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World Journal of Gastroenterology 2011年第43期17卷 4779-4786页

作者： Gui-Fang Guo Wen-Qi Jiang Bei Zhang Yu-chen cai Rui-hua Xu Xu-Xian chen Fang Wang Liang-Ping Xia State Key Laboratory of Oncology Cancer Center Sun Yat-Sen University Guangzhou 510060 Guangdong Province China

AIM:To investigate the utility of Beclin-1 and LC3,two autophagy-related proteins,in predicting the cetuximab efficacy in advanced colorectal cancer(ACRC) . METHODS:The data of 85 patients with ACRC treated at the Sun Yat-sen University Cancer Center from March 1,2005 to December 31,2008 were studied,including 45 cases treated with cetuximab-containing chemotherapy and 40 cases treated with non-cetuximab-containing ***-1 and LC3 expression was evaluated by immunohistochemistry,and KRAS status was evaluated by polymerase chain reaction. RESULTS:Beclin-1 and LC3 expression in ACRC wassignificantly correlated(r=0.44,P<0.01);however,LC3 was more highly expressed in cancerous tissues than in normal tissues(Z=-2.63,P<0.01) .In the cetuximab-containing chemotherapy group,patients with low LC3 expression had higher objective response rates(ORRs) than those with high LC3 expression(52.9%vs 17.9%,P=0.01) ,and patients with low Beclin-1 expression had a longer median progressionfree survival(PFS) than their counterparts with higher Beclin-1 expression(9.0 mo vs 3.0 mo,P=0.01) . However,neither of these predictive relationships was detected in the group treated with non-cetuximabcontaining *** with wild-type KRAS had higher ORRs(42.3%vs 9.1%,P=0.049) and disease control rates(DCRs)(73.1%vs 36.4%,P= 0.035) ,and longer median PFS(5.5 mo vs 2.5 mo,P= 0.02) than those with mutant KRAS in the cetuximabcontaining chemotherapy *** Beclin-1(P= 0.52) nor LC3(P=0.32) expression was significantly correlated with KRAS status. CONCLUSION:Patients with low Beclin-1 expression had a longer PFS than those with high Beclin-1 expression,and patients with low LC3 expression had a higher ORR in ACRC patients treated with cetuximab-containing chemotherapy.

关键词： Beclin-1 Cetuximab Colorectal neoplasms Drug therapy LC3

Experimental research of stent anastomosis of gastrojejunostomy in a porcine model

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Chinese Medical Journal 2011年第3期124卷 408-412页

作者： cai Xiu-jun YU Yi-chen cai hua-jie WANG Yi-fan Department of General Surgery Sir Run Run Shaw HospitalCollege of Medicine Zhejiang University the Institute of Minimally Invasive Surgery of Zhejiang University HangzhouZhejiang 310016 China

Background Gastrojejunostomy is one of the most frequently used procedures for general surgeons. The creation of anastomosis between various parts of the gastrointestinal tract is a basic technical component and major task in the daily practice of almost all gastrointestinal procedures. This research evaluated a new procedure of making gastrointestinal anastomosis with *** Twenty experimental mini-pigs were randomized into two groups. In stent anastomosis group （SA）, the anastomoses were constructed with a poly-levolactic acid stent. In hand-sewn group （HA）, the anastomoses were performed with a single-layer continuous suture. Abdominal X-ray with intraluminal contrast was performed on the 10th postoperative day. Five pigs of each group were sacrificed on the postoperative days 3 and 14 to determine anastomotic bursting pressure in situ, hydroxyproline concentration, and histopathological evaluation of the anastomotic *** There was no intraoperative morbidity or mortality. The median time needed for the sutured anastomosis was （21.7±2.3） minutes and for the stent anastomosis was （11.9±1.9） minutes （P 〈0.001）. Abdominal X-ray with intraluminal contrast demonstrated normal gas distribution and showed no evidence of leakage or obstruction. Macroscopic appearance at the longitudinal opening of anastomosis was always good in both groups. The median anastomotic bursting pressure was （18.2±1.6） kPa in SA group on postoperative day 3, compared with （11.7±3.2） kPa in HA group （P=0.003）. The anastomotic bursting pressure on day 14 was not significantly different between SA group （（27.1±2.6）kPa） and HA group （（28.3±1.7） kPa）（P=0.388）. The hydroxyproline concentrations were not significantly *** The stent anastomosis was not considered to be more difficult than a sutured anastomosis. This method is proved to be safe and feasible compared with the traditional hand-sewn method in the porcine model. The method increases early anastomotic stre

