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Spray and mixing characteristics of liquid jet in a tubular gas-liquid atomization mixer

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Chinese Journal of Chemical Engineering 2021年第6期34卷 1-11页

作者： Lingzhen Kong jiaqing chen Tian Lan Huan Sun Kuisheng Wang School of Mechanical Engineering Beijing Institute of Petrochemical TechnologyBeijing 102617China Beijing Key Laboratory of Pipeline Critical Technology and Equipment for DeepWater Oil&Gas Development Beijing 102617China College of Mechanical and Electrical Engineering Beijing University of Chemical TechnologyBeijing 100029China

For the design and optimization of a tubular gas-liquid atomization mixer,the atomization and mixing characteristics of liquid jet breakup in the limited tube space is a key *** this study,the primary breakup process of liquid jet columnwas analyzed by high-speed camera,then the droplet size and velocity distribution of atomized droplets were measured by Phase-Doppler anemometry(PDA).The hydrodynamic characteristics of gas flow in tubular gas-liquid atomization mixer were analyzed by computational fluid dynamics(CFD)numerical *** results indicate that the liquid flow rate has little effect on the atomization droplet size and atomization pressure drop,and the gas flowrate is themain influence *** all experimental gas flowconditions,the liquid jet column undergoes a primary breakup process,forming larger liquid blocks and *** the gas flow rate(Qg)is less than 127 m^(3)·h^(−1),the secondary breakup of large liquid blocks and droplets does not occur in venturi throat *** Sauter mean diameter(SMD)of droplets measured at the outlet is more than 140μm,and the distribution is *** Qg>127 m^(3)·h^(−1),the large liquid blocks and droplets have secondary breakup process at the throat *** SMD of droplets measured at the outlet is less than 140μm,and the distribution is *** 127

关键词： Atomization mixing Liquid jet Primary breakup Droplet breakup Droplet size

Oil–water pre-separation with a novel axial hydrocyclone

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Chinese Journal of Chemical Engineering 2018年第1期26卷 60-66页

作者： Meili Liu jiaqing chen Xiaolei Cai Yanhe Han Si Xiong Department of Environmental Engineering Beijing Institute of Petrochemical Technology

A novel hydrocyclone with guide vanes, named as axial hydrocyclone(AHC), is designed to tackle the problem of oil–water separation faced by most mature oilfields. Optimal design of the AHC is carried out by using numerical methods. The effects of guide vanes, cone angle, tapered angle and overflow pipe on the oil–water separation are discussed in this paper. The results show that a double swirling flow is generated in the tapered section where oil–water separation occurs. Both the cylindrical and the tapered section have important influences on AHC performance. On the basis of single factor results, response surface methodology is employed to optimize the AHC design. The experimental results indicate that the novel AHC has an excellent performance for the oil–water separation.

关键词： Axial hydrocyclone Oil-water pre-separation Computational fluid dynamicsLow resistance Structure design

Two-Sided Empirical Bayes Test for the Exponential Family with Contaminated Data

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Wuhan University Journal of Natural Sciences 2013年第6期18卷 466-470页

作者： chen jiaqing JIN Qianyu chen Zhiqiang LIU Cihua College of Science Wuhan University of Technology College of Mathematics and Statistics Huazhong University of Science and Technology

In this study, the two-sided Empirical Bayes test （EBT） rules for the parameter of continuous one-parameter exponential family with contaminated data （errors in variables） are constructed by a deconvolution kernel method. The asymptotically optimal uniformly over a class of prior distributions and uniform rates of convergence, which depends on two types of the error distribu- tions for the proposed EBT rules, are obtained under suitable con- ditions. Finally, an example about the main results of this paper is given.

