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miRNA-21-5p is an important contributor to the promotion of injured peripheral nerve regeneration using hypoxia-pretreated bone marrow-derived neural crest cells

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Neural Regeneration Research 2025年第1期20卷 277-290页

作者： Meng Cong Jing-Jing Hu Yan Yu Xiao-Li Li Xiao-Ting Sun Li-Ting Wang Xia Wu Ling-Jie Zhu Xiao-Jia Yang Qian-ru He Fei ding Hai-Yan Shi School of Medicine Nantong UniversityNantongJiangsu ProvinceChina Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education and Coinnovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Department of Physiology Jiangsu Health Vocational CollegeNanjingJiangsu ProvinceChina Department of Pathology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina

Our previous study found that rat bone marrow–derived neural crest cells(acting as Schwann cell progenitors)have the potential to promote long-distance nerve ***-based therapy can enhance peripheral nerve repair and regeneration through paracrine bioactive factors and intercellular ***,the complex contributions of various types of soluble cytokines and extracellular vesicle cargos to the secretome remain *** investigate the role of the secretome and extracellular vesicles in repairing damaged peripheral nerves,we collected conditioned culture medium from hypoxia-pretreated neural crest cells,and found that it significantly promoted the repair of sensory neurons damaged by oxygen-glucose *** mRNA expression of trophic factors was highly expressed in hypoxia-pretreated neural crest *** performed RNA sequencing and bioinformatics analysis and found that miR-21-5p was enriched in hypoxia-pretreated extracellular vesicles of neural crest ***,to further clarify the role of hypoxia-pretreated neural crest cell extracellular vesicles rich in miR-21-5p in axonal growth and regeneration of sensory neurons,we used a microfluidic axonal dissociation model of sensory neurons in vitro,and found that hypoxia-pretreated neural crest cell extracellular vesicles promoted axonal growth and regeneration of sensory neurons,which was greatly dependent on loaded ***,we constructed a miR-21-5p-loaded neural conduit to repair the sciatic nerve defect in rats and found that the motor and sensory functions of injured rat hind limb,as well as muscle tissue morphology of the hind limbs,were obviously *** findings suggest that hypoxia-pretreated neural crest extracellular vesicles are natural nanoparticles rich in ***-21-5p is one of the main contributors to promoting nerve regeneration by the neural crest cell *** helps to explain the mechanism of action of the secretome and e

关键词： axotomy cell-free therapy conditioned medium extracellular vesicles hypoxic preconditioning microRNA oxygen-glucose deprivation peripheral nerve injury Schwann cell precursors

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降香黄檀、鸡冠刺桐、刺桐、白花油麻藤

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广东园林 2009年第2期31卷 76-77页

作者：陈定如王缺

落叶或半落叶乔木，高10m～20m。树干略弯斜，分枝低；树皮幼时灰色，平滑。壮龄后褐色，粗糙，纵裂；小枝柔软，具凸起小皮孔。树冠广伞形。叶互生，一回奇数羽状复叶，有互生小叶7～13片，总叶柄基部膨大；小叶纸质或近革质，卵形、... 详细信息

落叶或半落叶乔木，高10m～20m。树干略弯斜，分枝低；树皮幼时灰色，平滑。壮龄后褐色，粗糙，纵裂；小枝柔软，具凸起小皮孔。树冠广伞形。叶互生，一回奇数羽状复叶，有互生小叶7～13片，总叶柄基部膨大；小叶纸质或近革质，卵形、卵状椭圆形至长椭圆形，先端钝或渐尖，

关键词：鸡冠刺桐降香黄檀油麻藤白花落叶乔木椭圆形小叶树干

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优良乡土香花植物假鹰爪的生物学特性和园林应用

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广东园林 2007年第2期29卷 49-50页

作者：韩宙陈定如深圳国际园林花卉博览园管理处广东深圳518040 华南师范大学生命科学学院广东广州510631

假鹰爪是华南广有分布的优良乡土香花植物。目前处于野生状态,在园林中罕见应用。该文就其生物学特性、繁殖栽培和园林应用进行叙述。

关键词：假鹰爪香花植物生物学特性繁殖栽培园林绿化

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中国无忧树、海南红豆、火焰树、炮仗花

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广东园林 2011年第1期33卷 77-78,88页

作者：陈定如王缺

中国无忧树（火焰花）苏木科Saraca dives Pierre常绿乔木,高10～25m。树皮灰褐色,平滑,皮孔明显,内皮层淡红色;幼枝近方形而略扁,两侧具凹槽。树冠广卵形。叶互生,一回偶数羽状复叶,小叶4～7对,下部一对较小;小叶片近革质,长圆形至长... 详细信息

中国无忧树（火焰花）苏木科Saraca dives Pierre常绿乔木,高10～25m。树皮灰褐色,平滑,皮孔明显,内皮层淡红色;幼枝近方形而略扁,两侧具凹槽。树冠广卵形。叶互生,一回偶数羽状复叶,小叶4～7对,下部一对较小;小叶片近革质,长圆形至长圆状披针形,

