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Overcoming adaptive resistance in AML by synergistically targeting FOXO3A-GNG7-mTOR axis with FOXO3A inhibitor Gardenoside and rapamycin

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Genes & Diseases 2024年第1期11卷 397-412页

作者： zhe chen Qian Guo Shichen Huang Lei Li Feng Wu Zhilong Liu Zhigang Li Tao chen Guanbin Song Shuangnian Xu Jieping chen Yu Hou Department of Hematology Southwest HospitalThird Military Medical University(Army Medical University)Chongqing 400038China Institute of Life Sciences Chongqing Medical UniversityChongqing 400016China Key Laboratory of Biorheological Science and Technology Ministry of EducationCollege of BioengineeringChongqing UniversityChongqing 400044China Chongqing Foreign Language School Chongqing 400039China

Therapeutic targeting FOxO3A(a forkhead transcription factor)represents a prom-ising strategy to suppress acute myeloid leukemia(AML).However,the effective inhibitors that target FOXO3A are lacking and the adaptive response signaling weakens the cytotoxic effect of FOxO3A depletion on AML ***,we show that FOxO3A deficiency induces a compensa-tory response involved in the reactive activation of mTOR that leads to signaling rebound and adaptive *** metabolism acts downstream of mTOR to provoke activa-tion of JNK/c-JUN via reactive oxygen species(ROS).At the molecular level,FOXO3A directly binds to the promoter of G protein gamma subunit 7(GNG7)and preserves its expression,while GNG7 interacts with mTOR and restricts phosphorylated activation of ***,combinatorial inhibition of FOXO3A and mTOR show a synergistic cytotoxic effect on AML cells and prolongs survival in a mouse model of *** a structure-based virtual screening,we report one potent small-molecule FOxO3A inhibitor(Gardenoside)that exhibits a strong effect of anti-FOXO3A DNA *** synergizes with rapamycin to substantially reduce tumor burden and extend survival in AML patient-derived xenograft *** results demonstrate that mTOR can mediate adaptive resistance to FOxO3A inhibition and validate a combinatorial approach for treating AML.

关键词： AML Combinatorial inhibition FOXO3A GNG7 mTOR

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Plotinus:A Satellite Internet Digital Twin System

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Journal of Communications and Information Networks 2024年第1期9卷 24-33页

作者： Yue Gao Kun Qiu zhe chen Wenjun Zhu Qi Zhang Handong Luo Quanwei Lin Ziheng Yang Wenhao Liu The Intelligent Networking and Computing Research Center and School of Computer Science Fudan UniversityShanghai 200433China

The development of space-air-ground integrated networks (SAGIN) requires sophisticated satellite Internet emulation tools that can handle complex, dynamic topologies and offer in-depth analysis. Existing emulation platforms struggle with challenges like the need for detailed implementation across all network layers, real-time response, and scalability. This paper proposes a digital twin system based on microservices for satellite Internet emulation,namely Plotinus,which aims to solve these problems. Plotinus features a modular design, allowing for easy replacement of the physical layer to emulate different aerial vehicles and analyze channel interference. It also enables replacing of path computation methods to simplify testing and deploying algorithms. In particular, Plotinus allows for real-time emulation with live network traffic,enhancing practical network models. The evaluation result shows Plotinus’s effective emulation of dynamic satellite networks with real-world devices. Its adaptability for various communication models and algorithm testing highlights Plotinus’s role as a vital tool for developing and analyzing SAGIN systems, offering a cross-layer,real-time,and scalable digital twin system.

关键词： network emulation framework dynamic topology adjustment microservice architecture

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Ultrasonic vibration enabled under-liquid forming of metallic glasses

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Science Bulletin 2024年第2期69卷 163-166页

作者： Xin Li Luyao Li Sajad Sohrabi Jia'nan Fu zhen Li zhe chen Rongce Sun Yu Zhang Jinbiao Huang Heting Zhang Jian Zhu Xiangyan chen Kaikai Song Jiang Ma School of Mechanical Electrical&Information EngineeringShandong UniversityWeihai 264209China State Key Laboratory of Radio Frequency Heterogeneous Integration College of Mechatronics and Control EngineeringShenzhen UniversityShenzhen 518060China Department of Mechanics and Aerospace Engineering Southern University of Science and TechnologyShenzhen 518055China Shenzhen Research Institute of Shandong University Shenzhen 518057China

Advancements in forming technology offer significant advantages for the manufacturing industry,including enhanced efficiency,energy conservation,and improved material utilization[1].However,traditional additive manufacturing[2],thermoplastic forming[3],and laser cutting[4]encounter challenges when applied in under-liquid environments,mainly due to difficulties in temperature control and heat source provision.

