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Levosimendan does not reduce the mortality of critically ill adult patients with sepsis and septic shock: a meta-analysis

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Chinese Medical Journal 2019年第10期132卷 1212-1217页

作者： Fang Feng Yu chen Min Li Jiao-Jiao Yuan Xue-Ni Chang chen-ming dong Department of Intensive Care Unit Lanzhou University Second Hospital Lanzhou University Lanzhou Gansu 730030 China

Background: Previous studies on whether or not levosimendan improved the prognosis of patients with sepsis and septic shock been inconsistent. We aimed to provide an updated analysis of the therapeutic value of levosimendan in adult patients with sepsis and septic shock, in order to provide evidence-based medical evidence for its use. Methods: PubMed, Embase, Cochrane Library, Wanfang Data, and CNKI were searched until August 2018 without language restriction. Randomized controlled studies of levosimendan with either inotropic drugs or placebo for the treatment of sepsis or septic shock were enrolled. The primary outcome was mortality, and cardiac index and serum lactate levels were the secondary outcomes. Results: A total of 20 randomized controlled studies were included in this meta-analysis, including 1467 patients, with 738 patients in the experimental group (levosimendan group) and 729 patients in the control group (other inotropic drugs or placebo). There were no significant differences in mortality between the levosimendan and control groups (fixed-effect relative risk [RR]= 0.90, 95% confidence interval [CI][0.79, 1.03], P = 0.13). Levosimendan increased the cardiac index (VMD [weighted mean difference]= 0.51, 95% CI [0.06, 0.95], P = 0.02);and serum lactate levels were lower (VMD =—1.04, 95% CI [—1.47,—0.60], P< 0.00001). Conclusions: Based on current clinical evidence, levosimendan does not reduce mortality in adult critically ill patients with sepsis and septic shock. Physicians should use levosimendan with caution in patients with sepsis and septic shock.

关键词： Levosimendan Sepsis Septic shock Meta-analysis

Activation of peroxymonosulfate by sustainable biomass-based carbon nanotubes for controlling the spread of plant viruses in water environments

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Journal of Environmental Sciences 2025年第3期149卷 99-112页

作者： Jian Tang Yujie Wang JunMa Yujie chen ming chen College of Resources and Environment Yangtze UniversityWuhan 430100China Key Laboratory of Reservoir Aquatic Environment Chongqing Institute of Green and Intelligent TechnologyChinese Academy of SciencesChongqing 400714China Chongqing School University of Chinese Academy of SciencesChongqing 400714China School of Geography and Tourism Chongqing Normal UniversityChongqing 400714China

With the increasing demand for water in hydroponic systems and agricultural irrigation,viral diseases have seriously affected the yield and quality of *** removing plant viruses in water environments,virus transmission can be prevented and agricultural production and ecosystems can be *** so far,there have been few reports on the removal of plant viruses in water ***,in this study,easily recyclable biomass-based carbon nanotubes catalysts were synthesized with varying metal activities to activate peroxymonosulfate(PMS).Among them,the magnetic 0.125Fe@NCNTs-1/PMS system showed the best overall removal performance against pepper mild mottle virus,with a 5.9 log_(10)removal within 1 ***,the key reactive species in the 0.125Fe@NCNTs-1/PMS system is^(1)O_(2),which can maintain good removal effect in real water matrices(river water and tap water).Through RNA fragment analyses and label free analysis,it was found that this system could effectively cleave virus particles,destroy viral proteins and expose their *** capsid protein of pepper mild mottle virus was effectively decomposed where serine may be the main attacking sites by^(1)O_(2).Long viral RNA fragments(3349 and 1642 nt)were cut into smaller fragments(∼160 nt)and caused their *** summary,this study contributes to controlling the spread of plant viruses in real water environment,which will potentially help protect agricultural production and food safety,and improve the health and sustainability of ecosystems.