关键词： empirical Bayes test asymptotic optimal conver-gence rate contaminated data

An improved typhoon monitoring model based on precipitable water vapor and pressure

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Geodesy and Geodynamics 2024年第3期15卷 276-290页

作者： Junyu Li Haojie Li Lilong Liu jiaqing chen Yibin Yao Mingyun Hu Liangke Huang Fade chen Tengxu Zhang Lv Zhou College of Geomatics and Geoinformation Guilin University of TechnologyGuilin 541006China Guangxi Key Laboratory of Spatial Information and Geomatics Guilin 541006China Qinzhou Institute of Surveying and Mapping for Housing and Urban-Rural Development Co. Ltd.Qinzhou 535000China School of Geodesy and Geomatics Wuhan UniversityWuhan 430079China School of Resources and Environmental Science and Engineering Hubei University of Science and TechnologyXianning 437100China

The potential of monitoring the movement of typhoons using the precipitable water vapor(PWV) has been confirmed. However, monitoring the movement of typhoon is focused on PWV, making it difficult to describe the movement of a typhoon in detail minutely and resulting in insufficient accuracy. Hence,based on PWV and meteorological data, we propose an improved typhoon monitoring mode. First, the European Centre for Medium-Range Weather Forecasts Reanalysis 5-derived PWV(ERA5-PWV) and the Global Navigation Satellite System-derived PWV(GNSS-PWV) were compared with the reference radiosonde PWV(RS-PWV). Then, using the PWV and atmospheric parameters derived from ERA5, we discussed the anomalous variations of PWV, pressure(P), precipitation, and wind speed during different typhoons. Finally, we compiled a list of critical factors related to typhoon movement, PWV and P. We developed an improved multi-factor typhoon monitoring mode(IMTM) with different models(i.e.,IMTM-I and IMTM-II) in different cases with a higher density of GNSS observation or only Numerical Weather Prediction(NWP) data. The IMTM was evaluated through the reference movement speeds of HATO and Mangkhut from the China Meteorological Observatory Typhoon Network(CMOTN). The results show that the root mean square(RMS) of the IMTM-I is 1.26 km/h based on ERA5-P and ERA5-PWV,and the absolute bias values are mostly within 2 km/h. Compared with the models considering the single factor ERA5-P/ERA5-PWV, the RMS of the IMTM-I is improved by 26.3% and 38.5%, respectively. The IMTM-II model manifests a residual of only 0.35 km/h. Compared with the single-factor model based on GNSS-PWV/P, the residual of the IMTM-II model is reduced by 90.8% and 84.1%, respectively. These results propose that the typhoon movement monitoring approach combining PWV and P has evident advantages over the single-factor model and is expected to supplement traditional typhoon monitoring.

关键词： Typhoon GNSS/ERA5 PWV Pressure Monitoring Improved model

Pharmacometabolomic prediction of individual differences of gastrointestinal toxicity complicating myelosuppression in rats induced by irinotecan

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Acta Pharmaceutica Sinica B 2019年第1期9卷 157-166页

作者： Yiqiao Gao Wei Li jiaqing chen Xu Wang Yingtong Lv Yin Huang Zunjian Zhang Fengguo Xu Key Laboratory of Drug Quality Control and Pharmacovigilance (Ministry of Education) State Key Laboratory of Natural MedicineChina Pharmaceutical University Jiangsu Key Laboratory of Drug Screening China Pharmaceutical University

Pharmacometabolomics has been already successfully used in toxicity prediction for one specific adverse effect. However in clinical practice, two or more different toxicities are always accompanied with each other, which puts forward new challenges for pharmacometabolomics. Gastrointestinal toxicity and myelosuppression are two major adverse effects induced by Irinotecan(CPT-11),and often show large individual differences. In the current study, a pharmacometabolomic study was performed to screen the exclusive biomarkers in predose serums which could predict late-onset diarrhea and myelosuppression of CPT-11 simultaneously. The severity and sensitivity differences in gastrointestinal toxicity and myelosuppression were judged by delayed-onset diarrhea symptoms, histopathology examination, relative cytokines and blood cell counts. Mass spectrometry-based non-targeted and targeted metabolomics were conducted in sequence to dissect metabolite signatures in predose serums. Eventually,two groups of metabolites were screened out as predictors for individual differences in late-onset diarrhea and myelosuppression using binary logistic regression, respectively. This result was compared with existing predictors and validated by another independent external validation set. Our study indicates the prediction of toxicity could be possible upon predose metabolic profile. Pharmacometabolomics can be a potentially useful tool for complicating toxicity prediction. Our findings also provide a new insight into CPT-11 precision medicine.

