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Solvent-Free Manufacturing of lithium-Ion Battery Electrodes via Cold Plasma

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Energy & Environmental Materials 2024年第1期7卷 28-33页

作者： Zhiming liang Tianyi li Holden Chi Joseph Ziegelbauer Kai Sun ming Wang wei zhang Tuo liu Yang-Tse cheng zonghai chen Xiaohong Gayden Chunmei Ban Paul M.Rady Department of Mechanical Engineering University of Colorado BoulderBoulder CO 80309USA Advanced Photon Source Argonne National LaboratoryLemont IL 60439USA Intecells Inc. Southfield MI 48084USA Department of Materials Science and Engineering Michigan Center for Materials CharacterizationUniversity of MichiganAnn Arbor MI 48109USA Department of Chemical and Materials Engineering University of KentuckyLexington KY 40506USA Department of Chemistry University of KentuckyLexington KY 40506USA Chemical Sciences and Engineering Division Argonne National LaboratoryLemont IL 60439USA

Slurry casting has been used to fabricate lithium-ion battery electrodes for decades,which involves toxic and expensive organic solvents followed by high-cost vacuum drying and electrode *** work presents a new manufacturing method using a nonthermal plasma to create inter-particle binding without using any polymeric binding materials,enabling solvent-free manufacturing electrodes with any electrochemistry of *** cold-plasma-coating technique enables fabricating electrodes with thickness(>200 pm),high mass loading(>30 mg cm^(-2)),high peel strength,and the ability to print lithium-ion batteries in an arbitrary *** crosscutting,chemistry agnostic,platform technology would increase energy density,eliminate the use of solvents,vacuum drying,and calendering processes during production,and reduce manufacturing cost for current and future cell ***,lithium iron phosphate and lithium cobalt oxide were used as examples to demonstrate the efficacy of the cold-plasma-coating *** is found that the mechanical peel strength of cold-plasma-coating-manufactured lithium iron phosphate is over an order of magnitude higher than that of slurry-casted lithium iron phosphate *** cells assembled with a graphite anode and the cold-plasma-coating-lithium iron phosphate cathode offer highly reversible cycling performance with a capacity retention of 81.6%over 500 *** the highly conductive cathode material lithium cobalt oxide,an areal capacity of 4.2 mAh cm^(-2)at 0.2 C is *** anticipate that this new,highly scalable manufacturing technique will redefine global lithium-ion battery manufacturing providing significantly reduced plant footprints and material costs.

关键词： cold plasma deposition lithium-ion battery solvent-free manufacturing

Allele-defined genome reveals biallelic differentiation during cassava evolution

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Molecular Plant 2021年第6期14卷 851-854页

作者： wei Hu Changmian Ji haitao shi Zhe liang Zehong Ding Jianqiu Ye Wenjun Ou Gang Zhou weiwei Tie Yan Yan Jinghao Yang Xiaoying Yang Yunxie wei Zhiqiang Jin Jianghui Xie ming Peng Wenquan Wang Anping Guo Biyu Xu Jianchun Guo Songbi chen liming Ma mingcheng Wang Yang Zhou Xiaolong li Ruoxi li Siyi Guo Xinhui Xiao Zhongqing Wan Feifei An Jie zhang Qingyun Leng Yin li Ray ming Kaimian li Sanya Research Institute of Chinese Academy of Tropical Agricultural Sciences SanyaHainanChina Hainan Key Laboratory for Biosafety Monitoring and Molecular Breeding in Off-Season Reproduction Regions Key Laboratory of Biology and Genetic Resources of Tropical CropsInstitute of Tropical Bioscience and BiotechnologyChinese Academy of Tropical Agricultural SciencesHaikouHainanChina Hainan Key Laboratory for Protection and Utilization of Tropical Bioresources Hainan Institute for Tropical Agricultural ResourcesChinese Academy of Tropical Agricultural SciencesHaikouHainanChina Biomarker Technologies Corporation BeijingChina Hainan Key Laboratory for Sustainable Utilization of Tropical Bioresources College of Tropical CropsHainan UniversityHaikouHainanChina Biotechnology Research Institute Chinese Academy of Agricultural SciencesBeijingChina Tropical Crops Genetic Resources Institute Chinese Academy of Tropical Agricultural SciencesHaikouHainanChina College of Food Science and Technology Qilu University of Technology(Shandong Academy of Sciences)JinanChina Fu Foundation School of Engineering and Applied Science Columbia UniversityNew YorkUSA State Key Laboratory of Crop Stress Adaptation and Improvement School of Life SciencesHenan UniversityKaifengChina The Genetic Engineering International Cooperation Base of Chinese Ministry of Science and Technology the Key Laboratory of Molecular Biophysics of Chinese Ministry of EducationCollege of Life Science and TechnologyHuazhong University of Science&TechnologyWuhanChina FAFU and UIUC-SIB Joint Center for Genomics and Biotechnology Fujian Provincial Key Laboratory of Haixia Applied Plant Systems BiologyKey Laboratory of GeneticsBreeding and Multiple Utilization of CropsMinistry of EducationFujian Agriculture and Forestry UniversityFuzhouChina Department of Plant Biology University of Illinois at Urbana-ChampaignUrbanaILUSA

