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新疆公路工程设计阶段工程造价控制的实践研究

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重庆交通学院学报 2005年第5期24卷 97-100页

作者：陈飞捷陈昌武谢福君新疆公路规划勘测设计院新疆乌鲁木齐810024 襄樊市交通规划设计院湖北襄樊434801 湖南省衡阳市交通局湖南衡阳412001

新疆自治区公路建设起步晚,发展快,条件特殊.在建设投资日益增长的条件下,如何合理控制造价,对工程建设全过程进行造价控制,本文从公路设计工作入手,对目前设计中存在的问题及解决途径作了研究.

关键词：公路设计造价控制改革

Trinuclear gold-catalyzed site-selective alkylation of peptides

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Science China Chemistry 2025年第1期 249-256页

作者： Qing-Yun Fang chengyihan Gu Yinghan chen Wencheng Yan Yong Liang Weipeng Li chengjian Zhu jie Han Jin Xie State Key Laboratory of Coordination Chemistry Jiangsu Key Laboratory of Advanced Organic Materials Chemistry and Biomedicine Innovation Center (Chem BIC) School of Chemistry and Chemical Engineering Nanjing University Green Catalysis Center College of Chemistry Zhengzhou University State Key Laboratory of Natural Medicines China Pharmaceutical University

Selective modification of peptides has always been a challenging issue. The selective alkylation of peptides can alter the biological activity and physical properties of molecules, and it has gained significant research interest. We herein disclose an intriguing gold-catalyzed alkylation of peptides using bench-stable unactivated alkyl bromides under photoredox catalysis. A wide range of structurally diverse primary, secondary and tertiary alkyl bromides serve as effective coupling partners to precisely connect with the α-C(sp3)–H in glycine residue of peptides. This protocol demonstrates an exceptionally broad scope for alkyl halides and excellent tolerance for a wide range of useful functional groups. A series of relay transformations to construct cyclic peptides, to proceed click reaction and to realize peptide fluorescence labeling further enhance its synthetic practicality. In addition, mechanistic studies and density functional theory(DFT) calculations reveal an inner-sphere and subsequent outersphere single electron transfer(SET) mechanism.

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AI预测天然染料在丝绸上的最佳染色工艺与色牢度研究

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丝绸 2025年第1期62卷 40-48页

作者：刘莹陈杰南宁师范大学美术与设计学院南宁530001 武汉大学物理科学与技术学院武汉430000

随着环境问题的日益严峻,为了提高实验效率、节约成本,推动可持续发展战略在染料与纺织品领域的应用,文章首先对天然染料染色的数据进行了收集与预处理,然后采用Xgboost集成学习算法构建AI模型并进行了模型训练与验证,评估了模型的有效... 详细信息

随着环境问题的日益严峻,为了提高实验效率、节约成本,推动可持续发展战略在染料与纺织品领域的应用,文章首先对天然染料染色的数据进行了收集与预处理,然后采用Xgboost集成学习算法构建AI模型并进行了模型训练与验证,评估了模型的有效性和预测精度。该模型实现了天然染料在丝绸上染色工艺与效果的高效模拟与预测,从而显著缩短了实验时间并降低了资源损耗。这一方法提高了研究效率和经济效益。研究表明,该模型在预测反应最佳酸碱度(pH值)、水洗色牢度(CFW)和摩擦色牢度(CFR)方面具有较高的准确率,在验证集中三者的预测准确率高达94.12%、93.75%、100%,在真实的测试集上分别拥有87.50%、94.12%、82.35%的准确率,同时具备有效性与可迁移性。集成学习的方法通过极小的部署成本和极短的耗时为天然染料染色性能的探索给出了极具价值的指导,也为AI机器学习与纺织染色的学科的交叉应用拓展了可能性。

关键词： AI预测 Xgboost 天然染料丝绸色牢度

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近海单桩式风机地震响应分区耦合分析方法

岩土工程学报 2025年第1期47卷 96-105页

作者：徐小凤陈少林孙杰南京航空航天大学民航学院土木与机场工程系江苏南京211106 中国能源建设集团江苏省电力设计院有限公司江苏南京211106

海上风机是低碳可持续能源的重要战略选择之一,其地震安全性问题是急需解决的重要课题。将近海单桩式风机三维地震响应问题看作波动散射问题,结合人工边界条件实现海域场地的波动输入,并基于广义饱和多孔介质统一计算框架,发展了一套海... 详细信息

