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第十次全国分析毒理学大会暨第六届分析毒理专业委员会会议

作者： Yun Wu Dongyang Nie Xinlei ge Mindong chen Nanjing University of Information Science and Technology

Over the past several years,China has suffered from severe air quality deterioration,especially fine particulate matter(PM) *** PM contains only a small proportion of trace elements(TrElems),due to their no-degradability,high toxicity and high bioaccumulation,the corresponding impacts on human health cannot be *** risk assessment of TrElems in PM has often been estimated based on the total element concentrations or more recently on the phosphate buffered saline(PBS)-soluble ***,PM can be transported into human body through ingestion,dermal contact and inhalation,and we should not ignore the varying solubility of TrElems in different body fluids via different exposure *** this study,the bioaccessibility of particulate-bound TrElems(V,Mn,Co,Ni,Cu,As,Cd and Pb) were investigated using three kinds of simulated body fluids,artificial lung fluid(ALF),artificial sweat(AS),and artificial gastric juice(AGJ),comparing with the commonly used *** all solutions,V,Mn,Cu,As,and Pb presented high bioaccessibility(>60%),while Ni showed low bioaccessibility(～20%) and thus a decreased risk to human health(Table 1).There was also a notable variation in elemental bioaccessibility among different simulated body fluids,which might be attributed to the effects of solution pH,solubility product and chelating *** and non-carcinogenic effects were evaluated using ALF,AS and AGJ-soluble fractions(representing the corresponding exposure routes:inhalation,dermal contact and ingestion) according to the United States Environmental Protection Agency(USEPA) human health risk assessment model(Figure 1).The studied elements in PM appeared to cause non-carcinogenic and carcinogenic effects as indicated by high HIs(>1) and CRs(>1×10-6).Moreover,ingestion pathway was the primary route to increase the potential health risks,and children were more sensitive than adults to PM *** with traditional evaluation methods,an overestim

关键词： fine particulate matter trace elements health risk simulated body fluids

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Numerical and Experimental Investigation of a Serpentine Inlet Constructed with a Polynomial

Numerical and Experimental Investigation of a Serpentine Inl...

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作者： Changjie ge Bin chen Yinhui Shang Rui Han chengdu Aircraft Industrial（Group） Co. Ltd

The investigation of the serpentine inlet is particularly important due to the high stealth requirements of the next generation unmanned aerial vehicle（UAV）.The paper presents a design method of generating a serpentine inlet controlled by a center line which is a *** serpentine inlet is designed considering the positions of the airborne equipment,the stealth and aerodynamic *** study includes numerical simulations based on the Reynolds-averaged Navier-Stokes simulation approach and experiments in wind *** aerodynamic performances of the serpentine inlet at different inflow Mach numbers,mass flow ratios and angles of attack are ***,the flow structures are studied at several critical conditions and the performance and distortion of the designed serpentine inlet are acceptable without any flow control.

关键词： Serpentine inlet UAV Circumferential distortion index Numerical and experimental investigation

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Observer-based event-triggered control for cyber-physical systems under unknown periodic DoS jamming attacks

Observer-based event-triggered control for cyber-physical sy...

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第30届中国控制与决策会议

作者： Songlin Hu Yongfang Gu Xiaoli chen Hui ge Institute of Advanced Technology Nanjing University of Posts and Telecommunications School of Automation Nanjing University of Posts and Telecommunications School of Telecommunications and Information Engineering Nanjing University of Posts and Telecommunications

This paper is concerned with observer-based event-triggered control for cyber-physical systems（CPSs） subject to unknown periodic Denial-of-Service（Do S） jamming attacks, which aim to impede the communication on measurement and control channels. Firstly, in order to limit network resources, a resilient observer-based event-triggering communication scheme is designed under the unknown periodic Do S attacks whose Do S frequency and Do S duration are constrained. Secondly, stability criterion and stabilization conditions of the studied system are obtained by using piecewise Lyapunov functional approach. Based on those conditions, the co-design method of the event-triggering parameters,the controller and observer gains is proposed. Finally, a practical example is employed to verify the effectiveness of the obtained theoretical results.