Dear Editor,Generation of heterozygous genomes by hybridization between or within species can help maintain plant diversity and serve as a potential source of new species(Baek et al.,2018).Moreover,genomic heterozygosity is associated with genomic coadaptation,developmental stability,and *** definition of alleles in haplotypes is necessary to precisely characterize allelic variation controlling agriculturally important traits(Shi et al.,2019).Currently,most released genomes have mosaic assembly of haplotypes due to random selection or collapse of alleles during genome assembly(Shi et al.,2019),which masked allelic variation and functional differentiation of divergent alleles in heterozygous species.

关键词： maintain evolution assembly

High-throughput screening of SARS-CoV-2 main and papain-like protease inhibitors

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Protein & Cell 2023年第1期14卷 17-27页

作者： Yi Zang mingbo Su Qingxing Wang Xi cheng Wenru zhang Yao Zhao Tong chen Yingyan Jiang Qiang Shen Juan Du Qiuxiang Tan Peipei Wang lixin Gao Zhenming Jin Mengmeng zhang Cong li Ya Zhu Bo Feng Bixi Tang Han Xie ming-wei Wang mingyue Zheng Xiaoyan Pan haitao Yang Yechun Xu Beili Wu Leike zhang Zihe Rao Xiuna Yang Hualiang Jiang Gengfu Xiao Qiang Zhao Jia li The National Center for Drug Screening Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China State Key Laboratory of Drug Research and CAS Key Laboratory of Receptor Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China School of Pharmaceutical Science and Technology Hangzhou Institute for Advanced StudyUCASHangzhou 310024China School of Chinese Materia Medica Nanjing University of Chinese MedicineNanjing 210023China University of Chinese Academy of Sciences Beijing 100049China State Key Laboratory of Virology Wuhan Institute of VirologyCenter for Biosafety Mega-ScienceChinese Academy of SciencesWuhan 430071China Shanghai Institute for Advanced Immunochemical Studies and School of life Science and Technology ShanghaiTech UniversityShanghai 201210China CAS Center for Excellence in Biomacromolecules Chinese Academy of SciencesBeijing 100101China Zhongshan Branch the Institute of Drug Discovery and DevelopmentChinese Academy of SciencesGuangdong 528400China

The global COVID-19 coronavirus pandemic has infected over 109 million people,leading to over 2 million deaths up to date and still lacking of effective drugs for patient ***,we screened about 1.8 million small molecules against the main protease(M^(pro))and papain like protease(PL^(pro)),two major proteases in severe acute respiratory syndrome-coronavirus 2 genome,and identified 1851M^(pro)inhibitors and 205 PL^(pro)inhibitors with low nmol/l activity of the best *** these inhibitors,eight small molecules showed dual inhibition effects on both M^(pro)and PL^(pro),exhibiting potential as better candidates for COVID-19 *** best inhibitors of each protease were tested in antiviral assay,with over 40%of M^(pro)inhibitors and over 20%of PL^(pro)inhibitors showing high potency in viral inhibition with low *** X-ray crystal structure of SARS-CoV-2 M^(pro)in complex with its potent inhibitor 4a was determined at 1.8Å*** with docking assays,our results provide a comprehensive resource for future research on anti-SARS-CoV-2 drug development.

