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Cardiac-targeted PIASy gene silencing mediates deSUMOylation of caveolin-3 and prevents ischemia/reperfusion-induced Na_(v)1.5 downregulation and ventricular arrhythmias

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Military Medical Research 2023年第3期10卷 342-358页

作者： chen-chen hu Xin Wei Jin-Min Liu Lin-Lin Han cheng-Kun Xia Jing Wu Tao You A-Fang Zhu Shang-Long Yao Shi-Ying Yuan Hao-Dong Xu Zheng-Yuan Xia Ting-Ting Wang Wei-Ke Mao Department of Anesthesiology Institute of Anesthesiology and Critical Care MedicineUnion HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of Cardiology the Second Affiliated Hospital of Soochow UniversitySuzhou 215004JiangsuChina Department of Anesthesiology Peking Union Medical College HospitalCAMS and PUMCBeijing 100730China Department of Pathology University of WashingtonSeattleWA 98195USA State Key Laboratory of Pharmaceutical Biotechnology the University of Hong KongHong Kong 999077China Department of Anesthesiology Affiliated Hospital of Guangdong Medical UniversityZhanjiang 524000GuangdongChina

Background:Abnormal myocardial voltage-gated sodium channel 1.5(Nav1.5)expression and function cause lethal ventricular arrhythmias during myocardial ischemia–reperfusion(I/R).Protein inhibitor of activated STAT Y(PIASy)-mediated caveolin-3(Cav-3)small ubiquitin-related modifier(SUMO)modification affects Cav-3 binding to the Nav1.5.PIASy activity is increased after myocardial I/R,but it is unclear whether this is attributable to plasma membrane Nav1.5 downregulation and ventricular arrhythmias.Methods:Using recombinant adeno-associated virus subtype 9(AAV9),rat cardiac PIASy was silenced using intraventricular injection of PIASy short hairpin RNA(shRNA).After two weeks,rat hearts were subjected to I/R and electrocardiography was performed to assess malignant arrhythmias.Tissues from peri-infarct areas of the left ventricle were collected for molecular biological measurements.Results:PIASy was upregulated by I/R(Phuman embryonic kidney 293 T(HEK293T)cells and isolated adult rat cardiomyocyte models exposed to hypoxia/reoxygenation(H/R),we confirmed that increased PIASy promoted C

关键词： Ventricular arrhythmia Na_(v)1.5 Caveolin-3 Protein inhibitor of activated STAT Y SUMOylation

Annexin A1 Mimetic Peptide AC2-26 Inhibits Sepsis-induced Cardiomyocyte Apoptosis through LXA4/PI3K/AKT Signaling Pathway

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Current Medical Science 2018年第6期38卷 997-1004页

作者： Li ZHANG Yan-lei ZHENG Rong-hua hu Li Zhu chen-chen hu Fei chenG Shi LI Jian-guo LI Intensive Care Unit Zhongnan Hospital of Wuhan UniversityWuhan 430071China Intensive Care Unit Hubei Cancer HospitalWuhan 430079China

The aim of the present study was to explore the effects of annexin A1(ANXA1) mimetic peptide AC2-26 on sepsis-induced cardiomyocyte apoptosis in vivo and in vitro and the underlying mechanisms.In the in vivo study,a rat septic model was established by the cecal ligation and puncture (CLP).The rats were divided into control group,sepsis group and AC2-26 group.The rats in the AC2-26 group were intraperitoneally injected with AC2-26(1mg/kg)2h before CLP,and those in the control group and sepsis group were injected with the same volume of normal saline.The myocardial tissue was examined by hematoxylin and eosin (HE)staining and transmission electron microscopy (TEM).Furthermore,myocardial apoptosis was measured by terminal dUTP nick end-labeling (TUNEL)assay.In the in vitro study,H9C2cells were cultured and divided into three groups:control group,in which cells were only given the basic culture medium;LPS group,in which cells were treated with 10μg/mL LPS;AC2-26 group,in which cells were treated with 0.5μmol/L AC2-262h before 10μg/mL LPS was given.The apoptosis of H9C2 cells was detected by flow cytometry.The levels of lipoxin A4 receptor (LXA4),phosphoinositide3-kinase (PI3K)and protein kinase B (PKB or AKT)protein were measured by Western blotting, the activity of NF-KB and the level of TNF-α by ELISA and the activities of caspase-3/8by using the caspase activity kits.The in vivo study showed that the myocardial pathological damage and myocardial ultrastructural damage were significantly alleviated and the myocardial apoptosis significantly decreased in the AC2-26 group as compared with the sepsis group (P<0.05 for all). The in vivo study revealed that the apoptosis of H9C2 cells was profoundly ameliorated in the AC2-26 group relative to the sepsis group (P<0.05).The protein expression levels of LXA4 were significantly up-regulated,and those of PI3K and AKT prominently down-regulated in the AC2-26 group when compared with those in the LPS group (P<0.05 for all).The activity of NF-κB was greatly inhibited and the le

