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Chromatographic and mass spectroscopic guided discovery of Trichoderma peptaibiotics and their bioactivity

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Engineering Microbiology 2024年第2期4卷 62-76页

作者： Adigo Setargie chen Wang Liwen Zhang Yuquan Xu Biotechnology Research Institute The Chinese Academy of Agricultural Sciences12 Zhongguancun South StreetBeijing 100081China Institute of Biotechnology Bahir Dar UniversityP.O.Box.79Bahir DarEthiopia

Peptaibiotics are linear or cyclic peptide antibiotics characterized by the non-proteinogenic amino acid,alpha-aminoisobutyric *** exhibit a wide range of bioactivity against various *** report presents a comprehensive review of analytical methods for Trichoderma cultivation,production,isolation,screening,pu-rification,and characterization of peptaibiotics,along with their *** techniques are currently available for each step,and we focus on describing the most commonly used and recently developed chromato-graphic and spectroscopic *** peptaibiotics requires efficient culture media,growth con-ditions,and isolation and purification *** combination of chromatographic and spectroscopic tools offers a better opportunity for characterizing and identifying *** evaluation of the chemical and biological properties of this compound has also been explored concerning its potential application in pharma-ceutical and other *** review aims to summarize available data on the techniques and tools used to screen and purify peptaibiotics from Trichoderma fungi and bioactivity against various pathogens.

关键词： Chromatography peptaibiotics spectroscopy Trichoderma

Knowledge Graph Completion Method of Combining Structural Information with Semantic Information

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Chinese Journal of Electronics 2024年

作者： Binhao HU Jianpeng ZHANG Hongchang chen School of Cyber Science and Engineering Zhengzhou University National Digital Switching System Engineering & Technological R&D Center (NDSC)

With the development of knowledge graphs, a series of applications based on knowledge graphs have emerged. The incompleteness of knowledge graphs makes the effect of the downstream applications and affected by the quality of the knowledge graphs. To improve the quality of knowledge graphs, translation-based graph embeddings, such as TransE, learn structural information by rep-resenting triples as low-dimensional dense vectors. However, is difficult to generalize to unseen entities, Entities that are not observed during training but appear during testing. The other methods use the powerful representational ability of pre-trained language models to learn entity descriptions and contextual representation of triples. Although they are robust to incompleteness, but they need to calculate the score of all candidate entities for each triple during inference. We consider combining two models to enhance the robustness of unseen entities by semantic information, and prevent combined explosion by reducing inference overhead through structured information. We use a pre-training language model to code triples and learn the semantic information within them, and then use a hyperbolic space-based distance model to learn structural information and integrate the two types of information together. We evaluate our model by performing link prediction experi-ments in standard datasets. In experiments, our model achieves better performances than state-of-the-art methods on two standard datasets.

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Transcription factor EHF interacting with coactivator AJUBA aggravates malignancy and acts as a therapeutic target for gastroesophageal adenocarcinoma

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Acta Pharmaceutica Sinica B 2024年第5期14卷 2119-2136页

作者： Li Peng Yanyi Jiang Hengxing chen Yongqiang Wang Qiusheng Lan Shuiqin chen Zhanwang Huang Jingyuan Zhang Duanqing Tian Yuntan Qiu Diankui Cai Jiangyun Peng Daning Lu Xiaoqing Yuan Xianzhu Yang Dong Yin Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Guangdong-Hong Kong Joint Laboratory for RNA MedicineSun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China Medical Research Center Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China Hefei Institutes of Physical Science Chinese Academy of SciencesHefei 230031China Department of Gastrointestinal Surgery Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China Department of Hepatobiliary Surgery Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China School of Biomedical Sciences and Engineering South China University of TechnologyGuangzhou International CampusGuangzhou 511442China

Transcriptional dysregulation of genes is a hallmark of tumors and can serve as targets for cancer drug ***,it is extremely challenging to develop small-molecule inhibitors to target abnormally expressed transcription factors(TFs)except for the nuclear receptor family of *** is known about the interaction between TFs and transcription cofactors in gastroesophageal adenocarcinoma(GEA)or the therapeutic effects of targeting TF and transcription cofactor *** this study,we found that ETS homologous factor(EHF)expression is promoted by a core transcriptional regulatory circuitry(CRC),specifically ELF3-KLF5-GATA6,and interference with its expression suppressed the malignant biological behavior of GEA ***,we identified Ajuba LIM protein(AJUBA)as a new coactivator of EHF that cooperatively orchestrates transcriptional network activity in ***,we identified KRAS signaling as a common pathway downstream of EHF and ***,dual targeting of EHF and AJUBA by lipid nanoparticles cooperatively attenuated the malignant biological behaviors of GEA in vitro and in *** conclusion,EHF is upregulated by the CRC and promotes GEA malignancy by interacting with AJUBA through the KRAS *** of both EHF and its coactivator AJUBA through lipid nanoparticles is a novel potential therapeutic strategy.