关键词： high-throughput screening SARS CoV-2 main papain-like proteases

First experimental constraints on WIMP couplings in the effective field theory framework from CDEX

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Science China(Physics,Mechanics & Astronomy) 2021年第8期64卷 15-22页

作者： Yi Wang Zhi Zeng Qian Yue liTao Yang KeJun Kang YuanJing li Mehment Agartioglu HaiPeng An JianPing Chang JingHan chen YunHua chen JianPing cheng cheng Yi Chiang WenHan Dai Zhi Deng ChangHao Fang XinPing Geng Hui Gong QiuJu Guo XuYuan Guo HongJian He li He Shengming He Jinwei Hu Tuchen Huang HanXiong Huang haitao Jia liPing Jia Xi Jiang HauBin li JianMin li Jin li mingXuan li RenmingJie li Xia li YuLan li Bin liao FongKay lin ShinTed lin ShuKui liu YanDong liu Yu liu YuanYuan liu ZhongZhi liu Hao Ma YuCai Mao QiYuan Nie JinHua Ning Hui Pan NingChun Qi Jie Ren XiChao Ruan ChangSong Shang Vivek Sharma Ze She Lakhwinder Singh Monoj Kumar Singh TianXi Sun ChangJian Tang weiYou Tang Yang Tian GuangFu Wang li Wang Qing Wang Yu chen Wang Yunxiang Wang Zhen Wang Henry Tsz-King Wong ShiYong Wu Yucheng Wu HaoYang Xing Yin Xu Tao Xue YuLu Yan Nan Yi ChunXu Yu HaiJun Yu JianFeng Yue ming Zeng BingTao zhang Lei zhang FengShou zhang ZhenYu zhang KangKang Zhao mingGang Zhao JiFang Zhou ZuYing Zhou JingJun Zhu Key Laboratory of Particle and Radiation Imaging(Ministry of Education) Department of Engineering PhysicsTsinghua UniversityBeijing 100084China Department of Physics Tsinghua UniversityBeijing 100084China Institute of Physics Academia SinicaTaipei 11529China NUCTECH Company Beijing 100084China YaLong River Hydropower Development Company Chengdu 610051China College of Nuclear Science and Technology Beijing Normal UniversityBeijing 100875China College of Physics Sichuan UniversityChengdu 610065China School of Physics Peking UniversityBeijing 100871China Sino-French Institute of Nuclear and Technology Sun Yet-sen UniversityZhuhai 519082China Department of Nuclear Physics China Institute of Atomic EnergyBeijing 102413China Department of Physics Banaras Hindu UniversityVaranasi 221005India Department of Physics Beijing Normal UniversityBeijing 100875China School of Physics Nankai UniversityTianjin 300071China

We present weakly interacting massive particles(WIMPs) search results performed using two approaches of effective field theory from the China Dark Matter Experiment(CDEX), based on the data from both CDEX-1B and CDEX-10 stages. In the nonrelativistic effective field theory approach, both time-integrated and annual modulation analyses were used to set new limits for the coupling of WIMP-nucleon effective operators at 90% confidence level(C.L.) and improve over the current bounds in the low mχregion. In the chiral effective field theory approach, data from CDEX-10 were used to set an upper limit on WIMP-pion coupling at 90% C.L. We for the first time extended the limit to the m_(χ)<6 GeV/c^(2) region.

关键词： WIMP EFT CDEX dark matter annual modulation

Short-term and oncological outcomes of natural orifice specimen extraction surgery(NOSES)for colorectal cancer in China:a national database study of 5055 patients

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Science Bulletin 2022年第13期67卷 1331-1334,M0003页

