chemotherapy history. Treatment was repeated until disease progression, unacceptable toxicity or patients＇ refusal. Results Seven, six and ten patients received Endostar as first-, second- and third-line therapy, respectively. A total of 75 cycles were administered. Twenty-one patients were assessable for responses. The overall response rate and disease control rate were 19.0% and 47.6%, respectively. All the four partial responses were among patients receiving Endostar as first-line therapy, whose response rate was 57.1%. The median time to progression and overall survival were 2.6 months （95% CI, 2.0-3.2 months） and 10.3 months （95% CI, 3.9-16.7 months）, respectively. Toxicity was tolerable, with grade 3-4 toxicities observed for leucopenia （30.4%）, neutropenia （34.8%）, thrombocytopenia （17.4%） and anemia （13.0%）. Three patients （13.0%） encountered transient sinus bradycardia with spontaneous remission. Conclusion Endostar combined with chemotherapy is well-tolerated in patients with metastatic colorectal and gastric cancers, and it is relatively effective as a first-line therapy.

关键词： Endostar chemotherapy metastatic colorectal cancer gastric cancer

Copper and silver interactions at various exposure levels in a marine copepod, Acartia erythraea

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Journal of Environmental Science and Engineering 2009年第1期3卷 42-51页

作者： LONG Ai-min DANG Ai-cui cheng yuan-yue CHEN Shao-yong LI Chun-di LED Laboratory South China Sea Institute of Oceanology Chinese Academy of Sciences Guangzhou 510301 China Graduate School Chinese Academy of Sciences Beoing 100039 China Guangzhou Institute of Geochemistry Chinese Academy of Sciences Guangzhou 510640 China

Marine copepods, Acartia erythraea, were exposed separately to aqueous Cu and Ag media and to a Cu＋Ag mixture in a series of experiments during which the metal body burden and partitioning in the exoskeleton and polar and nonpolar parts of the animal cells were measured and the uptake and effiux rate constants for Cu and Ag were calculated. The metal uptake and effiux rate constants were 1.04×10^3±1.00×10^2 L·g^-1·d^-1 and 9.28× 102＋ 1.43×10-2 d^-1 for Cu and 1.60× 104＋1.78×10^3L·g^-1·d^-1and 9.23×10^2 -4- 9.1 1×10^3d^-1 for Ag, respectively. For both Cu and Ag, the uptake rate constants when the copepods were exposed to solutions of a single metal were generally higher than that when the copepods were exposed to metal mixtures. The results suggest an antagonistic interaction between waterborne Cu and Ag exists in marine copepods. The different distributions of Cu and Ag among the exoskeleton and polar and nonpolar parts of the copepods revealed that the metal bioavailability in copepods exposed to metal mixtures enhanced in some degree compared to copepods exposed to single metal solutions.

关键词： copepods copper effiux rate constant silver uptake rate constant

Low temperature fabrication of high performance and transparent Pt counter electrodes for use in flexible dye-sensitized solar cells

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Chinese Science Bulletin 2012年第18期57卷 2329-2334页

作者： XIAO YaoMing,WU JiHuai,cheng CunXi,CHEN yuan,yue GenTian,LIN JianMing,HUANG MiaoLiang,FAN LeQing & LAN Zhang Engineering Research Center of Environment-Friendly Functional Materials,Ministry of Education,Institute of Materials Physical Chemistry,Huaqiao University,Quanzhou 362021,China Engineering Research Center of Environment-Friendly Functional Materials Ministry of Education Institute of Materials Physical Chemistry Huaqiao University Quanzhou China

High performance Pt counter electrode is prepared by using vacuum thermal decomposition at a relatively low (120℃) temperature on a flexible polyethylene naphthalate substrate coated with indium-doped tin oxide for use in flexible dye-sensitized solar *** obtained Pt counter electrode shows a good chemical stability,high light transmittance,and high electrocatalytic activity for the I3-/I-redox *** energy conversion efficiency of a flexible dye-sensitized solar cell based on the prepared Pt counter electrode and a TiO 2 /Ti photoanode reaches 5.14% under a simulated solar light irradiation with intensity of 100 mW cm-2.

关键词：染料敏化太阳能电池铂电极热分解柔性循环伏安对电极性能真空

利用三维荧光光谱和吸收光谱研究雨水中CDOM的光学特性

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光谱学与光谱分析 2010年第9期30卷 2413-2416页

作者：程远月郭卫东龙爱民陈绍勇中国科学院南海海洋研究所中国科学院热带海洋环境动力学重点实验室广东广州510301 近海海洋环境科学国家重点实验室(厦门大学) 厦门大学海洋与环境学院福建厦门361005 中国科学院广州地球化学研究所广东广州510640

利用荧光激发-发射矩阵光谱（excitation-emission matrix spectroscopy,EEMs）技术并结合吸收光谱初步研究了2007年厦门梅雨季节期间雨水中有色溶解有机物（CDOM）的光学特性。结果表明,雨水CDOM的吸收光谱随波长呈指数衰减,代表雨水C... 详细信息