关键词： Pepper mild mottle virus Removal Plant virus spread Biomass-based carbon nanotubes Water environments

Low-temperature chlorination roasting technology for the simultaneous recovery of valuable metals from spent LiCoO_(2)cathode material

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 80-91页

作者： Junjie Shi Changle Hou Jingjing dong dong chen Jianzhong Li Key Laboratory for Ecological Metallurgy of Multimetallic Mineral(Ministry of Education) Northeastern UniversityShenyang 110819China School of Metallurgy Northeastern UniversityShenyang 110819China

With the continuous increase in the disposal volume of spent lithium-ion batteries(LIBs),properly recycling spent LIBs has become essential for the advancement of the circular *** study presents a systematic analysis of the chlorination roasting kinetics and proposes a new two-step chlorination roasting process that integrates thermodynamics for the recycling of LIB cathode *** activation energy for the chloride reaction was 88.41 kJ/mol according to thermogravimetric analysis–derivative thermogravimetry data obtained by using model-free,model-fitting,and Z(α)function(αis conversion rate).Results indicated that the reaction was dominated by the first-order(F1)model when the conversion rate was less than or equal to 0.5 and shifted to the second-order(F2)model when the conversion rate exceeded *** conditions were determined by thoroughly investigating the effects of roasting temperature,roasting time,and the mass ratio of NH_(4)Cl to LiCoO_(2).Under the optimal conditions,namely 400℃,20 min,and NH_(4)Cl/LiCoO_(2)mass ratio of 3:1,the leaching efficiency of Li and Co reached 99.43% and 99.05%,*** of the roasted products revealed that valuable metals in LiCoO_(2)transformed into CoCl_(2) and ***,the reaction mechanism was elucidated,providing insights for the establishment of a novel low-temperature chlorination roasting technology based on a crystal structure *** technology can guide the development of LIB recycling processes with low energy consumption,low secondary pollution,high recovery efficiency,and high added value.

关键词： spent lithium-ion battery thermodynamics chlorination roasting kinetics circular economy

Turbulent Agglomeration of Microparticles in a Cylinder Wake Flow Using LES-DEM:Focusing on the Effect of the Reynolds Number

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Journal of Thermal Science 2025年第1期34卷 34-49页

作者： WANG Shuang MU Lin LI Xue XIE Jun dong ming School of Energy and Power Engineering Dalian University of TechnologyDalian 116024China School of Optical Information and Energy Engineering Wuhan Institute of TechnologyWuhan 430205China School of Energy and Environment Shenyang Aerospace UniversityShenyang 110136China

Turbulent agglomeration is viewed as a promising technology for enhancing fine particle removal *** better understand particle transport,agglomeration behaviors,and fluid-particle interactions,we numerically explored these phenomena under cylindrical vortex wake influence using a coupled large eddy simulation and discrete element method(LES-DEM)*** validity of the LES approach was verified by comparison with available direct numerical simulation(DNS)*** adopted the Johnson-Kendall-Roberts(JKR)contact model for particle-particle *** particle dispersion and agglomeration characteristics of particles with different diameters(d_(p)=2-20μm)in the laminar and transition of shear layer(TrSL)flow regimes were *** particles were concentrated at the vortex centers,while larger particles accumulated around the *** agglomeration efficiency exhibited an M-shaped profile spanwise(y-direction).With increasing Reynolds number,the agglomeration efficiency and turbulence intensity *** particle agglomeration efficiency peaks at a certain Reynolds ***,at higher Reynolds numbers,reducing the residence time of particles in the flow field decreases the agglomeration efficiency.