海上风机是低碳可持续能源的重要战略选择之一,其地震安全性问题是急需解决的重要课题。将近海单桩式风机三维地震响应问题看作波动散射问题,结合人工边界条件实现海域场地的波动输入,并基于广义饱和多孔介质统一计算框架,发展了一套海水-饱和海床-风机耦合作用高效分区分析方法,实现了综合考虑土-结构相互作用效应和流固耦合效应的近海单桩式风机三维地震响应分析,并分析了海水深度、海床波速和地震波入射角度对近海单桩式风机地震响应的影响。分析结果表明,海水深度和海床剪切波速的变化,一方面会改变自由场,另一方面会改变海域场地-风机体系的自振特性,从而影响风机结构的地震反应。当海水增加到某深度时,体系自振频率与地震波输入频率接近时,风机的地震响应会急剧增大;海床剪切波速对塔底弯矩的影响要比对位移的影响大;当入射角度增大时,塔顶水平向位移和加速度以及塔底弯矩均有不同程度的减小,塔顶竖向位移和加速度均有不同程度的增大。本文没有考虑海床和风机的非线性,考虑非线性时的影响规律需进一步研究。

关键词：近海单桩式风机地震响应分析土-结构相互作用流固耦合

Sulfolane‑Based Flame‑Retardant Electrolyte for High‑Voltage Sodium‑Ion Batteries

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Nano-Micro Letters 2025年第2期17卷 498-516页

作者： Xuanlong He jie Peng Qingyun Lin Meng Li Weibin chen Pei Liu Tao Huang Zhencheng Huang Yuying Liu Jiaojiao Deng Shenghua Ye Xuming Yang Xiangzhong Ren Xiaoping Ouyang Jianhong Liu Biwei Xiao Jiangtao Hu Qianling Zhang Graphene Composite Research Center College of Chemistry and Environmental EngineeringShenzhen UniversityShenzhen 518060People’s Republic of China Center of Electron Microscopy State Key Laboratory of Silicon and Advanced Semiconductor MaterialsSchool of Materials Science and EngineeringZhejiang UniversityHangzhou 310027People’s Republic of China GRINM(Guangdong)Research Institute for Advanced Materials and Technology FoshanGuangdong 528051People’s Republic of China College of Energy Engineering Zhejiang UniversityHangzhouZhejiang 310027People’s Republic of China School of Materials Science and Engineering Xiangtan UniversityXiangtan 411105People’s Republic of China Shenzhen Eigen-Equation Graphene Technology Co.Ltd Shenzhen 518000People’s Republic of China

Sodium-ion batteries hold great promise as next-generation energy storage ***,the high instability of the electrode/electrolyte interphase during cycling has seriously hindered the development of *** particular,an unstable cathode–electrolyte interphase(CEI)leads to successive electrolyte side reactions,transition metal leaching and rapid capacity decay,which tends to be exacerbated under high-voltage ***,constructing dense and stable CEIs are crucial for high-performance *** work reports localized high-concentration electrolyte by incorporating a highly oxidation-resistant sulfolane solvent with non-solvent diluent 1H,1H,5H-octafluoropentyl-1,1,2,2-tetrafluoroethyl ether,which exhibited excellent oxidative stability and was able to form thin,dense and homogeneous *** excellent CEI enabled the O3-type layered oxide cathode NaNi_(1/3)Mn_(1/3)Fe_(1/3)O_(2)(NaNMF)to achieve stable cycling,with a capacity retention of 79.48%after 300 cycles at 1 C and 81.15%after 400 cycles at 2 C with a high charging voltage of 4.2 *** addition,its nonflammable nature enhances the safety of *** work provides a viable pathway for the application of sulfolane-based electrolytes on SIBs and the design of next-generation high-voltage electrolytes.