作者： Xu Guan Xiyue Hu Zheng Jiang Ye wei Donghui Sun Miao Wu haitao Zhou Hongliang Yao Junmin Song Guiyu Wang Junhong Hu mingyang Ren Qing Xu Jianchun Cai Jian Peng Dan Ma Yangchun Zheng Qingsi He Bo Jiang Zejun Wang Taiyuan li Su Yan Luchuan chen Tiegang li Zhiguo Xiong Pan Chi liang Kang Gang Yu Xiaodong Deng Hong zhang ming Xie Jianbao wei Hongyan Gong Xuejun Sun weidong Zang Yongmao Song Peng He Zhengqi Wen Chunxu zhang Yusheng Wang Yinggang chen Guangwei Xie mingzhang li Shaojun Yu Haiying liu Min Pu Chuangang Fu Xishan Wang on behalf of China NOSES Alliance Department of Colorectal Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of General Surgery Zhongshan HospitalFudan UniversityShanghai 200032China Department of Gastrointestinal and Anal Surgery Jilin University First HospitalChangchun 130021China Department of Gastrointestinal Surgery The Second People’s Hospital of YibinYibin 644000China Department of Gastrointestinal Surgery The Second Xiangya HospitalCentral South UniversityChangsha 410011China Department of Anorectal Surgery First Affiliated HospitalZhengzhou UniversityZhengzhou 450052China Department of Colorectal Cancer Surgery The Second Affiliated Hospital of Harbin Medical UniversityHarbin 150081China Department of Gastrointestinal Surgery Affiliated Hospital of North Sichuan Medical CollegeNanchong 637000China Department of Gastrointestinal Surgery Renji HospitalShanghai JiaoTong University School of MedicineShanghai 200240China Department of Gastrointestinal Surgery Zhongshan Hospital of Xiamen UniversityXiamen 361004China Department of General Surgery Xiangya HospitalCentral South UniversityChangsha 410008China Department of General Surgery Xinqiao HospitalThird Military Medical UniversityChongqing 400037China Department of Gastrointestinal Surgery Sichuan Cancer HospitalChengdu 610041China Department of General Surgery Shandong University Qilu HospitalJinan 250012China Department of Colorectal and Anal Surgery Shanxi Cancer HospitalTaiyuan 030013China Department of Gastrointestinal Surgery The Affiliated Cancer Hospital of Guizhou Medical UniversityGuiyang 550008China Department of General Surgery The First Affiliated Hospital of Nanchang UniversityNanchang 330006China Department of Gastrointestinal Surgery Qinghai University Affiliated HospitalXining 810012China Department of Gastrointestinal Surgery Fujian Medical University Cancer HospitalFuzhou 350014China Depar

经自然腔道取标本手术(NOSES)通过无切口理念与常规手术器械的结合,表现出极佳的微创效果,并带给患者全新的就医感受.目前,尽管NOSES已广泛用于结直肠肿瘤治疗,大量研究也表明相比常规腹腔镜手术,NOSES具有恢复快、创伤小、疼痛轻等优势... 详细信息

经自然腔道取标本手术(NOSES)通过无切口理念与常规手术器械的结合,表现出极佳的微创效果,并带给患者全新的就医感受.目前,尽管NOSES已广泛用于结直肠肿瘤治疗,大量研究也表明相比常规腹腔镜手术,NOSES具有恢复快、创伤小、疼痛轻等优势,但绝大多数研究均为小样本、单中心回顾性研究.本研究旨在通过分析我国5055例结直肠肿瘤NOSES患者数据,进一步探讨NOSES的短期疗效与预后.研究对象中,经直肠NOSES占整体比例的90.3%,经阴道NOSES占9.7%.NOSES术后短期并发症发生率为14.1%,吻合口瘘发生率为4.9%,腹盆腔感染率为1.9%.患者3年总生存率为93.2%,无病生存率为82.2%,局部复发率为3.6%.研究结果提示NOSES具有较好的安全性与可行性,为其应用于结直肠肿瘤治疗提供了证据.

关键词：结直肠肿瘤肿瘤学并发症发生率无病生存率吻合口瘘回顾性研究总生存率经直肠

Feasibility and physics potential of detecting ^(8)B solar neutrinos at JUNO

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Chinese Physics C 2021年第2期45卷 93-110页

