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平行式快速路出口交通组织方法研究

交通运输系统工程与信息 2024年第3期24卷 232-239页

作者：陈永恒李世豪杨绥程刘博湛天舒吉林大学交通学院长春130022

针对平行式快速路出口排队溢出的交通问题,本文提出平行式快速路出口在无信号控制和信号控制情况下的5种交通组织方法,根据主辅车流的车头时距分布,建立主辅车流产生延误的计算模型。从方案选择的角度,以车均延误为评价指标,研究平行式... 详细信息

针对平行式快速路出口排队溢出的交通问题,本文提出平行式快速路出口在无信号控制和信号控制情况下的5种交通组织方法,根据主辅车流的车头时距分布,建立主辅车流产生延误的计算模型。从方案选择的角度,以车均延误为评价指标,研究平行式快速路不同交通流量状态下出口最适合采用的交通组织方法。结果表明:当平行式快速路主路驶出车流和辅路车流的总流量低于1500 pcu·h^(-1)时,采取无信号让行的控制方法。主路驶出交通量较高时,采用主路驶出优先控制;辅路交通量较高时,采用辅路优先控制。当总流量在[1500,2300]pcu·h^(-1)时,采用辅路信号与让行相结合的控制方法。当主路驶出交通量较大时,采用辅路信号主路优先控制;当辅路交通量较大时,采用辅路信号辅路优先控制。当总流量高于2300 pcu·h^(-1)时,采用主辅全信号的控制方法。

关键词：交通工程交通方案选择交通流理论城市快速路驶出交通车均延误模型

Targeting p53 pathways:mechanisms,structures,and advances in therapy

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Signal Transduction and Targeted Therapy 2023年第4期8卷 1399-1433页

作者： Haolan Wang Ming Guo Hudie Wei yongheng chen Department of Oncology NHC Key Laboratory of Cancer ProteomicsLaboratory of Structural BiologyNational Clinical Research Center for Geriatric DisordersXiangya HospitalCentral South UniversityChangshaHunan 410008China

The TP53 tumor suppressor is the most frequently altered gene in human cancers,and has been a major focus of oncology *** p53 protein is a transcription factor that can activate the expression of multiple target genes and plays critical roles in regulating cell cycle,apoptosis,and genomic stability,and is widely regarded as the“guardian of the genome”.Accumulating evidence has shown that p53 also regulates cell metabolism,ferroptosis,tumor microenvironment,autophagy and so on,all of which contribute to tumor *** in TP53 not only impair its tumor suppressor function,but also confer oncogenic properties to p53 *** p53 is mutated and inactivated in most malignant tumors,it has been a very attractive target for developing new anti-cancer ***,until recently,p53 was considered an“undruggable”target and little progress has been made with p53-targeted ***,we provide a systematic review of the diverse molecular mechanisms of the p53 signaling pathway and how TP53 mutations impact tumor *** also discuss key structural features of the p53 protein and its inactivation by oncogenic *** addition,we review the efforts that have been made in p53-targeted therapies,and discuss the challenges that have been encountered in clinical development.

关键词： metabolism drugs mechanisms

Comparative characterization of two natural humic acids in the Pearl River Basin, China and their environmental implications

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Journal of Environmental Sciences 2010年第11期22卷 1695-1702页

作者： Juan Liu Jin Wang yongheng chen Holger Lippold Johanna Lippmann-Pipke Key Laboratory of Water Safety and Protection in the Pearl River Delta Ministry of Education Guangzhou University Guangzhou 510006 China. Forschungzentrum Dresden Rossendorf Institute of Radiochemistry Research Site Leipzig Leipzig 04318 Germany

Two humic acids （HAs） were isolated from contaminated river sediments present under comparative conditions in the Pearl River Basin, China. YFHA （the HA extracted at an open pyrite mining area in Yunfu） exhibited a lower absorption intensity for certain bands in the Fourier transform infrared spectra, a lower E 4 /E 6 value （the UV absorbances at 465 nm （E 4 ） and 665 nm （E 6 ））, a lower apparent molecular weight, a lower polarity and a lower oxygen functionality in comparison with GZHA （the HA isolated at an urban living area in Guangzhou）. All these differences indicated a higher degree of humification of YFHA than GZHA. Overall, the enrichment patterns of permanent heavy metals in the studied HAs were similar to those in corresponding sediments. In particular, YFHA exhibited high enrichment of trace element Tl, a characteristic concomitant from the mining of the pyrite minerals. The adsorption isotherms of two HAs for goethite and pyrolusite, two representative geological materials, conformed to the Langmuir equation. Based on the qualitative relationships between the Langmuir constants of the adsorption isotherms and the chemical characteristics of HAs, the main mechanism of HA adsorption on these materials was suggested to be hydrophobic interaction. This study highlighted the promising use of HA as a peculiar bio-indicator of uncommon trace metal contaminations. The HA adsorption mechanism on representative geological materials further provided a theoretical basis for the study on the unusual metal behavior in complex environmental settings.

