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Final optics damage online inspection in high power laser facility

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Optoelectronics Letters 2019年第4期15卷 306-311页

作者： WEI Fu-peng chen feng-dong TANG Jun PENG Zhi-tao LIU Guo-dong Institute of Optical Measurement and Intellectualization Harbin Institute of Technology Harbin 150001 China Research Center of Laser Fusion China Academy of Engineering Physics Mianyang 621900 China

For the laser-induced damage(LID) in large-aperture final optics, we present a novel approach of damage online inspection and its experimental system, which solves two problems: classification of true and false LID and size measurement of the LID. We first analyze the imaging principle of the experimental system for the true and false damage sites, then use kernel-based extreme learning machine(K-ELM) to distinguish them, and finally propose hierarchical kernel extreme learning machine(HK-ELM) to predict the damage size. The experimental results show that the classification accuracy is higher than 95%, the mean relative error of the predicted LID size is within 10%. So the proposed method meets the technical requirements for the damage online inspection.

关键词： laser-induced damage(LID) kernel-based extreme learning machine(K-ELM) hierarchical kernel extreme learning machine(HK-ELM)

Ephrin-A2 and-A3 are negative regulators of the regenerative potential of Müller cells

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Chinese Medical Journal 2014年第19期127卷 3438-3442页

作者： Zhu Ruilin Cho Kin-Sang chen dong feng Yang Liu Department of Ophthalmology Peking University First Hospital KeyLaboratory of Vision Loss and Restoration Ministry of EducationBeijing China Schepens Eye Research Institute Massachusetts Eye and EarHarvard Medical School Boston MA USA

Background In a previous study, we demonstrated that ephrin-A2 and -A3 negatively regulate the growth of neural progenitor cells in the central nervous system. Adult mice deficient in ephrin-A2 and -A3 （A2＋A3＋） displayed active ongoing neurogenesis throughout the brain, and mice deficient in ephrin-A3 alone showed increased proliferation of ciliary epithelium derived retinal stem cells. This study aimed to detect that the increase in proliferation and neurogenic potential of MOiler cells is influenced by the absence of ephrin-A2 and -A3. Methods We assessed the retinal and MOiler cell expression of ephrin-As and their receptor and neural progenitor cell markers by immunostaining and real-time PCR. We cultured purified primary MOiler cells derived from wild-type and A2＋A3＋ mice in a defined culture medium that enables trans-differentiation of Mu11er cells into retinal neurons. To evaluate proliferating MOiler cells in vivo, we injected 5＇-ethylnyl-2-deoxiuridine （EdU） intraperitoneally to adult mice. Results Expression of ephrin-A2/A3 and their receptor EphA4 were detected in the retinas of adult mice, with EphA4 expression particularly enriched in MOiler cells. MOiler cells of A2＋A3＋ mice exhibited significantly elevated expression of retinal progenitor cell markers, Pax6 and Chx10, when compared with those from wild-type mice. Moreover, a higher percentage of Mu11er cells of A2＋A3＋ mice trans-differentiated and became recoverin＋ and β-Ⅲ-tublin＋ in the culture than those from wild type mice. Strikingly, an increased number of EdU＋ retinal cells was detected in the retinas of adult A2＋A3＋ mice as compared with wild-type mice. Conclusions Ephrin-A2 and -A3 are negative regulators of the proliferative and neurogenic potentials of Mu11er cells. Manipulating ephrin-A signaling may thus represent a novel strategy for stimulating neuroregeneration from endogenous progenitors to participate in retinal repair in case of disease or damage.