作者： Angel Abusleme Thomas Adam Shakeel Ahmad Sebastiano Aiello Muhammad Akram Nawab Ali Fengpeng An Guangpeng An Qi An Giuseppe Andronico Nikolay Anfimov Vito Antonelli Tatiana Antoshkina Burin Asavapibhop João Pedro Athayde Marcondes de André Didier Auguste Andrej Babic Wander Baldini Andrea Barresi Eric Baussan Marco Bellato Antonio Bergnoli Enrico Bernieri David Biare Thilo Birkenfeld Sylvie Blin David Blum Simon Blyth Anastasia Bolshakova Mathieu Bongrand Clément Bordereau Dominique Breton Augusto Brigatti Riccardo Brugnera Riccardo Bruno Antonio Budano Max Buesken Mario Buscemi Jose Busto Ilya Butorov Anatael Cabrera Hao Cai Xiao Cai Yanke Cai Zhiyan Cai Antonio Cammi Agustin Campeny Chuanya Cao Guofu Cao Jun Cao Rossella Caruso Cédric Cerna Jinfan Chang Yun Chang Pingping chen Po-An chen Shaomin chen Shenjian chen Xurong chen Yi-Wen chen Yixue chen Yu chen zhang chen Jie cheng Yaping cheng Alexander Chepurnov Davide Chiesa Pietro Chimenti Artem Chukanov Anna Chuvashova Gérard Claverie Catia Clementi Barbara Clerbaux Selma Conforti Di Lorenzo Daniele Corti Salvatore Costa Flavio Dal Corso Christophe De La Taille Jiawei Deng Zhi Deng Ziyan Deng Wilfried Depnering Marco Diaz Xuefeng Ding Yayun Ding Bayu Dirgantara Sergey Dmitrievsky Tadeas Dohnal Georgy Donchenko Jianmeng Dong Damien Dornic Evgeny Doroshkevich Marcos Dracos Frédéric Druillole Shuxian Du Stefano Dusini Martin Dvorak Timo Enqvist Heike Enzmann Andrea Fabbri Lukas Fajt Donghua Fan Lei Fan Can Fang Jian Fang Marco Fargetta Anna Fatkina Dmitry Fedoseev Vladko Fekete li-cheng Feng Qichun Feng Richard Ford Andrey Formozov Amélie Fournier Haonan Gan Feng Gao Alberto Garfagnini Alexandre Göttel Christoph Genster Marco Giammarchi Agnese Giaz Nunzio Giudice Franco Giuliani Maxim Gonchar Guanghua Gong Hui Gong Oleg Gorchakov Yuri Gornushkin Marco Grassi Christian Grewing Maxim Gromov Vasily Gromov minghao Gu Xiaofei Gu Yu Gu Mengyun Guan Nunzio Guardone Maria Gul Cong Guo Jingyuan Guo Wanlei Guo Xinheng Guo Yuhang Guo Paul Hackspacher Caren Hagner Ran Han Yan Yerevan Physics Institute YerevanArmenia Universitélibre de Bruxelles BrusselsBelgium Universidade Estadual de Londrina LondrinaBrazil Pontificia Universidade Catolica do Rio de Janeiro RioBrazil Pontificia Universidad Católica de Chile SantiagoChile Universidad Tecnica Federico Santa Maria ValparaisoChile Beijing Institute of Spacecraft Environment Engineering BeijingChina Beijing Normal University BeijingChina China Institute of Atomic Energy BeijingChina Institute of High Energy Physics BeijingChina North China Electric Power University BeijingChina School of Physics Peking UniversityBeijingChina Tsinghua University BeijingChina University of Chinese Academy of Sciences BeijingChina Jilin University ChangchunChina College of Electronic Science and Engineering National University of Defense TechnologyChangshaChina Chongqing University ChongqingChina Dongguan University of Technology DongguanChina Jinan University GuangzhouChina Sun Yat-Sen University GuangzhouChina Harbin Institute of Technology HarbinChina University of Science and Technology of China HefeiChina The Radiochemistry and Nuclear Chemistry Group in University of South China HengyangChina Wuyi University JiangmenChina Shandong University JinanChina Institute of Modern Physics Chinese Academy of SciencesLanzhouChina Nanjing University NanjingChina Guangxi University NanningChina East China University of Science and Technology ShanghaiChina School of Physics and Astronomy Shanghai Jiao Tong UniversityShanghaiChina Tsung-Dao Lee Institute Shanghai Jiao Tong UniversityShanghaiChina Institute of Hydrogeology and Environmental Geology Chinese Academy of Geological SciencesShijiazhuangChina Nankai University TianjinChina Wuhan University WuhanChina Xi’an Jiaotong University Xi’anChina Xiamen University XiamenChina School of Physics and Microelectronics Zhengzhou UniversityZhengzhouChina Institute of Physics National Chiao-Tung University Hsinchu National United University Miao-Li Department of Physics National T

