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Asian Herpetological Research 2020年第4期11卷 297-311页

作者： Huijun SHEN Yanjun ZHU Zhen LI zhuo chen Xiaohong chen College of Life Sciences Henan Normal UniversityXinxiang 453007HenanChina

The Odorrana schmackeri sensu la to is a group of cascade frogs that are widely distributed in southern ***,their taxonomy has long been unresolved and several cryptic species have been reported in the past *** analyses revealed the existence of three sympatrie species(i.c,***,*** and ***2) at the type locality of ***(Gaojiayan Town,Yichang City,Hubei Province,China).However,the lack of an original description for the holotype specimen(SMF6241) of *** poses a confusing and controversial problem in species nomination within this ***,we reevaluate the taxonomic affinities of SMF6241 and examine the distinctness of ***2 based on specimens from the type *** use integrative approaches that combine morphology with 10 microsatellite loci and *** discriminant analysis of morphological characteristics revealed three distinct groupings(i.e.,***,*** and ***2) and attributed SMF6241 to *** clustering analysis of nuclear DNA also identified three corresponding *** addition,analysis of interspecific variation in morphometrics and acoustics showed divergence between ***2 and its sympatric *** lines of evidence from morphological,molecular and bioacoustic approaches suggest the species status of ***2,namely Odorrana ichangensis chen,***,this study resolves the taxonomic assignment of the holotype of *** and provides an example for species delimitation using integrative approaches.

关键词： integrative taxonomy new species Odorrana ichangensis chen sp.nov. Odorrana schmackeri sensu lato reevaluation

Experimental investigation of dynamic mass transfer during droplet formation using micro-LIF in a coaxial microchannel

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Chinese Journal of Chemical Engineering 2021年第11期34卷 51-58页

作者： zhuo chen Qiqiang Xiong Shaowei Li Yundong Wang Jianhong Xu The State Key Laboratory of Chemical Engineering Department of Chemical EngineeringTsinghua UniversityBeijing 100084China Collaborative Innovation Center of Advanced Nuclear Energy Technology Institute of Nuclear and New Energy TechnologyTsinghua UniversityBeijing 100084China

The mass transfer of Rhodamine 6G from the droplet to the continuous phase in a coaxial micro-channel is studied using micro-LIF(Laser-Induced Fluorescence).The mass distribution inside droplet is measured and *** experimental results affirm that there exists the internal circulation inside the droplet and it could enhance the convective mass *** stagnant center of vortices is also *** extraction fraction could reach 40%80%.In order to establish the mass transfer model,different flow rates of the dispersed and continuous phase are *** high continuous phase flow rate and low dispersed phase flow rate are both beneficial to enhance mass transfer by expediting the internal circulation.A modified mass transfer model is found to calculate the extraction fraction.A good agreement between the model and experiment in various conditions demonstrates that the mass transfer model in this work is reliable and feasible.

关键词： Droplet formation Micro-LIF measurement Internal circulation Mass transfer model

A microextraction approach for rapid extraction and separation of Mn(Ⅱ) and Co(Ⅱ) using saponified D2EHPA system

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Frontiers of Chemical Science and Engineering 2022年第6期16卷 963-972页

作者： Yiwei Zhou chen zhuo Jinpei Huang Haipeng Liu Jianhong Xu The State Key Laboratory of Chemical Engineering Department of Chemical EngineeringTsinghua UniversityBeijing 100084China

In this paper,we proposed a microextraction approach for the extraction and separation of Mn(Ⅱ)and Co(Ⅱ)from sulfate solution simulating leachate of spent lithium-ion battery cathode materials using saponified di-(2-ethylhexyl)phosphoric acid *** effects of the following operational variables were investigated:equilibrium pH,tri-«-butyl phosphate concentration,saponification rate,two-phase ratio and residence *** results showcased that the microextractor can reach the extraction equilibrium within 20 s,thereby greatly reducing necessary extraction time comparing to that of conventional *** volumetric mass transfer coefficient showed 8-21 times larger than that of batch *** the help of microextractor,95%of Mn(Ⅱ)was extracted with a single theoretical stage at a chosen two-phase ratio of 3:1,and the separation factor β_(Mn/Co) was as large as *** the subsequent stripping step,more than 99%of manganese from loaded phase was easily stripped under optimal *** microextraction approach greatly enhances the mass transfer while enabling a continuous and controllable extraction process within a simple structure *** extracting spent electrode material with microextractors,the comprehensive recovery of mangenese can reach 96%.The microextraction approach has a good applicability in the spent lithium-ion battery cathode materials recycling at both bench and industrial scales.

