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Science China Life Sciences 2025年第1期68卷 300-302页

作者： Ze-Min Lin Mai Xiang Wen-Hui Wei Shu-Hui Fan Li chen jie Wang Xiao-Qian Yang Chun-Hao Yang Shi-Jun He Jian-Ping Zuo Laboratory of Immunopharmacology State Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of Sciences School of Pharmacy University of Chinese Academy of Sciences School of Pharmacy Nanjing University of Chinese Medicine State Key Laboratory of Drug Research Department of Medicinal ChemistryShanghai Institute of Materia MedicaChinese Academy of Sciences Innovation Research Institute of Traditional Chinese Medicine Shanghai University of Traditional Chinese Medicine Experiment Center for Science and Technology Shanghai University of Traditional Chinese Medicine

Dear Editor, Phenotypic drug discovery, which observes compound effects on physiology,has given way to targeting specific molecules, but has revived by using modern methods to find drugs based on therapeutic outcomes in disease models(Vincent et al., 2022). Osteoarthritis(OA) is a prevalent chronic joint disorder, primarily affecting knee joints, with osteoclast activation due to low-grade inflammation resulting in increased bone resorption and structural changes in the joint(Katz et al.,2021).

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近海单桩式风机地震响应分区耦合分析方法

岩土工程学报 2025年第1期47卷 96-105页

作者：徐小凤陈少林孙杰南京航空航天大学民航学院土木与机场工程系江苏南京211106 中国能源建设集团江苏省电力设计院有限公司江苏南京211106

海上风机是低碳可持续能源的重要战略选择之一,其地震安全性问题是急需解决的重要课题。将近海单桩式风机三维地震响应问题看作波动散射问题,结合人工边界条件实现海域场地的波动输入,并基于广义饱和多孔介质统一计算框架,发展了一套海... 详细信息

海上风机是低碳可持续能源的重要战略选择之一,其地震安全性问题是急需解决的重要课题。将近海单桩式风机三维地震响应问题看作波动散射问题,结合人工边界条件实现海域场地的波动输入,并基于广义饱和多孔介质统一计算框架,发展了一套海水-饱和海床-风机耦合作用高效分区分析方法,实现了综合考虑土-结构相互作用效应和流固耦合效应的近海单桩式风机三维地震响应分析,并分析了海水深度、海床波速和地震波入射角度对近海单桩式风机地震响应的影响。分析结果表明,海水深度和海床剪切波速的变化,一方面会改变自由场,另一方面会改变海域场地-风机体系的自振特性,从而影响风机结构的地震反应。当海水增加到某深度时,体系自振频率与地震波输入频率接近时,风机的地震响应会急剧增大;海床剪切波速对塔底弯矩的影响要比对位移的影响大;当入射角度增大时,塔顶水平向位移和加速度以及塔底弯矩均有不同程度的减小,塔顶竖向位移和加速度均有不同程度的增大。本文没有考虑海床和风机的非线性,考虑非线性时的影响规律需进一步研究。

关键词：近海单桩式风机地震响应分析土-结构相互作用流固耦合

Sulfolane‑Based Flame‑Retardant Electrolyte for High‑Voltage Sodium‑Ion Batteries

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Nano-Micro Letters 2025年第2期17卷 498-516页

作者： Xuanlong He jie Peng Qingyun Lin Meng Li Weibin chen Pei Liu Tao Huang Zhencheng Huang Yuying Liu Jiaojiao Deng Shenghua Ye Xuming Yang Xiangzhong Ren Xiaoping Ouyang Jianhong Liu Biwei Xiao Jiangtao Hu Qianling Zhang Graphene Composite Research Center College of Chemistry and Environmental EngineeringShenzhen UniversityShenzhen 518060People’s Republic of China Center of Electron Microscopy State Key Laboratory of Silicon and Advanced Semiconductor MaterialsSchool of Materials Science and EngineeringZhejiang UniversityHangzhou 310027People’s Republic of China GRINM(Guangdong)Research Institute for Advanced Materials and Technology FoshanGuangdong 528051People’s Republic of China College of Energy Engineering Zhejiang UniversityHangzhouZhejiang 310027People’s Republic of China School of Materials Science and Engineering Xiangtan UniversityXiangtan 411105People’s Republic of China Shenzhen Eigen-Equation Graphene Technology Co.Ltd Shenzhen 518000People’s Republic of China

