检索结果-南通市图书馆

Effect of maternal age on the outcomes of in vitro fertilization and embryo transfer(IVF-ET)

在线全文

学校读者我要写书评

暂无评论

Science China(Life Sciences) 2012年第8期55卷 694-698页

作者： YAN JunHao WU KeLiang TANG Rong DING LingLing chen zi-jiang Centre for Reproductive Medicine Provincial Hospital affiliated to Shandong UniversityJinan 250021China

This is a retrospective,observational study to evaluate the effect of maternal age on the outcomes of in vitro fertilization and embryo transfer(IVF-ET).11830 IVF-ET cycles from 10268 women were *** groups of different maternal age periods were *** groups were 21 30 years old group(4549 cycles),31-35 years old group(4424 cycles),36-40 years old group(2429 cycles),and over 40 years old group(428 cycles).The mean starting dose of Gn and mean total dose of Gn in each cycle were significantly higher(P<0.01),while the mean retrieved oocyte number was significantly lower(P<0.01) in groups of higher maternal age period than those in each of the lower *** biochemical pregnancy rate and the clinical pregnancy rate were significantly lower(P<0.01),while the miscarriage rate was significantly higher(P<0.01) in groups of higher maternal age period than those in the lower *** difference was found in two-pronuclear zygotes(2PN) rate and good quality embryo rate among different *** defect rate was also comparable in the born babies in different *** the group with patients' age over 40 years old,the pregnancy rate was 26.87%,the clinical pregnancy rate was 19.39%,while the miscarriage rate after clinical pregnancy was 36.14%.To draw the conclusion,patients with higher maternal age had worse IVF *** women of fertile age,patients between 20 and 30 years old have the best IVF *** over 40 years old have poor IVF outcome and high miscarriage rate,which suggested the necessity of preimplantation genetic screening(PGS).

关键词： in vitro fertilization outcome pregnancy rate miscarriage rate birth defect maternal age

在线全文

学校读者我要写书评

暂无评论

妇科生殖内分泌学的临床研究进展

中华妇产科杂志 2009年第9期44卷 655-657页

作者：陈子江山东大学附属省立医院生殖医学中心济南250021

近30年来，生殖医学的临床和基础研究均取得了重大进展，成为现代生命科学领域一门令人瞩目的学科。在美国，不孕症的发病率约为7％，约有2％的妇女曾因不孕相关问题就诊。对于许多不孕的夫妇而言，最终需借助体外受精（IVF）技术来实... 详细信息

近30年来，生殖医学的临床和基础研究均取得了重大进展，成为现代生命科学领域一门令人瞩目的学科。在美国，不孕症的发病率约为7％，约有2％的妇女曾因不孕相关问题就诊。对于许多不孕的夫妇而言，最终需借助体外受精（IVF）技术来实现其生育的愿望。美国每年的1VF周期数已经由1996年的30000上升至2005年的130000，IVF获得的试管婴儿占新生儿总数的1％；在我国，近年来试管婴儿的出生率也成倍增加拉。。作为生殖医学重要组成部分的生殖内分泌学，其进展可谓日新月异，研究领域已经由以往单纯的妇科内分泌扩展至生殖医学和人类生殖健康等诸多方面。

关键词：生殖内分泌学妇科内分泌临床研究生殖医学试管婴儿不孕症生命科学体外受精

在线全文

学校读者我要写书评

暂无评论

电积法生产铜粉的开发与研制

中国有色冶金 2010年第4期39卷 59-64页

作者：陈自江金川集团公司精炼厂甘肃金昌737100

试验研究了以硫酸铜为原料,采用电积法生产铜粉的各种工艺条件,并依据试验研究确定的工艺条件,制备出了符合国家标准的铜粉,产品能满足电解铜粉使用领域的要求。

关键词：铜粉电积硫酸铜

乙烯基树脂混凝土电解槽的性能及在湿法冶金中的应用

在线全文

学校读者我要写书评

暂无评论

中国有色冶金 2011年第5期40卷 29-33页

作者：陈自江金川集团有限公司甘肃金昌737100

分析了传统钢筋水泥混凝土加玻璃钢内衬电解槽存在的问题,叙述了乙烯基树脂混凝土电解槽的技术优势、经济优势,国内外的应用现状以及我国企业研发和生产概况。

关键词：聚合物混凝土电解槽乙烯基树脂湿法冶金经济性防腐

Twin dilivery of a 46,XY gonadal dysgenetic woman following vitrified oocytes donation

