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Metabolic reprogramming: a new option for the treatment of spinal cord injury

Neural Regeneration Research 2025年第4期20卷 1042-1057页

作者： Jiangjie chen jinyang chen Chao Yu Kaishun Xia Biao Yang Ronghao Wang Yi Li Kesi Shi Yuang Zhang Haibin Xu Xuesong Zhang Jingkai Wang Qixin chen chengzhen Liang Department of Orthopedics The Second Affiliated Hospital of Zhejiang University School of MedicineHangzhouZhejiang ProvinceChina Orthopedics Research Institute of Zhejiang University Zhejiang UniversityHangzhouZhejiang ProvinceChina Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province HangzhouZhejiang ProvinceChina Clinical Research Center of Motor System Disease of Zhejiang Province HangzhouZhejiang ProvinceChina Qiandongnan Prefecture People’s Hospital KailiGuizhou ProvinceChina Department of Orthopedics Fourth Medical CenterChinese PLA General HospitalBeijingChina

Spinal cord injuries impose a notably economic burden on society,mainly because of the severe after-effects they *** the ongoing development of various therapies for spinal cord injuries,their effectiveness remains ***,a deeper understanding of metabolism has opened up a new therapeutic opportunity in the form of metabolic *** this review,we explore the metabolic changes that occur during spinal cord injuries,their consequences,and the therapeutic tools available for metabolic *** spinal cord metabolism is characterized by independent cellular metabolism and intercellular metabolic ***,spinal cord injury results in metabolic disorders that include disturbances in glucose metabolism,lipid metabolism,and mitochondrial *** metabolic disturbances lead to corresponding pathological changes,including the failure of axonal regeneration,the accumulation of scarring,and the activation of *** rescue spinal cord injury at the metabolic level,potential metabolic reprogramming approaches have emerged,including replenishing metabolic substrates,reconstituting metabolic couplings,and targeting mitochondrial therapies to alter cell *** available evidence suggests that metabolic reprogramming holds great promise as a next-generation approach for the treatment of spinal cord *** further advance the metabolic treatment of the spinal cord injury,future efforts should focus on a deeper understanding of neurometabolism,the development of more advanced metabolomics technologies,and the design of highly effective metabolic interventions.

关键词： axons glycolysis metabolic reprogramming metabolism mitochondria neural regeneration neuroprotection oxidative phosphorylation spinal cord injury therapy

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Track correlation algorithm based on CNN-LSTM for swarm targets

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Journal of Systems Engineering and Electronics 2024年第2期35卷 417-429页

作者： chen jinyang WANG Xuhua chen Xian Research Institute for National Defense Engineering Academy of Military SciencesLuoyang 471023China Information Engineering University Zhengzhou 450001China School of Computer Science and Technology Xidian UniversityXi’an 710071China

The rapid development of unmanned aerial vehicle(UAV) swarm, a new type of aerial threat target, has brought great pressure to the air defense early warning system. At present, most of the track correlation algorithms only use part of the target location, speed, and other information for *** this paper, the artificial neural network method is used to establish the corresponding intelligent track correlation model and method according to the characteristics of swarm ***, a route correlation method based on convolutional neural networks (CNN) and long short-term memory (LSTM)Neural network is designed. In this model, the CNN is used to extract the formation characteristics of UAV swarm and the spatial position characteristics of single UAV track in the formation,while the LSTM is used to extract the time characteristics of UAV swarm. Experimental results show that compared with the traditional algorithms, the algorithm based on CNN-LSTM neural network can make full use of multiple feature information of the target, and has better robustness and accuracy for swarm targets.

关键词： track correlation correlation accuracy rate swarm target convolutional neural network(CNN) long short-term memory(LSTM)neural network

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Recyclable Fenton-like catalyst based on zeolite Y supported ultrafine,highly-dispersed Fe_2O_3 nanoparticles for removal of organics under mild conditions

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Chinese Chemical Letters 2019年第2期30卷 324-330页

作者： Xuanyu Yang Xiaowei cheng Ahmed A.Elzatahry jinyang chen Abdulaziz Alghamdi Yonghui Deng Department of Chemistry State Key Laboratory of Molecular Engineering of Polymers Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials iChEM (Collaborative Innovation Center of Chemistry for Energy Materials) Fudan University Materials Science and Technology Program College of Arts and Sciences Qatar University School of Environmental and Chemical Engineering Shanghai University Department of Chemistry College of Science King Saud University State Key Lab of Transducer Technology Shanghai Institute of Microsystem and Information Technology Chinese Academy of Sciences