关键词： Denial-of-service jamming attacks Event-triggered control Observer-based cyber-physical systems Piecewise Lyapunov functional

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Influence of the neck parameter on the fission dynamics within the two-center shell model parametrization

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Chinese Physics C 2022年第12期46卷 217-225页

作者： Li-Le Liu Xi-Zhen Wu Yong-Jing chen Cai-Wan Shen Zhu-Xia Li Zhi-Gang ge Neng-Chuan Shu China Nuclear Data Center China Institute of Atomic EnergyBeijing 102413China School of Science Huzhou UniversityHuzhou 313000China

The influence of the neck parameter on the fission dynamics at low excitation energy is studied based on the three-dimensional Langevin approach,in which the nuclear shape is described with the two-center shell model(TCSM)parametrization,and the elongation,mass asymmetry,and fragment deformation are set to be the generalized coordinates of the Langevin *** first study the influence of the neck parameter on the scission *** find that there is almost no obvious correlation between the neck parameter and mass asymmetryηat the scission point,indicating that has no evident impact on the fragment mass *** elongation Z_(0)=R_(0) and its correlation with the mass asymmetryηat the scission point are clearly influenced by the neck parameter,which has a strong effect on the total kinetic energy(TKE)distribution of the *** pre-neutron emission fragment mass distributions for 14 MeV n+^(233;235;238)U and^(239)Pu are calculated,and then,based on these results,the post-neutron emission fragment mass distributions are obtained by using the experimental data of prompt neutron *** calculated post-neutron emission fragment mass distributions can reproduce the experimental data *** TKE distributions for 14 MeV n+^(235)U fission are calculated for ε=0.25,0.35,and 0.45,and the results show that the TKE distribution cannot be described very well for the three ***,the trend of the calculated TKE distribution withεis just as expected from the scission configuration *** results with ε=0.35 present a better agreement with the experiment data compared with the other two cases.

关键词： nuclear fission two-center shell model fragment mass distribution scission configuration

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Ionic liquid engineering enabled in-plane orientated 1D perovskite nanorods for efficient mixed-dimensional perovskite photovoltaics

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InfoMat 2023年第8期5卷 81-93页

作者： Fei Wang Dawei Duan Kang Zhou YZBXue Xiao Liang Xianfang Zhou Chuangye ge Chao Zhou Jin Xiang Jiajie Zhu Quanyao Zhu Haoran Lin Yumeng Shi Yonghua chen Gang Li Hanlin Hu Hoffmann Institute of Advanced Materials Shenzhen PolytechnicShenzhenthe People's Republic of China State Key Laboratory of Advanced Technology for Materials Synthesis and Processing School of Materials Science and EngineeringWuhan University of TechnologyWuhanthe People's Republic of China Oxford Instruments Technology(Shanghai)Co.Ltd. Shanghaithe People's Republic of China International Collaborative Laboratory of 2D Materials for Optoelectronics Science and Technology of Ministry of Education Institute of Microscale OptoelectronicsShenzhen UniversityShenzhenthe People's Republic of China School of Physics Science and Engineering Tongji UniversityShanghaithe People's Republic of China Key Laboratory of Flexible Electronics(KLoFE)&Institute of Advanced Materials(IAM) School of Flexible Electronics(Future Technologies)Nanjing Tech University(NanjingTech)Nanjingthe People's Republic of China Department of Electronic and Information Engineering Research Institute for Smart Energy(RISE)The Hong Kong Polytechnic UniversityKowloonHong Kongthe People's Republic of China

Mixed-dimensional engineering of perovskite material has been demonstrated as a facile and promising strategy to improve both photovoltaic performance and long-term stability of perovskite solar cells(PSCs).In this study,we report an in-plane preferred orientation of 1D perovskite induced by an ionic liquid(IL)of 1-(3-cyanopropyl)-3-methylimidazolium chloride(CPMIMCl)for the first time via sequential deposition approach,leading to a mixed dimensional perovskite thin *** generated one-dimensional(1D)CPMIMPbI3 with in-plane orientation resides at the grain boundaries of three-dimensional(3D)perovskite can be appreciably observed from the morphology level,leading to creation of high-quality films with large grain size with more efficient defect ***,the dispersion of IL in the bulk phase of perovskite material allows for the formation of 1D perovskite for multiple level passivation to inhibit non-radiative recombination and optimize carrier *** IL engineering strategy not only yields a mixed-dimensional perovskite heterostructure with in-plane orientation 1D perovskite nano-rods but also significantly improves the opto-electronic property with suppressed trap *** a result,the CPMIMCl-treated PSCs show an enhanced photovoltaic performance with a champion power conversion efficiency(PCE)up to 24.13%.More importantly,benefiting from the hydrophobicity of formed 1D perovskite and defects suppression,the corresponding PSC demonstrates an excellent longterm stability and maintain 97.1%of its pristine PCE at 25C under 50%RH condition over 1000 *** research provides an innovative perspective for employing the low dimensional engineering to optimize the performance and stability of photovoltaic devices.