关键词： sepsis AC2-26 H9C2 apoptosis inflammation

A Review of Contact Electrification at Diversified Interfaces and Related Applications on Triboelectric Nanogenerator

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Nano-Micro Letters 2024年第1期16卷 106-130页

作者： Jun hu Mitsumasa Iwamoto Xiangyu chen CAS Center for Excellence in Nanoscience Beijing Institute of Nanoenergy and NanosystemsChinese Academy of SciencesBeijing 100083People’s Republic of China School of Nanoscience and Engineering University of Chinese Academy of SciencesBeijing 100049People’s Republic of China Department of Physical Electronics Tokyo Institute of Technology2‑12‑1 S3‑33 O‑OkayamaMeguro‑KuTokyo 152‑8552Japan

The triboelectric nanogenerator(TENG)can effectively collect energy based on contact electrification(CE)at diverse interfaces,including solid–solid,liquid–solid,liquid–liquid,gas–solid,and gas–liquid.This enables energy harvesting from sources such as water,wind,and sound.In this review,we provide an overview of the coexistence of electron and ion transfer in the CE process.We elucidate the diverse dominant mechanisms observed at different interfaces and emphasize the interconnectedness and complementary nature of interface studies.The review also offers a comprehensive summary of the factors influencing charge transfer and the advancements in interfacial modification techniques.Additionally,we highlight the wide range of applications stemming from the distinctive characteristics of charge transfer at various interfaces.Finally,this review elucidates the future opportunities and challenges that interface CE may encounter.We anticipate that this review can offer valuable insights for future research on interface CE and facilitate the continued development and industrialization of TENG.

关键词： Contact electrification Interfaces Triboelectric nanogenerators Diversified applications

An improved interval model updating method via adaptive Kriging models

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Applied Mathematics and Mechanics(English Edition) 2024年第3期45卷 497-514页

作者： Sha WEI Yifeng chen hu DING Liqun chen Shanghai Key Laboratory of Mechanics in Energy Engineering Shanghai Frontier Science Center of MechanoinformaticsShanghai Institute of Applied Mathematics and MechanicsSchool of Mechanics and Engineering ScienceShanghai UniversityShanghai 200072China Shanghai Institute of Aircraft Mechanics and Control Shanghai 200092China

Interval model updating(IMU)methods have been widely used in uncertain model updating due to their low requirements for sample data.However,the surrogate model in IMU methods mostly adopts the one-time construction method.This makes the accuracy of the surrogate model highly dependent on the experience of users and affects the accuracy of IMU methods.Therefore,an improved IMU method via the adaptive Kriging models is proposed.This method transforms the objective function of the IMU problem into two deterministic global optimization problems about the upper bound and the interval diameter through universal grey numbers.These optimization problems are addressed through the adaptive Kriging models and the particle swarm optimization(PSO)method to quantify the uncertain parameters,and the IMU is accomplished.During the construction of these adaptive Kriging models,the sample space is gridded according to sensitivity information.Local sampling is then performed in key subspaces based on the maximum mean square error(MMSE)criterion.The interval division coefficient and random sampling coefficient are adaptively adjusted without human interference until the model meets accuracy requirements.The effectiveness of the proposed method is demonstrated by a numerical example of a three-degree-of-freedom mass-spring system and an experimental example of a butted cylindrical shell.The results show that the updated results of the interval model are in good agreement with the experimental results.

