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Chinese Chemical Letters 2024年第5期35卷 259-264页

作者： Zhenjie Yang chenyang Hu Xuan Pang xuesi chen Key Laboratory of Polymer Ecomaterials Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China

It is of great interest to make a degradable material widely tailorable to replace petroleum-derived products among diverse ***,we report the construction of a new multi-purpose degradable material for the first time via a simple ternary copolymerization system comprisingε-caprolactone(ε-CL),cyclohexane oxide(CHO)and CO_(2).Under low pressure of 1 bar∼5 bar,the ring-opening polymerization(ROP)ofε-CL and ring-opening copolymerization(ROCOP)of CO_(2) and CHO can simultaneously *** carbonate units are randomly distributed on the polymer *** random terpolymers have controllable molar mass(10-106 kDa)and compositions(4-33 mol%CO_(2)).And the obtained materials show large-span tunability from tough plastic to elastomer and even adhesive.

关键词： Polyesters CO_(2)-derived copolymers Random copolymerization Elastomers Adhesives

Injectable chitosan hydrogels loaded with antioxidant agent as first-aid dressings for second-degree burn wounds

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Science China(Technological Sciences) 2024年第3期67卷 891-901页

作者： REN Hui ZHANG Zhen LU KaiLun SHEN YuanYuan HE ChaoLiang chen xuesi CAS Key Laboratoryof Polymer Ecomaterials Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China School of Applied Chemistry and Engineering University of Science and Technology of ChinaHefei 230026China

Burn wounds are destructive skin traumas typically of irregular shape and large area. Prone to infection, they require frequent dressing replacement, and painless removal of dressings from burn wounds remains a major challenge. This study focuses on the dynamic characteristics and treatment difficulty of burn wounds. Hydrogel dressings based on glycol chitosan and propionaldehyde-or benzaldehyde-terminated 4-arm poly(ethylene glycol) were designed on the basis of Schiff base cross-linking networks. The hydrogels exhibited shape-adaptability, self-healing and fast-degradation properties, which makes these hydrogels suitable for burn wounds. Salvianolic acid B(SaB)-loaded hydrogel exhibited good antioxidant properties in vitro. In a rat model of deep second-degree burn wounds, the SaB-loaded hydrogel could quickly reduce wound temperature, regulate wound oxidant microenvironment, promote angiogenesis, and accelerate wound healing. Thus, the drug-loaded hydrogel shows significant potential as a first-aid dressing for treatment of burn wounds.

关键词： hydrogel dressing fast-degradation shape-adaptability stress relaxation burn wound treatment

Introducing urea into tirapazamine derivatives to enhance anticancer therapy

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National Science Review 2024年第4期11卷 245-253页

作者： Yajun Xu Jianlin Lv Chaoying Kong Ya Liu Kun Wang Zhaohui Tang xuesi chen Key Laboratory of Polymer Ecomaterials Changchun Institute of Applied ChemistryChinese Academy of Sciences School of Applied Chemistry and Engineering University of Science and Technology of China

Tirapazamine（TPZ） has been approved for multiple clinical trials relying on its excellent anticancer ***,as a typical hypoxia-activated prodrug（HAP）,TPZ did not exhibit survival advantages in Phase Ⅲ clinical trials when used in combination therapy due to the insufficient hypoxia levels in patients' *** this study,to improve the therapeutic effects of TPZ,we first introduced urea to synthesize a series of urea-containing derivatives of *** urea-containing TPZ derivatives showed increased hypoxic cytotoxicity（9.51-30.85-fold） compared with TPZ,while maintaining hypoxic ***,one of these derivatives,showed 20-fold higher cytotoxicity than TPZ while maintaining a similar hypoxic cytotoxicity *** highly efficiently deliver TPZP to the tumors and reduce its side effects on healthy tissues,we further prepared TPZP into a nanodrug with fibrin-targeting ability:***4-NPs,a vascular disrupting agent,was used to increase the fibrin level within tumors and exacerbate tumor *** being combined with CA4-NPs,FT11-TPZP-NPs can accumulate in the hypoxia-aggravated tumors and activate sufficiently to kill tumor *** a single-dose treatment,FT11-TPZP-NPs+CA4-NPs showed a high inhibition rate of 98.1% against CT26 tumor models with an initial volume of ～480 mm3and four out of six tumors were completely eliminated;it thereby exerted a significant antitumor *** study provides a new strategy for improving the therapeutic effect of TPZ and other HAPs in anticancer therapy.