关键词： Sodium-ion batteries Sulfolane-based electrolyte High voltage Layered oxide cathode Flame retardant

Maintaining moderate levels of hypochlorous acid promotes neural stem cell proliferation and differentiation in the recovery phase of stroke

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Neural Regeneration Research 2025年第3期20卷 845-857页

作者： Lin-Yan Huang Yi-De Zhang jie chen Hai-Di Fan Wan Wang Bin Wang Ju-Yun Ma Peng-Peng Li Hai-Wei Pu Xin-Yian Guo Jian-Gang Shen Su-Hua Qi School of Medical Technology Xuzhou Key Laboratory of Laboratory DiagnosticsXuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Pharmacy Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina Department of Laboratory Medicine Branch Hospital of Huai’an First People’s HospitalHuai’anJiangsu ProvinceChina Department of Laboratory Medicine the Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Chinese Medicine The University of Hong KongHong Kong Special Administrative RegionChina

It has been shown clinically that continuous removal of ischemia/reperfusion-induced reactive oxygen species is not conducive to the recovery of late ***,previous studies have shown that excessive increases in hypochlorous acid after stroke can cause severe damage to brain *** previous studies have found that a small amount of hypochlorous acid still exists in the later stage of stroke,but its specific role and mechanism are currently *** simulate stroke in vivo,a middle cerebral artery occlusion rat model was established,with an oxygen-glucose deprivation/reoxygenation model established in vitro to mimic *** found that in the early stage(within 24 hours)of ischemic stroke,neutrophils produced a large amount of hypochlorous acid,while in the recovery phase(10 days after stroke),microglia were activated and produced a small amount of hypochlorous ***,in acute stroke in rats,hypochlorous acid production was prevented using a hypochlorous acid scavenger,taurine,or myeloperoxidase inhibitor,4-aminobenzoic acid *** results showed that high levels of hypochlorous acid(200μM)induced neuronal apoptosis after oxygen/glucose deprivation/***,in the recovery phase of the middle cerebral artery occlusion model,a moderate level of hypochlorous acid promoted the proliferation and differentiation of neural stem cells into neurons and *** suggests that hypochlorous acid plays different roles at different phases of cerebral ischemia/reperfusion *** levels of hypochlorous acid(5 and 100μM)promoted nuclear translocation ofβ-*** transfection of single-site mutation plasmids,we found that hypochlorous acid induced chlorination of theβ-catenin tyrosine 30 residue,which promoted nuclear ***,our study indicates that maintaining low levels of hypochlorous acid plays a key role in the recovery of neurological function.

关键词： cell differentiation cerebral ischemia/reperfusion injury chlorination hypochlorous acid microglia neural stem cell neurogenesis nuclear translocation stroke β-catenin

Printing perovskite and graphene parallel structure-based optical-mechanical sensors for human-machine interaction

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Science China Technological Sciences 2025年

作者： Sisi chen jiemin ZHANG Nan chenG Wenbo LI Jing LIU Hongfei XIE jie ZHANG Yueying chenG Xiaotong ZHAO Meng SU Yanlin SONG Key Laboratory of Green Printing CAS Research/Education Center for Excellence in Molecular Sciences Institute of ChemistryChinese Academy of Sciences (ICCAS) University of Chinese Academy of Sciences Weiyang College Tsinghua University Department of Cardiovascular Surgery First Medical Center PLA General Hospital AECC Beijing Institute of Aeronautical Materials Beijing Institute of Graphene Technology Beijing Engineering Research Centre of Graphene Application School of Integrated Circuit & Beijing National Research Center for Information Science and Technology (BNRist) Tsinghua University

Surgical robots are designed to provide enhanced precision and dexterity compared to manual surgical procedures,which mainly rely on multimodal sensing technologies for the surgeon to seamlessly operate the robotic arms and *** with single-mode sensors, optical and mechanical bi-modal sensors provide improved precision, enhanced safety,and robustness of human-machine interaction systems. Here, the template-guided and pneumatic printing technologies are combined to construct perovskite and graphene parallel structures with both optical and mechanical sensing capabilities. The printed uniformly crystallized perovskite microstructure exhibits fast and sensitive photoelectric response characteristics,enabling shadow recognition functionality. The combination of graphene and elastic rubber endows the great printability to prepare parallel structures near the perovskite arrays for force sensing capabilities. Thus, the printed perovskite and graphene structures possess non-contact optical sensing capabilities to detect hand position by recognizing shadows between the hand and the sensor, as well as contact mechanical sensing capabilities to detect touch force applied by the hand. It provides a synergistic platform for real-time and multidimensional feedback to improve human-machine interaction.

