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Effect of U0126 on Expression of Bc1-2/Bax in Neurons after Hypoxic Injury in Vitro

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Effect of U0126 on Expression of Bc1-2/Bax in Neurons after ...

Antifungal activities and action mechanisms of compounds from Tribulus terrestris L.

第六届国际脑血管病高峰论坛

作者： Guo DJ,chen YH,Zhao yb~* Department of Neurology,Shanghai First people’s hospital,Shanghai Jiao Tong University,Shanghai 200080,China

Objective:To study the effect of U0126 on the expression of Bcl-2/Bax in neurons after hypoxic injury in ***:Brains from 1 day postnatal S-D rats were taken for in vitro neuron culture.3 days later,the cultures were divided randomly into three groups:drugtreated, hypoxia and normal *** in drug-treat and hypoxia group were subjected

关键词： Hypoxic injury Apoptosis Mitogen activated protein kinases(MAPKs)

来源： cnki会议评论

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第二军医大学学报 2006年第5期27卷 492-492页

作者： Zhang JD Xu Z Cao yb chen HS Yan L An MM Gao PH Wang Y Jia XM Jiang YY Department of Pharmacology College of Pharmacy Second Military Medical University Shanghai 200438 China

Antifungal activity of natural products is being studied widely. Saponins are known to be antifungal and antibacterial. We used bioassay-guided fractionation to have isolated eight steroid saponins from Tribulus terrestris L. , which were identified as hecogenin-3-O-beta-D-glucopyranosyl ( 1→4 )-beta-D-galactopyranoside ( TTS-8), tigogenin-3-O-beta-D-glucopyranosyl ( 1→4 )-beta-D-galactopyranoside ( TTS-9 ), hecogenin-3-O-beta-D-glucopyranosyl ( 1→2 )-beta-D-glucopyranosyl ( 1 4 )-beta-D-galactopyranoside ( TTS-10 ), hecogenin-3-O-beta-D-xylopyranosyl ( 1→3 )-beta-D-glucopyranosyl ( 1→4 )-beta-D-galactopyranoside ( TTS-11 ), tigogenin-3-O-beta-D-xylopyranosyl ( 1→2 )-[- beta-D-xylopyranosyl ( 1→3 ) ]-beta-D-glucopyranosyl (1→4)-[alpha-L-rhamnopyranosyl (1→2)]-beta-D-galactopyranoside (TTS-12), 3-O-Ebeta-D-xylopyranosyl (1→2)-[beta-D- xylopyranosyl (1→3)]-beta-D-glucopyranosyl ( 1→4)-[alpha-L-rhamnopyranosyl ( 1→2 )]-beta-D-galactopyranosy13-26-O-beta- D-glucopyranosyl-22-methoxy-(3beta, 5alpha, 25R)-furostan-3,26-diol (TTS-13), hecogenin-3-O-beta-D-glucopyranosyl ( 1→2)-[beta-D-xylopyranosyl ( 1→3 )]-beta-D-glucopyranosyl ( 1→4 )-beta-D-galactopyranoside ( TTS-14 ), tigogenin-3-O-beta-D- glucopyranosyl ( 1→2 )-[ beta-D-xylopyranosyl ( 1→3 )]-beta-D-glucopyranosyl ( 1→4 )-beta-D-galaetopyranoside ( TTS-15 ). The in vitro antifungal activities of the eight saponins against five yeasts, Candida albicans, Candida glabrata, Candida parapsilosis, Candida tropicalis and Cryptococcus neoformans were studied using microbroth dilution assay. In vivo activity of TTS-12 in a Candida albicans vaginal infection model was studied in particular. The results showed that TTS-12 and TTS-15 were very effective against several pathogenic candidal species and Cryptococcus neoformans in vitro. It is noteworthy that TTS-12 and TTS-15 were very active against Candida albicans (MIC50 = 10 and 2.3 microg/ml) and Cryptococcus neoformans (MIC50 = 1.7 and 6. 7 microg/ml).

关键词： Tribulus terrestris L 抗真菌活性抗菌药

Neural networks-based iterative learning control consensus for periodically time-varying multi-agent systems

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Science China(Technological Sciences) 2024年第2期67卷 464-474页

作者： chen JiaXi LI JunMin chen WeiSheng GAO WeiFeng School of Mathematics and Statistics Xidian UniversityXi'an 710071China School of Aerospace Science and Technology Xidian UniversityXi'an 710071China

In this paper,the problem of adaptive iterative learning based consensus control for periodically time-varying multi-agent systems is studied,in which the dynamics of each follower are driven by nonlinearly parameterized terms with periodic *** networks and Fourier base expansions are introduced to describe the periodically time-varying dynamic *** this basis,an adaptive learning parameter with a positively convergent series term is constructed,and a distributed control protocol based on local signals between agents is designed to ensure accurate consensus of the closed-loop ***,consensus algorithm is generalized to solve the formation control ***,simulation experiments are implemented through MATLAB to demonstrate the effectiveness of the method used.