关键词： tirapazamine vascular disrupting agent hypoxia-activated prodrug combretastatin A4 urea

A metal-free coordination–insertion ring-opening polymerization of tetrahydrofuran by the central metalloid bis(pentafluorophenyl)(phenoxy)borane

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Chinese Chemical Letters 2024年第3期35卷 419-422页

作者： cheng Wu Yixuan Liu Chunsheng Xiao chenyang Hu Xuan Pang xuesi chen Key Laboratory of Polymer Ecomaterials Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China School of Applied Chemistry and Engineering University of Science and Technology of ChinaHefei 230026China

A new strategy for the metal-free coordination–insertion ring-opening polymerization of tetrahydrofuran by the central metalloid Boron has been first ***(pentafluorophenyl)(phenoxy)borane was used as a catalyst for the polymerization reaction *** polytetrahydrofuran with high molecular weight and narrow molecular weight distribution could be *** proposed mechanism was studied by MALDI-TOF,ESI-MS and O-18 isotope labeling analyses as a metal-free coordination insertion mechanism.

关键词： Metal-free catalyst Bis(pentafluorophenyl)(phenoxy)borane Coordination–insertion mechanism Ring-opening polymerization Polytetrahydrofuran

Modularized viromimetic polymer nanoparticle vaccines(VPNVaxs) to elicit durable and effective humoral immune responses

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National Science Review 2024年第03期11卷 200-214页

作者： Zichao Huang Xinyu Zhuang Liping Liu Jiayu Zhao Sheng Ma Xinghui Si Zhenyi Zhu Fan Wu Ningyi Jin Mingyao Tian Wantong Song xuesi chen Key Laboratory of Polymer Ecomaterials Changchun Institute of Applied ChemistryChinese Academy of Sciences School of Applied Chemistry and Engineering University of Science and Technology of China Changchun Veterinary Research Institute Chinese Academy of Agricultural Sciences Jilin Biomedical Polymers Engineering Laboratory State Key Laboratory of Polymer Physics and Chemistry Changchun Institute of Applied Chemistry Chinese Academy of Sciences

Virus-like particle(VLP) vaccines had shown great potential during the COVID-19 pandemic, and was thought to be the next generation of antiviral vaccine technology due to viromimetic structures. However,the time-consuming and complicated processes in establishing a current recombinant-protein–based VLP vaccine has limited its quick launch to the out-bursting pandemic. To simplify and optimize VLP vaccine design, we herein report a kind of viromimetic polymer nanoparticle vaccine(VPNVax), with subunit receptor-binding domain(RBD) proteins conjugated to the surface of polyethylene glycol-b-polylactic acid(PEG-b-PLA) nanoparticles for vaccination against SARS-CoV-2. The preparation of VPNVax based on synthetic polymer particle and chemical post-conjugation makes it possible to rapidly replace the antigens and construct matched vaccines at the emergence of different viruses. Using this modular preparation system, we identified that VPNVax with surface protein coverage of 20%–25% had the best immunostimulatory activity, which could keep high levels of specific antibody titers over 5 months and induce virus neutralizing activity when combined with an aluminum adjuvant. Moreover, the polymer nano-vectors could be armed with more immune-adjuvant functions by loading immunostimulant agents or chemical chirality design. This VPNVax platform provides a novel kind of rapidly producing and efficient vaccine against different variants of SARS-CoV-2 as well as other viral pandemics.