利用荧光激发-发射矩阵光谱（excitation-emission matrix spectroscopy,EEMs）技术并结合吸收光谱初步研究了2007年厦门梅雨季节期间雨水中有色溶解有机物（CDOM）的光学特性。结果表明,雨水CDOM的吸收光谱随波长呈指数衰减,代表雨水CDOM相对含量的吸收系数a（300）范围在0.27~3.45 m-1,均值为1.08 m-1;且降雨初期CDOM含量高于降雨后期。这表明人类活动和当地的大气污染或空气质量对雨水中CDOM的贡献。雨水CDOM的EEMs光谱揭示出2类4个主要荧光峰（2个类腐殖质荧光A和C与2个类蛋白质荧光B和S）的存在。其中2个类腐殖质荧光A和C之间以及2个类蛋白质荧光B和S之间均存在一定的正相关性,说明其具有相同来源或存在某种内部联系。2个类腐殖质荧光与吸收系数a（300）之间的强正相关性,说明其控制吸收特性的基团可能与控制其荧光特性的基团具有相似性质。结果表明雨水CDOM高吸收和荧光特性在大气化学中的作用不容轻视,在受大气水体影响的太阳辐射的光谱衰减中可能起着潜在的重要作用。

关键词：有色溶解有机物荧光激发-发射矩阵光谱吸收雨水

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海草生态系中DOM的三维荧光光谱特征

光谱学与光谱分析 2015年第1期35卷 141-145页

作者：程远月王帅龙胡水波周沉冤施震李芊黄小平中国科学院、南海海洋研究所、热带海洋环境国家重点实验室、热带海洋生物资源与生态重点实验室广东广州510301 中国科学院大学北京100049

利用荧光激发-发射矩阵光谱（EEMs）技术研究了海南省陵水县新村湾海草生态系中溶解有机物（DOM）的三维荧光光谱特征。EEMs谱图表明,海草生态系中的DOM存在3个类腐殖质荧光A（230/430nm）,C（350/440nm）,M（300/380~400nm）和2个类蛋... 详细信息

利用荧光激发-发射矩阵光谱（EEMs）技术研究了海南省陵水县新村湾海草生态系中溶解有机物（DOM）的三维荧光光谱特征。EEMs谱图表明,海草生态系中的DOM存在3个类腐殖质荧光A（230/430nm）,C（350/440nm）,M（300/380~400nm）和2个类蛋白质荧光R（230/355~375nm）,N（280~300/365~380nm）。各荧光信号平均荧光强度的变化规律为R（0.304RU）〉A（0.194RU）〉M（0.147RU）〉N（0.125RU）〉C（0.051RU）。类腐殖质荧光和类蛋白质荧光均表现为离岸近含量高;2个明显的低值区,分别出现在该湾海草茂密的西南部和东南部。各荧光信号在该湾的分布特征表明,控制类腐殖质荧光和类蛋白质荧光的动力学因素相同。荧光N与M和R之间以及荧光C与A之间具有较好的正相关关系,表明这些荧光具有相同的来源属性及地化行为。较高的荧光指数FI（均值为1.81）、较高的自生源指标BIX（均值为1.44）和较低的腐殖化指标HIX（HIXa和HIXb的均值分别为4.2和0.81）均表明海草生态系中DOM的强自生来源贡献和弱腐殖化程度。研究结果表明,海草生态系中DOM具有非常独特的荧光特征,不同于其他水生生态系。

关键词：溶解有机物三维荧光光谱海草海南

近岸沉积物再悬浮期间所释放溶解有机物的荧光特征

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地球化学 2008年第1期37卷 51-58页

作者：程远月郭卫东胡明辉厦门大学海洋与环境学院福建厦门361005

对采自厦门湾九龙江入海河口的4个沉积物样品进行了室内再悬浮模拟实验,利用荧光激发-发射矩阵光谱(EEMs)研究了再悬浮过程中从沉积物中释放出的有色溶解有机物(CDOM)的荧光特征,同时通过与相应站位沉积物间隙水和底层水的对比分析,探... 详细信息

对采自厦门湾九龙江入海河口的4个沉积物样品进行了室内再悬浮模拟实验,利用荧光激发-发射矩阵光谱(EEMs)研究了再悬浮过程中从沉积物中释放出的有色溶解有机物(CDOM)的荧光特征,同时通过与相应站位沉积物间隙水和底层水的对比分析,探讨了河口近岸海域的沉积物再悬浮作用作为水体中溶解有机物来源之一的可能性。结果表明,对给定站位,CDOM相对荧光强度和溶解有机碳(DOC)含量分布变化非常一致,均为间隙水最高,再悬浮次之,底层水最低;站位之间,底层水和再悬浮水样中CDOM相对荧光强度随盐度的降低而增加,从海端向河端增加的趋势明显。EEMs分析表明,各样品中均存在类腐殖质荧光与类蛋白质荧光团,且模拟实验也表明再悬浮作用可释放类腐殖质与类蛋白质荧光物质到底层水中,表明底质再悬浮将是近岸水体中CDOM的一个重要来源。与相应的底层水相比,间隙水的荧光峰(如峰A/C)的位置发生红移。再悬浮样品中EEMs的荧光团同时表现出相应底层水和间隙水的特征,但是荧光峰(峰A和峰C)的最大激发和发射波长更接近底层水中相应荧光团,与间隙水相比,则发生谱峰位置的蓝移。近海端样品中荧光峰M明显,随着盐度的降低,底层水和再悬浮水样的r(M/C)值逐渐降低,且海源的峰M由海端向河端逐渐消失,表明峰M属于海洋自生来源。本研究区域DOM的荧光指数在1.61～1.93之间,表明近海端样品DOM主要为生物来源,而近河端样品DOM主要为陆源输入,或者为陆源与生物活动共同作用的结果。