关键词： humic acid permanent metal load adsorption goethite pyrolusite

Synthesis, Antibacterial Activities and Nuclease Properties of Ternary Copper（II） Complex Containing 2-（2＇-Pyridyl）benzothiazole and Glycinate

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Chinese Journal of Chemistry 2012年第2期30卷 303-310页

作者： Lu,Yanmei chen,yongheng ou,Zhibin chen,Shi Zhuang,Chuxiong Le,Xueyi Department of Applied Chemistry South China Agricultural UniversityGuangzhouGuangdong 510642China College of Life-Science South China Agricultural UniversityGuangzhouGuangdong 510642China Institute of Biomaterial South China Agricultural UniversityGuangzhouGuangdong 510642China

A new ternary complex [Cu（PBT）（Gly）（H2O）]ClO4 （PBT=2-（2＇-pyridyl）benzothiazole, and Gly=glycinate） has been synthesized and characterized by elemental analysis, molar conductivity, and IR methods. The complex, structurally characterized by single-crystal X-ray crystallography, shows a slightly distorted square-pyramidal coordination geometry in which two nitrogen atoms of PBT and the carboxylate oxygen atom O and the amino nitrogen atom N of Gly bind at the basal plane, a water molecule is coordinated at the apical position. The complex, Cu（ClO4）2 and flee PBT were each tested for their ability to inhibit the growth of two Gram（--）（Escherichia coil, Salmonella） and two Gram（＋）（Bacillus subtilis, Staphylococcus aureus） microorganisms. The complex showed good antibacterial activities against the microorganisms compared with free PBT and Cu（C104）2. The interaction between the complex and calf thymus DNA in aqueous solution was investigated using electronic spectroscopy, fluorescence spectroscopy, circular dichroic spectroscopy, and viscosity measurements. Results suggest that the complex could bind to DNA by an intercalative mode. In addition, the result of agarose gel electrophoresis showed that the complex can cleave the plasmid DNA by hydroxyl radicals and singlet oxygen-like species under the condition of physiological pH and room temperature.

关键词： copper(II) complex 2-(2'-pyridyl)benzothiazole glycinate DNA antibacterial activity

Optimization of Crosswalk Width Based on Bi-Directional Pedestrian Crossing Time at Signalized Intersections

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Journal of Beijing Institute of Technology 2018年第2期27卷 285-292页

作者： Ningbo Cao yongheng chen Zhaowei Qu Liying Zhao Yanfei Li Qiujie Yang College of Transportation Jilin UniversityChangchun 130022China Tianjin Transportation Research Institute Tianjin 300074China

The effects of the interactions between bi-directional pedestrians on the crossing time and the crosswalk width are studied. Firstly,the crossing process of bi-directional pedestrians is *** total crosswalk time is divided into a discharge time and a crossing time. The interactions between bi-directional pedestrians are quantified with the drag force theory. Then,a model is developed to study the crossing time based on the kinetic energy theory and momentum theory. Subsequently,the related parameters of the proposed model are calibrated with observed information. The relationships among crosswalk width,signal time,pedestrian volume and level of service are simulated with the proposed model. The results are verified and compared with other models. The proposed model has an absolute value of relative error of 9. 38%,which is smaller than that of the Alhajyaseen model（ 15. 26%） and Highway Capacity Manual（ HCM） model（ 12. 42%）. Finally,suggested crosswalk widths at different conditions are successfully estimated with the proposed crossing time model.

关键词： signalized crosswalks bi-directional pedestrian drag force theory crossing time cross-walk width

建筑垃圾/废弃物在道路工程中的应用研究进展综述——基于CiteSpace的文献计量分析

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市政技术 2024年第1期42卷 30-34,40页

作者：蔡江波帅泽志陈永恒胡文军张晗中建筑港集团有限公司山东青岛266000 山东建筑大学山东济南250101

为探究国内外建筑垃圾/废弃物在道路工程中的应用研究进展,筛选了CNKI数据库2001—2022年386篇期刊论文和WoS数据库2007—2022年449篇期刊论文进行可视化分析,利用CiteSpace软件绘制了发文数量、关键词聚类等科学知识图谱。研究结果表明... 详细信息

为探究国内外建筑垃圾/废弃物在道路工程中的应用研究进展,筛选了CNKI数据库2001—2022年386篇期刊论文和WoS数据库2007—2022年449篇期刊论文进行可视化分析,利用CiteSpace软件绘制了发文数量、关键词聚类等科学知识图谱。研究结果表明:该领域的研究自2008年起呈快速增长趋势,中英文期刊论文发文量均在2020年达到顶峰;国内外都广泛地将建筑垃圾/废弃物应用到道路工程中,并对其性能、机理等各方面展开了深入的研究,但国外的研究面更广,研究手段、理论水平、技术方法针对性也更强。未来,该领域的研究将会更倾向于再生技术、可持续发展和环境保护等方面。

关键词：建筑垃圾/废弃物道路工程 CiteSpace 可视化分析应用

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Speciation analysis of metals (Tl,Cd and Pb) in Tl-containing pyrite and its cinder from Yunfu Mine,China,by ICP-MS with sequential extraction

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Chinese Journal Of Geochemistry 2010年第1期29卷 113-119页

