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B-cell lymphoma-2 phosphorylation at Ser70 site-related autophagy mediates puerarin-inhibited the apoptosis of MC3T3-E1 cells during osteoblastogenesis

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Journal of Traditional Chinese Medicine 2024年第1期44卷 27-34页

作者： LI Xi lin Xiangquan chen Dongdong LIU Hui the Third Clinical Medical College Fujian Medical University Department of Orthopedics Fuzhou Second HospitalFuzhou 350007China

OBJECTIVE:To explore the relationship between autophagy and apoptosis regulated by puerarin during ***:In this study,the effects of puerarin on the autophagic activity and apoptosis level of osteoblast precursors(MC3T3-E1 cells)was ***,the roles of puerarin on B-cell lymphoma-2(Bcl-2)phosphorylation at different sites in osteoblast precursors were *** effect of puerarin on the interaction between Bcl-2 and autophagy regulatory molecule or pro-apoptotic molecule was also investigated using Co-immunoprecipitation *** addition,the effect of puerarin on mitochondrial membrane potential of osteoblast precursors was also identified by mitochondrial membrane potential fluorescence probe ***:Our results showed that puerarin can promote the autophagic activity and apoptosis level of *** addition,puerarin promoted Bcl-2phosphorylation at Ser70 site,and the dissociation of Bcl-2-Beclin1 ***,puerarin could enhance the binding of Bcl-2-Bcl-2-Associated X(Bax)complex in MC3T3-E1 ***,puerarin increased the mitochondrial membrane potential of MC3T3-E1 ***:Therefore,puerarin promotes Beclin1into autophagy flux through Bcl-2 phosphorylation at Ser70,thereby enhancing autophagy of osteoblast precursors,which mediates its anti-apoptotic role during ***,the dissociation of Bcl-2-Beclin1 complex is conducive to the binding of Bcl-2-Bax complex,which resists the apoptosis of osteoblast precursors via the increased mitochondrial membrane potential.

关键词： puerarin osteoblasts autophagy apoptosis lymphoma B-cell

Ferroelectric-controlled graphene plasmonic surfaces for all-optical neuromorphic vision

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Science China(Technological Sciences) 2024年第3期67卷 765-773页

作者： chen JianBo LIU Yu LI ShangDong lin lin LI YaDong HUANG Wen GUO JunXiong School of Electronic Information and Electrical Engineering Institute for Advanced StudyChengdu UniversityChengdu 610106China School of Integrated Circuits Tsinghua UniversityBeijing 100084China School of Integrated Circuits(National Exemplary Schoolof Microelectronics) Universityof Electronic Science and Technologyof China Chengdu 610054China Jincheng Research Institute of Opto-mechatronics Industry Jincheng 048000China Shanxi Key Laboratory of Advanced Semiconductor Optoelectronic Devices and Integrated Systems Jincheng 048000China Engineering Research Center of Digital Imaging and Display Ministry of EducationSoochow UniversitySuzhou 215006China

Artificial visual systems can recognize desired objects and information from complex environments, and are therefore highly desired for pattern recognition, object detection, and imaging applications. However, state-of-the-art artificial visual systems with high recognition performances that typically consist of electronic devices face the challenges of requiring huge storage space and high power consumption owing to redundant data. Here, we report a terahertz(THz) frequency-selective surface using a graphene split-ring resonator driven by ferroelectric polarization for efficient visual system applications. The downward polarization of the ferroelectric material offers an ultrahigh electrostatic field for doping p-type graphene with an anticipated Fermi level. By optimizing the geometric parameters of the devices and modulating the carrier behaviors of graphene, our plasmonic devices exhibit a tunable spectral response in a range of 1.7–6.0 THz with continuous transmission values. The alloptical neural network using graphene plasmonic surfaces designed in this study exhibited excellent performance in visual preprocessing and convolutional filtering and achieved an ultrahigh recognition accuracy of up to 99.3% in training the Modified National Institute of Standards and Technology(MNIST) handwritten digit dataset. These features demonstrate the great potential of graphene plasmonic devices for future smart artificial vision systems.