关键词： 1D/3D perovskite ionic liquid perovskite solar cells stability

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盐酸帕罗西汀肠溶缓释片治疗重性抑郁障碍的临床疗效和安全性

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中国临床药理学杂志 2010年第8期26卷 581-585页

作者：王雪芹张鸿燕舒良赵靖平孙学礼马崔高成阁谭庆荣李占江谢世平栗克清杨甫德许秀峰李玲芝黄兰北京大学第六医院北京100191 中南大学湘雅二医院精神卫生研究所长沙410011 四川大学华西医院心理卫生中心成都610041 广州脑科医院广州510370 西安交通大学第一医院精神科西安710061 第四军医大学西京医院西安710032 首都医科大学附属安定医院北京100088 南京脑科医院南京210029 河北省第六人民医院河北保定071000 北京市回龙观医院北京100096 昆明医学院第一附属医院昆明650032

目的评价帕罗西汀肠溶缓释片(抗重性抑郁障碍药)治疗重性抑郁障碍的疗效和安全性。方法用随机双盲对照多中心临床研究方法,帕罗西汀肠溶缓释片组(n=209)25～62.5mg.d-1;帕罗西汀速释片组(n=209)20～50mg.d-1,疗程8周。结果帕罗西汀肠溶... 详细信息

目的评价帕罗西汀肠溶缓释片(抗重性抑郁障碍药)治疗重性抑郁障碍的疗效和安全性。方法用随机双盲对照多中心临床研究方法,帕罗西汀肠溶缓释片组(n=209)25～62.5mg.d-1;帕罗西汀速释片组(n=209)20～50mg.d-1,疗程8周。结果帕罗西汀肠溶缓释片组和速释片组研究终点的HAMD-17评分相对基线分别下降了14.8(7.0)分和15.1(6.7)分,HAMD-17评分相对基线变化的最小二乘方均数(LSmeans)分别为-14.9分和-15.2分,组间差异(0.3分)无统计学意义(P>0.05),组间差异的95%CI(-1.0,1.6)上限小于方案所设定的非劣效界值(2.5),表明帕罗西汀肠溶缓释片治疗重性抑郁障碍非劣效于帕罗西汀速释片。因胃肠道不良事件而暂停试验或提前退出研究的比例,肠溶缓释片组患者低于速释片组(3.4%vs7.3%)。结论治疗中国重性抑郁障碍患者,帕罗西汀肠溶缓释片非劣效于帕罗西汀速释片,安全性相似,肠溶缓释片可能有更好的胃肠道耐受性。

关键词：重性抑郁障碍帕罗西汀肠溶缓释片帕罗西汀速释片

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颗粒粒径对激光喷涂镍涂层碱水电解催化性能的影响

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材料保护 2024年第9期57卷 1-9页

作者：齐昊添葛成杰叶鑫宇桂雄辉张勤号任潞陈秀勇所新坤宁波大学机械工程与力学学院多维增材制造研究所浙江宁波315211

激光喷涂技术是一种新型热喷涂技术,其原理是利用激光作为热源加热粉末,使颗粒达到熔化或半熔化状态,并在基体表面形成涂层。采用激光喷涂技术在镍网表面制备镍涂层,采用扫描电子显微镜(SEM)表征所制备涂层的表面形貌,通过电化学方法表... 详细信息