关键词： extraction equilibrium mass transfer coeffi-cient microextraction multicomponent extraction di-(2-ethylhexyl)phosphoric acid

Progress in the applications of flux analysis of metabolic networks

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Chinese Science Bulletin 2010年第22期55卷 2315-2322页

作者： chen Qi WANG zhuo WEI DongQing College of Life Science & Biotechnology Shanghai Jiao Tong University Shanghai 200240 China

The metabolic network has become a hot topic in the area of system biology and flux-based analysis plays a very important role in understanding the characteristics of organism metabolic networks. We review mainly the static methods for analyzing metabolic networks such as flux balance analysis (FBA), minimization of metabolic adjustment (MOMA), regulatory on / off minimization (ROOM), and dynamic flux balance analysis with linear quadratic regulator (DFBA-LQR). Then several kinds of commonly used software for flux analysis are introduced briefly and compared with each other. Finally, we highlight the applications of metabolic network flux analysis, especially its usage combined with other biological characteristics and its usage for drug design. The idea of combining the analysis of metabolic networks and other biochemical data has been gradually promoted and used in several aspects such as the combination of metabolic flux and the regulation of gene expression, the influence of protein evolution caused by metabolic flux, the relationship between metabolic flux and the topological characteristics, the optimization of metabolic engineering. More comprehensive and accurate properties of metabolic networks will be obtained by integrating metabolic flux analysis, network topological characteristics and dynamic modeling.

关键词：代谢网络代谢通量网络分析应用线性二次型调节器网络流量分析现代艺术博物馆代谢流量分析

Asymmetric Dimethylarginine Predicts One-year Recurrent Cardiovascular Events: Potential Biomarker of "Toxin Syndrome" in Coronary Heart Disease

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Chinese Journal of Integrative Medicine 2019年第5期25卷 327-333页

作者： XU Hao chen zhuo SHANG Qing-hua GAO Zhu-ye YU Chang-an SHI Da-zhuo chen Ke-ji Cardiovascular Diseases Center Xiyuan HospitalChina Academy of Chinese Medical SciencesBeijing(100091)China Department of Cardiology China-Japan Friendship HospitalBeijing(100029)China

Objective: To examine the prognostic value of serum levels of asymmetric dimethylarginine(ADMA)in patients with stable coronary heart disease(CHD) thus explore a potential biomarker of "toxin syndrome" in ***: In this prospective nested case-control study, 36 of 1,503 Chinese patients with stable CHD experienced at least 1 recurrent cardiovascular event(RCE) during 1-year fol ow-up. Serum levels of ADMA at the start of fol ow-up were compared between these 36 cases and 36 controls which matched to cases in terms of gender, age, history of hypertension, and myocardial infarction. Results: Based on the crude model, subjects in the 2 highest ADMA quartiles showed signi?cantly higher risk of developing RCE than those in the lowest ADMA quartile [odds ratio(OR) 4.09, 95%confidence interval(CI) 1.01 to 16.58; OR 6.76, 95% CI 1.57 to 29.07]. This association was also observed in the case-mix model(OR 5.51, 95% CI 1.23 to 24.61; OR 7.83, 95% CI 1.68 to 36.41) and multivariable model(OR 6.64,95% CI 1.40 to 31.49; OR 13.14, 95% CI 2.28 to 75.71) after adjusting for confounders. The multivariable model which combined ADMA and high-sensitivity C-reactive protein(hs CRP) showed better predictive power with areas under the receiver operator characteristic curves(0.779) than the model of either ADMA(0.694) or hs CRP(0.636). Conclusion:Serum ADMA level may be a potential biomarker of "toxin syndrome" in CHD which shows favorable prognostic value in predicting 1-year RCE in patients with stable CHD. [The registration number is Chi CTR-PRNRC-07000012]

关键词： asymmetric dimethylarginine recurrent cardiovascular event nested case-control study coronary heart disease toxin syndrome

Prediction on Failure Pressure of Pipeline Containing Corrosion Defects Based on ISSA-BPNNModel

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Energy Engineering 2024年第3期121卷 821-834页

作者： Qi Zhuang Dong Liu zhuo chen PetroChina Changqing Oilfield Company The Second Gas Production PlantXi’an710000China PetroChina Changqing Oilfield Company Safety and Environmental Supervision Department Co.Ltd.Xi’an710000China Sinopec Northwest Oilfield Company The Second Oil Production Plant Co.Ltd.Urumqi830016China

Oil and gas pipelines are affected by many factors,such as pipe wall thinning and pipeline *** prediction of failure pressure of oil and gas pipelines can provide technical support for pipeline safety *** at the shortcomings of the BP Neural Network(BPNN)model,such as low learning efficiency,sensitivity to initial weights,and easy falling into a local optimal state,an Improved Sparrow Search Algorithm(ISSA)is adopted to optimize the initial weights and thresholds of BPNN,and an ISSA-BPNN failure pressure prediction model for corroded pipelines is *** 61 sets of pipelines blasting test data as an example,the prediction model was built and predicted by MATLAB software,and compared with the BPNN model,GA-BPNN model,and SSA-BPNN *** results show that the MAPE of the ISSA-BPNN model is 3.4177%,and the R2 is 0.9880,both of which are superior to its comparison *** the ISSA-BPNN model has high prediction accuracy and stability,and can provide support for pipeline inspection and maintenance.