The Jiangmen Underground Neutrino Observatory(JUNO)features a 20 kt multi-purpose underground liquid scintillator sphere as its main *** of JUNO's features make it an excellent location for^8B solar neutrino measurements,such as its low-energy threshold,high energy resolution compared with water Cherenkov detectors,and much larger target mass compared with previous liquid scintillator *** this paper,we present a comprehensive assessment of JUNO's potential for detecting^8B solar neutrinos via the neutrino-electron elastic scattering process.A reduced 2 MeV threshold for the recoil electron energy is found to be achievable,assuming that the intrinsic radioactive background^(238)U and^(232)Th in the liquid scintillator can be controlled to 10^(-17)g/*** ten years of data acquisition,approximately 60,000 signal and 30,000 background events are *** large sample will enable an examination of the distortion of the recoil electron spectrum that is dominated by the neutrino flavor transformation in the dense solar matter,which will shed new light on the inconsistency between the measured electron spectra and the predictions of the standard three-flavor neutrino oscillation *** m^(2)_(21)=4.8times10^(-5);(7.5times10^(-5))eV^(2),JUNO can provide evidence of neutrino oscillation in the Earth at approximately the 3sigma(2sigma)level by measuring the non-zero signal rate variation with respect to the solar zenith ***,JUNO can simultaneously measureDelta m^2_(21)using^8B solar neutrinos to a precision of 20% or better,depending on the central value,and to sub-percent precision using reactor antineutrinos.A comparison of these two measurements from the same detector will help understand the current mild inconsistency between the value of Delta m^2_(21)reported by solar neutrino experiments and the KamLAND experiment.

关键词： neutrino oscillation solar neutrino JUNO

Sub-percent precision measurement of neutrino oscillation parameters with JUNO

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Chinese Physics C 2022年第12期46卷 28-49页

作者： Angel Abusleme Thomas Adam Shakeel Ahmad Rizwan Ahmed Sebastiano Aiello Muhammad Akram Abid Aleem Fengpeng An Qi An Giuseppe Andronico Nikolay Anfimov Vito Antonelli Tatiana Antoshkina Burin Asavapibhop João Pedro Athayde Marcondes de André Didier Auguste weidong Bai Nikita Balashov Wander Baldini Andrea Barresi Davide Basilico Eric Baussan Marco Bellato Antonio Bergnoli Thilo Birkenfeld Sylvie Blin David Blum Simon Blyth Anastasia Bolshakova Mathieu Bongrand Clément Bordereau Dominique Breton Augusto Brigatti Riccardo Brugnera Riccardo Bruno Antonio Budano Jose Busto Ilya Butorov Anatael Cabrera Barbara Caccianiga Hao Cai Xiao Cai Yanke Cai Zhiyan Cai Riccardo Callegari Antonio Cammi Agustin Campeny Chuanya Cao Guofu Cao Jun Cao Rossella Caruso Cédric Cerna Chi Chan Jinfan Chang Yun Chang Guoming chen Pingping chen Po-An chen Shaomin chen Xurong chen Yixue chen Yu chen Zhiyuan chen Zikang chen Jie cheng Yaping cheng Yu Chin cheng Alexey Chetverikov Davide Chiesa Pietro Chimenti Artem Chukanov Gérard Claverie Catia Clementi Barbara Clerbaux Selma Conforti Di Lorenzo Daniele Corti Flavio Dal Corso Olivia Dalager Christophe De La Taille Zhi Deng Ziyan Deng Wilfried Depnering Marco Diaz Xuefeng Ding Yayun Ding Bayu Dirgantara Sergey Dmitrievsky Tadeas Dohnal Dmitry Dolzhikov Georgy Donchenko Jianmeng Dong Evgeny Doroshkevich Marcos Dracos Frédéric Druillole Ran Du Shuxian Du Stefano Dusini Martin Dvorak Timo Enqvist Heike Enzmann Andrea Fabbri Donghua Fan Lei Fan Jian Fang Wenxing Fang Marco Fargetta Dmitry Fedoseev Zhengyong Fei li-cheng Feng Qichun Feng Richard Ford Amélie Fournier Haonan Gan Feng Gao Alberto Garfagnini Arsenii Gavrikov Marco Giammarchi Nunzio Giudice Maxim Gonchar Guanghua Gong Hui Gong Yuri Gornushkin Alexandre Göttel Marco Grassi Vasily Gromov minghao Gu Xiaofei Gu Yu Gu Mengyun Guan Yuduo Guan Nunzio Guardone Cong Guo Jingyuan Guo Wanlei Guo Xinheng Guo Yuhang Guo Paul Hackspacher Caren Hagner Ran Han Yang Han Miao He wei He Tobias Heinz Patrick Hellmuth Yuekun Heng Rafael Herrera YuenKeung Ho Yerevan Physics Institute YerevanArmenia Universiélibre de Bruxelles BrusselsBelgium Universidade Estadual de Londrina LondrinaBrazil Pontificia Universidade Catolica do Rio de Janeiro Rio de JaneiroBrazil Pontificia Universidad Católica de Chile SantiagoChile Universidad Tecnica Federico Santa Maria ValparaisoChile Beijing Institute of Spacecraft Environment Engineering BeijingChina Beijing Normal University BeijingChina China Institute of Atomic Energy BeijingChina Institute of High Energy Physics BeijingChina North China Electric Power University BeijingChina School of Physics Peking UniversityBeijingChina Tsinghua University BeijingChina University of Chinese Academy of Sciences BeijingChina Jilin University ChangchunChina College of Electronic Science and Engineering National University of Defense TechnologyChangshaChina Chongqing University ChongqingChina Dongguan University of Technology DongguanChina Jinan University GuangzhouChina Sun Yat-Sen University GuangzhouChina Harbin Institute of Technology HarbinChina University of Science and Technology of China HefeiChina The Radiochemistry and Nuclear Chemistry Group in University of South China HengyangChina Wuyi University JiangmenChina Shandong University JinanChinaand Key Laboratory of Particle Physics and Particle Irradiation of Ministry of EducationShandong UniversityQingdaoChina Institute of Modern Physics Chinese Academy of SciencesLanzhouChina Nanjing University NanjingChina Guangxi University NanningChina East China University of Science and Technology ShanghaiChina School of Physics and Astronomy Shanghai Jiao Tong UniversityShanghaiChina Tsung-Dao Lee Institute Shanghai Jiao Tong UniversityShanghaiChina Institute of Hydrogeology and Environmental Geology Chinese Academy of Geological SciencesShijiazhuangChina Nankai University TianjinChina Wuhan University WuhanChina Xi'an Jiaotong University Xi'anChina Xiamen University XiamenChina School of Physics and Microelectronics Zhengzhou UniversityZhengzhou