激光喷涂技术是一种新型热喷涂技术,其原理是利用激光作为热源加热粉末,使颗粒达到熔化或半熔化状态,并在基体表面形成涂层。采用激光喷涂技术在镍网表面制备镍涂层,采用扫描电子显微镜(SEM)表征所制备涂层的表面形貌,通过电化学方法表征电极的析氢反应(HER)和析氧反应(OER)催化活性,研究了镍的颗粒粒径对涂层电解催化性能的影响。结果表明:颗粒粒径会影响颗粒在通过激光时的熔化程度。随着颗粒粒径的减小,所制备的电极表面沉积的颗粒数量增加,在电极表面发现孔洞结构颗粒,同时电极的析氢和析氧过电位下降,双层电容值增加,阻抗降低,表明制备的电极的HER和OER活性提升。平均粒径为45μm粉末所制备的电极在HER和OER中展现出最佳催化活性,当电流密度为10 mA/cm^(2)时,其过电位分别为416 mV和371 mV。本研究为高效率低成本绿色制备碱水电解制氢催化电极提供了一种新方法。

关键词：碱水电解制氢激光喷涂镍涂层颗粒粒径析氢反应析氧反应组织结构

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基于CT能谱成像探讨慢性阻塞性肺疾病与骨质密度相关性

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临床放射学杂志 2024年第7期43卷 1186-1190页

作者：潘红红陈伟彬华北理工大学附属医院唐山063000 天津医科大学肿瘤医院 300202

目的基于CT能谱成像探讨慢性阻塞性肺疾病(COPD)患者的严重程度与其骨质密度的相关性。方法搜集2021年1月至2022年9月行肺功能检查及胸部能谱CT检查的患者共171例。记录肺功能指标一秒率(FEV1/FVC%)及第1秒用力呼气容积占预计值百分比(F... 详细信息

目的基于CT能谱成像探讨慢性阻塞性肺疾病(COPD)患者的严重程度与其骨质密度的相关性。方法搜集2021年1月至2022年9月行肺功能检查及胸部能谱CT检查的患者共171例。记录肺功能指标一秒率(FEV1/FVC%)及第1秒用力呼气容积占预计值百分比(FEV1%pred)。根据COPD诊断指南将患者分为5组,非COPD组(A组)、轻度COPD组(B组)、中度COPD组(C组)、重度COPD组(D组)、极重度COPD组(E组)。利用ge AW4.7后处理工作站测量患者中段胸椎(T_(5~8))的骨密度能谱参数:羟基磷灰石(HAP)(水)、Ca(水)、HAP(脂)、能谱曲线斜率(λ),并得出其中段胸椎平均值。比较5组间骨密度能谱参数的差异性,分析COPD患者肺功能参数与其骨密度能谱参数的相关性。结果5组间HAP(水)、钙(水)、HAP(脂)、λ差异均有统计学意义(P均D组及E组,B组>D组及E组,C组>D组及E组(P均0.6,P均<0.001)。结论COPD患者肺功能受损程度的加重,尤其重度及以上水平,会导致骨质密度减低。

关键词：慢性阻塞性肺疾病 CT能谱成像骨质密度

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Exogenous acid fibroblast growth factor inhibits ischemia-reperfusion-induced damage in intestinal epithelium via regulating P53 and P21WAF-1 expression

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World Journal of Gastroenterology 2005年第44期11卷 6981-6987页

作者： Wei chen Xiao-Bing Fu Shi-Li ge Tong-Zhu Sun Zhi-Yong Sheng Key Research Laboratory of Wound Repair Burns Institute 304^th Clinical Department General Hospital of PLABeijing 100037 China Institute of Radiation Medicine Beijing 100850 China