Sodium-ion batteries hold great promise as next-generation energy storage ***,the high instability of the electrode/electrolyte interphase during cycling has seriously hindered the development of *** particular,an unstable cathode–electrolyte interphase(CEI)leads to successive electrolyte side reactions,transition metal leaching and rapid capacity decay,which tends to be exacerbated under high-voltage ***,constructing dense and stable CEIs are crucial for high-performance *** work reports localized high-concentration electrolyte by incorporating a highly oxidation-resistant sulfolane solvent with non-solvent diluent 1H,1H,5H-octafluoropentyl-1,1,2,2-tetrafluoroethyl ether,which exhibited excellent oxidative stability and was able to form thin,dense and homogeneous *** excellent CEI enabled the O3-type layered oxide cathode NaNi_(1/3)Mn_(1/3)Fe_(1/3)O_(2)(NaNMF)to achieve stable cycling,with a capacity retention of 79.48%after 300 cycles at 1 C and 81.15%after 400 cycles at 2 C with a high charging voltage of 4.2 *** addition,its nonflammable nature enhances the safety of *** work provides a viable pathway for the application of sulfolane-based electrolytes on SIBs and the design of next-generation high-voltage electrolytes.

关键词： Sodium-ion batteries Sulfolane-based electrolyte High voltage Layered oxide cathode Flame retardant

Maintaining moderate levels of hypochlorous acid promotes neural stem cell proliferation and differentiation in the recovery phase of stroke

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Neural Regeneration Research 2025年第3期20卷 845-857页

作者： Lin-Yan Huang Yi-De Zhang jie chen Hai-Di Fan Wan Wang Bin Wang Ju-Yun Ma Peng-Peng Li Hai-Wei Pu Xin-Yian Guo Jian-Gang Shen Su-Hua Qi School of Medical Technology Xuzhou Key Laboratory of Laboratory DiagnosticsXuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Pharmacy Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina Department of Laboratory Medicine Branch Hospital of Huai’an First People’s HospitalHuai’anJiangsu ProvinceChina Department of Laboratory Medicine the Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Chinese Medicine The University of Hong KongHong Kong Special Administrative RegionChina

It has been shown clinically that continuous removal of ischemia/reperfusion-induced reactive oxygen species is not conducive to the recovery of late ***,previous studies have shown that excessive increases in hypochlorous acid after stroke can cause severe damage to brain *** previous studies have found that a small amount of hypochlorous acid still exists in the later stage of stroke,but its specific role and mechanism are currently *** simulate stroke in vivo,a middle cerebral artery occlusion rat model was established,with an oxygen-glucose deprivation/reoxygenation model established in vitro to mimic *** found that in the early stage(within 24 hours)of ischemic stroke,neutrophils produced a large amount of hypochlorous acid,while in the recovery phase(10 days after stroke),microglia were activated and produced a small amount of hypochlorous ***,in acute stroke in rats,hypochlorous acid production was prevented using a hypochlorous acid scavenger,taurine,or myeloperoxidase inhibitor,4-aminobenzoic acid *** results showed that high levels of hypochlorous acid(200μM)induced neuronal apoptosis after oxygen/glucose deprivation/***,in the recovery phase of the middle cerebral artery occlusion model,a moderate level of hypochlorous acid promoted the proliferation and differentiation of neural stem cells into neurons and *** suggests that hypochlorous acid plays different roles at different phases of cerebral ischemia/reperfusion *** levels of hypochlorous acid(5 and 100μM)promoted nuclear translocation ofβ-*** transfection of single-site mutation plasmids,we found that hypochlorous acid induced chlorination of theβ-catenin tyrosine 30 residue,which promoted nuclear ***,our study indicates that maintaining low levels of hypochlorous acid plays a key role in the recovery of neurological function.