关键词： microparticle particle agglomeration discrete element method large eddy simulation

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船闸输水过程闸室船舶系缆力数值模拟

船舶力学 2015年第1期19卷 78-85页

作者：陈明梁应辰宣国祥陈明栋重庆交通大学国家内河航道整治工程技术研究中心重庆400074 中华人民共和国交通运输部北京100736 南京水利科学研究院南京210029

文章基于"船舶—水流"耦合动力响应,建立了船闸闸室船舶纵向和横向受力方程及其运动控制方程。利用FLUENT软件,采用RNG k-ε三维紊流模型,运用VOF法捕捉自由液面,阀门的开启过程及船舶运动利用动网格技术,船舶的运动控制及系缆力的并行... 详细信息

文章基于"船舶—水流"耦合动力响应,建立了船闸闸室船舶纵向和横向受力方程及其运动控制方程。利用FLUENT软件,采用RNG k-ε三维紊流模型,运用VOF法捕捉自由液面,阀门的开启过程及船舶运动利用动网格技术,船舶的运动控制及系缆力的并行计算程序采用用户自定义函数(UDF)进行编写。针对带格栅消能室的船闸集中输水系统,进行了灌水过程的闸室船舶系缆力数值模拟研究,通过与模型试验系缆力过程线的比较,证明了数值方法的正确性和有效性。数值研究了消能室内有无设置辅助消能工情形下的闸室船舶系缆力,并分析了辅助消能工的功能和效果。

关键词：船闸船舶系缆力模型试验数值模拟

Temperature-sensitive Micelles as Artificial Chaperones for Insulin Protection

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Chinese Journal of Polymer Science 2025年第2期43卷 350-359页

作者： Jia-Wen chen Yan Xiao Mei-dong Lang Shanghai Key Laboratory of Advanced Polymeric Materials Key Laboratory for Ultrafine Materials of Ministry of EducationSchool of Materials Science and EngineeringEast China University of Science and TechnologyShanghai200237China

Insulin is an essential and versatile protein taking part in the control of blood glucose levels and protein ***,under prolonged storage or high temperature stress,insulin tends to unfold and aggregate into toxic amyloid fibrils,leading to loss of physiological *** by natural chaperones,a series of temperature-sensitive polycaprolactone-based micelles were designed to prevent insulin from *** micelles were fabricated through the self-assembly of amphiphilic copolymers of methoxy poly(ethylene glycol)-poly(4-diethylformamide caprolactone-co-caprolactone)(mPEG_(17)-P(DECL-co-CL)),which had a regular spherical morphology with particle sizes of about 100 *** addition,the lower critical solution temperature(LCST)of the micelles could be tuned to 9 and 29℃by changing the ratio of DECL to *** from the temperature-sensitivity of DECL segment,the binding ability of micelles to insulin could be modulated by changing the *** LCST,micelles effectively inhibited insulin aggregation and protected it from thermal inactivation due to the strong binding ability between the hydrophobic segment DECL and *** LCST,DECL segment returned to hydrophilic and bound weakly with insulin,leading to the release of insulin and assisting in its recovery of secondary ***,these temperature-sensitive micelles provided an effective strategy for insulin protection.

关键词： Temperature-sensitive Insulin Micelles Chaperones

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基于分段编码自动生成产品结构树的研究

计算机集成制造系统 2005年第7期11卷 1014-1018页

作者：陈东明常桂然东北大学软件学院辽宁沈阳110004 东北大学计算中心辽宁沈阳110004

提出了一种基于分段代码自动生成产品结构树的算法。企业的编码分为识别码与分类码,识别码是零部件的惟一标志,往往采用分段的方式进行组织,可按固定段长或分隔符分界分段。识别码的分段信息与零部件在产品结构中的结构信息一致。充分... 详细信息

提出了一种基于分段代码自动生成产品结构树的算法。企业的编码分为识别码与分类码,识别码是零部件的惟一标志,往往采用分段的方式进行组织,可按固定段长或分隔符分界分段。识别码的分段信息与零部件在产品结构中的结构信息一致。充分利用编码本身的结构信息解析字符串,具有较强的通用性。此算法已应用于设计研究院的产品数据管理系统中,形成了以设备清单生成产品结构树枝干、以图纸代号生成叶节点的产品结构树自动生成算法。

关键词：分段编码产品结构产品数据管理识别码

Vacuum ammonia stripping from liquid digestate:Effects of pH,alkalinity,temperature,negative pressure and process optimization