关键词： multi-agent systems adaptive iterative learning control nonlinearly parameterized dynamics Fourier series expansion neural networks

Multifunctional photon conversion materials for enhancing silicon solar cells

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Light(Science & Applications) 2024年第4期13卷 598-601页

作者： Yiyan Zhang Guanying chen MIIT Key Laboratory of Critical Materials Technology for New Energy Conversion and Storage School of Chemistry and Chemical EngineeringHarbin Institute of Technology150001 HarbinChina

A type of multifunctional erbium(Er^(3+))and ytterbium(yb^(3+))codoped NaY(WO4)2 phosphors,with simultaneous photon upconversion,photon quantum cutting,and luminescence ratiometric temperature sensing abilities,have b... 详细信息

关键词： photon luminescence quantum

Recent progress in lanthanide ions doped inorganic metal halide perovskites

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Journal of Rare Earths 2024年第2期42卷 237-250,I0001页

作者： Yiyan Zhang Tianyu Zhao Guanying chen MIIT Key Laboratory of Critical Materials Technology for New Energy Conversion and Storage School of Chemistry and Chemical EngineeringState Key Laboratory of Urban Water Resource and EnvironmentKey Laboratory of Micro-systems and Micro-structuresMinistry of EducationHarbin Institute of TechnologyHarbin150001China

Benefiting from their large molar extinction coefficient,high carrier mobility,narrow and tunable emissions,inorganic metal halide perovskites(IMHPs) demonstrate great potential in various optoelectrical devices including solar cells,light emitting diodes and photodetectors in the past few *** ions doping,well-known as a modification method of semiconductors,has been extensively applied in IMHPs as *** metal ions have been doped in IMHPs including alkali metals,alkali earth metals,transition metals and lanthanide metals,which either improve their optical performances or induce intriguing brand-new *** them,lanthanide metals feature plentiful energy levels and stable optical properties and are one of the most noteworthy *** we review recent progress in lanthanide ions doped *** summarize yb,Eu or Er ions singly doping in detail,which was the most investigated species in *** lanthanide ions are also reviewed ***,we introduce lanthanide ions multi-doped IMHPs and at last we put forward several potential development *** the interests in lanthanide ions doped IMHPs rise,researchers have made some achievements in the *** though,there are more unexplored *** there are review articles focusing on metal ions doped IMHPs or lanthanide ions doped perovskites,this review aims to provide an overall introduction of lanthanide ions doped *** review may help researchers learn about lanthanide ions doped IMHPs and is to inspire researchers to make further promotion in this field.

关键词： Halide perovskite Lanthanide Doping Rare earths

A Fluctuation Test for Structural Change Detection in Heterogeneous Panel Data Models

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Journal of Systems Science & Complexity 2024年第3期37卷 1184-1208页

作者： LI Fuxiao XIAO Yanting chen Zhanshou Department of Applied Mathematics Xi'an University of TechnologyXi'an 710048China School of Mathematics and Statistics Qinghai Normal UniversityXining 810008China Academy of Plateau Science and Sustainability Xining 810008China

Structural change in panel data is a widespread phenomena. This paper proposes a fluctuation test to detect a structural change at an unknown date in heterogeneous panel data models with or without common correlated effects. The asymptotic properties of the fluctuation statistics in two cases are developed under the null and local alternative hypothesis. Furthermore, the consistency of the change point estimator is proven. Monte Carlo simulation shows that the fluctuation test can control the probability of type I error in most cases, and the empirical power is high in case of small and moderate sample sizes. An application of the procedure to a real data is presented.

关键词： Common correlated effects fuctuation test heterogeneous panel data models structural change detection

Multimodal fusion recognition for digital twin

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Digital Communications and Networks 2024年第2期10卷 337-346页

作者： Tianzhe Zhou Xuguang Zhang Bing Kang Mingkai chen Key Laboratory of Broadband Wireless Communication and Sensor Network Technology Ministry of EducationNanjing University of Posts and TelecommunicationsNanjing210003China

The digital twin is the concept of transcending reality,which is the reverse feedback from the real physical space to the virtual digital *** hold great prospects for this emerging *** order to realize the upgrading of the digital twin industrial chain,it is urgent to introduce more modalities,such as vision,haptics,hearing and smell,into the virtual digital space,which assists physical entities and virtual objects in creating a closer ***,perceptual understanding and object recognition have become an urgent hot topic in the digital *** surface material classification schemes often achieve recognition through machine learning or deep learning in a single modality,ignoring the complementarity between multiple *** order to overcome this dilemma,we propose a multimodal fusion network in our article that combines two modalities,visual and haptic,for surface material *** the one hand,the network makes full use of the potential correlations between multiple modalities to deeply mine the modal semantics and complete the data *** the other hand,the network is extensible and can be used as a universal architecture to include more *** show that the constructed multimodal fusion network can achieve 99.42%classification accuracy while reducing complexity.

