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含水率对红层泥岩填料刚度劣化特性及微观结构影响研究

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岩土力学 2024年第7期45卷 1976-1986页

作者：陈康刘先峰袁胜洋马杰陈忆涵蒋关鲁西南交通大学高速铁路线路工程教育部重点实验室四川成都610031 西南交通大学土木工程学院四川成都610031 加拿大皇家军事学院加拿大金士顿K7K7B4 新疆工程学院新疆乌鲁木齐830023

为研究含水率对红层泥岩填料刚度劣化规律和微观结构的影响,开展了不同含水率下三轴不排水剪切试验、压汞试验和扫描电镜试验,基于能量守恒定律推导了填料刚度劣化与弹塑性应变能增量间的关系。结果表明:填料黏聚力随含水率增加而降低,... 详细信息

为研究含水率对红层泥岩填料刚度劣化规律和微观结构的影响,开展了不同含水率下三轴不排水剪切试验、压汞试验和扫描电镜试验,基于能量守恒定律推导了填料刚度劣化与弹塑性应变能增量间的关系。结果表明:填料黏聚力随含水率增加而降低,内摩擦角则随含水率增加先增加后降低。填料结构损伤由应变能转化引起,从宏观上表现为刚度劣化。归一化刚度比值随塑性应变能增量占比增加而线性降低,随应力发展呈非线性衰减。以最优含水率为界,当试样在干侧时,填料有较好的荷载抵抗能力;湿侧填料荷载抵抗能力远低于干侧。损伤应力等值线与等含水率线构成上下界为对数曲线的状态面。填料孔隙分布在干侧为单峰形态,粒间接触较为紧密,结构稳定性好。在湿侧呈双峰结构,团聚体排列定向性程度较低。填料应在干侧压实填筑,推荐采用5%~7%作为填筑目标含水率。

关键词：路基填料红层泥岩刚度劣化应变能微观结构

血府逐瘀汤联合西药治疗慢性阻塞性肺疾病的Meta分析

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中国处方药 2024年第4期22卷 16-22页

作者：孙佳齐亚丽陈燚含李洋王琪王艳学青海大学西宁810000 青海省人民医院西宁810000 贵德县河西镇中心卫生院青海海南813000

目的系统评价血府逐瘀汤联合西医常规治疗慢性阻塞性肺疾病的疗效。方法使用计算机查阅以下数据库:中国知网(CNKI)、维普(VIP)、中国生物医学文献数据库(CBM)、万方、PubMed、Cochrane Library、Embase等数据库。查阅内容为血府逐瘀汤... 详细信息

目的系统评价血府逐瘀汤联合西医常规治疗慢性阻塞性肺疾病的疗效。方法使用计算机查阅以下数据库:中国知网(CNKI)、维普(VIP)、中国生物医学文献数据库(CBM)、万方、PubMed、Cochrane Library、Embase等数据库。查阅内容为血府逐瘀汤联合西医常规治疗慢性阻塞性肺疾病的临床随机对照试验,查阅时间为以上数据库建库起至2023年7月。由两名评估人员通过Cochrane风险偏倚从随机方法、分配隐藏、盲法、结局数据、选择报道、其他偏倚方面以High risk、Low risk及Unclear risk评价文献质量。运用RevMan 5.3软件对提取的数据进行Meta分析。结果共纳入27项随机对照研究,共计囊括1861例患者,其中观察组934例,对照组927例。Meta分析结果:中医疗效:血府逐瘀汤联合西医常规治疗效果优于单用西医常规治疗[OR=4.11,95%CI(2.85,5.91),Z=7.61,P<0.00001]。肺功能:第1秒用力呼气容积(FEV1)明显改善[MD=0.19,95%CI(0.05,0.32),Z=2.68,P=0.007];用力肺活量(FVC)明显改善[MD=0.17,95%CI(0.09,0.25),Z=4.19,P<0.0001];第1秒用力呼气容积占用力肺活量的百分比(FEV1/FVC)明显改善[MD=3.23,95%CI(1.66,4.80),Z=4.03,P<0.0001];血气分析:动脉血氧分压(PaO_(2))显著改善[MD=5.79,95%CI(3.44,8.13),Z=4.84,P<0.00001];动脉血二氧化碳分压(PaCO_(2))显著改善[MD=-3.85,95%CI(-6.09,-1.61),Z=3.38,P=0.0007]。血流变:血浆黏度改善[MD=-0.33,95%CI(-0.52,-0.14),Z=3.37,P=0.0008];红细胞压积差异无统计学意义[MD=-0.04,95%CI(-0.13,0.04),Z=1.00,P=0.32];纤维蛋白原明显改善[MD=-0.77,95%CI(-0.95,-0.59),Z=8.24,P<0.00001]。6分钟步行试验改善[MD=33.04,95%CI(16.81,49.26),Z=3.99,P<0.0001]。结论在传统西药基础上结合血府逐瘀汤方治疗慢性阻塞性肺疾病对多个结局指标有明显改善。