关键词： glasses liquid metallic

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Gut microbiota affects the estrus return of sows by regulating the metabolism of sex steroid hormones

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Journal of Animal Science and Biotechnology 2024年第2期15卷 578-599页

作者： Min Liu Jia Zhang Yunyan Zhou Shuqi Xiong Mengqing Zhou Lin Wu Qin Liu zhe chen Hui Jiang Jiawen Yang Yuxin Liu Yaxiang Wang Congying chen Lusheng Huang National Key Laboratory of Swine Genetic Improvement and Germplasm Innovation Jiangxi Agricultural UniversityNanchang 330045China

Background Sex hormones play important roles in the estrus return of post-weaning *** studies have demonstrated a complex and bi-directional regulation between sex hormones and gut ***,the extent to which the gut microbiota affects estrus return of post-weaning sows is largely *** In this study,we first screened 207 fecal samples from well-phenotyped sows by 16S rRNA gene sequencing and identified significant associations between microbes and estrus return of post-weaning *** metagenomic sequencing data from 85 fecal samples,we identified 37 bacterial species that were significantly associated with estrus *** returning sows were characterized by increased abundances of *** and *** and decreased abundances of ***,***,and *** changes in gut microbial composition significantly altered the functional capacity of steroid hormone biosynthesis in the gut *** results were confirmed in a validation *** changes in sex steroid hormones and related compounds were found between normal and non-return sows via metabolome *** integrated analysis of differential bacterial species,metagenome,and fecal metabolome provided evidence that normal return-associated bacterial species *** and Prevotella *** in the degradation of pregnenolone,progesterone,and testosterone,thereby promoting estrogen ***,the microbial metabolites related to sow energy and nutrient supply or metabolic disorders also showed relationships with sow estrus *** An integrated analysis of differentially abundant bacterial species,metagenome,and fecal metabolome revealed the involvement of *** and Prevotella *** sow estrus *** findings provide deep insight into the role of gut microbiota in the estrus return of post-weaning sows and the complex cross-talk between gut microbiota and sex hormones,suggesting that the manipulatio

关键词： Estrus return Fecal metabolome Gut microbiota Metagenomics Sex steroid hormones Sow

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Analysis of the Effect of Humanistic Care in the Process of Pre-Hospital Emergency Care

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Journal of Clinical and Nursing Research 2024年第8期8卷 302-305页

作者： Rui Cao zhe chen Shaanxi Provincial People’s Hospital Xi’an 710068Shaanxi ProvinceChina

Objective:To explore the effectiveness of humanistic care in pre-hospital emergency ***:From April 2020 to January 2021,80 pre-hospital emergency patients were *** patients were randomly divided into two groups:a control group(n=40),which received conventional care,and an experimental group(n=40),which received humanistic *** effects of nursing care and psychological state were compared between the two ***:The experimental group showed better nursing outcomes and a more positive psychological state compared to the control group(P<0.05).Conclusion:Humanistic care in pre-hospital emergency settings is more effective in reducing patients’anxiety and depression,enhancing the operational abilities and service attitudes of nursing staff,and increasing the emergency success rate.

关键词： Humanistic care Pre-hospital emergency care Negative emotion Effect analysis

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Application Effect of Staged Health Education in the Nursing Care of Patients with Upper Gastrointestinal Bleeding

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Journal of Contemporary Educational Research 2024年第4期8卷 204-208页

作者： zhe chen Rui Cao Department of Gastroenterology Shaanxi Provincial People’s HospitalXi’an 710068Shaanxi ProvinceChina

Objective:To investigate the application effect of staged health education in the care of patients with upper gastrointestinal ***:This study takes health education in the care of patients with upper gastrointestinal bleeding as the main direction.160 patients with upper gastrointestinal bleeding who received treatment in our hospital were selected as samples,and the grouping software was used to divide them into the reference group and the study group,with 80 patients *** reference group and the study group used routine health education and staged health education *** research data were recorded during the nursing process,analyzed,and used as research ***:The compliance behavior of the study group was higher than that of the reference group after the staged nursing care,and at the same time,the nursing care satisfaction of the study group was higher than that of the reference group(P<0.05).Conclusion:The use of staged health education for the care of patients with upper gastrointestinal bleeding not only enhances the degree of patient awareness and compliance but also improves nursing satisfaction,which is worthy of promotion and application.

关键词： Staged health education Upper gastrointestinal bleeding Application effect

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Study on the Application of Refined Nursing Care in The Care for Elderly Patients with Reflux Esophagitis

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Journal of Clinical and Nursing Research 2024年第4期8卷 69-72页

作者： zhe chen Rui Cao Shaanxi Provincial People’s Hospital Xi’an 710068Shaanxi ProvinceChina

Objective: To investigate the application effect of refined nursing care in the care for elderly patients with reflux esophagitis. Methods: Following the difference in nursing style, 84 cases of elderly patients with reflux esophagitis admitted to our hospital from May 2022 to May 2023 were randomly grouped into a control group and a research group, with 42 cases each. The control group was given conventional nursing care and the research group was given refined nursing care. The psychological state and treatment adherence of the two groups of patients after the nursing intervention were compared. Results: After the nursing intervention, the self-rating anxiety scale (SAS) and self-rating depression scale (SDS) scores of the research group were lower than those of the control group (P < 0.05). The treatment compliance of the research group was better than the control group (P < 0.05). Conclusion: The implementation of refined nursing care for elderly patients with reflux esophagitis exhibited a significant effect on improving the patient’s psychological state, treatment compliance, and rehabilitation.