关键词： graphene plasmon ferroelectric frequency selective surface artificial vision system

Precise determination of the pole position of the exotic Z_(c)(3900)

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Science China(Physics,Mechanics & Astronomy) 2024年第9期67卷 84-90页

作者： Yun-Hua chen Meng-lin Du Feng-Kun Guo School of Mathematics and Physics University of Science and Technology BeijingBeijing 100083China School of Physics University of Electronic Science and Technology of ChinaChengdu 611731China CAS Key Laboratory of Theoretical Physics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China School of Physical Sciences University of Chinese Academy of SciencesBeijing 100049China Peng Huanwu Collaborative Center for Research and Education Beihang UniversityBeijing 100191China

We perform a unified description of the experimental data of the π^(+)π^(-)and J/ψπ^(±)invariant mass spectra for e^(+)e^(-)→J/ψπ^(+)π^(-)and the D^(0)D^(*-)mass spectrum for e^(+)e^(-)→D^(0)D^(*-)π^(+)at e^(+)e^(-)center-of-mass energies 4.23 and 4.26 *** analysis takes into account open-charm meson loops that contain triangle singularities,the J/ψπ-DD^(*)coupled-channel interaction respecting unitarity,and the strong ππ-KK final state interaction using dispersion *** analysis leads to a precise determination of the Z_(c)(3900)pole with the pole mass and width(3880.7±1.7_(stat)±22.4_(syst))MeV and(35.9±1.4_(stat)±15.3_(syst))MeV,respectively,and hints at that the DD^(*)molecular and non-molecular components are of similar importance in the Z_(c)(3900)formation.

关键词： exotic hadrons dispersion relations final state interaction triangle singularity

Implications of the Stellar Mass Density of High-z Massive Galaxies from JWST on Warm Dark Matter

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Research in Astronomy and Astrophysics 2024年第1期24卷 128-134页

作者： Hengjie lin Yan Gong Bin Yue Xuelei chen National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Science Center for China Space Station Telescope National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China Department of Physics College of SciencesNortheastern UniversityShenyang 110819China Center for High Energy Physics Peking UniversityBeijing 100871China

A significant excess of the stellar mass density at high redshift has been discovered from the early data release of James Webb Space Telescope(JWST),and it may require a high star formation ***,this will lead to large number density of ionizing photons in the epoch of reionization(EoR),so that the reionization history will be changed,which can arise tension with the current EoR *** dark matter(WDM),via the free streaming effect,can suppress the formation of small-scale structure as well as low-mass *** provides an effective way to decrease the ionizing photons when considering a large star formation efficiency in high-z massive galaxies without altering the cosmic reionization *** the other hand,the constraints on the properties of WDM can be derived from the JWST *** this work,we study WDM as a possible solution to reconcile the JWST stellar mass density of high-z massive galaxies and reionization *** find that,the JWST high-z comoving cumulative stellar mass density alone has no significant preference for either CDM or WDM *** using the observational data of other stellar mass density measurements and reionization history,we obtain that the WDM particle mass with mw=0.51_(-0.12)^(+0.22) keV and star formation efficiency parameter f_(*)^(0)> 0.39 in 2σ confidence level can match both the JWST high-z comoving cumulative stellar mass density and the reionization history.

关键词： Cosmology (cosmology:)dark matter (cosmology:)large-scale structure of universe

Optimal SOC Headroom of Pump Storage Hydropower for Maximizing Joint Revenue from Day-ahead and Real-time Markets Under Regional Transmission Organization Dispatch

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Journal of Modern Power Systems and Clean Energy 2024年第1期12卷 238-250页

作者： Yikui Liu Bing Huang Yang lin Yonghong chen Lei Wu Electrical and Computer Engineering Department Stevens Institute of TechnologyHobokenNJ 07030USA Midcontinent Independent System Operator Inc.CarmelIN 46032USA