关键词： cell differentiation cerebral ischemia/reperfusion injury chlorination hypochlorous acid microglia neural stem cell neurogenesis nuclear translocation stroke β-catenin

Printing perovskite and graphene parallel structure-based optical-mechanical sensors for human-machine interaction

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Science China Technological Sciences 2025年

作者： Sisi chen jiemin ZHANG Nan chenG Wenbo LI Jing LIU Hongfei XIE jie ZHANG Yueying chenG Xiaotong ZHAO Meng SU Yanlin SONG Key Laboratory of Green Printing CAS Research/Education Center for Excellence in Molecular Sciences Institute of ChemistryChinese Academy of Sciences (ICCAS) University of Chinese Academy of Sciences Weiyang College Tsinghua University Department of Cardiovascular Surgery First Medical Center PLA General Hospital AECC Beijing Institute of Aeronautical Materials Beijing Institute of Graphene Technology Beijing Engineering Research Centre of Graphene Application School of Integrated Circuit & Beijing National Research Center for Information Science and Technology (BNRist) Tsinghua University

Surgical robots are designed to provide enhanced precision and dexterity compared to manual surgical procedures,which mainly rely on multimodal sensing technologies for the surgeon to seamlessly operate the robotic arms and *** with single-mode sensors, optical and mechanical bi-modal sensors provide improved precision, enhanced safety,and robustness of human-machine interaction systems. Here, the template-guided and pneumatic printing technologies are combined to construct perovskite and graphene parallel structures with both optical and mechanical sensing capabilities. The printed uniformly crystallized perovskite microstructure exhibits fast and sensitive photoelectric response characteristics,enabling shadow recognition functionality. The combination of graphene and elastic rubber endows the great printability to prepare parallel structures near the perovskite arrays for force sensing capabilities. Thus, the printed perovskite and graphene structures possess non-contact optical sensing capabilities to detect hand position by recognizing shadows between the hand and the sensor, as well as contact mechanical sensing capabilities to detect touch force applied by the hand. It provides a synergistic platform for real-time and multidimensional feedback to improve human-machine interaction.

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Tanshinone IIA Inhibits Growth of Keratinocytes through Cell Cycle Arrest and Apoptosis:Underlying Treatment Mechanism of Psoriasis

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Tanshinone IIA Inhibits Growth of Keratinocytes through Cell...

Deciphering fungal metabolon coupling tandem inverse-electrondemand Diels-Alder reaction and semipinacol rearrangement for the biosynthesis of spiro polycyclic alkaloids

2011年中医外科学术年会

作者： Fu Lun Li,Rong Xu,Xin Li,jie chen,Yi-fei Wang,Bin Fan,Lin Geng,Bin Li~1 Department of Dermatology,Yueyang Hospital of Integrated Traditional Chinese and Western Medicine,affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai(200437), China

Tanshinone IIA is one of the major active ingredients purified from Salvia miltiorrhiza radix used in Traditional Chinese Medicine to treat psoriasis and other inflammatory *** aim of the present investigation was to elucidate the cellular mechanisms whereby tanshinone IIA leads to cell cycle arrest and apoptosis in vitro in keratinocytes,the target cells in psoriasis. Tanshinone IIA inhibited proliferation of mouse keratinocytes in a dose-and time-dependent manner and induced apoptosis,resulting in S phase arrest accompanied by down-regulation of pCdk2 and cyclin A protein ***,tanshinone IIA-induced apoptosis and mitochondrial membrane potential changes were also further demonstrated by DNA fragmentation, single cell gel electrophoresis assay(SCGE),Hoechst staining,and flow cytometry detection of BrdU stained *** was partially blocked by the caspase-3 inhibitor Ac-DEVD-CHO. Mitochondrial regulation of apoptosis further downstream was investigated,showing changes in the mitochondrial membrane potential,cytochrome c release into the cytoplasm,and enhanced activation of cleaved caspase-3 and *** was also no translocation of apoptosis-inducing factor(AIF)from mitochondria to the nucleus in apoptotic keratinocytes,indicating tanshinone IIA-induced apoptosis occurs mainly through the caspase *** conclusion,the current studies demonstrated that tanshinone IIA inhibited growth of keratinocytes by cell cycle S phase arrest and inducing apoptosis by mitochondrial disruption and the caspase *** findings provide the molecular mechanisms by which tanshinone IIA can be used to treat psoriasis and support the traditional use of Salvia miltiorrhiza Bungee(Labiatae)for psoriasis and related skin diseases.