关键词：血府逐瘀汤慢性阻塞性肺疾病 Meta分析循证医学

Preliminary limits on deviation from the inverse-square law of gravity in the solar system:a power-law parameterization

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Research in Astronomy and Astrophysics 2014年第8期14卷 1019-1028页

作者： Meng-Yao Liu Ze-Hao Zhong yi-chen han Xiao-Yu Wang Zong-Shui Yang yi Xie School of Astronomy and Space Science Nanjing University Key Laboratory of Modern Astronomy and Astrophysics Nanjing UniversityMinistry of Education

New physics beyond the standard model of particles might cause a deviation from the inverse-square law of gravity. In some theories, it is parameterized by a power-law correction to the Newtonian gravitational force, which might originate from the simultaneous exchange of particles or modified and extended theories of gravity. Using the supplementary advances of the perihelia provided by INPOP 10a （IMCCE, France） and EPM2011 （IAA RAS, Russia） ephemerides, we obtain preliminary limits on this correction. In our estimation, we take the Lense-Thirring effect due to the Sun＇s angular momentum into account. The parameters of the power-law correction and the uncertainty of the Sun＇s quadrupole moment are simultaneously estimated with the method of minimizing X2. From INPOP10a, we find N - 0.605 for the exponent of the power-law correction. However, from EPM2011, we find that, although it yields N = 3.001, the estimated uncertainty in the Sun＇s quadrupole moment is much larger than the value given by current observations. This might be caused by the intrinsic nonlinearity in the power-law correction, which makes the estimation very sensitive to the supplementary advances of the perihelia.

关键词： gravitation- ephemerides- celestial mechanics

Gravitational Field Excitation from the First Term of Quantum Wilson Loop

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Communications in Theoretical Physics 2006年第1X期46卷 77-86页

作者： SHAO Liang SHAO Dan SHAO Chang-Gui H. Noda chen yi-han Department of Applied Physics Wuhan University of Science and Technology Wuhan 430081 China Department of Physics Jianghan University Wuhan 430056 China Institute of Theoretical Physics Hubei University Wuhan 430062 China Department of Mathematical Sciences Ibaraki University Mito 310-8512 Japan

In 4-dimensional R-gravity, using the linear and square terms of the expanding expression of the space-time connection, we calculate the possible curvature excitation （order k^4） of gravitational field, which is given by the first term of quantum Wilson loop （w） through two-point Green＇s function of the connection. At the same time using the tree diagram propagators of gravitons, the lowest order （k^4） correction to （w） is also calculated through the graviton self-energy in the term. Under the accuracy condition up to order k^4, we have obtained a complete expression of the excitation contributed from the leading term （w^（2））of （w）.

