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SEDIMENTARY PROCESS OF THE CENOzOIC BASIN AND ITS RESPONSE TO THE SLIP-HISTORY OF THE ALTYN TAGH FAULT, NW CHINA

地学前缘 2000年第S1期7卷 245-246页

作者： chen zhengle 1, zhang yueqiao 1, {2. Xuanhua 1,wang xiaofeng 1, z.washburn 2.j.arrowsmith 2.wt5,5”bx](1 The Institute of Geomechanics, Chinese Academy of Geological Sciences, Beijing 100081,China 2.Department of Geology, Arizona State Unive

The NEE\|striking Altyn Tagh Fault (ATF) has been well known as one major point to know the growth history of the Tibetan plateau. Lots of investigations done since 1970’s were mostly focus on active features, particularly on determining slip, slip rate and their distribution along the fault. However, Cenozoic slip\|history of this fault remains poorly understood, and the age of initiation and total offset are controversial. Several Cenozoic sedimentary basins develop in Suo’erkulinan to Mangya regions (Fig.1). Their sedimentary processes are closely related with the ATF. The studies of the Neogene sedimentary sequences and the reconstruction of the paleo\|geography are essential to establish the displacement history of the fault during Late *** at the southern side of the ATF, the Suo’erkulinan basin consists of more than 600\|meter\|thick Pliocene Shizigou Formation below and about 12.\|meter\|thick Early to Middle Pleistocene Qigequan Formation above according to the 1∶2.0000 geological map by Xinjiang Province. An obvious erosional surface can be seen on the top of the lower sequence. Sediments in the Shizigou Formation are characterized by 400\|meter\|thick yellow to red cobble\|sized conglomerates in the bottom, up\|grading to sandstones and grey\|green mudstones. This indicated that the sedimentary facies changed from alluvial fan to fluvial fan and sediments became more and more mature. The upper sequence, the Qigequan Formation, corresponds to an alluvial facies series composed of yellow to white cobble\|sized conglomerates intercalated with lenticular sandstones. Paleo\|current indicators showed that the Shizhigou conglomeratic series were sourced from northwest. Well\|developed syn\|sedimentary faults, normal faults mostly inherited from syn\|sedimentary faults, and some striation lineations on the surface indicated transtensional tectonic environment of the strike\|slip faulting.

关键词： Altyn Tagh fault Cenozoic basins sedimentary process slip\| history reconstruction of the paleo\|geography

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Leafhopper salivary carboxylesterase suppresses jA-Ile synthesis to facilitate initial arbovirus transmission in rice phloem

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Plant Communications 2024年第9期5卷 116-135页

作者： Yunhua Chi Hongxiang zhang Siyu chen Yu cheng xiaofeng zhang Dongsheng jia Qian chen Hongyan chen Taiyun Wei Vector-borne Virus Research Center Fujian Province Key Laboratory of Plant VirologyInstitute of Plant VirologyFujian Agriculture and Forestry UniversityFuzhouFujian 350002China

Plant jasmonoyl-L-isoleucine(jA-Ile)is a major defense signal against insect feeding,but whether or how insect salivary effectors suppress jA-Ile synthesis and thus facilitate viral transmission in the plant phloem remains *** carboxylesterases(CarEs)are the third major family of detoxification ***,we identify a new leafhopper CarE,CarE10,that is specifically expressed in salivary glands and is secreted into the rice phloem as a saliva *** CarE10 directly binds to rice jasmonate resistant 1(jAR1)and promotes its degradation by the proteasome ***,the direct association of CarE10 with jAR1 clearly impairs jAR1 enzyme activity for conversion of jA to jA-Ile in an in vitro jAIle synthesis system.A devastating rice reovirus activates and promotes the co-secretion of virions and CarE10 via virus-induced vesicles into the saliva-storing salivary cavities of the leafhopper vector and ultimately into the rice phloem to establish initial ***,a virus-mediated increase in CarE10 secretion or overexpression of CarE10 in transgenic rice plants causes reduced levels of jAR1 and thus suppresses jA-Ile synthesis,promoting host attractiveness to insect vectors and facilitating initial viral *** findings provide insight into how the insect salivary protein CarE10 suppresses host jA-Ile synthesis to promote initial virus transmission in the rice phloem.