关键词： stent gastrojejunostomy anastomotic bursting pressure hydroxyproline

近红外透射光谱法检测三组分食用调和油含量的研究

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光谱学与光谱分析 2009年第8期29卷 2099-2102页

作者：刘福莉陈华才中国计量学院光学与电子科技学院浙江省现代计量测试技术及仪器重点实验室浙江杭州310018

以大豆油、花生油和玉米油三组分食用调和油为研究对象,采集样品在10000～4200cm-1范围内的近红外透射光谱,对光谱进行不同预处理后结合偏最小二乘法分别建立调和油中三组分的定量分析模型,并检验模型预测的准确度和精密度。结果显示,... 详细信息

以大豆油、花生油和玉米油三组分食用调和油为研究对象,采集样品在10000～4200cm-1范围内的近红外透射光谱,对光谱进行不同预处理后结合偏最小二乘法分别建立调和油中三组分的定量分析模型,并检验模型预测的准确度和精密度。结果显示,一阶导数结合多元散射校正(FD+MSC),一阶导数结合减去一条直线(FD+SLS)以及一阶导数(FD)进行光谱预处理,可以得到大豆油、花生油以及玉米油含量的最优定标模型,分别是在5450.1～4597.7cm-1,7521.3～6098.1cm-1和9993.7～7498.2cm-1谱区范围内获得的。各预测模型的相关系数R2和预测均方根RMSEP分别为99.89%,1.09%;99.88%,1.17%;99.76%,1.48%;配对t检验值在0.3719～0.0079之间;预测相对标准偏差RSD均小于1.50%。表明傅里叶变换近红外透射光谱分析技术可以快速准确可靠地检测三组分食用调和油中大豆油、花生油、玉米油的含量。

关键词：近红外光谱食用调和油偏最小二乘法透射光谱定量分析模型

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近红外光谱温度修正定量分析模型的研究

光谱学与光谱分析 2005年第6期25卷 890-893页

作者：张军陈华才陈星旦中国科学院长春光学精密机械与物理研究所应用光学国家重点实验室吉林长春130022

以小麦粉末样品为实验材料,研究了环境温度对近红外光谱定量分析结果的影响。将环境温度作为外部变量,使用不同温度下的4 5个样品建立了测定小麦蛋白质含量的温度修正模型,预测不同温度下的小麦样品的蛋白质含量,结果同以2 2℃恒温下4 ... 详细信息

以小麦粉末样品为实验材料,研究了环境温度对近红外光谱定量分析结果的影响。将环境温度作为外部变量,使用不同温度下的4 5个样品建立了测定小麦蛋白质含量的温度修正模型,预测不同温度下的小麦样品的蛋白质含量,结果同以2 2℃恒温下4 5个样品建立的模型进行了比较。分析结果表明:温度修正模型的预测标准差(SEP)平均为0 333,而恒温模型(2 2℃)的预测标准差随着环境温度与建模时温度差的增大而增大,当环境温度4℃时,SEP =0 6 0 16。温度修正模型可以有效的提高近红外光谱定量分析精度。

关键词：近红外光谱温度修正模型定量分析

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过度自信委托代理人间的薪酬合同研究

系统工程理论与实践 2014年第6期34卷 1379-1387页

作者：李娟郝忠原陈彩华南京大学工程管理学院南京210093

委托-代理模型中,委托人委托代理人销售产品并付给代理人一定的报酬.委托人和代理人对随机需求的均值或方差的估计存在误差,由此产生绝对过度自信和相对过度自信.委托人可提供的薪酬合同有两种:线性合同和阈值合同.在委托人和代理人持... 详细信息

委托-代理模型中,委托人委托代理人销售产品并付给代理人一定的报酬.委托人和代理人对随机需求的均值或方差的估计存在误差,由此产生绝对过度自信和相对过度自信.委托人可提供的薪酬合同有两种:线性合同和阈值合同.在委托人和代理人持有的不同自信度组合中,分别给出了线性合同和阈值合同下的最优参数.研究得出:对委托人而言,当且仅当其关于不确定性需求方差的信念较代理人悲观,并且对市场需求位于零点附近的可能性的估计较代理人小时,阈值合同优于线性合同;否则,在线性合同和阈值合同下,委托人的均衡期望收益相等.