关键词： interval model updating(IMU) non-probabilistic uncertainty adaptive Kriging model surrogate model grey number

Geometric phase-encoded stimuli-responsive cholesteric liquid crystals for visualizing real-time remote monitoring:humidity sensing as a proof of concept

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Light(Science & Applications) 2024年第2期13卷 283-293页

作者： Shi-Long Li Zhao-Yi chen Peng chen Wei hu Chaohong huang Sen-Sen Li Xuejia hu Yan-Qing Lu Lu-Jian chen Department of Electronic Engineering School of Electronic Science and EngineeringXiamen University361005 XiamenChina College of Engineering and Applied Sciences Nanjing University210093 NanjingChina Fujian Key Laboratory of Ultrafast Laser Technology and Applications Xiamen University361005 XiamenChina

Liquid crystals are a vital component of modern photonics,and recent studies have demonstrated the exceptional sensing properties of stimuli-responsive cholesteric liquid crystals.However,existing cholesteric liquid crystal-based sensors often rely on the naked eye perceptibility of structural color or the measurement of wavelength changes by spectrometric tools,which limits their practical applications.Therefore,developing a platform that produces recognizable sensing signals is critical.In this study,we present a visual sensing platform based on geometric phase encoding of stimuli-responsive cholesteric liquid crystal polymers that generates real-time visual patterns,rather than frequency changes.To demonstrate this platform’s effectiveness,we used a humidity-responsive cholesteric liquid crystal polymer film encoded with a q-plate pattern,which revealed that humidity causes a shape change in the vortex beam reflected from the encoded cholesteric liquid crystal polymers.Moreover,we developed a prototype platform towards remote humidity monitoring benefiting from the high directionality and long-range transmission properties of laser beams carrying orbital angular momentum.Our approach provides a novel sensing platform for cholesteric liquid crystals-based sensors that offers promising practical applications.The ability to generate recognizable sensing signals through visual patterns offers a new level of practicality in the sensing field with stimuli-responsive cholesteric liquid crystals.This platform might have significant implications for a broad readership and will be of interest to researchers working in the field of photonics and sensing technology.

关键词： humidity visual liquid

A whole-net cooperative positioning method based on CDGNSS and inter-vehicle ranging

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Chinese Journal of Aeronautics 2024年第2期37卷 401-416页

作者： Shan hu Hongbo ZHAO chen ZhuANG School of Electronics and Information Engineering Beihang UniversityBeijing 100191China

Relative positioning is recognized as an important issue for vehicles in urban environments.Multi-vehicle Cooperative Positioning(CP)techniques which fuse the Global Navigation Satellite System(GNSS)and inter-vehicle ranging have attracted attention in improving the performance of baseline estimation between vehicles.However,current CP methods estimate the baselines separately and ignore the interactions among the positioning information of different baselines.These interactions are called’information coupling’.In this work,we propose a new multivehicle precise CP framework using the coupled information in the network based on the Carrier Differential GNSS(CDGNSS)and inter-vehicle ranging.We demonstrate the benefit of the coupled information by deriving the Cramer-Rao Lower Bound(CRLB)of the float estimation in CP.To fully use this coupled information,we propose a Whole-Net CP(WN-CP)method which consists of the Whole-Net Extended Kalman Filter(WN-EKF)as the float estimation filter,and the Partial Baseline Fixing(PBF)as the ambiguity resolution part.The WN-EKF fuses the measurements of all baselines simultaneously to improve the performance of float estimation,and the PBF strategy fixes the ambiguities of the one baseline to be estimated,instead of full ambiguity resolution,to reduce the computation load of ambiguity resolution.Field tests involving four vehicles were conducted in urban environments.The results show that the proposed WN-CP method can achieve better performance and meanwhile maintain a low computation load compared to the existing methods.

关键词： GNSS Cooperative positioning Baseline Ambiguity resolution Information coupling

Dynamics and vibration reduction performance of asymmetric tristable nonlinear energy sink

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Applied Mathematics and Mechanics(English Edition) 2024年第3期45卷 389-406页

作者： Hongyan chen Youcheng ZENG hu DING Siukai LAI Liqun chen School of Mechanical Engineering University of Science and Technology BeijingBeijing 100083China Shanghai Key Laboratory of Mechanics in Energy Engineering Shanghai Frontier Science Center of MechanoinformaticsShanghai Institute of Applied Mathematics and MechanicsSchool of Mechanics and Engineering ScienceShanghai UniversityShanghai 200444China Department of Civil and Environmental Engineering The Hong Kong Polytechnic UniversityKowloonHong KongChina