关键词： Muller cell stem cell retinal regeneration

Catharmus tinctorius volatile oil promote the migration of mesenchymal stem cells via ROCK2/Myosin light chain signaling

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Chinese Journal of Natural Medicines 2019年第7期17卷 506-516页

作者： LIU Ya-Mei LI Wang-Yang XU Liang-Liang YU Li-Juan LUO Yi-Wen LI Xi-Can ZHANG Xun-Chao XIONG Yun-Pu chen Hong-Tai ZHU Jun-Lang chen chen XIE Yu-Lu chen dong-feng WANG Bin College of Basic Medical Guangzhou University of Chinese Medicine Guangzhou 510006 China Innovative Research & Development Lab. ofTCM Guangzhou University of Chinese Medicine Guangzhou 510006 China The Second Affiliated Hospital of Hunan University of Chinese Medicine Changsha 410208 China The First A ffiliated Hospital of Guangzhou University of Chinese Medicine Lingnan Medical Research Center of Guangzhou University of Chinese Medicine Guangzhou 510000 China Department of Traumatology the Third Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine Guangzhou 510240 China School of Chinese Herbal Medicine Guangzhou University of Chinese Medicine Guangzhou 510006 China Department of Orthopaedics Guangzhou Orthopedic hospital Guangzhou 510030 China Department of Anatomy The Research Center of Basic Integrative Medicine Guangzhou University of Chinese Medicine Guangzhou 510006 China

MSC transplantation has been explored as a new clinical approach to stem cell-based therapies for bone diseases in regenerative medicine due to their osteogenic capability. However, only a small population of implanted MSC could successfully reach the injured areas. Therefore, enhancing MSC migration could be a beneficial strategy to improve the therapeutic potential of cell transplantation. Catharmus tinctorius volatile oil(CTVO) was found to facilitate MSC migration. Further exploration of the underlying molecular mechanism participating in the pro-migratory ability may provide a novel strategy to improve MSC transplantation efficacy. This study indicated that CTVO promotes MSC migration through enhancing ROCK2 mRNA and protein expressions. MSC migration induced by CTVO was blunted by ROCK2 inhibitor, which also decreased myosin light chain(MLC) ***, the si RNA for ROCK2 inhibited the effect of CTVO on MSC migration ability and attenuated MLC phosphorylation,suggesting that CTVO may promote BMSC migration via the ROCK2/MLC signaling. Taken together, this study indicates that *** volatile oil could enhance MSC migration via ROCK2/MLC signaling in vitro. C. tinctorius volatile oil-targeted therapy could be a beneficial strategy to improve the therapeutic potential of cell transplantation for bone diseases in regenerative medicine.

关键词： Catharmus tinctorius Volatile oil MSC Migration ROCK2/MLC signaling

Endolymphatic sac papillary tumor： a case report

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Chinese Medical Journal 2011年第22期124卷 3828-3829页

作者： YU Shun-jiang chen Yi-dong GAO feng QIU Xiao-guang CHANG Hong Department of Radiation Oncology Beijing Shijitan Hospital ＆ Peking University No. 9 Clinical College Beijing 100038 China

Endolymphatic sac papillary tumor （ELST） is an extremely rare and aggressive tumor characterized by hearing loss and temporal bone destruction. A case with clinical, imaging, pathologic and treatment data is reported and relevant literature is reviewed. A 25-year-old woman, with ELST underwent craniotomy for tumor subtotal resection, and the diagnosis was confirmed by pathologic examination. Postoperative radiotherapy consisted of 50.4 Gy/28 f was given accordingly. The patient is currently alive with no signs of tumor recurrence locally and no radiation side-effects observed after one year follow-up. Complete resection is impossible in most cases, local resection, adjuvant radiotherapy may provide favored local control. A long-term follow-up is highly advocated in consideration of its slow development course.

关键词： endolymphatic sac papillary tumor temporal bone surgery radiotherapy

基于特征地图的移动机器人全局定位与自主泊位方法

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电子学报 2010年第6期38卷 1256-1261页

作者：陈凤东洪炳镕哈尔滨工业大学电气工程与自动化学院黑龙江省哈尔滨150001 哈尔滨工业大学计算机科学与技术学院黑龙江省哈尔滨150001

提出一种新的移动机器人全局定位与自主泊位方法.该方法分为两阶段:离线阶段,采用SIFT(Scale In-variant Feature Transform)算法并提出一种基于DD-BBF(Double Direction Best Bin First)的特征匹配方法实现视觉特征三维重建;将进化策... 详细信息