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2011年第7期124卷 1109-1110页

作者： GAO Shan-shan SHENG Yan LI Yuan LI Mei YANG Hui-jun chen zi-jiang Shandong Provincial Key Laboratory of Reproductive Medicine Center for Reproductive Medicine Provincial Hospital Affiliated to Shandong University Jinan Shandong 250012 China

A 46,XY gonadal dysgenetic woman gave birth to two healthy girls following vitrified oocytes donation. The loss of SRY gene was considered as the cause of this patient. Although similar cases have been reported about pregnancies of 46,XY pure gonadal dysgenetic women, successful delivery from vitrified oocytes has been hardly reported yet. Oocytes vitrification technique provides a beneficial way by saving superfluous oocytes from the pregnancy patients to these women who need.

关键词： gonadal dysgenesis oocyte vitrification," SRY deletion

在线全文

学校读者我要写书评

暂无评论

拓宽视野，开创妇科内分泌研究新局面

中华妇产科杂志 2010年第8期45卷 561-563页

作者：陈子江山东大学附属省立医院生殖医学中心济南250021

近30年来，随着生物医学的不断发展与创新和辅助生殖技术（ART）的革命性突破，妇科内分泌学取得了有目共睹的进步。随着对妇科内分泌系统疾病的深入研究，妇科内分泌对女性长期健康产生深远影响的认识更加深入；逐步深入的基础研究使... 详细信息

近30年来，随着生物医学的不断发展与创新和辅助生殖技术（ART）的革命性突破，妇科内分泌学取得了有目共睹的进步。随着对妇科内分泌系统疾病的深入研究，妇科内分泌对女性长期健康产生深远影响的认识更加深入；逐步深入的基础研究使我们从遗传、免疫、细胞生物学和分子生物学等方面对妇科内分泌疾病的发病机制有了更深入的了解；

关键词：妇科内分泌内分泌系统疾病辅助生殖技术内分泌疾病分子生物学细胞生物学生物医学内分泌学

Elective single blastocyst transfer is more suitable for normal responders than for high responders

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2013年第11期126卷 2125-2128页

作者： WU Ke-liang ZHAO Hai-bin LIU Hui ZHONG Wan-xia YU Guan-ling chen zi-jiang Center for Reproductive Medicine Provincial Hospital Affiliated to Shandong University National Research Center for Assisted Reproductive Technology and Reproductive Genetics China Key laboratory for Reproductive Endocrinology of Ministry of Education Shandong Provincial Key Laboratory of Reproductive Medicine Jinan Shandong 250021 China

Background Embryo quality and receptivity of the endometrium are two factors that determine the results of in vitro fertilization/intra-cytoplasmic sperm injection-embryo transfer （IVF/ICSI-ET）. There is no consensus of the optimal transfer strategy for normal responders or high responders. The current study aimed to find the optimal transfer strategy for different subgroups of patients. Methods From April 2010 to December 2010, patients who meet the following criteria were included in this study; primary infertility, female age 〈35 years, FSH level on female cycle day 2-3 〈12 mlU/ml, at least six good quality embryos available on day *** clinical outcomes using different transfer strategies between normal responders and high responders were reviewed and compared. Results For the normal responders, the clinical pregnancy rate of day three double-embryo transfer （DET） was comparable to that of day five elective single blastocyst transfer （eSBT）, 64.04% vs. 60.33% （P〉0.05）. For the high responders, the clinical pregnancy rate of day five eSBT was significantly lower than that of day three DET, 43.35% vs. 57.21% （P〈0.05）. For the high responders, the rates of clinical pregnancy and implantation in frozen-thawed embryo transfer （FET） cycles were notably higher than in eSBT cycles （64.56% vs. 43.35% and 62.11% vs. 43.35% respectively）（P〈0.05）. Conclusions For normal responders, eSBT might be an applicabte strategy to reduce multiple pregnancy rates while maintaining acceptable overall pregnancy rates. And in order to reduce multiple pregnancies and increase the chance of pregnancy of high responders, FET may be a preferable strategy.