JUNO is a multi-purpose neutrino observatory under construction in the south of *** publication presents new sensitivity estimates for the measurement of the △m_(31)^(2),△m_(21)^(2),sin^(2)θ_(12),and sin^(2)θ_(13) oscillation parameters using reactor antineutrinos,which is one of the primary physics goals of the *** sensitivities are obtained using the best knowledge available to date on the location and overburden of the experimental site,the nuclear reactors in the surrounding area and beyond,the detector response uncertainties,and the reactor antineutrino spectral shape constraints expected from the TAO satellite *** is found that the △m_(21)^(2) and sin^(2)θ_(12) oscillation parameters will be determined to 0.5%precision or better in six years of data *** the same period,the △m_(31)^(2) parameter will be determined to about 0.2%precision for each mass ordering *** new precision represents approximately an order of magnitude improvement over existing constraints for these three parameters.

关键词： neutrino oscillation reactor antineutrino precision measurement JUNO

肝癌免疫检查点抑制剂相关不良反应管理中国专家共识(2021版)

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中华消化外科杂志 2021年第12期20卷 1241-1258页

作者：施国明黄晓勇任正刚陈漪程蕾蕾杜世锁方艺葛宁灵李爱民李苏李晓牧卢倩陆品相孙建方王汉萍魏来徐立杨国欢曾昭冲张岚张力赵海涛赵灵赵明周爱萍刘荣乐刘新会伍家鸣张莹樊嘉周俭中华医学会肿瘤学分会肝癌学组复旦大学附属中山医院肝肿瘤外科&肝移植科复旦大学肝癌研究所上海200032 复旦大学附属中山医院肝肿瘤内科复旦大学肝癌研究所上海200032 复旦大学附属中山医院心内科上海200032 复旦大学附属中山医院放疗科上海200032 复旦大学附属中山医院肾内科上海200032 南方医科大学中西医结合医院肝胆胰肿瘤科广州510315 中山大学肿瘤防治中心临床研究部广州510060 复旦大学附属中山医院内分泌科上海200032 清华大学附属北京清华长庚医院肝胆胰中心 102218 上海市徐汇区中心医院普通外科 200020 中国医学科学院皮肤病医院皮肤病理研究室南京210042 中国医学科学院北京协和医院呼吸与危重症医学科 100730 中山大学肿瘤防治中心肝脏外科广州510060 中国医学科学院北京协和医院肝胆外科 100730 复旦大学附属中山医院妇科肿瘤科上海200032 中山大学肿瘤防治中心微创介入治疗科华南国家重点实验室广州510060 中国医学科学院肿瘤医院肿瘤内科北京100021 不详

免疫检查点抑制剂(ICIS)的临床应用显著改善肝细胞癌(简称肝癌)病人预后随着ICIs在肝癌中的广泛应用,免疫相关不良反应(irAE)越来越受到重视,肝癌复杂的疾病特征和多手段结合的治疗模式对irAE管理提出挑战。因此,《肝癌免疫检查点抑制... 详细信息