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Journal of Environmental Sciences 2025年第3期149卷 638-650页

作者： Qiuhong chen donghai Yang Xiang chen Xiankai Wang Bin dong Xiaohu Dai State Key Laboratory of Pollution Control and Resource Reuse College of Environmental Science and EngineeringTongji UniversityShanghai 200092China YANGTZE Eco-Environment Engineering Research Center National Engineering Research Center of Eco-environment Protection for Yangtze River Economic BeltChina Three Gorges CorporationWuhan 430010China

High ammonia-nitrogen digestate has become a key bottleneck limiting the anaerobic digestion of organic solid *** ammonia stripping can simultaneously remove and recover ammonia nitrogen,which has attracted a lot of attention in recent *** investigate the parameter effects on the efficiency and mass transfer,five combination conditions(53℃ 15 kPa,60°C 20 kPa,65°C 25 kPa,72°C 35 kPa,and 81°C 50 kPa)were conducted for ammonia stripping of sludge *** results showed that 80%of ammonia nitrogen was stripped in 45 min for all experimental groups,but the ammonia transfer coefficient varied under different conditions,which increased with the rising of boiling point temperature,and reached the maximum value(39.0 mm/hr)at 81°C 50 *** ammonia nitrogen removal efficiency was more than 80%for 30 min vacuum stripping after adjusting the initial pH to above 9.5,and adjustment of the initial alkalinity also affects the pH value of liquid *** was found that pH and alkalinity are the key factors influencing the ammonia nitrogen dissociation and removal efficiency,while temperature and vacuum mainly affect the ammonia nitrogen mass transfer and removal *** terms of the mechanism of vacuum ammonia stripping,it underwent alkalinity destruction,pH enhancement,ammonia nitrogen dissociation,and free ammonia *** this study,two-stage experiments of alkalinity destruction and ammonia removal were also carried out,which showed that the two-stage configuration was beneficial for ammonia *** provides a theoretical basis and practical technology for the vacuum ammonia stripping from liquid digestate of organic solid waste.

关键词： Liquid digestate Vacuum ammonia stripping Alkalinity Mass transfer Process optimization

Stretchable All-Small-Molecule Organic Solar Cells Enabled by Polymer Elastomer Confinement

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Chinese Journal of Polymer Science 2025年第2期43卷 271-277页

作者： chen-Yi Zhang Yu-Qiang Liu Hong-Xiang Li Xin-Yue Cui Zheng-dong Wei Yue-Heng Liu ming-Hua Li An-dong Zhang Pei cheng Zhi-Shan Bo College of Textiles&Clothing State Key Laboratory of Bio-fibers and Eco-textilesQingdao UniversityQingdao266071China State Key Laboratory of Polymer Materials Engineering College of Polymer Science and EngineeringSichuan UniversityChengdu610065China College of Materials Science and Engineering Qingdao UniversityQingdao266071China Beijing Key Laboratory of Energy Conversion and Storage Materials College of ChemistryBeijing Normal UniversityBeijing100875China

Intrinsic stretchability is a promising attribute of polymer organic solar cells(OSCs).However,rigid molecular blocks typically exhibit poor tensile properties,rendering polymers vulnerable to mechanical *** this study,we introduce a different approach utilizing all-small-molecule donors and acceptors to fabricate stretchable *** elastomer,styrene-b-ethylene-butylene-styrene(SEBS),was embedded to modulate film crystallization and *** effectively confines the growth process of donors and acceptors,leading to enhancement of the crystallization quality,thus contributing to enhanced device ***,SEBS can absorb and release mechanical stress during stretching,thereby preventing mechanical degradation of donors and *** mechanical properties of the OSCs were significantly improved by the incorporation of ***,the crack-onset strain increased from 1.03% to 5.99% with SEBS *** findings present a straightforward strategy for achieving stretchable OSCs using all small molecules,offering a different perspective for realizing stretchable devices.

关键词： All-small-molecule Organic solar cells Elastomer Stretchability Flexibility