A versatile wet impregnation method was employed to conveniently and controllably deposit Fe_2O_3 nanoparticles on zeolites including commercial Y, mordenite and ZSM-5 with the similar framework Si/Al ratios and crystal sizes, respectively. The ultrafine Fe_2O_3 nanoparticles in size of 5 nm can be highly dispersed on zeolite Y matrix due to its much better wettability than ZSM-5 and mordenite. By using the obtained Fe_2O_3/zeolite composite as the heterogeneous Fenton-like catalysts, the degradation of phenol as a model reaction was systematically investigated, including the zeolite supports, particle size and dispersion of Fe_2O_3, and reaction conditions of H_2O_2 concentration, temperature, and pH value. The catalyst based on zeolite Y with Fe loading of 9% exhibited the best phenol degradation efficiency (> 90%)in neutral pH within 2 h. Its high catalytic activity in Fenton reaction can be attributed to the bifunctional properties of strong surface BrФnsted acidity and high reactivity of octahedral Fe^(3+) in the highlydispersed ultrafine Fe_2O_3 nanoparticles in size of 5 nm, which were the primary active centers to quickly decompose H_2O_2 into hydroxyl radicals. Since phenol degradation can be performed under mild conditions of ambient temperature (283-323 K) and a wide pH range (4.0-7.0), the catalysts can be easily recovered for recyclable use with stable degradation activity, which own the immense potential in deep treatment of organic pollutants in industrial wastewater.

关键词： Fenton-like reaction Zeolite Fe2O3 nanoparticles Highly-dispersed Phenol degradation

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A nonchlorinated solvent-processed polymer semiconductor for high-performance ambipolar transistors

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National Science Review 2022年第4期9卷 139-147页

作者： Jie Yang Yaqian Jiang Zhiyuan Zhao Xueli Yang Zheye Zhang jinyang chen Junyu Li Wei Shi Shuai Wang Yunlong Guo Yunqi Liu Beijing National Laboratory for Molecular Sciences Key Laboratory of Organic SolidsInstitute of ChemistryChinese Academy of Sciences School of Chemistry and Chemical Engineering Huazhong University of Science and Technology

Ambipolar polymer semiconductors are potentially serviceable for logic circuits, light-emitting field-effect transistors(LFETs) and polymer solar cells(PSCs). Although several high-performance ambipolar polymers have been developed, their optoelectronic devices are generally processed from toxic chlorinated solvents. To achieve the commercial applications of organic FETs(OFETs), the polymers should be processed from nonchlorinated solvents, instead of chlorinated solvents. However, most conjugated polymers show poor solubility in nonchlorinated solvents. It is of great importance to develop ambipolar polymers that can be processed from nonchlorinated solvents. Here, we develop a nonchlorinated solvent processed polymer named poly[7-fluoro-N, N′-di(4-decyltetradecyl)-7′-azaisoindigo-6′,6′′-(thieno[3,2-b]thiophene-2,5-diyl)-7′′′-fluoro-N′′, N′′′-di(4-decyltetradecyl)-7′′-azaisoindigo-6,6′′′-([2,2′′-bithiophene]-5,5′′-diyl)](PITTI-BT) by designing a monomer with a large molar mass. The polymer displays good solubility in p-xylene(PX). Well-aligned films of PITTI-BT are achieved by an off-center spin-coating(SC) method. Based on the high-quality films, the OFETs fabricated from PX solution achieve record ambipolar performance with hole and electron mobilities of 3.06 and2.81 cm~2 V-1s-1, respectively. The combination of nonchlorinated solvents and good alignment process offers an effective and eco-friendly approach to obtain high-performance ambipolar transistors.