In response to the increasing penetration of volatile and uncertain renewable energy,the regional transmission organizations(RTOs)have been recently focusing on enhancing the models of pump storage hydropower(PSH)plants,which are one of the key flexibility assets in the day-ahead(DA)and real-time(RT)markets,to further boost their flexibility provision *** by the recent research works that explored the potential benefits of excluding PSHs’cost-related terms from the objective functions of the DA market clearing model,this paper completes a rolling RT market scheme that is compatible with the DA ***,with the vision that PSHs could be permitted to submit state-of-charge(SOC)headrooms in the DA market and to release them in the RT market,this paper uncovers that PSHs could increase the total revenues from the two markets by optimizing their SOC headrooms,assisted by the proposed tri-level optimal SOC headroom ***,in the proposed tri-level model,the middle and lower levels respectively mimic the DA and RT scheduling processes of PSHs,and the upper level determines the optimal headrooms to be submitted to the RTO for maximizing the total revenue from the two *** case studies quantify the profitability of the optimal SOC headroom submissions as well as the associated financial risks.

关键词： Pump storage hydropower energy market state-of-charge(SOC) headroom market revenue tri-level problem

Rhodium-Catalyzed Asymmetric Transfer Hydrogenation of Heterocyclic Diaryl Ketones:Facile Access to Key Intermediate of Baloxavir

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Chinese Journal of Chemistry 2024年第1期42卷 43-47页

作者： Li Wang Renwei Xiao Jingyuan Song Long-Sheng Zheng Qiwei Lang gen-Qiang chen Xumu Zhang Shenzhen Key Laboratory of Small Molecule Drug Discovery and Synthesis Department of Chemistryand Medi-PingshanSouthern University of Science and TechnologyShenzhenGuangdong 518000China Academy for Advanced Interdisciplinary Studies Southern Universityof Science and TechnologyShenzhenGuangdong 518000China Chemistry and Chemical Engineering Guangdong Laboratory ShantouGuangdong 515031China

Transition metal-catalyzed asymmetric transfer hydrogenation has been proven to be a powerful approach for the synthesis of chiral ***,a highly efficient and enantioselective transfer hydrogenation of dibenzoheptaheterocyclic ketones catalyzed by an arene-tethered TsDPEN-based Rh(ll)catalyst has been successfully developed,and a variety of dibenzoheptaheterocyclic ketones were reduced by a 1/1 mixture of formic acid and DBU(1,8-diazabicyclo[5.4.0]undec-7-ene)with high yields and *** this method,the asymmetric reduction of 7,8-difluorodibenzo[b,e]thiepin-11(6H)-one has been realized,providing the key intermediate of baloxavir marboxil with>99% yield and>99% ee at a substrate/catalyst molar ratio of 1000.

关键词： Asymmetric transfer hydrogenation Baloxavir Chiral alcohol Enantioselectivity Heterocyclic diaryl ketone Rhodium(Ⅱ)

Nonlinear dynamics of a circular curved cantilevered pipe conveying pulsating fluid based on the geometrically exact model

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Applied Mathematics and Mechanics(English Edition) 2024年第2期45卷 261-276页

作者： Runqing CAO Zilong GUO Wei chen Huliang DAI lin WANG Department of Engineering Mechanics School of Aerospace EngineeringHuazhong University of Science and TechnologyWuhan 430074China Hubei Key Laboratory for Engineering Structural Analysis and Safety Assessment Wuhan 430074China State Key Laboratory of Intelligent Manufacturing Equipment and Technology School of Mechanical Science and EngineeringHuazhong University of Science and TechnologyWuhan 430074China

Due to the novel applications of flexible pipes conveying fluid in the field of soft robotics and biomedicine,the investigations on the mechanical responses of the pipes have attracted considerable *** fluid-structure interaction(FSI)between the pipe with a curved shape and the time-varying internal fluid flow brings a great challenge to the revelation of the dynamical behaviors of flexible pipes,especially when the pipe is highly flexible and usually undergoes large *** this work,the geometrically exact model(GEM)for a curved cantilevered pipe conveying pulsating fluid is developed based on the extended Hamilton's *** stability of the curved pipe with three different subtended angles is examined with the consideration of steady fluid *** attention is concentrated on the large-deformation resonance of circular pipes conveying pulsating fluid,which is often encountered in practical *** constructing bifurcation diagrams,oscillating shapes,phase portraits,time traces,and Poincarémaps,the dynamic responses of the curved pipe under various system parameters are *** mean flow velocity of the pulsating fluid is chosen to be either subcritical or *** numerical results show that the curved pipe conveying pulsating fluid can exhibit rich dynamical behaviors,including periodic and quasi-periodic *** is also found that the preferred instability type of a cantilevered curved pipe conveying steady fluid is mainly in the flutter of the second *** a moderate value of the mass ratio,however,a third-mode flutter may occur,which is quite different from that of a straight pipe system.