关键词： leafhopper salivary protein CarE10 jAR1 degradation jA-Ile synthesis rice phloem initial viral transmission

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CENOzOIC DISPLACEMENT HISTORY OF THE ALTYN TAGH FAULT:GEOLOGICAL EVIDENCE FROM FIELD OBSERVATIONS IN SOUERKULI AND MANGAR REGIONS, NW CHINA

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地学前缘 2000年第S1期7卷 210-211页

作者： zhang yueqiao 1, {2., z.washburn 2. wang xiaofeng 1, j. R.arrowsmith 2.1 The Institute of Geomechanics, Chinese Academy of Geological Sciences, Beijing 100081, China 2.Department of Geology, Arizona State University, Tempe, Az, 852.7,USA

The ENE\|striking Altyn Tagh Fault (ATF) has been well known as a large, active left\|lateral strike\|slip fault that bounds the thrusting systems in NE *** fault has been the focal point in the debate between the discrete extrusion vs. distributed crustal shortening models. Although its active left\|lateralstrike\|slip features have been largely investigated and well documented by both satellite imagery and air\|photo interpretations and field observations, little study has been done upon its Cenozoic displacement history. Questions about the age of initiation and total offset accumulated on the fault remain controversial. A key area to resolve such question is located along the central segment of the fault in the Souerkuli and Mangar regions, where Neogene sedimentary basins well develop and are mostly distributed in three zones, namely from east to west: the Gobiling, Yitunbulak and Yusuale Tagh (Fig.1). Our field investigations were conducted along the ATF cutting the Yitunbulak and Gebiling Neogene sedimentary basins. Two stratigraphic unconformities observed within this Neogene conglomeratic series allow a separation of three major stratigraphic sequences and record the initiation and major deformational episodes of ATF during Cenozoic. An early stratigraphic unconformity occurred between a yellow depositional series below and early Pliocene red\|colored conglomeratic mudstones above. A later stratigraphic unconformities occurred between early and late Pliocene sedimentary series. The lower series below the early stratigraphic unconformities is mainly composed of a conglomeratic rocks containing cobbles and pebbles of basement rock units (mostly mylonitic granites, limestones and quartzes); this series has been poorly mapped and dated; its age could be assigned to late Oligocene to early Miocene; this series tilts to NW with an angle of about 30° and is overlain in angular unconformity by early Pliocene pebble\|sized conglomerates. A weathering zone on

关键词： left\|lateral offset Cenozoic Altyn Tagh fault

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An inducible CRISPR activation tool for accelerating plant regeneration

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Plant Communications 2024年第5期5卷 109-122页

作者： Cuimei zhang Yajun Tang Shanjie Tang Lei chen Tong Li Haidi Yuan Yujun Xu Yangyan zhou Shuaibin zhang jianli wang Hongyu Wen Wenbo jiang Yongzhen Pang Xian Deng xiaofeng Cao junhui zhou Xianwei Song Qikun Liu State Key Laboratory of Protein and Plant Gene Research School of Advanced Agricultural SciencesPeking UniversityBeijing 100871China Peking University Institute of Advanced Agricultural Sciences Shandong Laboratory of Advanced Agricultural Sciences at WeifangShandong 261000China National Center for Plant Gene Research Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China Grass and Science Institute of Heilongjiang Academy of Agricultural Sciences Heilongjiang 150086China Institute of Animal Science Chinese Academy of Agricultural SciencesBeijing 100193China Key Laboratory of Seed Innovation and National Center for Plant Gene Research Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China

The inducible CRISPR activation(CRISPR-a)system offers unparalleled precision and versatility for regu-lating endogenous genes,making it highly sought after in plant *** this study,we developed a chem-ically inducible CRISPR-a tool for plants called ER-Tag by combining the LexA-VP16-ER inducible system with the SunTag CRISPR-a *** systematically compared different induction strategies and achieved high efficiency in target gene *** demonstrated that guide RNAs can be multiplexed and pooled for large-scale screening of effective morphogenic genes and gene pairs involved in plant *** experiments showed that induced activation of these morphogenic genes can accelerate regenera-tion and improve regeneration efficiency in both eudicot and monocot plants,including alfalfa,woodland strawberry,and *** study expands the CRISPR toolset in plants and provides a powerful new strategy for studying gene function when constitutive expression is not feasible or ideal.