关键词：海南红豆中国火焰炮仗花常绿乔木小叶片苏木科内皮层

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观光木、红花荷、红花檵木、云南黄素馨

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广东园林 2010年第1期32卷 78-79页

作者：陈定如王缺

观光木木兰科常绿乔木，高10～20（～30）m。树干通直，树皮浅灰褐色，皮层略厚，有香味。树冠广卵形。芽、小枝、叶背面、叶柄、及花梗均被黄棕色糙状毛；嫩枝有托叶环痕及疏生白色皮孔。叶互生，叶片纸质，倒卯状椭圆形至长圆形，长... 详细信息

观光木木兰科常绿乔木，高10～20（～30）m。树干通直，树皮浅灰褐色，皮层略厚，有香味。树冠广卵形。芽、小枝、叶背面、叶柄、及花梗均被黄棕色糙状毛；嫩枝有托叶环痕及疏生白色皮孔。叶互生，叶片纸质，倒卯状椭圆形至长圆形，长8～18cm，宽4～8cm，先端急尖或钝，基部楔形，全缘，羽状脉明显；

关键词：观光木云南黄素馨红花荷常绿乔木椭圆形木兰科树干褐色

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二乔木兰、乐昌含笑、含笑、火力楠

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广东园林 2009年第1期31卷 75-76页

作者：陈定如王缺

落叶灌木或小乔木，高3～10cm。分枝低。芽被灰色绢毛；树皮灰色，嫩枝棕色，疏生圆形、白色皮孔。树冠卵形，疏散。叶互生，纸质，倒卵形或倒卵状椭圆形。长6～17（-22）cm，宽4～10（～14）cm，先端圆而具短急尖。基部宽楔形。全缘，... 详细信息

落叶灌木或小乔木，高3～10cm。分枝低。芽被灰色绢毛；树皮灰色，嫩枝棕色，疏生圆形、白色皮孔。树冠卵形，疏散。叶互生，纸质，倒卵形或倒卵状椭圆形。长6～17（-22）cm，宽4～10（～14）cm，先端圆而具短急尖。基部宽楔形。全缘，边缘呈线状透明，网脉明显，腹面中、侧脉微凹而在背面明显凸起。花于枝顶单生，先叶开放；花被片6～9片，长10～15cm，外面紫红色，内面白色。

关键词：乐昌含笑火力楠木兰落叶灌木椭圆形小乔木花被片紫红色

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Industrial Control Anomaly Detection Based on Distributed Linear Deep Learning

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Computers, Materials & Continua 2025年第1期82卷 1129-1150页

作者： Shijie Tang Yong ding Huiyong Wang School of Computer Science and Information Security Guilin University of Electronic TechnologyGuilin541004China School of Electronic Engineering and Automation Guilin University of Electronic TechnologyGuilin541004China Guangxi Engineering Research Center of Industrial Internet Security and Blockchain Guilin University of Electronic TechnologyGuilin541004China Institute of Cyberspace Technology HKCT Institute for Higher EducationHong Kong999077China School of Mathematics&Computing Science Guilin University of Electronic TechnologyGuilin541004China

As more and more devices in Cyber-Physical Systems(CPS)are connected to the Internet,physical components such as programmable logic controller(PLC),sensors,and actuators are facing greater risks of network attacks,and fast and accurate attack detection techniques are *** key problem in distinguishing between normal and abnormal sequences is to model sequential changes in a large and diverse field of time *** address this issue,we propose an anomaly detection method based on distributed deep *** method uses a bilateral filtering algorithm for sequential sequences to remove noise in the time series,which can maintain the edge of discrete *** use a distributed linear deep learning model to establish a sequential prediction model and adjust the threshold for anomaly detection based on the prediction error of the validation *** method can not only detect abnormal attacks but also locate the sensors that cause *** conducted experiments on the Secure Water Treatment(SWAT)and Water Distribution(WADI)public *** experimental results show that our method is superior to the baseline method in identifying the types of attacks and detecting efficiency.

关键词： Anomaly detection CPS deep learning MLP(multi-layer perceptron)

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Modeling and control of a rigid-flexible coupling robot for narrow space manipulations

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Science China Technological Sciences 2025年

作者： Kuangda chen Huan ZHAO Jiexin ZHANG Mei FENG Yiwei WANG Jinliang WANG Han ding State Key Laboratory of Intelligent Manufacturing Equipment and Technology Huazhong University of Science and Technology Key Laboratory of CNC Equipment Reliability Ministry of Education Jilin University School of Medical Equipment Science and Engineering Huazhong University of Science and Technology