作者： WANG Chunlin chen yongheng PAN Jianyang ZHANG Ping QI Jianying LIU Juan LI Xiangping WANG Jin State Key Laboratory of Organic Geochemistry Guangzhou Institute of Geochemistry Chinese Academy of Sciences Guangzhou 510640 China School of Environmental Science and Engineering Guangzhou University Guangzhou 510006 China Graduate University of Chinese Academy of Sciences Beijing 100049 China Hangzhou Environmental Monitoring Center Station Hangzhou 310007 China

The speciation of heavy metals such as thallium,cadmium and lead existing in pyrite and pyrite cinder was analyzed by ICP-MS with a sequential extraction *** distribution patterns of these metals including exchangeable,reducible,oxidizable and residual fractions were ***,Cd and Pb in pyrite and pyrite cinder samples from each extraction step were determined by inductively coupled plasma mass spectrometry(ICP-MS).Under the optimized instrumental conditions,detection limits of Tl,Cd and Pb in different matrices were within the range of 0.006-0.07 μg/L,and the relative standard deviations ranged from 0.8% to 1.2%.The accuracy of Tl,Cd and Pb determination was checked by analyzing two certified reference *** results demonstrate that trace Tl,Cd and Pb in the samples can be accurately *** sequential extraction results revealed that the percent contents of Tl,Cd and Pb in exchangeable,reducible and oxidizable fractions in pyrite cinder are different from those in pyrite and in pyrite ***,Cd and Pb mostly are distributed in residual ***,the mobility of metals in pyrite is higher than that in pyrite *** distributions of Tl,Cd and Pb in the non-residual fraction are not dominant in pyrite cinder,the total concentrations of them could not be ***,attention must be paid to the risk of potential pollution by pyrite cinder.

关键词：电感耦合等离子体质谱连续提取形态分析黄铁矿重金属铊镉铅

A Survey on Model Predictive Control of DFIGs in Wind Energy Conversion Systems

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CSEE Journal of Power and Energy Systems 2024年第3期10卷 1085-1104页

作者： Shuo Yan Junyu chen Minghao Wang yongheng Yang Jose M.Rodriguez STEM College RMIT UniversityMelbourneAustralia Hong Kong Polytechnic University Hong KongChina State Key Laboratory of Internet of Things for Smart City(UM) Department of Electrical and Computer EngineeringUniversity of MacaoMacaoChina College of Electrical Engineering Zhejiang UniversityHangzhou 310027China Universidad San Sebastin Campus BellavistaSantiago de ChileCLSantiago de Chile 000000Chile IEEE

This paper presents a comprehensive study on the model predictive control(MPC)of doubly fed induction generators(DFIG)in wind energy conversion systems(WECS);in particular the MPC of the rotor side *** general principle of prevalent MPC strategies is discussed to introduce the theoretical framework in the first ***,mainstream and high-performance MPC methods of DFIGs have been identified as model predictive current control(MPCC),model predictive torque control(MPTC),and model predictive power control(MPPC).Starting from analyzing dynamic models,these MPC strategies are investigated in terms of operating principles and technical *** paper further investigates implementation of MPC strategies in unbalanced *** on the quantitative and qualitative analysis of several case studies,performance of various MPC schemes is compared and their special features are *** for designing MPC strategies of DFIGs in WECS are provided.

关键词： Doubly fed induction generator(DFIG) model predictive control(MPC) wind energy

Environmental exposure and flux of thallium by industrial activities utilizing thallium-bearing pyrite

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Science China Earth Sciences 2013年第9期56卷 1502-1509页

作者： chen yongheng WANG ChunLin LIU Juan WANG Jin QI JianYing WU YingJuan Key Laboratory of Waters Safety & Protection in the Pearl River Delta Ministry of EducationGuangzhou University Guangdong Provincial Academy of Environmental Science Department of Geosciences Taiwan University South China Institute of Environmental Science Ministry of Environmental Protection

Thallium(Tl) is a typical toxic heavy metal,with higher toxicity to mammals than Hg,Cd,and *** assessments of its environmental exposure and flux are central to effective management and control of Tl *** paper first presents in detail the environmental exposure and flux of Tl by typical industrial activities utilizing Tl-bearing pyrite minerals to produce sulfuric *** this purpose,sequential extraction and Inductively Coupled Plasma Mass Spectrometry(ICP-MS) were used to investigate total content and geo-chemical partitioning of Tl in raw pyrite ores and solid roasting wastes,thereby uncovering Tl distribution and transformation during the production *** showed that some portions of Tl bearing in the minerals went into vapor,which transferred Tl into different processes;and some portions of Tl went into water during the gas washing procedure,leaving some other portions remained in the solid *** importantly,detailed investigation revealed that 40% of Tl in the pyrite minerals was active,among which 25% of Tl originally in the pyrite minerals was washed into water during gas cleaning process and 15% of active Tl retained in the *** latter portion of active Tl could be possibly transferred to the soil or water with the slag deposal or being reused;and 60% of Tl remained relatively stable in the residual phase.

关键词： Environmental exposure and flux of thallium by industrial activities utilizing thallium-bearing pyrite