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Administration of imatinib in the first 90 days after allogeneic hematopoietic cell transplantation in patients with Philadelphia chromosome-positive acute lymphoblastic leukemia

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Chinese Medical Journal 2011年第2期124卷 246-252页

作者： chen Huan LIU Kai-yan XU Lan-ping LIU Dai-hong chen yu-hong SHI hong-xia HAN Wei ZHAN Xiao-hui WANG yu ZHAO Ting HUANG Xiao-jun Peking University Institute of Hematology Peking University People's Hospital Beijing 100044 China

Background Relapse happens frequently after allogeneic hematopoietic cell transplantation （alIo-HCT） in the patients with Philadelphia chromosome-positive acute lymphoblastic leukemia （Ph^＋ ALL）. Detection of the minimal residual disease （MRD） before and after alIo-HCT is associated with higher relapse rate. Early administration of imatinib after alIo-HCT may prevent recurrent Ph^＋ ALL. The aim of this study was to evaluate the safety and efficacy of imatinib in preventing hematological relapse when imatinib was administrated in the first 90 days after alIo-HCT. Methods Patients with Ph^＋ ALL that underwent alIo-HCT were enrolled in a prospective study. A TaqMan-based real-time quantitative polymerase chain reaction （RQ-PCR） technique was used to detect the MRD （bcr-abl transcript levels）. Imatinib therapy was initiated prior to 90 days after alIo-HCT if the patient＇s absolute neutrophil count （ANC） was above 1.0×10^9/L （without granulocyte colony-stimulating factor （G-CSF） administration） and the platelet count was greater than 50.0×10^9/L, or if the bcr-abl transcript levels were elevated in two consecutive tests, or if the bcr-abl transcript levels were 〉10.2 after the initial engraftment. The initial daily dose of imatinib was 400 mg/d for adults and 260 mg/m^2 for children （younger than 17 years）. Imatinib was administered for at least I month and the bcr-abl TaqMan results were negative for 3 consecutive tests, or complete molecular remission （CR^mol） was sustained for at least 3 months. Results From May 2005 to October 2008, 29 patients were enrolled in this study, of whom, 19 patients were male and 10 were female. The median age of the enrolled patients was 33 years （range 6-50 years）. Imatinib therapy was started at a median time of 60 days （range 20-122 days） post HCT （only one patient started Imatinib therapy at 122nd day after HCT）. Twenty-five adult patients could tolerate a dose of 300-400 mg/d of imatinib, and three children tolerated a dose of 260 mg

关键词： Philadelphia chromosome acute lymphoblastic leukemia allogeneic hematopoietic cell transplantation minimal residual disease

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Serum Calcium Level is Associated with Brachial-ankle Pulse Wave Velocity in Middle-aged and Elderly Chinese

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Biomedical and Environmental Sciences 2014年第8期27卷 594-600页

作者： DENG Xin Ru ZHANG Yin Fei WANG Tian Ge XU Bai Hui SUN Ji Chao ZHAO Lie Bin XU Min chen yu hong WANG Wei Qing BI yu Fang LU Jie Li Key Laboratory for Endocrine and Metabolic Diseases Ministry of Health Ruijin Hospital Shanghai Jiaotong University School of MedicineE-Institute of Shanghai Universities Shanghai Clinical Center for Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic DiseasesDepartment of Endocrinology and Metabolism Ruijin Hospital Shanghai Jiaotong University School of Medicine Department of Endocrinology and Metabolism Central Hospital of Jiading District Laboratory of Endocrine and Metabolic Diseases Institute of Health SciencesShanghai Institutes for Biological Sciences

Objective To study the relation between serum calcium level and elevated BaPWV in Chinese subjects. Methods The relation between serum calcium level and elevated BaPWV was studied in 9 615 subjects. The mean value of left and right BaPWV was analyzed. BaPWV was defined as high when it was31 752.5 cm/s （the upper quartile） either side. Results The BaPWV and its elevated percentage progressively increased across the quartiles of the serum calcium level （P〈0.05）. The prevalence of elevated BaPWV was significantly higher in subjects of the second, third and highest quartiles than in those of the lowest quartile （26.9%, 28.4%, and 33.2%vs 23.7%, P=0.0116, P=0.0004, and P〈0.0001）. Logistic regression analysis revealed that the risk of elevated BaPWV was 1.32- fold higher in subjects of the highest quartile than in those of the lowest quartile （OR=1.32, 95%CI：1.08-1.60）. Conclusion The elevated serum calcium level is related to an elevated BaPWV and a higher risk of arterial stiffness, independent of conventional risk factors, in middle-aged and elderly Chinese subjects.