AIM： To detect the effect of acid fibroblast growth factor （aFGF） on P53 and P21WAF-1 expression in rat intestine after ischemia-reperfusion （I-R） injury in order to explore the protective mechanisms of aFGF. METHODS： Hale rats were randomly divided into four groups, namely intestinal ischemia-reperfusion group （R）, aFGF treatment group （A）, intestinal ischemia group （I）, and sham-operated control group （C）. In group I, the animals were killed after 45 min of superior mesenteric artery （SHA） occlusion. In groups R and A, the rats sustained for 45 min of SHA occlusion and were treated with normal saline （0.15 mL） and aFGF （20 μg/kg, 0.15 mL）, then sustained at various times for up to 48 h after reperfusion. In group C, SHA was separated, but without occlusion. Apoptosis in intestinal villi was determined with terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick-end labeling technique （TUNEL）. Intestinal tissue samples were taken not only for RT- PCR to detect P53 and P21WAF-1 gene expression, but also for immunohistochemical analysis to detect P53 and P21WAF-1 protein expression and distribution. RESULTS： In histopathological study, ameliorated intestinal structures were observed at 2, 6, and 12 h after reperfusion in A group compared to R group. The apoptotic rates were （41.17±3.49）%, （42.83±5.23）%, and （53.33±6.92）% at 2, 6, and 12 h after reperfusion, respectively in A group, which were apparently lower than those in R group at their matched time points （50.67±6.95）%, （54.17±7.86）%, and （64.33±6.47）%, respectively, （P〈0.05））. The protein contents of P53 and P21WAF-1 were both significantly decreased in A group compared to R group （P〈0.05） at 2-12 h after reperfusion, while the mRNA levels of P53 and P21VVAF-1 in A group were obviously lower than those in R group at 6-12 h after reperfusion （P〈0.05）. CONCLUSION： P53 and P21WAF-1 protein accumulations are associated with intestinal barrier injury induced by I-R insult, while intravenous aFGF can all

关键词： Acid fibroblast growth factor Ischemia Reperfusion P53 gene P21WAF-1 gene

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Paleoclimate Modeling in China: A Review

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Advances in Atmospheric Sciences 2015年第2期32卷 250-275页

作者： JIANG Dabang YU ge ZHAO Ping chen Xing LIU Jian LIU Xiaodong WANG Shaowu ZHANG Zhongshi YU Yongqiang LI Yuefeng JIN Liya XU Ying JU Lixia ZHOU Tianjun YAN Xiaodong Nansen Zhu International Research Centre Institute of Atmospheric Physics Chinese Academy of Sciences Climate Change Research Center Chinese Academy of Sciences State Key Laboratory of Lake Science and Environment Nanjing Institute of Geography and LimnologyChinese Academy of Sciences State Key Laboratory of Severe Weather Chinese Academy of Meteorological Sciences School of Atmospheric Sciences Nanjing University Key Laboratory for Virtual geographic Environment of Ministry of Education School of Geography ScienceNanjing Normal University State Key Laboratory of Loess and Quaternary geology Institute of Earth Environment Chinese Academy of Sciences Department of Atmospheric and Oceanic Sciences School of Physics Peking University State Key Laboratory of Numerical Modeling for Atmospheric Sciences and geophysical Fluid Dynamics Institute of Atmospheric Physics Chinese Academy of Sciences China Meteorological Administration Training Center Key Laboratory of Western China’s Environmental Systems Lanzhou University National Climate Center China Meteorological Administration State Key Laboratory of Earth Surface Processes and Resource Ecology Beijing Normal University

This paper provides a review of paleoclimate modeling activities in China. Rather than attempt to cover all topics, we have chosen a few climatic intervals and events judged to be particularly informative to the international community. In historical climate simulations, changes in solar radiation and volcanic activity explain most parts of reconstructions over the last millennium prior to the industrial era, while atmospheric greenhouse gas concentrations play the most important role in the20 th century warming over China. There is a considerable model–data mismatch in the annual and boreal winter temperature change over China during the mid-Holocene [6000 years before present（ka BP）], while coupled models with an interactive ocean generally perform better than atmospheric models. For the Last Glacial Maximum（21 ka BP）, climate models successfully reproduce the surface cooling trend over China but fail to reproduce its magnitude, with a better performance for coupled models. At that time, reconstructed vegetation and western Pacific sea surface temperatures could have significantly affected the East Asian climate, and environmental conditions on the Qinghai–Tibetan Plateau were most likely very different to the present day. During the late Marine Isotope Stage 3（30–40 ka BP）, orbital forcing and Northern Hemisphere glaciation, as well as vegetation change in China, were likely responsible for East Asian climate change. On the tectonic scale,the Qinghai–Tibetan Plateau uplift, the Tethys Sea retreat, and the South China Sea expansion played important roles in the formation of the East Asian monsoon-dominant environment pattern during the late Cenozoic.

关键词： paleoclimate modeling China millennium orbital scale tectonic scale

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