关键词： nonchlorinated solvent high performance ambipolar transistor alignment

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Human hair follicle-derived mesenchymal stem cells promote tendon repair in a rabbit Achilles tendinopathy model

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Chinese Medical Journal 2023年第9期136卷 1089-1097页

作者： Yingyu Ma Zhiwei Lin Xiaoyi chen Xin Zhao Yi Sun Ji Wang Xiaozhou Mou Hai Zou jinyang chen Plastic and Reconstructive Surgery Center Department of Plastic and Reconstructive SurgeryZhejiang Provincial People’s HospitalAffiliated People’s Hospital of Hangzhou Medical CollegeHangzhouZhejiang 310014China Key Laboratory of Gastroenterology of Zhejiang Province Zhejiang Provincial People’s HospitalAffiliated People’s HospitalHangzhou Medical CollegeHangzhouZhejiang 310014China Clinical Research Institute Zhejiang Provincial People’s HospitalAffiliated People’s Hospital of Hangzhou Medical CollegeHangzhouZhejiang 310014China Zhejiang Healthfuture Biomedicine Co. LtdHangzhouZhejiang 310052China Department of Critical Care Fudan University Shanghai Cancer CenterShanghai 200032China Department of Oncology Shanghai Medical CollegeFudan UniversityShanghai 200032China

Background:Hair follicles are easily accessible and contain stem cells with different developmental origins,including mesenchymal stem cells(MSCs),that consequently reveal the potential of human hair follicle(hHF)-derived MSCs in repair and ***,the role of hHF-MSCs in Achilles tendinopathy(AT)remains *** present study investigated the effects of hHF-MSCs on Achilles tendon repair in ***:First,we extracted and characterized ***,a rabbit tendinopathy model was constructed to analyze the ability of hHF-MSCs to promote repair in *** observation and pathological and biomechanical analyses were performed to determine the effect of hHF-MSCs on AT,and quantitative real-time polymerase chain reaction,enzyme-linked immunosorbent assay,and immunohistochemical staining were performed to explore the molecular mechanisms through which hHF-MSCs affects ***,statistical analyses were performed using independent sample t test,one-way analysis of variance(ANOVA),and one-way repeated measures multivariate ANOVA as ***:Flow cytometry,a trilineage-induced differentiation test,confirmed that hHF-derived stem cells were derived from *** effect of hHF-MSCs on AT revealed that the Achilles tendon was anatomically healthy,as well as the maximum load carried by the Achilles tendon and hydroxyproline proteomic levels were ***,collagen I and III were upregulated in rabbit AT treated with hHF-MSCs(compared with AT group;P<0.05).Analysis of the molecular mechanisms revealed that hHF-MSCs promoted collagen fiber regeneration,possibly through Tenascin-C(TNC)upregulation and matrix metalloproteinase(MMP)-9 ***:hHF-MSCs can be a treatment modality to promote AT repair in rabbits by upregulating collagen I and *** analysis revealed that treatment of AT using hHF-MSCs promoted the regeneration of collagen fiber,possibly because of upregulation of TNC and downregulation

关键词： Human hair follicle-derived mesenchymal stem cells Tendinopathy Collagen type I Collagen type III

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实体与程序二元维度构建犯罪论体系的考察--以铃木茂嗣“二元的犯罪论”为中心

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社会科学战线 2021年第9期315卷 201-209页

作者：陈劲阳吉林大学法学院吉林长春130012

日本学者铃木茂嗣在对贝林的构成要件论批判的基础之上,提出二元的犯罪论,既实现刑法学上构成要件向犯罪类型的话语转换,又强调构成要件的概念复归刑事诉讼法范畴。铃木茂嗣将犯罪的评价要件事实与认定要件事实加以区分,立足于实体与程... 详细信息

日本学者铃木茂嗣在对贝林的构成要件论批判的基础之上,提出二元的犯罪论,既实现刑法学上构成要件向犯罪类型的话语转换,又强调构成要件的概念复归刑事诉讼法范畴。铃木茂嗣将犯罪的评价要件事实与认定要件事实加以区分,立足于实体与程序,即刑法学和刑事诉讼法学的二元维度建构犯罪论体系,给人以深刻启示。

关键词：二元的犯罪论铃木茂嗣构成要件贝林体系

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考虑脱空的方钢管混凝土短柱轴压性能有限元分析

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建筑结构学报 2015年第S1期36卷 324-329页

作者：叶勇李威陈锦阳清华大学土木工程系北京100084

采用ABAQUS有限元分析软件,通过合理选用材料本构、单元类型、网格划分和边界条件,建立了考虑核心混凝土均匀脱空的方钢管混凝土短柱的有限元分析模型,并采用试验结果进行验证。利用通过验证的有限元模型对带脱空缺陷的方钢管混凝土短... 详细信息