关键词： Geriatric reflux esophagitis Refined nursing care Application research

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A Study on the Application of Evidence-Based Nursing in The Care of Patients with Severe Acute Pancreatitis

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Journal of Clinical and Nursing Research 2024年第4期8卷 128-131页

作者： zhe chen Rui Cao Department of Gastroenterology Shaanxi Provincial People’s HospitalXi’an710068Shaanxi ProvinceChina

Objective: To explore the application research of evidence-based nursing in the care of patients with severe acute pancreatitis. Methods: This study focuses on evidence-based nursing care of severe acute pancreatitis. Patients with severe acute pancreatitis who received treatment in our hospital were selected, from which 80 cases were chosen for detailed analysis. The patients were randomly grouped into a control group (conventional nursing care) and a study group (evidence-based nursing care), with 40 patients each. Relevant research data were recorded during the nursing process, analyzed, and used as research indicators. Results: The hospitalization time and morbidity and mortality rate of the research group were shorter than those of the control group, and the recovery rate was higher than that of the control group (P < 0.05). Patient satisfaction with nursing care in the observation group was higher than in the control group (P < 0.05). Conclusion: For patients with severe acute pancreatitis, the use of evidence-based nursing methods effectively reduced the patient’s mortality rate, improved its curative effect, and also shortened the patient’s hospitalization time.

关键词： Severe acute pancreatitis Evidence-based nursing Applied research

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Integer multiple quantum image scaling based on NEQR and bicubic interpolation

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Chinese Physics B 2024年第4期33卷 259-273页

作者：蔡硕周日贵罗佳陈思哲 College of Information Engineering Shanghai Maritime UniversityShanghai 201306China Research Center of Intelligent Information Processing and Quantum Intelligent Computing Shanghai 201306China College of Merchant Marine Shanghai Maritime UniversityShanghai 201306China School of Mathematics and Computational Science Shangrao Normal UniversityShangrao 334001China

As a branch of quantum image processing,quantum image scaling has been widely ***,most of the existing quantum image scaling algorithms are based on nearest-neighbor interpolation and bilinear interpolation,the quantum version of bicubic interpolation has not yet been *** this work,we present the first quantum image scaling scheme for bicubic interpolation based on the novel enhanced quantum representation(NEQR).Our scheme can realize synchronous enlargement and reduction of the image with the size of 2^(n)×2^(n) by integral ***,the image is represented by NEQR and the original image coordinates are obtained through multiple CNOT ***,16 neighborhood pixels are obtained by quantum operation circuits,and the corresponding weights of these pixels are calculated by quantum arithmetic ***,a quantum matrix operation,instead of a classical convolution operation,is used to realize the sum of convolution of these *** simulation experiments and complexity analysis,we demonstrate that our scheme achieves exponential speedup over the classical bicubic interpolation algorithm,and has better effect than the quantum version of bilinear interpolation.

关键词： quantum image processing image scaling bicubic interpolation quantum circuit

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我国自然资源损害民刑救济机制一体化的制度设计

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暨南学报（哲学社会科学版） 2024年第4期46卷 84-96页

作者：陈哲湖南工商大学法学院

当遭遇重大自然资源损害时,民事责任与刑事责任可能兼而有之。然而,在规范和实践层面,自然资源损害陷入“碎片化”救济之泥淖,规范维度表现为救济程序设计的“杂乱无序”与“叠床架屋”,难以形成制度合力,司法场域表现为民刑救济由于“... 详细信息

当遭遇重大自然资源损害时,民事责任与刑事责任可能兼而有之。然而,在规范和实践层面,自然资源损害陷入“碎片化”救济之泥淖,规范维度表现为救济程序设计的“杂乱无序”与“叠床架屋”,难以形成制度合力,司法场域表现为民刑救济由于“因循守旧”的僵化思维而“顾此失彼”,无法统筹民刑责任。为此,有必要运用一体化之思路,以系统论为理论指引,融贯自然资源损害民刑救济机制于一体,确保学理层面的合法、正当;实践中亦应在一体化机制的运行下实现自然资源损害问题的一次性解决。在畅通自然资源损害民刑救济机制一体化之法治路径层面,应以“便捷高效、全面合理地救济自然资源损害”统领民刑救济机制一体化之构建,将救济主体明确统一为人民检察院,最终确定中级人民法院统一管辖同时涉及民事与刑事领域的自然资源损害案件,构建证明标准民刑区分对待,赔偿与罚金刑统筹适用等机制一体化的内部规则。

关键词：自然资源损害刑事附带环境民事公益诉讼民刑救济机制一体化统一管辖

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