关键词：委托代理过度自信线性合同阈值合同

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昆虫寄主标记信息素

生态学报 2005年第2期25卷 346-350页

作者：陈华才程家安中国计量学院生命科学学院杭州310018 浙江大学应用昆虫学研究所杭州310029

综述了昆虫寄主标记信息素的研究进展。昆虫寄主标记信息素是指由昆虫产生的用来标记寄主上有同种个体存在的化学物质。昆虫寄主标记信息素的主要生态学功能是调节昆虫的产卵行为 ,通过阻止自身或同种其它个体对已标记寄主的产卵选择 ,... 详细信息

综述了昆虫寄主标记信息素的研究进展。昆虫寄主标记信息素是指由昆虫产生的用来标记寄主上有同种个体存在的化学物质。昆虫寄主标记信息素的主要生态学功能是调节昆虫的产卵行为 ,通过阻止自身或同种其它个体对已标记寄主的产卵选择 ,或减少产卵量来减少后代之间对寄主资源的竞争。寄主标记信息素也会给释放着带来不利的影响 ,如信息盗用和盗寄生现象等。昆虫寄主标记信息素也调节昆虫近缘种之间对共同寄主资源的竞争。近缘种昆虫对相互寄主标记信息素识别能力的差异反映了不同昆虫对同一寄主资源竞争能力的强弱。寄主标记信息素产生和贮存的部位一般与外分泌腺、消化系统或生殖系统相联系 ,杜氏腺、毒腺、前胸腺、腹腺、下唇腺、后产卵管、卵巢、中肠和后肠等是产生或贮存寄主标记信息素的常见部位。产生的寄主标记信息素一般在成虫产卵时由产卵器、口器或排泄口释放到寄主体内或体表。卵寄生蜂的寄主标记信息素一般标记在寄主的体表 ,雌成蜂用触角检测 ;其它寄生蜂的寄主标记信息素常产在寄主体内 ,用产卵器检测 ;植食性昆虫的寄主标记信息素只产在寄主表面 ,用触角或产卵器检测。昆虫的产卵器、口器、触角或跗节上着生有感受寄主标记信息素的化感器 ,可以检测到标记在寄主体内或体表的寄主标记信息?

关键词：昆虫寄主标记标记信息素产卵行为

Prophylaxis of hepatitis B recurrence in post-liver transplantation patients with lamivudine-resistant YMDD mutant

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Chinese Medical Journal 2007年第16期120卷 1400-1403页

作者： ZHANG Qi cai Chang-jie LU Ming-qiang LI Xi JIANG Nan JIANG hua XU Chi LI hua WANG Gen-shu YI Shu-hong ZHANG Jian ZHANG Jun-feng YI Hui-min ZHANG Ying-cai chen Gui-hua Liver Transplant Center Third Affiliated Hospital of Sun Yat-sen University Transplantation Research Institute of Sun Yat-sen University Guangzhou 510630 China