Narrow space manipulations are crucial for equipment maintenance, as they eliminate the need for disassembly, thus reducing costs and increasing efficiency. Cable-driven flexible robots possess exceptional capabilities in maneuvering through narrow spaces, thanks to their interaction compliance and distal dexterity. However, their inherent low stiffness causes a decline in the location accuracy of the robot and could even lead to manipulation failure. To address this challenge, this paper proposes a novel type of rigid-flexible coupling robot, which increases the stiffness of the robot while ensuring the reachability within a narrow space. To achieve high-accuracy location in a narrow space, kinematic and control methods are proposed. Specifically,the robot forward kinematics are uniformly represented, and the closed-form inverse kinematics solution is derived. Furthermore, in cases where the robot?s structure fails to align with Pieper?s solution, a two-stage search strategy is utilized to solve the inverse kinematics, resulting in a high success rate of 99.1%. Based on the proposed kinematics, a rigid-dominated control method is then proposed to facilitate localization and pose alignment of target objects in narrow spaces. The practical comparative experiments show that the proposed robot has the capability of high accuracy control in narrow spaces.

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Controlled cationic ring-opening polymerization of L-lactide by organic ion pair: novel approach to isotactic-rich and crystalline polylactide

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Science China Chemistry 2025年第1期68卷 394-402页

作者： Zhiqiang ding Mingqian Wang Zijing Zhou Bin Wang Yuesheng Li Tianjin Key Laboratory of Composite & Functional Materials School of Materials Science and Engineering Tianjin University

Living/controlled cationic ring-opening polymerization （ROP） of L-lactide is a promising approach to isotactic-rich and crystalline poly（L-lactide）.In contrast with the unsubstituted lactones,L-LA can not be polymerized by organic Lewis acids or carbenium ions,and the state of the art in this field is the cationic ROP of L-LA catalyzed by Br?nsted acid/alcohol system via activated monomer ***,we reported the first example of controlled cationic ROP of L-LA by using Meerweintype ion pair[Me3O]+[B（C6F5）4]-as the catalyst.[Me3O]+[B（C6F5）4]-promoted rapid L-LA cationic polymerization in the absence of alcohol,producing isotactic-rich and crystalline PLLA without transesterification and epimerization side *** activated chain end mechanism,involving twice SN2 substitution and configuration-inversion （S→R→S） with the assistance of released Me2O,was proposed and further verified by density functional theory and control *** work expands the catalytic toolbox of isotactic-rich and crystalline polylactide *** represents a unique example of cationic-controlled polymerization of L-LA catalyzed by an organic ion pair.

关键词： organic ion pair controlled cationic ring-opening polymerization activated chain end mechanism isotactic-rich polylactide

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Chondroitinase ABC combined with Schwann cell transplantation enhances restoration of neural connection and functional recovery following acute and chronic spinal cord injury

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Neural Regeneration Research 2025年第5期20卷 1467-1482页

作者： Wenrui Qu Xiangbing Wu Wei Wu Ying Wang Yan Sun Lingxiao Deng Melissa Walker chen chen Heqiao Dai Qi Han Ying ding Yongzhi Xia George Smith rui Li Nai-Kui Liu Xiao-Ming Xu Spinal Cord and Brain Injury Research Group Stark Neurosciences Research InstituteDepartment of Neurological SurgeryIndiana University School of MedicineIndianapolisINUSA Department of Hand Surgery the Second Hospital of Jilin UniversityChangchunJilin ProvinceChina Shriners Hospitals Pediatric Research Center Temple University School of MedicinePhiladelphiaPAUSA Department of Anatomy&Cell Biology Indiana University School of MedicineIndianapolisINUSA

Schwann cell transplantation is considered one of the most promising cell-based therapy to repair injured spinal cord due to its unique growth-promoting and myelin-forming properties.A the Food and Drug Administration-approved Phase I clinical trial has been conducted to evaluate the safety of transplanted human autologous Schwann cells to treat patients with spinal cord injury.A major challenge for Schwann cell transplantation is that grafted Schwann cells are confined within the lesion cavity,and they do not migrate into the host environment due to the inhibitory barrier formed by injury-induced glial scar,thus limiting axonal reentry into the host spinal *** we introduce a combinatorial strategy by suppressing the inhibitory extracellular environment with injection of lentivirus-mediated transfection of chondroitinase ABC gene at the rostral and caudal borders of the lesion site and simultaneously leveraging the repair capacity of transplanted Schwann cells in adult rats following a mid-thoracic contusive spinal cord *** report that when the glial scar was degraded by chondroitinase ABC at the rostral and caudal lesion borders,Schwann cells migrated for considerable distances in both rostral and caudal *** Schwann cell migration led to enhanced axonal regrowth,including the serotonergic and dopaminergic axons originating from supraspinal regions,and promoted recovery of locomotor and urinary bladder ***,the Schwann cell survival and axonal regrowth persisted up to 6 months after the injury,even when treatment was delayed for 3 months to mimic chronic spinal cord *** findings collectively show promising evidence for a combinatorial strategy with chondroitinase ABC and Schwann cells in promoting remodeling and recovery of function following spinal cord injury.

关键词： axonal regrowth bladder function chondroitinase ABC functional recovery glial scar lentivirus migration Schwann cell spinal cord injury transplantation

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