关键词： excitation of gravitational field graviton self-energy correction complete expression of excitation of order k^4 in (w^(2))

A dynamic exploratory hybrid modelling framework for simulating complex and uncertain system

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Journal of Safety Science and Resilience 2024年第2期5卷 167-178页

作者： Gangqiao Wang han Xing Yongqiang chen yi Liu Institute of Big Data Inteligent Management and Decision-making College of ManagementShenzhen UniversityShenzhen 518060China School of Safety Science Tsinghua UniversityBejing 100084China Department of Mechanics and Engineering Science College of EngineeringPeking UniversityBejing 100871China

Complex disaster systems involve various components and mechanisms that could interact in complex ways and change over time,leading to significant deep *** to deep uncertainty,decision-makers have severe inadequacy of knowledge and often encounter unpredictable surprises that may emerge in the future,thus making it difficult to specify appropriate models and parameters to describe the system of *** this paper,we propose a dynamic exploratory hybrid modeling framework that fits data,models,and computational ex-periments together to simulate complex systems with deep *** the framework,one needs to develop multiple plausible models from a hybrid modeling perspective and perform enormous computational experi-ments to explore the diversity of future ***-time data is then incorporated into diverse forecasts to dynamically adjust the simulation *** ultimately enables an ongoing modeling and analysis process in which deep uncertainty would be gradually *** approach has been applied to a human-involved car-following system simulation under complex traffic *** results show that the proposed approach can improve the prediction accuracy while enhancing the sensitivity of the simulation system to uncertain changes in the system of interest.

关键词： Disaster modeling and analysis Deepuncertainty Hybrid modeling Adaptivesimulation

接枝型天然橡胶基吸水膨胀橡胶的制备及吸水膨胀性能

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合成橡胶工业 2024年第3期47卷 228-232页

作者：李鹏程陈伊涵元以中孙金煜田晓慧华东理工大学材料科学与工程学院上海200237

以脱蛋白天然橡胶(DPNR)胶乳作为改性橡胶的基材,在氧化还原引发体系作用下,基于橡胶大分子链中烯丙基与乙烯基单体的自由基乳液接枝共聚反应实现丙烯酸(AA)在DPNR链上的接枝共聚,从而制备了一种亲水性AA接枝改性DPNR共聚物(DPNR-g-PAA)... 详细信息

以脱蛋白天然橡胶(DPNR)胶乳作为改性橡胶的基材,在氧化还原引发体系作用下,基于橡胶大分子链中烯丙基与乙烯基单体的自由基乳液接枝共聚反应实现丙烯酸(AA)在DPNR链上的接枝共聚,从而制备了一种亲水性AA接枝改性DPNR共聚物(DPNR-g-PAA),通过傅里叶变换红外光谱、核磁共振氢谱、扫描电子显微镜和称重法表征了DPNR-g-PAA的分子结构、断面形貌和吸水膨胀性能。结果表明,DPNR-g-PAA作为吸水膨胀橡胶,其薄膜吸水率可达85.06%,DPNR的表面透湿性显著提高;与传统物理共混或溶液接枝共聚反应制备吸水膨胀橡胶工艺相比,由自由基乳液接枝共聚制得的DPNR-g-PAA具有一定的优势。

关键词：脱蛋白天然橡胶胶乳丙烯酸吸水膨胀橡胶接枝共聚吸水率吸水膨胀性能

Relativistic transformations between global and local velocities of an orbiter under IAU Resolutions

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Research in Astronomy and Astrophysics 2014年第10期14卷 1343-1350页

作者： Zong-Shui Yang yi-chen han Jing-Hao Liu Song-He Qin Zhen Wan Xiao-Yu Wang Ze-Hao Zhong Kai Zhu yi Xie School of Astronomy and Space Science Nanjing University Key Laboratory of Modern Astronomy and Astrophysics Nanjing UniversityMinistry of Education

Einstein＇s general relativity （GR） has become an inevitable part of deep space missions. According to the International Astronomical Union （IAU） Resolutions which are built in the framework of GR, several time scales and reference systems are recommended to be used in the solar system for control, navigation and scientific op- eration of a spacecraft. Under the IAU Resolutions, we derive the transformations be- tween global and local velocities of an arbitrary orbiter. These transformations might be used in orbit determination with Doppler tracking and prediction of Doppler ob- servables for the spacecraft. Taking the yingHuo-1 Mission as a technical example of future Chinese Mars explorations, we evaluate the significance and contributions of various components in the transformations. The largest contribution of the relativistic parts in the transformations can reach the level of ～ 5 × 10-5 m s^-1. This suggests that, for such a spacecraft like we have assumed, if the accuracy of Doppler tracking is better than ～ 5 × 10-5 m s^-1 then the relativistic parts of the transformations of velocities will be required.