关键词： CDOM 荧光特性再悬浮 EEMs 荧光指数

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海洋CDOM光吸收研究中若干问题的探讨

台湾海峡 2005年第3期24卷 289-298页

作者：韩宇超郭卫东程远月厦门大学海洋学系福建厦门361005

本文结合在厦门湾的现场调查和实验室分析,对目前海洋CDOM研究中的若干问题,从空白扣除、吸收系数和光谱斜率S值的估算方法、不同粒径滤膜对CDOM光学性质的影响等方面进行了探讨,并就河口混合过程中S值理论保守行为的判断进行了分析.结... 详细信息

本文结合在厦门湾的现场调查和实验室分析,对目前海洋CDOM研究中的若干问题,从空白扣除、吸收系数和光谱斜率S值的估算方法、不同粒径滤膜对CDOM光学性质的影响等方面进行了探讨,并就河口混合过程中S值理论保守行为的判断进行了分析.结果表明,测定水样时,应以过滤后的纯水作为空白.CDOM的吸收系数应进行校正以消除样品中非CDOM信号的影响.进行CDOM的S值估算时,不论是高浓度的河流端还是低浓度的海端水样,当波长范围相同时,非线性回归所得S值均大于线性回归.当波长范围不同时,对任何一种回归方法,S值随长波区成分增多而降低,线性回归方法其降低程度尤其明显.总之波长范围对非线性回归处理的影响很小,S值通过对校正后的吸收系数进行非线性回归处理,同时波长范围选300～500nm较为适宜.决定河口混合时S值变化的因素不仅仅是河海两个端元CDOM的S值,还有它们CDOM浓度的相对大小.滤膜对近海Ⅱ类水域CDOM光吸收的影响是不可忽略的,以采用0.2μm左右的滤膜过滤水样为宜.

关键词：海洋化学 CDOM 光吸收光谱斜率调查分析厦门湾

Advances in ethnopharmacology,phytochemistry and pharmacology of Erigerontis Herba and its Chinese medicine prescriptions

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Traditional Medicine Research 2025年第1期10卷 44-61页

作者： Yang Zhou yuan-Yan Huang Ding-yue Shang Ying Chen Meng Tian cheng-Yu Jin Xin Lu Bing-Chun Yan Han-Qing Pang Institute of Translational Medicine School of MedicineYangzhou UniversityYangzhou 225009China Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Senile Diseases Yangzhou UniversityYangzhou 225009China School of Medicine Nanjing University of Chinese MedicineNanjing 210023China State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources Guangxi Normal UniversityGuiling 541004China.

Erigerontis Herba(EH),the dried whole plant of Erigeron breviscapus,is well-known for circulating blood,activating meridians to alleviate pain,expelling wind,and clearing away *** has been extensively utilized in southern China for the treatment of stroke hemiplegia,chest stuffiness and pains,rheumatic arthralgia,headache,and *** review focuses on the botany,ethnopharmacology,phytochemistry,pharmacology and toxicity of EH and its related prescriptions to offer new insights for prospective research of *** information about EH was retrieved from ancient records and books,PubMed,China National Knowledge Infrastructure,Chinese Pharmacopoeia,Web of Science,Doctoral and Master’s Theses,and various electronic *** is a member of Compositae family and is mainly grown in southern *** Chinese medicine records that EH has the effects of circulating blood and removing blood stasis,expelling wind,and removing cold,as well as relieving rigidity of muscle and relieving *** now,nearly 200 ingredients have been characterized from EH,including flavonoids,caffeoyls,aromatic acids,coumarins,pentacyclic terpenoids,volatile oil and other *** extracts,EH related prescriptions(Dengzhan Xixin injection,Dengzhan Shengmai capsules,etc.)or compounds(scutellarin,scutellarein,etc.)possessed obvious therapeutic effects of ischemic stroke,cerebral hemorrhage,myocardial infarction,Alzheimer’s disease,diabetes and its complications,gastric cancer,bone,and joint degenerative ***,the major active compound of EH,has been used as a quality *** no obvious toxicity of EH has been *** to its traditional applications,ethnopharmacology,phytochemistry,pharmacology,and toxicity,EH was applied as a valuable herb for clinical application in food and medicine *** several compounds have been shown to possess diverse biological activities,the underlying mechanisms of their actions remain *** fully exploi

关键词： Erigeron breviscapus traditional applications ethnopharmacology phytochemistry pharmacology