采用ABAQUS有限元分析软件,通过合理选用材料本构、单元类型、网格划分和边界条件,建立了考虑核心混凝土均匀脱空的方钢管混凝土短柱的有限元分析模型,并采用试验结果进行验证。利用通过验证的有限元模型对带脱空缺陷的方钢管混凝土短柱的轴压性能进行研究,分析带脱空方钢管混凝土短柱的破坏形态、荷载-变形关系、钢管与混凝土的内力分配和界面接触应力,研究脱空对其受力性能的影响。结果表明:当混凝土脱空率小于0.1%时,方钢管混凝土轴压构件的承载力降低值小于5%,脱空的影响较小;当脱空率超过0.4%时,钢管与核心混凝土在构件达到轴压承载力前的相互作用基本不存在,两者分别受力、各自破坏。

关键词：方钢管混凝土短柱脱空有限元分析轴压性能

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融贯性:刑法修订中的实践进阶

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南京社会科学 2021年第12期 91-98页

作者：陈劲阳吉林大学法学院长春130012

自97新刑法实施以来,全国人大常委会先后对其进行了十二次修订。纵观历次刑法修订,我国刑法在不断的修订过程中更加趋于融贯,结构上更富有逻辑,保持罪刑关系设置的协调性、均衡性。遵从反思平衡的思维方式,考察历次刑法修订在促使刑法... 详细信息

自97新刑法实施以来,全国人大常委会先后对其进行了十二次修订。纵观历次刑法修订,我国刑法在不断的修订过程中更加趋于融贯,结构上更富有逻辑,保持罪刑关系设置的协调性、均衡性。遵从反思平衡的思维方式,考察历次刑法修订在促使刑法体系趋向融贯方面所呈现的特点,从诸多方面印证我国刑法体系融贯性的不同侧面:基于相同情况相同处理原则设定罪状、轻重有序兼顾平衡地设置罪刑关系、法律术语表述的协调与统一、法定刑配置的科学化与均衡化、规则的内部呼应与外部衔接趋于合理。

关键词：刑法修订融贯性罪刑关系

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Plasma Kinetic Resection of Prostate Combined Terazosin for Treatment of BPH Patient with Coexisting Hypertension

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Open Journal of Urology 2014年第5期4卷 57-62页

作者： Ming Zheng Mingqiang Zeng Chonghe Jiang jinyang chen Shuren Li Jiaxin Wang Department of Urology Qingyuan City People’s Hospital of Jinan University Qingyuan China Department of Urology Xiangtan Hospital of Nanhua University Xiangtan China

Objective: To evaluate the efficacy and safety of terazosin and plasma kinetic resection of the prostate (PKRP) in the treatment of benign prostatic hyperplasia (BPH) patients with coexisting hypertension. Methods: A total of 205 men who suffered from BPH with concomitant hypertension were enrolled in this study. They all received PKRP surgery and terazosin medication from one week before to 3 months after the operation. The procedures of efficacy and safety were evaluated by analysis of the changes in blood pressures, IPSS, Qmax and the drug related adverse events 4 weeks and 3 months after the operation. Results: The systolic blood pressure decreased from 161 ± 12.33 mmHg at baseline to 148 ± 7.27 mmHg four weeks (P?P?P?P?P?P?

关键词： Benign Prostatic Hyperplasia Hypertension Terazosin Plasma Kinetic Vaporization of the Prostate

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国家工作人员骗取差旅费行为的定性研究

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政治与法律 2021年第11期 52-62页

作者：陈劲阳吉林大学法学院吉林长春130012

对于国家工作人员骗取差旅费行为的定性,我国刑法学界存在贪污说与诈骗说之争。赞成贪污说的观点肯定该行为利用了职务上的便利,但没有论证清楚其所利用的是何种职务上的便利。赞成诈骗说的观点否定该行为利用了职务上的便利,但是该观... 详细信息

对于国家工作人员骗取差旅费行为的定性,我国刑法学界存在贪污说与诈骗说之争。赞成贪污说的观点肯定该行为利用了职务上的便利,但没有论证清楚其所利用的是何种职务上的便利。赞成诈骗说的观点否定该行为利用了职务上的便利,但是该观点混淆了职务犯罪与普通侵财犯罪的教义学界限。贪污罪中“利用职务上的便利”的本质是行使公共权力,国家工作人员骗取差旅费的行为,应定性为贪污罪,其所行使的公共权力是职务消费权,职务消费权属于衍生性的公共权力。

关键词：差旅费贪污罪诈骗罪职务便利职务消费权

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