关键词： inducible CRISPR activation morphogenic gene genetic transformation plant regeneration

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THE FORMATION AND EVOLUTION OF ALTYN TAGH FAULT SYSTEM AND ITS RELATIONSHIP TO THE GROwtH OF TIBETAN PLATEAU

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地学前缘 2000年第S1期7卷 264-264页

作者： wang xiaofeng\+1, Yin An\+2. Peter Rumelhart\+2. Eric Cowgill\+2. {2. Xuanhua\+1, {2. zhengle\+1, T.Mark Harrison\+2. zhang yueqiao\+1,zhang Qing\+1, zhou Xianqiang\+1[wt5,5”bx](1.Institute of Geomechanics, Chinese Academy of Geological Sciences, Bei

One of the focus views of the uplifting of Tibetan Plateau is the growth history of the plateau. This is an unresolved question because of the poor study in north margin, where the ATF (Altyn Tagh Fault) is acting an important role in the growth and deformation of the plateau. The fault links two huge contractional belts, e.g. Qilian Nan Shan and West Kunlun, and merges a series of thrusting\|folding arcs in southeast. Mapping of piercing points, such as unconformities between Cenozoic, Mesozoic and Paleozoic strata, and magmatic arcs, shows left slips of ca. 2.0km and ca. 550km along the middle and western segments of the ATF. About 140～450km of crustal shortening, approximately the same magnitude as the west segment of the ATF, is deduced from balanced sections in West Kunlun foreland thrusting belt. This implies that left\|slip displacement along the west segment of the ATF was absorbed by the contraction in West Kunlun. The ATF system merged bunches of WNW arcuated fold\|fault belts in Qaidam basin, implying anti\|clockwise rotation. Tertiary and some Lower to Middle Pleistocene strata involved in fold\|fault belts, and dip in ESE due to the uplifting of Altyn Tagh. The newest strata involved in the deformation is more and more younger from south to north, that is, from Lower Pliocene to Middle Pleistocene, showing the uplifting trends from south to north in the SE side of the fault.

关键词： Altyn Tagh fault slip magnitude basin growth series denudat ion

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Transcription factor EHF interacting with coactivator AjUBA aggravates malignancy and acts as a therapeutic target for gastroesophageal adenocarcinoma

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Acta Pharmaceutica Sinica B 2024年第5期14卷 2119-2136页

作者： Li Peng Yanyi jiang Hengxing chen Yongqiang wang Qiusheng Lan Shuiqin chen zhanwang Huang jingyuan zhang Duanqing Tian Yuntan Qiu Diankui Cai jiangyun Peng Daning Lu Xiaoqing Yuan Xianzhu Yang Dong Yin Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Guangdong-Hong Kong Joint Laboratory for RNA MedicineSun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China Medical Research Center Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China Hefei Institutes of Physical Science Chinese Academy of SciencesHefei 230031China Department of Gastrointestinal Surgery Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China Department of Hepatobiliary Surgery Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China School of Biomedical Sciences and Engineering South China University of TechnologyGuangzhou International CampusGuangzhou 511442China

Transcriptional dysregulation of genes is a hallmark of tumors and can serve as targets for cancer drug ***,it is extremely challenging to develop small-molecule inhibitors to target abnormally expressed transcription factors(TFs)except for the nuclear receptor family of *** is known about the interaction between TFs and transcription cofactors in gastroesophageal adenocarcinoma(GEA)or the therapeutic effects of targeting TF and transcription cofactor *** this study,we found that ETS homologous factor(EHF)expression is promoted by a core transcriptional regulatory circuitry(CRC),specifically ELF3-KLF5-GATA6,and interference with its expression suppressed the malignant biological behavior of GEA ***,we identified Ajuba LIM protein(AjUBA)as a new coactivator of EHF that cooperatively orchestrates transcriptional network activity in ***,we identified KRAS signaling as a common pathway downstream of EHF and ***,dual targeting of EHF and AjUBA by lipid nanoparticles cooperatively attenuated the malignant biological behaviors of GEA in vitro and in *** conclusion,EHF is upregulated by the CRC and promotes GEA malignancy by interacting with AjUBA through the KRAS *** of both EHF and its coactivator AjUBA through lipid nanoparticles is a novel potential therapeutic strategy.