关键词： reference systems -- method numerical-- space vehicles -- techniques radial velocities

Sodium metals for single emitter strong coupling:Alternative plasmonic candidates beyond noble metals

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Science China(Physics,Mechanics & Astronomy) 2024年第8期67卷 106-117页

作者： yi Zhang Shuying chen Yuning han Xiulai Xu Lin Zhou National Laboratory of Solid State Microstructures Collaborative Innovation Center of Advanced MicrostructuresJiangsu Key Laboratory of Artificial Functional MaterialsCollege of Engineering and Applied SciencesNanjing UniversityNanjing 210008China School of Information and Electronic Engineering(Sussex Artificial Intelligence Institute) Zhejiang Gongshang UniversityHangzhou 310018China Department of Physics&Astronomy University College LondonLondon WC1E 6BTUK State Key Laboratory for Mesoscopic Physics and Frontiers Science Center for Nano-optoelectronics School of PhysicsPeking UniversityBeijing 100871China

This work provides a theoretical investigation into the strong coupling between a single quantum emitter(QE)and the surface plasmons of sodium metals in two representative plasmonic systems,i.e.,the semi-infinite metal-dielectric interface and the metal nanoparticles(NPs)of monomer/dimer *** both configurations,sodium metals exhibit distinctly stronger coupling strength and lower optical loss in the optical region than their noble metal counterparts,demonstrating the ideal candidate characteristics for single-molecule-level strong couplings with distinctly facile operation *** results provide new insights into extreme light-matter interactions with potential applications in quantum information,optical sensors,quantum chemistry,etc.

关键词： sodium metals plasmonics single quantum emitter strong coupling pseudomode

Azocalixarenes: a scaffold of universal excipients with high efficiency

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Science China Chemistry 2024年第5期67卷 1697-1706页

作者： Yu-Xin Yue yi-Lin Lin Meng-Meng chen han-Wen Tian Rong Ma Ze-han Wang Fang-Yuan chen Yu-chen Pan Dong-Sheng Guo College of Chemistry State Key Laboratory of Elemento-Organic ChemistryKey Laboratory of Functional Polymer Materials(Ministry of Education)Frontiers Science Center for New Organic MatterCollaborative Innovation Center of Chemical Science and Engineering(Tianjin)Nankai UniversityTianjin 300071China

Excipients are important components of pharmaceutical preparations that affect their quality, safety, and efficacy. Macrocyclic receptors are a family of supramolecular excipients with several advantages, including molecular-level protection, small sizes,fast kinetics of host-guest recognition, and modular construction. With the continuous advances in the medical field, personalized and precision medicine requires the development of excipients with low dosages, integrated modifying effects, universality,and controlled release. To meet these requirements, we have developed a new family of macrocyclic excipients based on calixarenes by integrating their covalent(broad chemical design space) and noncovalent(wide range of substrates) ***, azocalixarenes(Azo CAs) were designed, showing high binding affinities to a broad spectrum of active pharmaceutical ingredients(APIs), selectivity to interferents, and responsiveness to hypoxic microenvironments. Due to their highly efficient and controllable recognition, Azo CAs serve as low-dose excipients for 30 APIs. Molecular encapsulation by Azo CAs results in the integrated modification of the physicochemical properties of APIs, including solubility, stability, bioavailability,and biocompatibility. Moreover, Azo CAs can be reduced by azoreductases overexpressed in hypoxic microenvironments,leading to the controlled release of APIs. Collectively, Azo CA excipients have broad application prospects for a series of diseases such as enteritis, arthritis, stroke, cancer, bacterial infection and kidney injury, with diverse therapeutic modalities,including chemotherapy, photodynamic therapy, photothermal therapy, immunotherapy, boron neutron capture therapy, radiotherapy, fluorescence imaging, and their combinations.

关键词： supramolecular chemistry host-guest systems excipient calixarene molecular recognition