关键词： Calcium Brachial-ankle pulse wave velocity Vascular stiffness

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Ideal Cardiovascular Health is Inversely Associated with Subclinical Atherosclerosis: A Prospective Analysis

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Biomedical and Environmental Sciences 2019年第4期32卷 260-271页

作者： WANG Long NIU Jing Ya ZHAO Zhi yun LI Mian XU Min LU Jie Li WANG Tian Ge chen yu hong WANG Shuang yuan DAI Meng LI Lin LIU Shan Shan WANG Wei Qing XU yu BI yu Fang National Clinical Research Center for Metabolic Diseases Shanghai Institute of Endocrine and Metabolic Diseasesand Department of Endocrine and Metabolic DiseasesRui-Jin HospitalShanghai Jiao Tong University School of Medicine

Objective Ideal cardiovascular health(CVH) could predict a lower risk of developing cardiovascular diseases. This study was conducted to investigate the association between ideal CVH and subclinical atherosclerosis in a population cohort of Chinese adults aged ≥ 40 years. Methods This study was designed as a cross-sectional analysis of 8,395 participants who had complete data at baseline and a prospective analysis of 4,879 participants who had complete data at 4.3 years of follow-up. Ideal CVH metrics were defined according to the American Heart Association. Subclinical atherosclerosis was evaluated by plaques in carotid arteries, carotid intima-media thickness(CIMT), brachial-ankle pulse wave velocity(baPWV), and urinary albumin-to-creatinine ratio(UACR). Results Both the prevalence and incidence of atherosclerosis measures were found to be decreased with increasing numbers of ideal CVH metrics at baseline(all P values for trend < 0.01). The levels of CIMT and UACR at follow-up showed an inverse and significant association with the numbers of ideal CVH metrics at baseline(both P values for trend < 0.05) but a borderline significant association with baPWV(P for trend = 0.0505). Taking participants with 0-1 ideal metric as reference, we found that participants with 5-6 ideal metrics had significantly lower risks of developing carotid plaques(odds ratio, OR = 0.46; 95% confidence interval, CI 0.27-0.79), increased CIMT(OR = 0.60; 95% CI 0.42-0.84), and increased baPWV(OR = 0.57; 95% CI 0.34-0.97) after full adjustments. A significant interactive effect of age and CVH was detected on CIMT and baPWV progression(both P values for interaction < 0.05). Conclusion The numbers of ideal CVH metrics showed a significant and inverse association with the risk of developing subclinical atherosclerosis in middle-aged and elderly Chinese adults, whereas its dose-response effect was attenuated in individuals aged ≥ 60 years and partially weakened in male participants.

关键词： Cardiovascular health Subclinical atherosclerosis Cohort

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带等压预燃的旋转爆震发动机循环效率分析

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推进技术 2019年第5期40卷 970-977页

作者：王丹陈宏玉严宇洪流西安航天动力研究所液体火箭发动机技术重点实验室陕西西安710100

针对煤油-空气旋转爆震发动机(RDE)点火困难问题,提出一种采用等压预燃的爆震循环模式。通过零维的热效率理论分析方法,建立了一种针对于带预燃的爆震热循环效率模型。结果表明,预燃爆震循环的热效率高于理想Brayton循环,低于理想爆震... 详细信息

针对煤油-空气旋转爆震发动机(RDE)点火困难问题,提出一种采用等压预燃的爆震循环模式。通过零维的热效率理论分析方法,建立了一种针对于带预燃的爆震热循环效率模型。结果表明,预燃爆震循环的热效率高于理想Brayton循环,低于理想爆震循环。预燃空气比例是热效率的重要影响因素,循环温比为2,预燃空气比例为0时,预燃爆震循环比理想Brayton循环热效率高26.4%,而当预燃空气量逐渐增加,预燃循环效率提升的比例逐渐变小。采用预燃方式有利于液态煤油的点火起爆,在低温比,低预燃空气比例条件下优势明显。试验中应当在保证煤油能够起爆的前提下采用尽可能少的预燃空气。

关键词：两级燃烧旋转爆震发动机热效率预燃性能分析

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Comparative Study on the Analgesic Effects of Different Moxibustion Methods with Tai-yi Moxa Stick in Treating Primary Dysmenorrhea

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Journal of Acupuncture and Tuina Science 2014年第5期12卷 300-305页