关键词： Digital twin Multimodal fusion Object recognition Deep learning Transfer learning

Recent advances in morphology control of platinum catalysts toward oxygen reduction reaction

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Frontiers in Energy 2024年第3期18卷 330-355页

作者： Shun chen Yanru LIU Xiaogang FU Wanglei WANG State Key Laboratory of Solidification Processing Atomic Control and Catalysis Engineering LaboratorySchool of Materials Science and EngineeringNorthwestern Polytechnical UniversityXi’an 710072China State Key Laboratory of Oral and Maxillofacial Reconstruction and Regeneration National Clinical Research Center for Oral DiseasesShaanxi Key Laboratory of StomatologyDepartment of Dental MaterialsSchool of StomatologyThe Fourth Military Medical UniversityXi’an 710032China

Exploring advanced platinum (Pt)-based electrocatalysts is vital for the widespread implementation of proton exchange membrane fuel cells (PEMFCs). Morphology control represents an effective strategy to optimize the behavior of Pt catalysts. In this work, an attempt is made to comprehensively review the effect of morphology control on the catalytic behavior of catalysts in the oxygen reduction reaction (ORR). First, the fundamental physicochemical changes behind morphology control, including exposing more active sites, generating appropriate lattice strains, and forming different crystalline surfaces, are highlighted. Then, recently developed strategies for tuning the morphologies of electrocatalysts, including core-shell structures, hollow structures, nanocages, nanowires, and nanosheets, are comprehensively summarized. Finally, an outlook on the future development of morphology control of Pt catalysts is presented, including rational design strategies, advanced in situ characterization techniques, novel artificial intelligence, and mechanical learning. This work is intended to provide valuable insights into designing the morphology and technological innovation of efficient redox electrocatalysts in fuel cells.

关键词： morphology platinum catalysts electrocatalysis ORR PEMFC

A near-infrared fluorescent probe for visualizing transformation pathway of Cys/Hcy and H2S and its applications in living system

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Chinese Chemical Letters 2024年第5期35卷 296-301页

作者： Yudi cheng Xiao Wang Jiao chen Zihan Zhang Jiadong Ou Mengyao She Fulin chen Jianli Li Key Laboratory of Synthetic and Natural Functional Molecule of the Ministry of Education Xi’an Key Laboratory of Functional Supramolecular Structure and MaterialsCollege of Chemistry&Materials ScienceNorthwest UniversityXi’an 710127China Key Laboratory of Resource Biology and Biotechnology in Western China Ministry of EducationBiomedicine Key Laboratory of Shaanxi ProvinceLab of Tissue Engineeringthe College of Life SciencesFaculty of Life Science&MedicineNorthwest UniversityXi’an 710069China

Sulfydryl-contained(-SH)substances including hydrogen sulfide(H_(2)S),cysteine(Cys),homocysteine(Hcy)and glutathione(GSH)play crucial roles in living systems,and their variations are closely associated with various ***,we developed a near-infrared intramolecular charge transfer(ICT)based fluorescent probe Y-NBD,achieving detection of Cys/Hcy and H_(2)S with different fluorescent signals(green-red for Cys/Hcy,red for H_(2)S),large Stokes shifts(∼100/105nm or 191 nm)and high signal-background-ratio,but not responding to GSH.Y-NBD was successfully applied to image exogenous/endogenous Cys/Hcy and H_(2)S in various living cancer cells(HeLa,A549,and HepG2)and in *** not only visualized the transformation pathway of several thiols in HepG2 cells but also verified that the intestine is the main site for the activation and metabolism of Y-NBD in zebrafish,as well as realized to evaluate the degree of drug-induced liver *** work provides a promising tool for imaging Cys/Hcy and H_(2)S in living systems and shows great potency in evaluating drug-induced liver injury and its treatment.

关键词： Fluorescent probe Near-infrared Hydrogen sulfide Cysteine/homocysteine Large Stokes shift Dicyanoisophorone Drug-induced liver injury