With its complex nonlinear dynamic behavior,the tristable system has shown excellent performance in areas such as energy harvesting and vibration suppression,and has attracted a lot of attention.In this paper,an asymmetric tristable design is proposed to improve the vibration suppression efficiency of nonlinear energy sinks(NESs)for the first time.The proposed asymmetric tristable NES(ATNES)is composed of a pair of oblique springs and a vertical spring.Then,the three stable states,symmetric and asymmetric,can be achieved by the adjustment of the distance and stiffness asymmetry of the oblique springs.The governing equations of a linear oscillator(LO)coupled with the ATNES are derived.The approximate analytical solution to the coupled system is obtained by the harmonic balance method(HBM)and verified numerically.The vibration suppression efficiency of three types of ATNES is compared.The results show that the asymmetric design can improve the efficiency of vibration reduction through comparing the chaotic motion of the NES oscillator between asymmetric steady states.In addition,compared with the symmetrical tristable NES(TNES),the ATNES can effectively control smaller structural vibrations.In other words,the ATNES can effectively solve the threshold problem of TNES failure to weak excitation.Therefore,this paper reveals the vibration reduction mechanism of the ATNES,and provides a pathway to expand the effective excitation amplitude range of the NES.

关键词： asymmetric nonlinear energy sink(NES) tristable vibration control po-tential barrier

Structural characteristics and drivers of greenhouse gas emissions at county-level and long-time scales:A case study of the Anji County,China

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Journal of Environmental Sciences 2024年第6期140卷 319-330页

作者： Zhouxiang Cai Liting hu Di chen Ying Zhang Xuekun Fang College of Environmental&Resource Sciences Zhejiang UniversityHangzhou 310058China Center for Global Change Science Massachusetts Institute of TechnologyCambridgeMA 02139United States Anji Meteorological Bureau Anji 313300China

To achieve carbon neutrality,the Chinese government needs to gain a comprehensive understanding of the sources and drivers of greenhouse gas(GHG)emissions,particularly at the county level.Anji County in eastern China is a typical example of an industrial transformation from quarrying to a low-carbon economy.This study analyzed the decoupling types and structural characteristics of GHG emissions and the driving factors of carbon dioxide(CO_(2))emissions in the Anji from 2006 to 2019,and explored the differences between countylevel and provincial-level or city-level results.It was observed that energy-related activities are the main source of GHG emissions in Anji and that economic development is the driving factor behind the increasing CO_(2)emissions.However,industrial transformation and upgradation coupled with the alternative use of clean energy limit the growth of GHG emissions.This study details the GHG emissions of county during the industrial transformation stage and provides corresponding policy recommendations for county governments.

关键词： County GHG emissions Decoupling Driving factors Policy recommendations

Trajectory tracking guidance of interceptor via prescribed performance integral sliding mode with neural network disturbance observer

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Defence Technology（防务技术） 2024年第2期32卷 412-429页

作者： Wenxue chen Yudong hu Changsheng Gao Ruoming An School of Astronautics Harbin Institute of TechnologyHarbin 150001China

This paper investigates interception missiles’trajectory tracking guidance problem under wind field and external disturbances in the boost phase.Indeed,the velocity control in such trajectory tracking guidance systems of missiles is challenging.As our contribution,the velocity control channel is designed to deal with the intractable velocity problem and improve tracking accuracy.The global prescribed performance function,which guarantees the tracking error within the set range and the global convergence of the tracking guidance system,is first proposed based on the traditional PPF.Then,a tracking guidance strategy is derived using the integral sliding mode control techniques to make the sliding manifold and tracking errors converge to zero and avoid singularities.Meanwhile,an improved switching control law is introduced into the designed tracking guidance algorithm to deal with the chattering problem.A back propagation neural network(BPNN)extended state observer(BPNNESO)is employed in the inner loop to identify disturbances.The obtained results indicate that the proposed tracking guidance approach achieves the trajectory tracking guidance objective without and with disturbances and outperforms the existing tracking guidance schemes with the lowest tracking errors,convergence times,and overshoots.

关键词： BP network neural Integral sliding mode control(ISMC) Missile defense Prescribed performance function(PPF) State observer Tracking guidance system