关键词： embryo transfer elective single blastocyst transfer high responder normal responder

在线全文

学校读者我要写书评

暂无评论

高度重视多囊卵巢综合征的规范化诊断与治疗

中华妇产科杂志 2007年第5期42卷 289-290页

作者：陈子江山东大学山东省立医院妇产科济南250021

多囊卵巢综合征（polycystic ovary syndrome，PCOS）是由生殖内分泌和代谢功能异常导致的排卵障碍性疾病，在育龄妇女中发病率为5％～10％，在无排卵的不孕症患者中约占70％。PCOS临床表现呈现高度异质性和复杂性，不仅影响生殖内分泌... 详细信息

多囊卵巢综合征（polycystic ovary syndrome，PCOS）是由生殖内分泌和代谢功能异常导致的排卵障碍性疾病，在育龄妇女中发病率为5％～10％，在无排卵的不孕症患者中约占70％。PCOS临床表现呈现高度异质性和复杂性，不仅影响生殖内分泌功能，而且易发较严重的远期并发症。目前其发病机制尚不清楚，诊断标准不够统一和精确，

关键词：多囊卵巢综合征规范化诊断生殖内分泌功能治疗障碍性疾病远期并发症功能异常育龄妇女

Comparison of the Developmental Potential and Clinical Results of In Vivo Matured Oocytes Cryopreserved with Different Vitrification Media

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2015年第22期128卷 3029-3034页

作者： Mei Li Miao-Miao Wang Hui Liu Ke-Liang Wu Shui-Ying Ma cheng Li Hai-Bin Zhao zi-jiang chen Center for Reproductive Medicine Provincial Hospital Affiliated to Shandong University National Research Center for Assisted Reproductive Technology andReproductive Genetics Key Laboratory for Reproductive Endocrinology of Ministry of EducatLon Shandong Provincial Key Laboratory of Reproductive Medicine Jinan Shandong 250021 China

Background： Oocyte vitrification is widely used throughout the world, but its clinical efficacy is inconsistent and depends on the vitrification media. This study compared the developmental potential and clinical results of in vivo matured oocytes cryopreserved with different vitrification media. Methods： This retrospective study involved vitrified-warmed oocytes at one in vitro fertilization laboratory. Vitrification media kits comprised the MC kit （ethylene glycol （EG] plus 1,2-propanediol [PROH]）, the KT kit （EG plus dimethyl sulphoxide [DMSO]）, and the Modified kit （EG plus DMSO and PROH kit）. Rates of oocyte survival and subsequent developmental potential were recorded and analyzed. The t-test and the Chi-square test were used to evaluate each method＇s efficacy. Results： Oocyte survival rate was significantly higher for the Modified kit （92.0%） than for the MC kit （88.2%）（P 〈 0.05） and the KT kit （77.3%）（P 〈 0.001）. The rate of high-quality embryo development in the Modified kit group （35.8%） was significantly higher than in the MC kit group （29.0%） and the KT kit group （28.3%）（P 〈 0.001 ）. No significant differences were observed in the clinical pregnancy and implantation rates among the MC, KT, and Modified kit groups （37.2% vs. 30.2% vs. 39.6%; 21.9% vs. 18.8% vs. 27.4%, respectively）（P 〉 0.05）. The high-quality embryo rate per warmed oocyte was significantly higher （23.4%） in the Modified kit group than in the other groups （P 〈 0.001）. The embryo utilization and live birth rates per warmed oocyte were the highest in the Modified kit group, but not significantly （P 〉 0.05）. Conclusions： Modified vitrification media are efficient for oocyte vitrification and. with further verification, may be able to replace commercially available media in future clinical applications.

关键词： Fertilization Live Birth Oocytes Pregnancy Vitrification Media