免疫检查点抑制剂(ICIS)的临床应用显著改善肝细胞癌(简称肝癌)病人预后随着ICIs在肝癌中的广泛应用,免疫相关不良反应(irAE)越来越受到重视,肝癌复杂的疾病特征和多手段结合的治疗模式对irAE管理提出挑战。因此,《肝癌免疫检查点抑制剂相关不良反应管理中国专家共识(2021版)》编审委员会组织多学科专家共同讨论并制订该共识该共识聚焦肝癌irAE管理相关问题,提出建议,旨在提高临床医师规范、安全用药的能力,从而使病人从免疫治疗中得到最大获益。

关键词：肝肿瘤免疫治疗免疫检查点抑制剂不良反应管理专家共识

79家医院718例结直肠肿瘤经自然腔道取标本手术回顾性研究

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中华结直肠疾病电子杂志 2017年第6期6卷 469-477页

作者：关旭王贵玉周主青周海涛陈瑛罡汤庆超宋军民蔡建春鲍传庆张宏刘雁军熊治国吴淼宋纯郑阳春蒋嘉睿燕速汪泳胡清林马丹任柯熊德海张兴宏杨明睿白月奎符炜李蜀华张诗峰柳俊刚莫显伟宫红彦江波王铁张安平朱平付涛胡军红贾文焯秦长江苏琪王道荣吴万庆赵紫罡朱洪波金武勇靖昌庆李德钢刘文志刘志春庞黎明汤东王小强杨国山姚坤厚张学明赵磊钟晓刚周雷朱州白雪峰陈超武陈诗伟陈泽华戴凌付振保高峰高浩高磊龚剑锋姜勇介建政金伟森李德川李军蔺宏伟刘宝林刘春庆刘明孟建彬邱健饶贵安孙东辉孙学军邰建东王志刚谢光伟谢铭韦烨严俊阎立昆杨丰杨鹤鸣杨万军陈路川叶再生喻志革赵中海钟鸣朱玉萍傅传刚王锡山国家癌症中心/中国医学科学院北京协和医学院肿瘤医院结直肠外科北京100021 中国NOSES联盟北京100021 同济大学附属东方医院胃肠肛肠外科上海200120

目的通过收集国内79家医院开展的结直肠肿瘤经自然腔道取标本手术(NOSES)病例,阐述NOSES术在结直肠肿瘤中的应用现状及其可行性。方法本研究最终共纳入718例结直肠肿瘤NOSES病例,收集资料包括患者术前一般资料、手术相关资料、术后病理... 详细信息

目的通过收集国内79家医院开展的结直肠肿瘤经自然腔道取标本手术(NOSES)病例,阐述NOSES术在结直肠肿瘤中的应用现状及其可行性。方法本研究最终共纳入718例结直肠肿瘤NOSES病例,收集资料包括患者术前一般资料、手术相关资料、术后病理资料以及随访资料。结果患者一般资料显示:患者平均年龄为59.4±10.8岁,患者平均BMI指数为22.9±6.3 kg/m2,直肠NOSES术患者占总数的72.3%,有3.5%的患者接受了术前新辅助治疗;术后病理资料显示,I^IV期患者分别占31.3%,26.8%,30.8%,0.8%;中分化腺癌比例占病例总数的62.1%,肿瘤最大直径平均为4.1±1.8 cm,淋巴结检出数目平均为13.4±3.5枚。本研究中76.2%的患者行腹腔镜直肠前切除术联合经自然腔道取标本手术;90.4%的患者采用经直肠取标本,经阴道取标本病例占9.6%;NOSES手术时间平均为210.5±39.4分钟,术中出血量平均为61.8±23.1 ml,术后排气时间平均为44.5±10.3小时,术后进食时间平均为64.9±14.6小时,术后住院时间为12.1±4.0天,并发症发生率为10.6%,术后肛门功能障碍者占总数的1.5%,未发现阴道功能障碍者。结论结直肠肿瘤NOSES术在我国广泛开展,且表现出巨大的推广潜力。同时,NOSES术符合肿瘤根治术要求,并具有良好的近期疗效,因此该技术是一种安全可靠的微创外科技术。

关键词：结直肠肿瘤经自然腔道取标本手术腹腔镜手术微创外科