作者： Wu Jiu-long chen hong-yu Tang Yi-chun Ma Xiao-yu Huan Jia-hui chen Ruo-yang Mo Hui Xu Xiu-zhu Shen Xiao-jing Wang yu-fan Zhang Jian-bin Wang Ling-ling The Second Clinical Medical College Nanjing University of Traditional Chinese Medicine The First Clinical Medical College Nanjing University of Traditional Chinese Medicine Department of English Hong Kong Polytechnic University

Objective: To compare the therapeutic effects of two different moxibustion methods both with tai-yi moxa stick in treating primary dysmenorrhea. Methods: Forty-three patients were randomized into two groups by the random number table according to their treatment orders. The causalgic group was intervened by causalgic stimulation with tai-yi moxa stick while the tepid group was treated by mild thermal stimulation with tai-yi moxa stick. Shiqizhui(EX-B 8) was selected for both groups. Visual analogue scale(VAS) was used for observation before and during the treatment by every 10 min to compare the clinical efficacies between the two groups. Results: Before treatment, there was no statistically significant difference in pain intensity between the two groups(P>0.05). After treatment, both groups achieved significant improvements in pain intensity(P 0.05), but the difference was enlarged comparing with that before treatment. The pain relief during the first 10 min of treatment was slower in the causalgic group than that in the tepid group. However, during the later 20 min, the pain relief in the calsalgia group gradually outpaced that in the tepid group. Conclusion: The two moxibustion methods with tai-yi moxa stick both have a good instant analgesic effect in treating primary dysmenorrhea. For patients with primary dysmenorrhea, if 30 min is regarded as the treatment time, mild stimulation was suggested to be used for the first 10 min, and causalgic stimulation for the later 20 min to achieve a better curative effect.

关键词： Dysmenorrhea Moxibustion Therapy Moxa Stick Moxibustion Point Shiqizhui(EX-B 8)

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交流输电系统的分岔与仿真研究

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高电压技术 2008年第3期34卷 533-536页

作者：杨秀陈鸿煜上海电力学院电力工程系上海200090 上海大学自动化系上海200072

为提高系统电压稳定水平,防止电压崩溃事故的发生,基于非线性动力系统的分岔理论,使用通用分岔分析软件AUTO2000对一个典型的3节点系统进行电压稳定的分析,得出了系统在3种不同发电机模型下的分岔点数值。研究发现,不同发电机模型的系... 详细信息

为提高系统电压稳定水平,防止电压崩溃事故的发生,基于非线性动力系统的分岔理论,使用通用分岔分析软件AUTO2000对一个典型的3节点系统进行电压稳定的分析,得出了系统在3种不同发电机模型下的分岔点数值。研究发现,不同发电机模型的系统经历的分岔过程不同,说明系统的电压稳定性随着发电机模型的不同而不同。但系统在到达鞍节点分岔前,都因为发生了Hopf分岔而失稳,因此Hopf分岔才是系统失稳的原因。研究还发现跟踪Hopf分岔点开始的极限环曲线可见系统还会经历一系列其它复杂分岔:环面折叠分岔、倍周期分岔和环面分岔;在不同的发电机模型下,系统因为不同的动态分岔点而失稳。时域仿真验证了此结论。

关键词：电力系统电压稳定鞍结分岔 Hopf分岔发电机模型时域仿真

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高压直流输电系统换相失败的仿真研究

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高电压技术 2008年第2期34卷 247-250,270页

作者：杨秀陈鸿煜上海电力学院电力工程系上海200090

换相失败是直流输电系统逆变器最常见的故障,当逆变器联接于弱交流系统时换相失败更容易发生,而以往的研究重点是换相失败的机理及数学推导,缺乏相应的仿真验证。为此,通过电磁暂态仿真研究了广泛使用的换相失败解析表达式及其不同短路... 详细信息

换相失败是直流输电系统逆变器最常见的故障,当逆变器联接于弱交流系统时换相失败更容易发生,而以往的研究重点是换相失败的机理及数学推导,缺乏相应的仿真验证。为此,通过电磁暂态仿真研究了广泛使用的换相失败解析表达式及其不同短路情况下的误差。结果表明:三相短路时最小电压降的计算公式与仿真结果相吻合,而单相接地故障时最小电压降的计算结果与仿真有一定误差;理论计算结果稍偏保守,但是仍然能够作为反映换相失败的一个指标。在此基础上分析研究直流控制系统对连续换相失败影响的结果表明:增大逆变站控制器增益和减小其时间常数均可以抑制换相失败的发生,有利于逆变侧交流电压的恢复与维持。

关键词：高压直流换相失败电磁暂态短路比仿真最小电压降

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On Graphs with Equal Connected Domination and 2-connected Domination Numbers

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Chinese Quarterly Journal of Mathematics 2010年第1期25卷 98-103页

作者： chen hong-yu ZHU Zhe-li School of Mathematics Shandong University Jinan 250100 China College of Information Science and Engineering Shandong Agriculture University Taian 271018 China

A subset S of V is called a k-connected dominating set if S is a dominating set and the induced subgraph S has at most k *** k-connected domination number γck（G） of G is the minimum cardinality taken over all minimal k-connected dominating sets of *** this paper,we characterize trees and unicyclic graphs with equal connected domination and 2-connected domination numbers.