关键词： Tanshinone IIA keratinocytes psoriasis mitochondria apoptosis

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Science China Chemistry 2025年第1期68卷 288-296页

作者： Shuai Liu Wen-Qiang Xu Ying-Tong Di Man-cheng Tang Ding-Kang chen Ming-Ming Cao Yao-Wen Chang Hong-Yu Tang Chun-Mao Yuan Jun-Bo Yang Zhi-Li Zuo Han Guo Zi-fei Xu Ying Zeng Yun-Dong Wu Xiao-Jiang Hao Key Laboratory of Phytochemistry and Natural Medicines (Chinese Academy of Sciences) Kunming Institute of Botany Chinese Academy of Sciences University of Chinese Academy of Sciences Lab of Computational Chemistry and Drug Design State Key Laboratory of Chemical Oncogenomics Peking University Shenzhen Graduate School Shenzhen Bay Laboratory State Key Laboratory of Microbial Metabolism School of Life Sciences & Biotechnology Shanghai Jiao Tong University State Key Laboratory of Functions and Applications of Medicinal Plants Guizhou Medical University Molecular Biology Experimental Center Germplasm Bank of Wild Species in Southwest China Kunming Institute of Botany Chinese Academy of Sciences Yunnan Key Laboratory for Wild Plant Resources Kunming Institute of Botany Chinese Academy of Sciences Research Unit of Chemical Biology of Natural Anti-Virus Products Chinese Academy of Medical Sciences

In the intricate process of natural product biosynthesis, a metabolon can enhance metabolic flux by associating sequential enzymes. A fungal metabolon, comprising of flavin-dependent monooxygenase Spe F and P450 monooxygenase Spe G, is identified in the biosynthesis of spiro polycyclic alkaloids(+)-notoamide B and its diastereomer(+)-versicolamide B. Using notoamide E as a substance, Spe F/Spe G metabolon can control the stereoselectivity of its 2,3-epoxidation, followed by hydrogen atom ion at C-17 to generate reactive epoxide tau-m A with dienyl iminium unit. Subsequently,(+)-notoamide B and(+)-versicolamide B are produced via tandem nonenzymatic inverse-electron-demand Diels-Alder reaction and semipinacol rearrangement. This provides the first example of metabolon in the biosynthesis of spiro-prenylated indole alkaloids.

关键词： metabolon Diels-Alder reaction semipinacol rearrangement biosynthesis notoamides spiro polycyclic alkaloids

FHL2 deficiency aggravates Candida albicans infection through decreased myelopoiesis

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Science China Life Sciences 2025年

作者： Rongmei Gao Kanchao chen Yimin Wang Rongxia Guo Xiaoyu Zhang Peng Wu Weili Wang Qingxiang Huang Xuemei Xie Shangda Yang Yanling Lü Qian Ren fei Liu Song chen Fengxia Ma Tao cheng Hui cheng State Key Laboratory of Experimental Hematology National Clinical Research Center for Blood Diseases Haihe Laboratory of Cell Ecosystem Institute of Hematology & Blood Diseases Hospital Chinese Academy of Medical Sciences & Peking Union Medical College CAMS Center for Stem Cell Medicine PUMC Department of Stem Cell and Regenerative Medicine