关键词： Irinotecan Individual differences Complicating toxicity Prediction Metabolomics Gastrointestinal toxicity Biomarkers Diarrhea

Flame Recognition in Video Images with Color and Dynamic Features of Flames

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Journal of Autonomous Intelligence 2019年第1期2卷 30-45页

作者： jiaqing chen Xiaohui Mu Yinglei Song Menghong Yu Bing Zhang School of Electronics and Information Sciences Jiangsu University of Science and TechnologyJiangsuZhenjiang 212003China

Recently,video based flame detection has become an important approach for early detection of fire under complex ***,the detection accuracy of most existing methods remains *** this paper,we develop a new algorithm that can significantly improve the accuracy of flame detection in video *** algorithm segments a video image and obtains areas that may contain flames by combining a two-step clustering based approach with the RGB color model.A few new dynamic and hierarchical features associated with the suspected regions,including the flicker frequency of flames,are then extracted and *** algorithm determines whether a suspected region contains flames or not by processing the color and dynamic features of the area altogether with a classifier,which can be a BP neural network,a k nearest neighbor classifier or a support vector *** results show that this algorithm is robust and efficient,and is able to significantly reduce the probability of false alarms.

关键词： Fire Detection RGB Color Model Dynamic Features Hierarchical Features Feature Fusion

Modified hyaluronic acid hydrogels with chemical groups that facilitate adhesion to host tissues enhance cartilage regeneration

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Bioactive Materials 2021年第6期6卷 1689-1698页

作者： jiaqing chen Jiabei Yang Li Wang Xuewei Zhang Boon Chin Heng Dong-An Wang Zigang Ge Department of Biomedical Engineering College of EngineeringPeking UniversityBeijing100871PR China School of Stomatology Peking UniversityBeijing100081PR China Department of Biomedical Engineering College of EngineeringCity University of Hong KongHong Kong SARPR China

Stable integration of hydrogel implants with host tissues is of critical importance to cartilage tissue *** and fabricating hydrogels with high adhesive strength,stability and regeneration potential are major challenges to be *** study fabricated injectable adhesive hyaluronic acid(HA)hydrogel modified by aldehyde groups and methacrylate(AHAMA)on the polysaccharide backbone with multiple anchoring mechanisms(amide bond through the dynamic Schiff base reaction,hydrogen bond and physical interpenetration).AHAMA hydrogel exhibited significantly improved durability and stability within a humid environment(at least 7 days),together with higher adhesive strength(43 KPa to skin and 52 KPa to glass),as compared to commercial fibrin glue(nearly 10 KPa)and HAMA hydrogel(nearly 20 KPa).The results showed that AHAMA hydrogel was biocompatible and could be easily and rapidly prepared in *** vitro cell culture experiments showed that AHAMA hydrogel could enhance proliferation(1.2-folds after 3 days)and migration(1.5-folds after 12 h)of bone marrow stem cells(BMSCs),as compared to cells cultured in a culture ***,in a rat osteochondral defect model,implanted AHAMA hydrogel significantly promoted integration between neo-cartilage and host tissues,and significantly improved cartilage regeneration(modified O’Driscoll histological scores of 16.0±4.1 and 18.3±4.6 after 4 and 12-weeks of post-implantation in AHAMA groups respectively,12.0±2.7 and 12.2±2.8 respectively in HAMA groups,9.8±2.4 and 11.5±2.1 respectively in untreated groups).Hence,AHAMA hydrogel is a promising adhesive biomaterial for clinical cartilage regeneration and other biomedical applications.

关键词： Cartilage regeneration Hydrogel Adhesion Schiff base reaction Hyaluronic acid Aldehyde