关键词： EHF AJUBA KRAS pathway Enhancer Core transcriptional regulatory circuitry Gastroesophageal adenocarcinoma Gastric adenocarcinoma Esophageal adenocarcinoma Transcription factor Coactivator Lipid nanoparticles

Tunable polarization holographic gratings obtained by varying the ratio of intensities of the recording beams

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Photonics Research 2024年第4期12卷 749-754页

作者： HONG chen ZIYAO LYU CHANGSHUN WANG State Key Laboratory of Advanced Optical Communication Systems and Networks School of Physics and AstronomyShanghai Jiao Tong UniversityShanghai 200240China State Key Laboratory of Space-Ground Integrated Information Technology Beijing Institute of Satellite Information EngineeringBeijing 100095China

Polarization holography has been extensively applied in many fields, such as optical science, metrology, and biochemistry, due to its property of polarization modulation. However, the modulated polarization state of diffracted light corresponds strictly to that of incident light one by one. Here, a kind of tunable polarization holographic grating has been designed in terms of Jones matrices, and intensity-based polarization manipulation has been realized experimentally. The proposed tunable polarization holographic grating is recorded on an azobenzene liquid-crystalline film by a pair of coherent light beams with orthogonal polarization states and asymmetrically controlled intensities. It is found that the diffracted light can be actively manipulated from linearly to circularly polarized based on the light intensity of the recording holographic field when the polarization state of incident light keeps constant. Our work could enrich the field of light manipulation and holography.

关键词： holographic recording Polarization

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Disentangling the electron-lattice dichotomy of the excitonic insulating phase in TaNi(SeS)with sulfur substitution and potassium deposition

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Science China(Physics,Mechanics & Astronomy) 2024年

作者： Tongrui Li Yang Liu Hongen Zhu Haiping chen Zhanfeng Liu Zhengming Shang Yuliang Li hui Tian Yunbo Wu Yuhao Hong Haihua Luo Yi Liu Guobin Zhang Lidong Zhang Yuqiao Guo Changzheng Wu Li Song Shengtao Cui Zhe Sun National Synchrotron Radiation Laboratory University of Science and Technology of China School of Chemistry and Materials Science University of Science and Technology of China School of Mechanics and Optoelectronic Physics Anhui University of Science and Technology CAS Key Laboratory of Strongly-coupled Quantum Matter Physics University of Science and Technology of China Collaborative Innovation Center of Advanced Microstructures

Ta2NiSe5is a promising candidate for hosting an excitonic insulator （EI） phase,a novel electronic state driven by electron-hole Coulomb ***,the role of electron-lattice coupling in the formation of the EI phase remains ***,we use angle-resolved photoemission spectroscopy （ARPES） to study the band structure evolution of Ta2Ni(Se1-xSx)5with sulfur substitution and potassium deposition,which modulate the band gap and the carrier concentration,*** find that the Ta 5d states originating from the bottom of the conduction band persist at the top of the valence band in the low-temperature monoclinic phase,indicating the importance of exciton condensation in opening the gap in the semi-metallic band *** also observe that the characteristic overlap between the conduction and valence bands can be restored in the monoclinic lattice by mild carrier injection,suggesting that the lattice distortion in the monoclinic phase is not the main factor for producing the insulating gap,but rather the exciton condensation in the electronic system is the dominant driving *** results shed light on the electron-lattice decoupling and the origin of the EI phase in Ta2Ni(Se1-xSx)5.

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6.4级漾濞地震某RC框架及其非结构部件震害分析

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工程力学 2024年第1期41卷 138-148页

作者：陈子峰林旭川陆新征陈辉杨凝周中一中国地震局工程力学研究所地震工程与工程振动重点实验室黑龙江哈尔滨150080 地震灾害防治应急管理部重点实验室黑龙江哈尔滨150080 清华大学土木工程系北京100084

2021年云南漾濞6.4级地震造成了较大范围的建筑破坏,在漾濞县城记录到的地震加速峰值(PGA)高达720.2 gal。在强震作用下,大量土木结构的民居发生了破坏,而约束砌体和钢筋混凝土(RC)结构的震害则相对较轻。现场震害调查发现,部分框架结... 详细信息