关键词： connected domination number 2-connected domination number trees unicyclic graphs

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Association between Coronary Atherosclerotic Plaque Composition and Cardiovascular Disease Risk

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Biomedical and Environmental Sciences 2019年第2期32卷 75-86页

作者： LI Lin WANG Long LIU Shan Shan ZHAO Zhi yun LI Mian WANG Tian Ge XU Min LU Jie Li chen yu hong WANG Shuang yuan DAI Meng HOU Ya Nan WU Xue Yan MA Li Na WANG Wei Qing XU yu BI yu Fang National Clinical Research Center for Metabolic Diseases Shanghai Institute of Endocrine and Metabolic Diseases and Department of Endocrine and Metabolic Diseases Rui-Jin Hospital Shanghai Jiao-Tong University School of Medicine

Objective The objective of this study is to determine whether coronary atherosclerotic plaque composition is associated with cardiovascular disease(CVD) risk in Chinese adults. Methods We performed a cross-sectional analysis in 549 subjects without previous diagnosis or clinical symptoms of CVD in a community cohort of middle-aged Chinese adults. The participants underwent coronary computed tomography(CT) angiography for the evaluation of the presence and composition of coronary plaques. CVD risk was evaluated by the Framingham risk score(FRS) and the 10-year atherosclerotic cardiovascular disease(ASCVD) risk score. Results Among the 549 participants, 267(48.6%) had no coronary plaques, 201(36.6%) had noncalcified coronary plaques, and 81(14.8%) had calcified or mixed coronary plaques. The measures of CVD risk including FRS and ASCVD risk score and the likelihood of having elevated FRS significantly increased across the groups of participants without coronary plaques, with noncalcified coronary plaques, and with calcified or mixed coronary plaques. However, only calcified or mixed coronary plaques were significantly associated with an elevated ASCVD risk score [odds ratio(OR) 2.41; 95% confidence interval(CI) 1.09-5.32] compared with no coronary plaques, whereas no significant association was found for noncalcified coronary plaques and elevated ASCVD risk score(OR 1.25; 95% CI 0.71-2.21) after multivariable adjustment. Conclusion Calcified or mixed coronary plaques might be more associated with an elevated likelihood of having CVD than noncalcified coronary plaques.

关键词： Coronary plaque composition Framingham risk score 10-year atherosclerotic cardiovascular disease risk score

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应用分岔理论分析SVC对电力系统电压稳定性的影响

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电力系统保护与控制 2009年第7期37卷 7-11,94页

作者：杨秀金红核郭晨吉陈雨陈鸿煜上海电力学院电力工程系上海200090 上海市电力公司超高压输变电公司上海200064 上海大学自动化系上海200072

基于分岔理论的电力系统电压稳定分析对于深入理解电压失稳机理有重要意义,特别是对于灵活交流输电系统,如静止无功补偿器等,分岔理论能够有效分析系统的动态控制特性对电压稳定的影响。利用非线性动力系统的分岔理论,使用通用分岔分析... 详细信息

基于分岔理论的电力系统电压稳定分析对于深入理解电压失稳机理有重要意义,特别是对于灵活交流输电系统,如静止无功补偿器等,分岔理论能够有效分析系统的动态控制特性对电压稳定的影响。利用非线性动力系统的分岔理论,使用通用分岔分析软件AUTO2000对典型的含SVC系统和不含SVC系统进行电压稳定的分析,得出了系统在两种情况下的分岔点数值。研究发现,通过添加静止无功补偿器(SVC),可以延迟系统的Hopf分岔点和鞍结分岔点,增加负荷极限,从而提高了系统电压稳定性。之后又通过双参数分岔分析确定了两维分岔边界。结果表明,在使用SVC控制器提高系统电压稳定性时,要详细考虑其参数对系统中各种分岔的影响,综合优化控制器的设计和安装。

关键词：电压稳定鞍结分岔 Hopf分岔静止无功补偿器

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