提出一种新的移动机器人全局定位与自主泊位方法.该方法分为两阶段:离线阶段,采用SIFT(Scale In-variant Feature Transform)算法并提出一种基于DD-BBF(Double Direction Best Bin First)的特征匹配方法实现视觉特征三维重建;将进化策略应用于Rao-Blackwellized粒子滤波器,并结合自适应重采样,实现了移动机器人同时定位和特征地图创建.在线阶段,采用基于HMM(Hidden Markov Model)的方法实现全局泊位位置识别;采用RANSAC算法实现全局度量定位;提出极点伺服控制方法,实现机器人精确自主泊位.在室内环境下的实验结果证实了该方法的优良性能.

关键词：移动机器人导航粒子滤波视觉伺服极线几何

Structural and Controllable Thermal Expansion Properties of Sc2-xAlxMo3O12

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Structural and Controllable Thermal Expansion Properties of ...

作者： WU Mei-mei chen dong-feng Department of Nuclear Physics

Materials with controllable thermal expansion are the subject of fundamental studies because of the important applications in high-precision optical mirrors,fiber optic systems,and electronic *** ScAlMoO(x=0.0,0.3,0.7...

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非酒精性脂肪性肝病的流行病学与自然史

中华肝脏病杂志 2008年第11期16卷 804-805页

作者：陈东风第三军医大学大坪医院野战外科研究所消化内科重庆400042

非酒精性脂肪性肝病（NAFLD）发病率不断攀高且起病渐趋低龄化，现已成为发达国家和地区第一大肝病，在我国亦有望成为慢性肝病的首要病因。

关键词：脂肪肝流行病学自然史

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基于动态阈值背景差分算法的目标检测方法

哈尔滨工业大学学报 2005年第7期37卷 883-884,955页

作者：陈凤东洪炳镕哈尔滨工业大学计算机科学与技术学院黑龙江哈尔滨150001

提出了基于动态阈值的背景差分算法、滤波算法和目标区域中心求解算法,并且将这种目标检测方法应用在视觉系统中进行目标检测与跟踪实验,实验结果证明了该目标检测方法的有效性和可靠性.

关键词：背景差分目标检测目标跟踪

Intrinsic determinants of optic nerve regeneration

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Chinese Medical Journal 2013年第13期126卷 2543-2547页

作者： ZHU Rui-lin CHO Kin-Sang GU0 chen-ying CHEW Justin chen dong-feng YANG Liu Department of Ophthalmology Peking University First Hospital Key Laboratory of Vision Loss and Restoration Ministry of Education Beijing 100034 China Schepens Eye Research Institute Massachusetts Eye and Ear Department of Ophthalmology Harvard Medical School Boston MA 02114 United States

Objective To review the functions of these intracellular signals in their regulation of retinal ganglion cell （RGC） axon regeneration. Data sources Relevant articles published in English or Chinese from 1970 to present were selected from PubMed. Searches were made using the terms ＂intrinsic determinants, axon regeneration, RGC, optic nerve regeneration, and central nervous system axon regeneration.＂ Study selection Articles studying the mechanisms controlling RGC and central nervous system （CNS） axon regeneration were reviewed. Articles focusing on the intrinsic determinants of axon regeneration were selected. Results Like other CNS neurons of mammals, RGCs undergo a developmental loss in their ability to grow axons as they mature, which is a critical contributing factor to the failure of nerve regeneration and repair after injury. This growth failure can be attributed, at least in part, by the induction of molecular programs preventing cellular overgrowth and termination of axonal growth upon maturation. Key intracellular signals and transcription factors, including B cell lymphoma/leukemia 2, cyclic adenine monophosphate, mammalian target of rapamycin, and Kr^Jppel-like transcription factors, have been identified to play central roles in this process. Conclusions Intense effort and substantial progress have been made to identify the various intrinsic growth pathways that regulate RGC axon regeneration. More work is needed to elucidate the mechanisms of and the interrelationship between the actions of these factors and to successfully achieve regeneration and repair of the severed RGC axons.

关键词： nerve regeneration retinal ganglion cells, intrinsic determinants cAMP roTOR PTEN, SOCS3