关键词： EHF AjUBA KRAS pathway Enhancer Core transcriptional regulatory circuitry Gastroesophageal adenocarcinoma Gastric adenocarcinoma Esophageal adenocarcinoma Transcription factor Coactivator Lipid nanoparticles

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A novel method for identifying SARS-CoV-2.infection mutants via an epitope-specific CD8^(+)T cell test

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Biosafety and Health 2024年第3期6卷 143-152页

作者： Congling Qiu Bo Peng Chanchan Xiao Pengfei chen Lipeng Mao Xiaolu Shi zhen zhang ziquan Lv Qiuying Lv Xiaomin zhang jiaxin Li Yanhao Huang Qinghua Hu Guobing chen Xuan zou xiaofeng Liang Department of Public Health and Preventive Medicine School of MedicineJinan UniversityKangtai Biological Vaccine Industry Research Institute/Disease Prevention and Control Institute of Jinan UniversityGuangzhou 510632China Shenzhen Center for Disease Control and Prevention Shenzhen 518020China Department of Microbiology and Immunology Institute of Geriatric ImmunologySchool of MedicineJinan UniversityGuangzhou 510632China Key Laboratory of Viral Pathogenesis&Infection Prevention and Control(jinan University) Ministry of EducationGuangzhou 510632China The Sixth Affiliated Hospital Jinan UniversityGuangzhou 510632China Department of Systems Biomedical Sciences School of MedicineJinan UniversityGuangzhou 510632China Microbiology Laboratory Shenzhen Center for Disease Control and PreventionShenzhen 518020China Department of Communicable Diseases Control and Prevention Shenzhen Center for Disease Control and PreventionShenzhen 518020China Central Laboratory Shenzhen Center for Disease Control and PreventionShenzhen 518020China

Since the outbreak of the coronavirus disease 2.19(COVID-19)epidemic in 2.19,the public health system has faced enormous *** the individuals who test positive for severe acute respiratory syndrome coronavirus 2.SARS-CoV-2.is a key step for interrupting chains of transmission of SARS-CoV-2.and reducing COVID-19-associated *** the increasing of asymptomatic infections,it is difficult to track asymptomatic infections through epidemiological surveys and virus whole-genome ***,due to the cross-reactivity of neutralizing antibodies produced by multiple virus subtypes,neutralizing antibody detection cannot be used to determine whether an individual has a history of infection with a specific subtype of *** recruited 4 human leukocyte antigen A2.HLA-A2.infections,15 individuals who received three doses of inactivated vaccines,and 30 breakthrough infections after vaccination and discussed a case-tracking approach to detect epitope-specific CD8^(+)T cells in the peripheral blood of close contacts,including accurate HLA typing based on ribonucleic acid(RNA)-sequencing and flow cytometry data and the comparison and characterization of SARS-CoV-2.HLA-A2.and HLA-A2. epitope-specific CD8^(+)T *** individuals who received three doses of inactivated vaccine,we observed that the CD8^(+)T cell specificity for ancestral epitopes was significantly higher than for mutated epitopes,and the fold change of CD8^(+)T cells corresponding to mutated epitopes relative to ancestral epitopes was less than *** enzyme-linked immunospot(ELISpot)results further validate this *** study forms a“method for understanding the infection history of SARS-CoV-2.subtypes based on the proportion of epitope-specific CD8^(+)T cells in the peripheral blood of subjects”,covering up to 46%of the population,including HLA-A2.and HLA-A2.+donors,providing a novel method for SARS-CoV-2.infected case tracing.

关键词： Asymptomatic coronavirus disease 2.19 (COVID-19) Epitopes Specific CD8^(+)T cell ELISpot

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基于纳米闪烁体的X射线发光生物分子测量与疾病治疗研究进展

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化学通报 2024年第9期87卷 1009-1019页

作者：徐新奇张珍珍陈小丰陈秋水杨黄浩福州大学化学学院新基石科学实验室福州350002

X射线发光是指闪烁体在X射线激发下发射出低能量光子的过程,在生物传感、医学成像、光动力治疗、光遗传等领域具有应用前景。相较于传统的紫外激发光,X射线对生物组织具有高穿透性且不会触发生物体的自荧光,可实现深组织、无背景、高灵... 详细信息

