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Potassium and calcium channels in different nerve cells act as therapeutic targets in neurological disorders

Neural Regeneration Research 2025年第5期20卷 1258-1276页

作者： Qing Qiu Mengting Yang Danfeng Gong Haiying Liang tingting chen Department of Pharmacology School of PharmacyNantong UniversityNantongJiangsu ProvinceChina Jiangsu Province Key Laboratory of Inflammation and Molecular Drug Target NantongJiangsu ProvinceChina Department of Pharmacy Longyan First Affiliated Hospital of Fujian Medical UniversityLongyanFujian ProvinceChina

The central nervous system, information integration center of the body, is mainly composed of neurons and glial cells. The neuron is one of the most basic and important structural and functional units of the central nervous system, with sensory stimulation and excitation conduction functions. Astrocytes and microglia belong to the glial cell family, which is the main source of cytokines and represents the main defense system of the central nervous system. Nerve cells undergo neurotransmission or gliotransmission, which regulates neuronal activity via the ion channels, receptors, or transporters expressed on nerve cell membranes. Ion channels, composed of large transmembrane proteins, play crucial roles in maintaining nerve cell homeostasis. These channels are also important for control of the membrane potential and in the secretion of neurotransmitters. A variety of cellular functions and life activities, including functional regulation of the central nervous system, the generation and conduction of nerve excitation, the occurrence of receptor potential, heart pulsation, smooth muscle peristalsis, skeletal muscle contraction, and hormone secretion, are closely related to ion channels associated with passive transmembrane transport. Two types of ion channels in the central nervous system, potassium channels and calcium channels, are closely related to various neurological disorders, including Alzheimer's disease, Parkinson's disease, and epilepsy. Accordingly, various drugs that can affect these ion channels have been explored deeply to provide new directions for the treatment of these neurological disorders. In this review, we focus on the functions of potassium and calcium ion channels in different nerve cells and their involvement in neurological disorders such as Parkinson's disease, Alzheimer's disease, depression, epilepsy, autism, and rare disorders. We also describe several clinical drugs that target potassium or calcium channels in nerve cells and could be u

关键词： astrocytes calcium channels central nervous system extracellular ion concentration microglia neurological disorders neurons potassium channels

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The Earliest Translations of Chinese Fiction into English Focus on The General History of China

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学术界 2017年第5期 267-278页

作者： chen tingting School of Foreign Studies Anhui University Hefei Anhui 230601 The Postdoctoral Station Fudan University Shanghai 200433

The first works of Chinese vernacular fiction available in the West were published 1735,when the French Jesuit Jean-Baptiste Du Halde compiled translations of three pieces of Chinese vernacular fiction from Jingu qiguan(Marvels Ancient and Modern).These were later translated into English in The General History of China(1736)edited by John *** three stories are"Lu Dalang gives money to re-unite his family","Zhuangzi bangs a drum and becomes an immortal",and"The bad servant sues his master because of a private grudge".The stories are framed by a dual purpose:they were a means to understand the nature of Chinese society,and they were also a pivot in the changing views of *** moral content of the stories is played out in ambiguous ways,varying between simplistic moral lessons of good and bad rewards for good and bad deeds,and a more amoral tone.

关键词：中国通史今古奇观中国虚构的事实转移

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Resource abstraction and data placement for distributed hybrid memory pool

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Frontiers of Computer Science 2021年第3期15卷 47-57页

作者： tingting chen Haikun LIU Xiaofei LIAO Hai JIN National Engineering Research Center for Big Data Technology and System Services Computing Technology and System Lab/Gluster and Grid Computing LabSchool of Gomputing Science and TechnologyHuazhong University of Science and TechnologyWuhan 430074China

Emerging byte-addressable non-volatile memory(NVM)technologies offer higher density and lower cost than DRAM,at the expense of lower performance and limited write *** have been many studies on hybrid NVM/DRAM memory management in a single physical ***,it is still an open problem on how to manage hybrid memories efficiently in a distributed *** paper proposes Alloy,a memory resource abstraction and data placement strategy for an RDMA-enabled distributed hybrid memory pool(DHMP).Alloy provides simple APIs for applications to utilize DRAM or NVM resource in the DHMP,without being aware of the hardware details of the *** propose a hotness-aware data placement scheme,which combines hot data migration,data replication and write merging together to improve application performance and reduce the cost of *** evaluate Alloy with several micro-benchmark workloads and public benchmark *** results show that Alloy can significantly reduce the DRAM usage in the DHMP by up to 95%,while reducing the total memory access time by up to 57%compared with the state-of-the-art approaches.