Hematopoiesis is a finely tuned process that generates all blood cell types through self-renewal and differentiation, which is crucial for maintaining homeostasis. Acute infections can prompt a hematopoietic response known as emergency myelopoiesis. In this study, using a Candida albicans (C. albicans) infection model, we demonstrated for the first time that disruption of Fhl2 led to increased fungal burden,heightened inflammatory response and reduced survival rates. Impaired myeloid hematopoiesis and immune cell production were evident, as proved by the decreased numbers of hematopoietic stem and progenitor cells (HSPCs) and granulocytes in the bone marrow of Fhl2-deficient mice. In conclusion, FHL2 regulated emergency myelopoiesis in response to C. albicans, affecting the host’s defense against pathogens.

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Quantify Urbanization-Induced Precipitation and Runoff Anomalies over the Qinhuai River Basin of China: Sensitivity Experiments with WRF-Hydro

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Journal of Meteorological Research 2024年第5期38卷 999-1020页

作者： jie WANG Shiguang MIAO fei chen Institute of Urban Meteorology China Meteorological AdministrationBeijing 100089 Key Laboratory of Urban Meteorology China Meteorological AdministrationBeijing 100089 China Meteorological Administration Hydro-Meteorology Key Laboratory Beijing 100081 Division of Environment and Sustainability The Hong Kong University of Science and TechnologyHong Kong 999077China

Urbanization-related precipitation and surface runoff changes have been widely investigated,but few studies have directly quantified these changes and their link to urbanization in the hydrological cycle.A two-way dynamically coupled atmospheric–hydrological modeling system,Weather Research and Forecasting(WRF)-Hydro,has been applied in this study to perform the *** offline WRF-Hydro was first calibrated and validated for several flooding events against gauge observed streamflow data,with the Nash–Sutcliffe efficiency reaching *** to the WRF model,WRF-Hydro resolves more detailed rainfall pattern features and reproduces the gauge rainfall with a correlation coefficient of ***,the impact of urbanization on hydrometeorological processes was investigated with coupled WRF-Hydro sensitivity simulations over the Qinhuai River basin of China during 2 June–31 July *** results indicate that urbanization enhances regional precipitation,resulting in an indirect increase in surface runoff,overland flow,and streamflow by 16.7,93.5,and 111.2 mm,respectively;however,the impervious area results in higher surface runoff,overland flow,and ***,changes in main hydrometeorological processes further impact the atmospheric–terrestrial water budget,resulting in a decrease in terrestrial water storage and an increase(a decrease)in precipitable water storage in the middle(lower)parts of the lower *** changes are likely associated with the warmer urban environment than rural *** water vapor and strengthened convective conditions in the middle part of the lower troposphere due to urban warming are advantageous to the formation of precipitation in urban areas,which in turn increases surface runoff,thereby facilitating the water cycle and altering the atmospheric–terrestrial water budget.

关键词： urbanization atmospheric-terrestrial water budget coupled Weather Research and Forecasting(WRF)-Hydro model thermodynamic condition

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连霍高速公路哈密—吐鲁番区间防风技术研究

交通标准化 2011年第11期39卷 105-110页

作者：陈飞捷马淑红马韫娟戈峰新疆公路规划勘察设计研究院新疆乌鲁木齐830002 北京大学水沙科学教育部重点实验室北京100871 清华大学北京100084 国家发改委宏观院北京100037

在沿线风害成因、分布特征、基本风速对比分析研究基础上,确定连霍高速百里风区防风区段和防风标准,提出高速公路强横风路段采用柔性防风阻沙栅的防风措施,对于今后我国高速公路风害防控技术研究和高速公路安全、高效行车具有一定的指... 详细信息

在沿线风害成因、分布特征、基本风速对比分析研究基础上,确定连霍高速百里风区防风区段和防风标准,提出高速公路强横风路段采用柔性防风阻沙栅的防风措施,对于今后我国高速公路风害防控技术研究和高速公路安全、高效行车具有一定的指导意义和科学借鉴作用。

关键词：连霍高速公路百里风区防风技术