2021年云南漾濞6.4级地震造成了较大范围的建筑破坏,在漾濞县城记录到的地震加速峰值(PGA)高达720.2 gal。在强震作用下,大量土木结构的民居发生了破坏,而约束砌体和钢筋混凝土(RC)结构的震害则相对较轻。现场震害调查发现,部分框架结构的震害明显重于同一区域的其他同类型结构,呈现明显、多样的非结构部件破坏特征。因此,该文对某震害较重的框架进行详细调查,分类分析结构及其非结构部件地震破坏细节;依据图纸及现场考察信息建立精细有限元分析模型,对此次地震的地震动破坏力特征以及该框架结构及其非结构部件的地震破坏机理进行了量化分析。分析结果表明:带填充墙框架仿真模型的分析结果与实际震害现象更接近;框架结构局部大空间、框架底部的约束形式和填充墙的布置形式的综合作用导致结构产生局部过大变形与各类非结构部件的严重破坏。在考虑填充墙对框架结构的作用效应后,结构的不规则性大幅增加,导致结构薄弱层的最大层间位移角相较纯框架模型增加127%,并且明显加剧非结构部件的震害。该文对该建筑震害现象的详细调查与仿真分析,可为结构抗震设计与应急救援决策提供参考。

关键词：地震钢筋混凝土框架非结构部件数值仿真现场调查震害机理

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大型集装箱船甲醇燃料舱结构设计

舰船科学技术 2024年第10期46卷 53-58页

作者：陈乐昆谢小龙刘晨霄王维昊中国船舶及海洋工程设计研究院上海200011

针对甲醇作为船舶替代燃料的特点,提出一种适用于大型集装箱船的甲醇燃料舱设计方案,以一艘大型集装箱船为例,采用有限元方法来验证甲醇燃料舱区域的结构强度,同时探讨燃料舱端部节点设计对船体结构强度的影响。为大型集装箱船甲醇燃料... 详细信息

针对甲醇作为船舶替代燃料的特点,提出一种适用于大型集装箱船的甲醇燃料舱设计方案,以一艘大型集装箱船为例,采用有限元方法来验证甲醇燃料舱区域的结构强度,同时探讨燃料舱端部节点设计对船体结构强度的影响。为大型集装箱船甲醇燃料舱的结构设计提供参考。

关键词：大型集装箱船甲醇燃料舱槽型舱壁有限元方法

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Regenerative rehabilitation:a novel multidisciplinary field to maximize patient outcomes

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Medical Review 2024年第5期4卷 413-434页

作者： Chunchu Deng Fatima Aldali Hongmei Luo Hong chen Department of Rehabilitation Medicine Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430030China

Regenerative rehabilitation is a novel and rapidly developing multidisciplinaryﬁeld that converges regenerative medicine and rehabilitation science,aiming to maximize the functions of disabled patients and their *** regenerative medicine provides state-of-the-art technologies that shed light on diﬃcult-to-treated diseases,regenerative rehabilitation offers rehabilitation interventions to improve the positive effects of regenerative ***,regenerative scientists and rehabilitation professionals focus on their aspects without enough exposure to advances in each other’sﬁ*** disconnect has impeded the development of thisﬁ***,this reviewﬁrst introduces cutting-edge tech-nologies such as stem cell technology,tissue engineering,biomaterial science,gene editing,and computer sciences that promote the progress pace of regenerative medicine,followed by a summary of preclinical studies and examples of clinical investigations that integrate rehabilitative methodologies into regenerative ***,challenges in thisﬁeld are discussed,and possible solutions are provided for future *** aim to provide a platform for regenerative and rehabilitative professionals and clinicians in other areas to better understand the progress of regenerative rehabilitation,thus contributing to the clinical translation and management of innovative and reliable therapies.

关键词： regenerative rehabilitation stem cell therapy rehabilitation strategies enhanced motor functions

Advances in Electrostatic Plasma Methods for Purification of Airborne Pathogenic Microbial Aerosols:Mechanism,Modeling and Application

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Environment & Health 2024年第9期2卷 596-617页

作者： Shanlong Tao Yong Zhu Mingxia chen Wenfeng Shangguan Research Center for Combustion and Environmental Technology School of Mechanical EngineeringShanghai Jiao Tong UniversityShanghai 200240PR China School of Mechanical and Power Engineering East China University of Science and TechnologyShanghai 200237PR China

The transmission of pathogenic airborne microorganisms significantly impacts public health and societal *** healthy indoor air quality in public spaces is *** various air purification technologies,electrostatic precipitation and atmospheric pressure nonthermal plasma are notable for their broad-spectrum effectiveness,high efficiency,cost-effectiveness,and *** review investigates the primary mechanisms by which these electrostatic methods collect and disinfect pathogenic *** also delves into recent advancements in enhancing their physical and chemical mechanisms for improve ***,a thorough summary of mathematical models related to the migration and deactivation of pathogenic aerosols in electrostatic purifiers is *** will help us to understand the behavior of aerosols in purification ***,the review discusses the current research on creating a comprehensive health protection system and addresses the challenges of balancing byproduct control with *** aim is to establish a foundation for future research and development in electrostatic aerosol purification and develop integrated air purification technologies that are both efficient and safe.

关键词： electrostatic microbial aerosols inactivation collection air purification