关键词： load balance distributed hybrid memory clouds

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Spatial impact of digital finance on carbon productivity

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Geoscience Frontiers 2024年第3期15卷 358-372页

作者： Huaping Sun tingting chen Christoph Nedopil Wang School of Finance and Economics Jiangsu UniversityZhenjiangChina School of Economics and Management University of Science and Technology BeijingBeijingChina Fanhai International School of Finance Fudan UniversityShanghaiChina

Low carbon productivity has been identified as a key direction for China’s future *** an important driving force for economic growth,the question of whether digital finance that is reliant on digital technology can support the development of a low-carbon urban economy remains *** on the carbon productivity measured by panel data from 201 cities for the period 2011-2020,this study applies the spatial Dubin model and threshold regression model to explore the impact of digital finance on carbon productivity,yielding the following key ***,the spatial distribution heterogeneity of carbon productivity in China’s eastern region is higher than that in the western region,and both productivity and digital finance are characterized by high(low)-high(low)dotted spatial ***,digital finance can significantly improve carbon productivity via two transmission channels:the human capital and marketization *** the same time,digital finance exerts a spatial spillover effect on carbon productivity,and rising local digital finance levels will increase carbon productivity in neighboring *** analysis indicates that the spillover effect of digital finance in urban agglomerations and eastern regions is more ***,fixed-asset investment has a positive nonlinear moderating effect on digital finance,thus improving carbon *** the per capita investment in fixed assets does not exceed 682.73 yuan,digital finance exerts only a limit pulling effect on carbon productivity;when it is higher than this value,the pulling effect is intensified.

关键词： Digital finance Carbon productivity Spatial spillover effect Fixed-asset investment Spatial heterogeneity

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Differentiability of Functions on Spheres and Criterions of Convexity

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Wuhan University Journal of Natural Sciences 2022年第4期27卷 273-280页

作者： chen tingting GUO Qi Department of Mathematics Suzhou University of Science and TechnologySuzhou 215009JiangsuChina

Some basic concepts for functions defined on subsets of the unit sphere,such as the s-directional derivative,s-gradient and s-Gateaux and s-Frechet differentiability etc,are introduced and *** concepts are different from the usual ones for functions defined on subsets of Euclidean spaces,however,the results obtained here are very ***,as applications,we provide some criterions of s-convexity for functions defined on unit spheres which are improvements or refinements of some known results.

关键词： spherical convexity spherically convex function Gateaux and Frechet differentiability criterion of convexity

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Ionic current rectification in asymmetric nanofluidic devices

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Chinese Chemical Letters 2020年第9期31卷 2414-2422页

作者： Yue Zhou Xuewei Liao Jing Han tingting chen chen Wang Department of Chemistry School of ScienceChina Pharmaceutical UniversityNanjing 211198China State Key Laboratory of Analytical Chemistry for Life Science School of Chemistry and Chemical EngineeringNanjing UniversityNanjing 210023China Testing&Analysis Center Nanjing Normal UniversityNanjing 210046China School of Chemistry and Chemical Engineering Nantong UniversityNantong 226019China

In recent decades,the properties and behaviors of nanofluidic devices have been widely explored in varied subjects such as engineering,physics,chemistry,and *** the rich properties of nanofluidics,ionic current rectification(ICR) is a unique phenomenon arising from asymmetric nanofluidic devices with electric double layer(EDL) *** ICR property is especially useful in applications including energy conversion,mass separation,sea water purification and *** this review,the ICR property in nanofluidics as well as the underlying mechanism is *** influencing factors concerning to the ICR property are systematically *** asymmetric geometry as well as the charge distribution is in charge of the ICR behavior occurring in nanofluidic *** review is aimed at readers who are interested in the fundamentals of mass transport in nanofluidics in general,as well as those who are willing to apply nanofluidics in various research fields.

关键词： Nanofluidics Ionic current rectification(ICR) Mass transport Electric double layer(EDL)

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A Quantitative Seismic Topographic Effect Prediction Method Based upon BP Neural Network Algorithm and FEM Simulation

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Journal of Earth Science 2024年第4期35卷 1355-1366页

作者： Qifeng Jiang Mianshui Rong Wei Wei tingting chen Shandong Seismic Hazard Prevention Center Shandong Earthquake AgencyJinan250014China Shandong Institute of Earthquake Engineering Jinan250021China Key Laboratory of Urban Security and Disaster Engineering of China Ministry of Education Beijing University of TechnologyBeijing100124China Publicity and Education Center Shandong Earthquake AgencyJinan250014China Shandong Earthquake Station Shandong Earthquake AgencyJinan250014China

Topography can strongly affect ground motion,and studies of the quantification of hill surfaces’topographic effect are relatively *** this paper,a new quantitative seismic topographic effect prediction method based upon the BP neural network algorithm and three-dimensional finite element method(FEM)was *** FEM simulation results were compared with seismic records and the results show that the PGA and response spectra have a tendency to increase with increasing elevation,but the correlation between PGA amplification factors and slope is not obvious for low *** BP neural network models were established for the prediction of amplification factors of PGA and response *** kinds of input variables’combinations which are convenient to achieve are proposed in this paper for the prediction of amplification factors of PGA and response spectra,*** absolute values of prediction errors can be mostly within 0.1 for PGA amplification factors,and they can be mostly within 0.2 for response spectra’s amplification *** input variables’combination can achieve better prediction performance while the other one has better expandability of the predictive ***,the BP models only employ one hidden layer with about a hundred nodes,which makes it efficient for training.