关键词： curved pipe conveying fluid pulsating fluid geometrically exact model(GEM) nonlinear dynamics parametric vibration flutter

An Innovation of Evaluation and Design of Vehicle Acceleration Sound Based on EEG Signals

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Journal of Bionic Engineering 2024年第1期21卷 344-361页

作者： Liping Xie XinYou lin Wan chen Zhien Liu Yawei Zhu College of Mechanical Engineering&Automation Fuzhou UniversityFuzhou 350108China Hubei Collaborative Innovation Center for Automotive Components Technology Wuhan University of TechnologyWuhan 430070China

There is a bottleneck in the design of vehicle sound that the subjective perception of sound quality that combines multiple psychological factors fails to be accurately and objectively ***,EEG signals are introduced in this paper to investigate the evaluation and design method of vehicle acceleration sound with powerful sound ***,the experiment of EEG acquisition and subjective evaluation under the stimulation of powerful vehicle sounds is conducted,respectively,then three physiological EEG features of PSD_β,PSD_γand DE are constructed to evaluate the vehicle sounds based on the correlation analysis ***,the Adaptive genetic Algorithm(AGA)is proposed to optimize the Elman model,where an intelligent model(AGA–Elman)is constructed to objectively predicate the perception of subjects for the vehicle sounds with powerful sound *** results demonstrate that the error of the constructed AGA–Elman model is only 2.88%,which outperforms than the traditional BP and Elman model;Finally,two vehicle acceleration sounds(Design1 and Design2)are designed based on the constructed AGA–Elman model from the perspective of order modulation and frequency modulation,which provide the acoustic theoretical guidance for the design of vehicle sound incorporating the EEG signals.

关键词： EEG signal Brain activity analysis Vehicle sound design Adaptive genetic algorithm-Elman model

Restraining growth of Zn dendrites by poly dimethyl diallyl ammonium cations in aqueous electrolytes

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Rare Metals 2024年第8期43卷 3735-3747页

作者： Xiang-Xin Zhang Yuan-Qiang chen Chang-Xin lin Yuan-Sheng lin Guo-lin Hu Yong-Chuan Liu Xi-Lai Xue Su-Jing chen Zhan-lin Yang Bai-Sheng Sa Yi-Ning Zhang Key Laboratory of Optoelectronic Materials Chemistry and Physics Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002China Helmholtz Institute Ulm(HIU) 89081 UlmGermany Karlsruhe Institute of Technology(KIT) 76021 KarlsruheGermany College of Materials Science and Engineering Fuzhou UniversityFuzhou350108China

Metallic zinc is an excellent anode material for Zn-ion batteries,but the growth of Zn dendrite severely hinders its practical ***,an efficient and economical cationic additive,poly dimethyl diallyl ammonium(PDDA) was reported,used in aqueous Zn-ion batteries electrolyte for stabilizing Zn *** growth of zinc dendrites can be significantly restrained by benefiting from the pronounced electrostatic shielding effect from PDDA on the Zn metal ***,the PDDA is preferentially absorbed on Zn(002) plane,thus preventing unwanted side reactions on Zn *** to the introduction of a certain amount of PDDA additive into the common ZnSO_(4)-based electrolyte,the cycle life of assembled Zn‖Zn cells(1 mA·cm^(-2) and 1 mAh·cm^(-2)) is prolonged to more than 1100 *** response to the perforation issue of Zn electrodes caused by PDDA additives,the problem can be solved by combining foamy copper with zinc *** real application,Zn-ion hybrid supercapacitors and MnO_(2)‖Zn cells were assembled,which exhibited excellent cycling stability with PDDA *** work provides a new solution and perspective to cope with the dendrite growth problem of Zn anode.

关键词： PDDA Electrostatic shielding effect Zn anode Zn dendrites