关键词： vaccine polymer nanomaterials SARS-CoV-2

Heterocyclic Molecules Tethered Branched Polymers with Innate Immune Stimulating Activity

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CCS Chemistry 2024年第5期6卷 1278-1288页

作者： Jiayu Zhao Liping Liu Yibo Wang Zichao Huang Yu Zhang Ruirui Qiao Thomas P.Davis Zhaohui Tang Wantong Song xuesi chen Key Laboratory of Polymer Ecomaterials Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022 School of Applied Chemistry and Engineering University of Science and Technology of ChinaHefei 230026 Laboratory of Chemical Biology Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022 Jilin Biomedical Polymers Engineering Laboratory Changchun 130022 Australian Institute of Bioengineering and Nanotechnology The University of QueenslandBrisbaneQueensland 4072

We report herein an interesting finding that heterocyclic molecules tethered branched polymers exhibit innate immune stimulating *** we conjugated a series of five-,six-,or seven-membered heterocyclic molecules to branched polyethylenimine(bPEI),over 70%of them could induce the secretion of interferon-β(IFN-β)from murine dendritic and human leukemia monocytic(DC2.4 and THP-1)cells through activating the stimulator of interferon genes(STING)*** further proved that this kind of innate stimulating activity was dependent on the macromolecular architecture as heterocyclic molecules tethered linear PEI(lPEI)or dendritic polyamidoamine(PAMAM)induced no or much less IFN-β***,we prepared a series of poly-L-lysine(PLL)-derivatives with different branches to tether with heterocyclic molecules and proved that this kind of bPEI-like structure was important in en hancing the binding affinity with STING proteins and for exhibiting innate stimulating activity.

关键词： bioactive materials polymers heterocycles branched structure immunity

A low-swelling hydrogel as a multirole sealant for efficient dural defect sealing and prevention of postoperative adhesion

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National Science Review 2024年第06期 294-307页

作者： Xueliang cheng Zhen Zhang Hui Ren Zheng Zou Yu Zhang Yang Qu xuesi chen Jianwu Zhao Chaoliang He CAS Key Laboratory of Polymer Ecomaterials Changchun Institute of Applied ChemistryChinese Academy of Sciences Department of Orthopedics The Second Norman Bethune Hospital of Jilin University School of Applied Chemistry and Engineering University of Science and Technology of China

Dural defects and subsequent complications, including cerebrospinal fluid（CSF） leakage, are common in both spine surgery and neurosurgery, and existing clinical treatments are still unsatisfactory. In this study, a tissue-adhesive and low-swelling hydrogel sealant comprising gelatin and o-phthalaldehyde（OPA）-terminated 4-armed poly（ethylene glycol）(4aPEG-OPA) is developed via the OPA/amine condensation reaction. The hydrogel shows an adhesive strength of 79.9 ± 12.0 k Pa on porcine casing and a burst pressure of 208.0 ± 38.0 cm H2O. The hydrogel exhibits a low swelling ratio at physiological conditions, avoiding nerve compression in the limited spinal and intracranial spaces. In rat and rabbit models of lumbar and cerebral dural defects, the 4aPEG-OPA/gelatin hydrogel achieves excellent performance in dural defect sealing and preventing CSF leakage. Moreover, local inflammation, epidural fibrosis and postoperative adhesion in the defect areas are markedly reduced. Thus, these findings establish the strong potential of the hydrogel sealant for the effective watertight closure of dural defects.

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基于古今医案云平台探讨针刺治疗急性期周围性面瘫的取穴规律

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基层中医药 2024年第9期3卷 95-103页

作者：陈学思白杨甘肃中医药大学针灸推拿学院甘肃兰州730000 庆阳市中医医院针灸推拿科甘肃庆阳745000

目的应用古今医案云平台探讨针刺治疗急性期周围性面瘫(PFP)选穴处方特点规律。方法通过检索中国期刊全文数据库(CNKI)、万方数据库(Wanfang)、维普数据库(VIP)、中国生物医学文献服务系统(SinoMed)4个数据库自建库以来针刺治疗急性期... 详细信息