关键词： seismic topographic effect finite element method BP neural network algorithm earthquake disaster prevention

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Enzyme-driven Nanorobots Walking Along Predesigned Tracks on the DNA Origami for Cargo Transport and Catalysis

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Chemical Research in Chinese Universities 2024年第2期40卷 333-342页

作者： NIE Cunpeng MA Tianran chen tingting CHU Xia State Key Laboratory of Chemo/Bio-Sensing and Chemometrics College of Chemistry and Chemical EngineeringHunan UniversityChangsha410082P.R.China

In molecular engineering,designing and synthesizing molecular machines with capable of performing complex tasks,remains a formidable *** is an excellent candidate for building molecular robots because it is highly ***,we present an artificial nanorobot,in which a DNA cube serves as the inert‘body’,and nucleic acid catalysts based on an enzymatic nicking reaction act as the‘legs’for *** nanorobot can execute a series of actions,such as‘start’,‘turn’,and‘stop’when it walks along a predefined *** performance could be confirmed and monitored by using an atomic force microscope(AFM)and fluorescence *** by biological machines,we artificially designed a series of specialized tasks that combined walking with control of cargo transport and ***-time fluorescence kinetics curves provide monitoring signals for cargo transport and catalytic *** work can enrich the toolbox of DNA machinery and has great potential for engineering molecular nanofactories.

关键词： DNA origami DNA nanorobot Controlled cargo transport DNAzyme catalysis

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EXISTENCE AND UNIQUENESS OF THE GLOBAL L^(1) SOLUTION OF THE EULER EQUATIONS FOR CHAPLYGIN GAS

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Acta Mathematica Scientia 2021年第3期41卷 941-958页

作者： tingting chen Aifang QU Zhen WANG School of Mathematics and Physics China University of GeosciencesWuhan 430074China Department of Mathematics Shanghai Normal UniversityShanghai 200234China School of Science Wuhan University of TechnologyWuhan 430070China

In this paper, we establish the global existence and uniqueness of the solution of the Cauchy problem of a one-dimensional compressible isentropic Euler system for a Chaplygin gas with large initial data in the space Lloc1. The hypotheses on the initial data may be the least requirement to ensure the existence of a weak solution in the Lebesgue measurable sense. The novelty and also the essence of the difficulty of the problem lie in the fact that we have neither the requirement on the local boundedness of the density nor that which is bounded away from vacuum. We develop the previous results on this degenerate *** method used is Lagrangian representation, the essence of which is characteristic *** key point is to prove the existence of the Lagrangian representation and the absolute continuity of the potentials constructed with respect to the space and the time *** achieve this by finding a property of the fundamental theorem of calculus for Lebesgue integration, which is a sufficient and necessary condition for judging whether a monotone continuous function is absolutely continuous. The assumptions on the initial data in this paper are believed to also be necessary for ruling out the formation of Dirac singularity of density. The ideas and techniques developed here may be useful for other nonlinear problems involving similar difficulties.

关键词： Compressible Euler equations linearly degenerate fields initial data in Lloc1 space without uniform bounds global well-posedness regularity

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Agronomic performance of drought-resistance rice cultivars grown under alternate wetting and drying irrigation management in southeast China

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The Crop Journal 2018年第5期6卷 482-494页

作者： Guang Chu tingting chen Song chen Chunmei Xu Danying Wang Xiufu Zhang China National Rice Research Institute Chinese Academy of Agricultural Sciences

Compared to drought-susceptible rice cultivars(DSRs),drought-resistance rice cultivars(DRRs)could drastically reduce the amount of irrigation water input and simultaneously result in higher grain yield under water-saving irrigation ***,the mechanisms underlying these properties are *** investigated how improved agronomic traits contribute to higher yield and higher water use efficiency(WUE)in DRRs than in DSRs under alternate wetting and drying(AWD).Two DRRs and two DSRs were field-grown in 2015 and 2016 using two different irrigation regimes:continuous flooding(CF)and *** CF,no statistical differences in grain yield and WUE were observed between DRRs and *** water under the AWD regime was 275–349 mm,an amount 49.8%–56.2% of that(552–620 mm)applied under the CF *** to CF,AWD significantly decreased grain yield in both DRRs and DSRs,with a more significant reduction in DSRs,and WUE was increased in DRRs,but not in DSRs,by 9.9%–23.0% under *** AWD,DRRs showed a 20.2%–26.2% increase in grain yield and an 18.6%–24.5% increase in WUE compared to *** to DSRs,DRRs showed less redundant vegetative growth,greater sink capacity,higher grain filling efficiency,larger root biomass,and deeper root distribution under *** conclude that these improved agronomic traits exert positive influences on WUE in DRRs under AWD.

关键词： Agronomic traits Alternate wetting and drying Drought-resistance rice cultivars Grain yield Water use efficiency

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