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Tanshinone IIA Inhibits Growth of Keratinocytes through Cell Cycle Arrest and Apoptosis:Underlying Treatment Mechanism of Psoriasis

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Tanshinone IIA Inhibits Growth of Keratinocytes through Cell...

FHL2 deficiency aggravates Candida albicans infection through decreased myelopoiesis

2011年中医外科学术年会

作者： Fu Lun Li,Rong Xu,Xin Li,jie chen,Yi-fei Wang,Bin Fan,Lin Geng,Bin Li~1 Department of Dermatology,Yueyang Hospital of Integrated Traditional Chinese and Western Medicine,affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai(200437), China

Tanshinone IIA is one of the major active ingredients purified from Salvia miltiorrhiza radix used in Traditional Chinese Medicine to treat psoriasis and other inflammatory *** aim of the present investigation was to elucidate the cellular mechanisms whereby tanshinone IIA leads to cell cycle arrest and apoptosis in vitro in keratinocytes,the target cells in psoriasis. Tanshinone IIA inhibited proliferation of mouse keratinocytes in a dose-and time-dependent manner and induced apoptosis,resulting in S phase arrest accompanied by down-regulation of pCdk2 and cyclin A protein ***,tanshinone IIA-induced apoptosis and mitochondrial membrane potential changes were also further demonstrated by DNA fragmentation, single cell gel electrophoresis assay(SCGE),Hoechst staining,and flow cytometry detection of BrdU stained *** was partially blocked by the caspase-3 inhibitor Ac-DEVD-CHO. Mitochondrial regulation of apoptosis further downstream was investigated,showing changes in the mitochondrial membrane potential,cytochrome c release into the cytoplasm,and enhanced activation of cleaved caspase-3 and *** was also no translocation of apoptosis-inducing factor(AIF)from mitochondria to the nucleus in apoptotic keratinocytes,indicating tanshinone IIA-induced apoptosis occurs mainly through the caspase *** conclusion,the current studies demonstrated that tanshinone IIA inhibited growth of keratinocytes by cell cycle S phase arrest and inducing apoptosis by mitochondrial disruption and the caspase *** findings provide the molecular mechanisms by which tanshinone IIA can be used to treat psoriasis and support the traditional use of Salvia miltiorrhiza Bungee(Labiatae)for psoriasis and related skin diseases.

关键词： Tanshinone IIA keratinocytes psoriasis mitochondria apoptosis

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Science China Life Sciences 2025年

作者： Rongmei Gao Kanchao chen Yimin Wang Rongxia Guo Xiaoyu Zhang Peng Wu Weili Wang Qingxiang Huang Xuemei Xie Shangda Yang Yanling Lü Qian Ren fei Liu Song chen Fengxia Ma Tao cheng Hui cheng State Key Laboratory of Experimental Hematology National Clinical Research Center for Blood Diseases Haihe Laboratory of Cell Ecosystem Institute of Hematology & Blood Diseases Hospital Chinese Academy of Medical Sciences & Peking Union Medical College CAMS Center for Stem Cell Medicine PUMC Department of Stem Cell and Regenerative Medicine

Hematopoiesis is a finely tuned process that generates all blood cell types through self-renewal and differentiation, which is crucial for maintaining homeostasis. Acute infections can prompt a hematopoietic response known as emergency myelopoiesis. In this study, using a Candida albicans (C. albicans) infection model, we demonstrated for the first time that disruption of Fhl2 led to increased fungal burden,heightened inflammatory response and reduced survival rates. Impaired myeloid hematopoiesis and immune cell production were evident, as proved by the decreased numbers of hematopoietic stem and progenitor cells (HSPCs) and granulocytes in the bone marrow of Fhl2-deficient mice. In conclusion, FHL2 regulated emergency myelopoiesis in response to C. albicans, affecting the host’s defense against pathogens.

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