目的应用古今医案云平台探讨针刺治疗急性期周围性面瘫(PFP)选穴处方特点规律。方法通过检索中国期刊全文数据库(CNKI)、万方数据库(Wanfang)、维普数据库(VIP)、中国生物医学文献服务系统(SinoMed)4个数据库自建库以来针刺治疗急性期PFP的随机对照研究文献,提取数据后建立腧穴处方数据库,采用古今医案云平台(V.2.3.7)进行数据分析。结果纳入文献245篇,统计分析腧穴总个数143个,总频次2 775次,针刺治疗急性期PFP应用频次前5位的腧穴为:地仓、合谷、阳白、颊车、翳风;腧穴归经前5位的为:足阳明胃经、足太阳膀胱经、非十四经脉(经外奇穴)、手少阳三焦经、足少阳胆经;应用频次前5位的穴对为:地仓-阳白、合谷-地仓、颊车-地仓、合谷-阳白、颊车-合谷;相互关系最强的穴位组合为:地仓-阳白、地仓-合谷、地仓-颊车、阳白-合谷、阳白-颊车。结论针刺治疗急性期PFP的腧穴归经以阳经为主,多应用头面部腧穴,临证可以地仓、合谷、阳白、颊车、翳风为主穴,随症加减,以上规律可进一步指导临床用于治疗急性期PFP取穴。

关键词：周围性面瘫针刺时间选穴规律数据挖掘

Bioactive polypeptide hydrogels modified with RGD and N-cadherin mimetic peptide promote chondrogenic differentiation of bone marrow mesenchymal stem cells

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Science China Chemistry 2020年第8期63卷 1100-1111页

作者： Yan Rong Zhen Zhang Chaoliang He xuesi chen Key Laboratory of Polymer Ecomaterials Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China University of Chinese Academy of Sciences Beijing 100039China University of Science and Technology of China Hefei 230026China

Cell-material and cell-cell interactions represent two crucial aspects of the regulation of cell *** the present study,poly(L-glutamic acid)(PLG)hydrogels were prepared by catalyst-free click crosslinking via a strain-promoted azide-alkyne cycloaddition(SPAAC)reaction between azido-grafted PLG(PLG-N3)and azadibenzocyclooctyne-grafted PLG(PLG-ADIBO).The bioactive peptides c(RGDfK)and N-cadherin mimetic peptide(N-Cad)were both conjugated to the PLG hydrogel(denoted PLG+RGD/N-Cad)in order to regulate cell-material and cell-cell *** time and storage modulus of the hydrogels were tunable through variations in the concentration of polypeptide *** hydrogels degraded gradually in the presence of *** viability of bone marrow mesenchymal stem cells(BMSCs)was maintained when cultured with extracts of the hydrogels or encapsulated within the *** was observed within 10 weeks following the subcutaneous injection of hydrogel solution in rats,displaying excellent histocompatibility in *** introduction of RGD into the PLG hydrogel promoted the adhesion of BMSCs onto the ***,when encapsulated within the PLG+RGD/NCad hydrogel,BMSCs secreted cartilage-specific matrix,in addition to chondrogenic gene and protein expression being significantly enhanced in comparison with BMSCs encapsulated in hydrogels without N-Cad *** findings suggest that these biodegradable,bioactive polypeptide hydrogels have great potential for use in 3D cell culture and in cartilage tissue engineering.

关键词： polypeptide hydrogel click crosslinking biofunctionalization 3D cell culture tissue engineering

Recent progress in cationic polymeric gene carriers for cancer therapy

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Science China Chemistry 2017年第3期60卷 319-328页

作者： Caina Xu Huayu Tian xuesi chen Key Laboratory of Polymer Ecomaterials Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022 China

In recent years,various carriers for gene delivery nave been developed for biomedical *** all kinds of gene carriers,cationic polymeric carriers for delivery therapeutic gene as non-viral carriers have received growing interests due to their improved high transfection efficiency with the relative *** particular,the advancement of novel polymeric gene carriers has gained much progress in the development of effective anticancer ***,this review focused on the development of cationic polymeric carriers for cancer therapy,including polyethylenimine(PEI),polyamidoamine(PAMAM) dendrimers,polylysine(PLL),chitosan and modified cationic *** recent progresses in the development of novel polymeric carriers for gene delivery,such as targeted gene carriers,responsive gene carriers and multifunctional gene carriers,were ***,the future perspectives in the development of novel polymeric carriers for delivery gene were presented.

关键词： polymeric gene carriers cancer therapy stimuli-responsive carriers multifunctional gene carriers