关键词： Oil and gas pipeline corrosion defect failure pressure prediction sparrow search algorithm BP neural network logistic chaotic map

On Double Vector Bundles

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Acta Mathematica Sinica,English Series 2014年第10期30卷 1655-1673页

作者： zhuo chen Zhang Ju LIU Yun He SHENG Department of Mathematics Tsinghua University Department of Mathematics and LMAM Peking University Department of Mathematics Jilin University

In this paper, we construct a category of short exact sequences of vector bundles and prove that it is equivalent to the category of double vector bundles. Moreover, operations on double vector bundles can be transferred to operations on the corresponding short exact sequences. In particular, we study the duality theory of double vector bundles in term of the corresponding short exact sequences. Examples including the jet bundle and the Atiyah algebroid are discussed.

关键词： Double vector bundles DVB sequences duality jet bundles

On the Existence of Global Bisections of Lie Groupoids

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Acta Mathematica Sinica,English Series 2009年第6期25卷 1001-1014页

作者： De Shou ZHONG zhuo chen Zhang Ju LIU Center of Mathematics China Youth University for Political Sciences Beijing 100089 P. R. China Department of Mathematics and LMAM Peking University Beijing 100871 P. R. China

We show that every source connected Lie groupoid always has global bisections through any given point. This bisection can be chosen to be the multiplication of some exponentials as close as possible to a prescribed curve. The existence of bisections through more than one prescribed point is also discussed. We give some interesting applications of these results.

关键词： Lie groupoid bisection exponential mad

The influence of physiological environment on the targeting effect of aptamer-guided gold nanoparticles

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Nano Research 2019年第1期12卷 129-135页

作者： Ding Ding Yinling Zhang Edward A.Sykes Long chen zhuo chen Weihong Tan Molecular Science and Biomedicine Laboratory(MBL) State Key Laboratory of Chemo/Bio-Sensing and ChemometricsCollege of Chemistry and Chemical Engineering and College of Life SciencesHunan UniversityChangsha 410082China School of Medicine Queens University81 Barrie StreetKingstonONK7L 3N6Canada Faculty of Science and Technology University of MacaoAvenida da UniversidadeMacao Taipa 999078China Department of Chemistry Departments of Physiology and Functional GenomicsCenter far Research at the Bio/Nano InterfaceUF Health Cancer CenterUF Genetics Institute and McKnight Brain InstituteUniversity of FloridaGainesvilleFlorida 32611USA Institute of Molecular Medicine Renji HospitalShanghai Jiao Tong University School of MedicineShanghai Jiao Tong UniversityShanghai 200240China

Aptamer guided nano medicine shows great promise in targeted cancer *** the loss of targeting capacity duri ng in vivo or clinical trials has largely hindered its popularity and there are no systematic studies to elucidate the ***,we investigated such loss of targeting capacity by examining how the physiological milieu affected targeting *** functionalized gold nanoparticle(AuNP)was chosen as the model and exposed to human blood serum that is used to mimic physiological *** light scattering(DLS),flow cytometry and label-free liquid chromatography tan dem mass spectrometry(LC-MS/MS)were employed to determi ne variations of NPs'surface chemistry and biological identities changes after serum *** showed that the targeting ability loss was caused by protein corona blocking,replacement and enzymatic cleavage of surface aptamer targeting ***,the aggregation issue is critical for the smaller *** of the protein corona profile indicated the accumulation of immune-related proteins on the surface of aptamer-conjugated NPs,which could induce immune response,resulting in rapid clearanee of NPs.

关键词： targeting effect aptamer nanomedicine physiological environment

Geochronology and geological significance of the strata of the Neoproterozoic Nanhua System,SW North China Craton

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Acta Geochimica 2023年第5期42卷 912-933页

作者： Guanxu chen Luo Jinhai Sun Gennian Meng Zhan Chang Yinglei chen zhuo School of Geography and Tourism Shaanxi Normal UniversityXi’an 710119China State Key Laboratory of Continental Dynamics Department of GeologyNorthwest UniversityXi’an 710069China Yanchang Oil Co. LtdXi’an 71600China

A set of low-grade clastic metamorphic and carbonate rocks,and greenschists outcropping in the southwestern(SW)margin of the North China Craton(NCC),was originally classified as the Paleoproterozoic Xiong’er Group according to stratigraphic *** verify the age,this paper carried out detrital zircon U–Pb LA-ICP-MS dating of low-grade clastic metamorphic rocks exposed in the Changqing area at the SW margin of the Ordos Block in the SW part of the *** from detrital zircon dating indicate that the metamorphic and carbonate rocks can be classified into the Neoproterozoic Nanhua System,which is the only Nanhua System stratum in this block so far,and it probably could provide new clues to Rodinia break-up and Snowball Earth of the *** nine peak ages of the low-grade clastic metamorphic rocks reflected its relatively complex provenance,and almost all major geological events experienced by the NCC basement since the Neoarchean,but some age peaks were difficult to correspond to that of the NCC,indicating that the southwestern part of the Ordos Block was also affected by the Qinling and Qiliang orogenic belts during Nanhua System of *** with provenance analysis,it was revealed that the current southwest boundary of the Ordos Block was the previous southwest boundary of the Ordos Block during the Qingbaikou-Nanhua Period of the Neoproterozoic.

关键词： The Ordos Block Low-grade metamorphic rocks Zircon U–Pb age Paleoproterozoic Neoproterozoic Nanhua System