Background The most frequently used therapy for post-transplantation recurrence of hepatitis B virus （HBV） infection is lamivudine, but this drug is associated with a high resistance rate due to YMDD mutant. In preliminary reports, adefovir dipivoxil （ADV） has been shown to have activity against lamivudine-resistant strains of HBV. However, clinical experience in treatment of HBV infection after liver transplantation （LT） is still not entirely clear. This study was aimed to evaluate the prophylactic efficacy of ADV plus hepatitis B immunoglobulin （HBIG） in patients with YMDD mutant before LT. Methods From March 2004 to March 2006, 16 patients with chronic hepatitis B had lamivudine-resistant YMDD mutants detected prior to liver transplantation and received treatment with ADV plus additional intramuscular HBIG after LT as prophylaxis against graft reinfection. Tests for liver function, serum HBsAg, anti-HBs （HBIG）, HBeAg, anti-HBc, anti-HBe, HBV-DNA, and creatinine were assessed pre- or post-liver transplantation. Results The median follow-up of these patients post-liver transplantation was 19.4 months. Fifteen patients survived and one patient died of recurrence of hepatocellular carcinoma （HCC）. There was significant difference （10.98% vs. 2.26%, P〈0.05） in YMDD mutant rate between the patients with HBV-DNA over 106 copies/ml and those with HBV-DNA less than 106 copies/mi. Fifteen patients （93.8%） had undetectable HBV-DNA at 4 weeks and 1 （6.3%） at 6 months after LT. No hepatitis B recurrence was detected by persistent testing of HBsAg, HBeAg, and HBV-DNA and no increase of serum creatinine level associated with ADV was observed in any of the patients. Conclusion ADV combined with intramuscular HBIG can effectively prevent patients with pre-transplantation YMDD mutant from HBV recurrence after LT.

关键词： liver transplantation adefovir dipivoxil YMDD mutant HBV recurrence

基于语音、表情与姿态的三模态普通话情感识别

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控制工程 2020年第11期27卷 2023-2029页

作者：陈彩华湖南广播电视大学信息学院湖南长沙410004

为了克服单模态普通话情感识别效率低、可靠性差的问题,对情感识别非常重要的语音、表情与姿态三个模态进行特征层融合,提出普通话三模态情感识别方法。首先从语音声学、面部表情和运动姿态中分别提取不同的情感特征,然后采用改进的遗... 详细信息

为了克服单模态普通话情感识别效率低、可靠性差的问题,对情感识别非常重要的语音、表情与姿态三个模态进行特征层融合,提出普通话三模态情感识别方法。首先从语音声学、面部表情和运动姿态中分别提取不同的情感特征,然后采用改进的遗传算法IAGA进行三模态情感特征融合,最后利用SVM分类器构建预测模型并完成情感识别。将三模态融合方法在CHEAVD中文多模态情感数据集进行测试,并和传统的单模态、双模态情感识别进行对比,实验结果表明,双模态融合的情感识别率要高于单模态,三模态融合的情感识别率高于双模态,验证了普通话三模态情感识别方法的有效性。

关键词：三模态普通话情感识别 IAGA SVM

Influence of polymer additives on turbulent energy cascading in forced homogeneous isotropic turbulence studied by direct numerical simulations

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Chinese Physics B 2012年第11期21卷 306-320页

作者：李凤臣蔡伟华张红娜王悦 School of Energy Science and Engineering Harbin Institute of Technology

Direct numerical simulations （DNS） were performed for the forced homogeneous isotropic turbulence （FHIT） with/without polymer additives in order to elaborate the characteristics of the turbulent energy cascading influenced by drag-reducing effects. The finite elastic non-linear extensibility-Peterlin model （FENE-P） was used as the conformation tensor equation for the viscoelastic polymer solution. Detailed analyses of DNS data were carried out in this paper for the turbulence scaling law and the topological dynamics of FHIT as well as the important turbulent parameters, including turbulent kinetic energy spectra, enstrophy and strain, velocity structure function, small-scale intermittency, etc. A natural and straightforward definition for the drag reduction rate was also proposed for the drag-reducing FHIT based on the decrease degree of the turbulent kinetic energy. It was found that the turbulent energy cascading in the FHIT was greatly modified by the drag-reducing polymer additives. The enstrophy and the strain fields in the FH1T of the polymer solution were remarkably weakened as compared with their Newtonian counterparts. The small-scale vortices and the small-scale intermittency were all inhibited by the viscoelastic effects in the FHIT of the polymer solution. However, the scaling law in a fashion of extended self-similarity for the FHIT of the polymer solution, within the presently simulated range of Weissenberg numbers, had no distinct differences compared with that of the Newtonian fluid case.

关键词： forced homogenous isotropic turbulence polymer additives turbulent energy cascading drag reduction