X射线发光是指闪烁体在X射线激发下发射出低能量光子的过程,在生物传感、医学成像、光动力治疗、光遗传等领域具有应用前景。相较于传统的紫外激发光,X射线对生物组织具有高穿透性且不会触发生物体的自荧光,可实现深组织、无背景、高灵敏的生物分析。近年来,基于纳米闪烁体的X射线发光在生物光子学领域中得到广泛研究,促进了X射线发光在分析化学和生物医学中的应用。本文首先对闪烁体的X射线发光机理进行了概述,接着重点介绍了纳米闪烁体作为光学探针在生物分子测量与疾病治疗中的研究进展,包括生物传感、活体成像和光动力治疗等,最后讨论了该领域存在的一些挑战和可能的解决方案。

关键词：纳米闪烁体 X射线发光光学探针生物分析

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Autophagy mediates a direct synergistic interaction during cotransmission of two distinct arboviruses by insect vectors

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Science China(Life Sciences) 2023年第7期66卷 1665-1681页

作者： Dongsheng jia Qifu Liang Hongyan chen Huan Liu Guangjun Li xiaofeng {2. Qian chen Aiming wang Taiyun Wei Vector-borne Virus Research Center State Key Laboratory of Ecological Pest Control for Fujian and Taiwan CropsFujian Agriculture and Forestry UniversityFuzhou350002China London Research and Development Centre Agriculture and Agri-Food CanadaLondonOntarioN5V 4T3Canada

Multiple viral infections in insect vectors with synergistic effects are common in nature,but the underlying mechanism remains ***,we find that rice gall dwarf reovirus(RGDV)facilitates the transmission of rice stripe mosaic rhabdovirus(RSMV)by co-infected leafhopper *** nucleoprotein(N)alone activates complete anti-viral autophagy,while RGDV nonstructural protein Pns11 alone induces pro-viral incomplete *** co-infected vectors,RSMVexploits Pns11-induced autophagosomes to assemble enveloped virions via N-Pns11-ATG5 ***,RSMV could effectively propagate in Sf9 *** of Pns11 in Sf9 cells or leafhopper vectors causes the recruitment of N from the ER to Pns11-induced autophagosomes and inhibits N-induced complete autophagic flux,finally facilitating RSMV *** summary,these results demonstrate a previously unappreciated role of autophagy in the regulation of the direct synergistic interaction during co-transmission of two distinct arboviruses by insect vectors and reveal the functional importance of virus-induced autophagosomes in rhabdovirus assembly.

关键词： autophagy synergistic interaction insect vector rhabdovirus co-transmission

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Preparation of Mesoporous Nano-Hydroxyapatite Using a Surfactant Template Method for Protein Delivery

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journal of Bionic Engineering 2012年第2期9卷 224-233页

作者： Xiaodong Wu xiaofeng Song Dongsong Li jianguo Liu Peibiao zhang Xuesi {2. Department of Bone and joint Surgery First Hospital of Jilin UniversityChangchun 130021P R.China Key Laboratory of Polymer Ecobiomaterials Changchun Institute of Applied ChemistryChinese Academy of SciencesChangehun 130022P.R.China

Mesoporous nano-hydroxyapatite （n-HA） has gained more and more attention as drug storage and release hosts. The aim of this study is to observe the effect of the ratio of surfactant to the theoretical yield of HA on the mesoporous n-HA, then to reveal the effect of the mesoporous nanostructure on protein delivery. The mesoporous n-HA was synthesized using the wet precipitation in the presence of cetyltrimethylammonium bromide （CTAB） at ambient temperature and normal atmospheric pressure. The morphology, size, crystalline phase, chemical composition and textural characteristics of the product were well characterized by X-ray Powder Diffraction （XRD）, Fourier Transform Infrared Spectroscopy （FTIR）, Scanning Electron Microscopy （SEM）, Transmission Electron Microscopy （TEM）, Dynamic Light Scattering （DLS） and N2.adsorption/desorption, respectively. The protein adsorption/release studies were also carried out by using Bovine Serum Albumin （BSA） as a model protein. The results reveal that the mesoporous n-HA synthesized with CTAB exhibits high pure phase, low crystallinity and the typical characteristics of the mesostructure. The BSA loading increases with the specific surface area and the pore volume of n-HA, and the release rates of BSA are different due to their different pore sizes and pore structures, n-HA synthesized with 0.5% CTAB has the highest BSA loading and the slowest release rate because of its highest surface area and smaller pore size. These mesoporous n-HA materials demonstrate a potential application in the field of protein delivery due to their bioactive, biocompatible and mesoporous properties.

关键词： hydroxyapatite nanoparticles mesostructure cetyltrimethylammonium bromide drug delivery

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