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NLRP3/ACS/Caspase-1信号通路在儿童腺病毒肺炎引发心肌应激损伤中的作用

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中华医院感染学杂志 2024年第14期34卷 2216-2220页

作者：王晓荣陈中慧聂建军李静邵雪飞南阳医学高等专科学校第一附属医院儿科河南南阳473000 南阳医学高等专科学校第一附属医院药学部河南南阳473000 南阳医学高等专科学校第一附属医院检验科河南南阳473000 南阳医学高等专科学校河南南阳473000

目的探讨NOD样受体蛋白3(NLRP3)/凋亡相关斑点样蛋白(ASC)/半胱氨酸蛋白酶1(Caspase-1)信号通路在儿童腺病毒肺炎引发心肌应激损伤中的作用.方法选取2021年1月-2023年1月于南阳医学高等专科学校第一附属医院就诊的腺病毒肺炎患儿112... 详细信息

目的探讨NOD样受体蛋白3(NLRP3)/凋亡相关斑点样蛋白(ASC)/半胱氨酸蛋白酶1(Caspase-1)信号通路在儿童腺病毒肺炎引发心肌应激损伤中的作用.方法选取2021年1月-2023年1月于南阳医学高等专科学校第一附属医院就诊的腺病毒肺炎患儿112例为研究对象,根据有无心肌损伤分为无心肌损伤组76例、心肌损伤组36例,检测并比较两组病毒滴度、心肌酶谱水平、炎性因子、氧化应激因子、NLRP3通路相关mRNA、蛋白表达水平.结果病毒载量为4×100~6×100 copy/μg的患儿占比最高,无心肌损伤组和心肌损伤组分别为33例(43.42%)、28例(45.16%);与无心肌损伤组比较,心肌损伤组肌钙蛋白Ⅰ(cTnI)、肌红蛋白(Mb)、肌酸激酶(CK)、肌酸激酶同工酶(CK-MB)、乳酸盐脱氢酶(LDH)、门冬氨酸氨基转移酶(AST)表达水平高,白细胞(WBC)计数、超敏C-反应蛋白(hs-CRP)、降钙素原(PCT)、白细胞介素(IL)-1β、IL-18、转化生长因子β(TGF-β)水平高,丙二醛(MDA)、超氧化物歧化酶(SOD)、谷胱甘肤过氧化物酶(GSH-Px)水平高(P<0.05);NLRP3、ACS、Caspase-1的mRNA转录水平及蛋白相对表达水平高(P<0.05).结论血清NLRP3、ACS、Caspase-1水平与腺病毒肺炎导致的心肌损伤相关指标相关,腺病毒可能是通过NLRP3/ACS/Caspase-1信号通路的激活介导氧化应激水平,参与病理损伤进程.

关键词：儿童腺病毒肺炎心肌损伤氧化应激 NOD样受体蛋白3/凋亡相关斑点样蛋白/半胱氨酸蛋白酶1

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巴斯德葡萄球菌引起导管相关血流感染1例

中国感染控制杂志 2024年第8期23卷 1040-1043页

作者：王崇圳钟山许丽霞王立程符晓莹李欢黎元莉朱雄陈海陈东科海南省三亚市四川大学华西三亚医院中心实验室海南三亚572000

1例患者因“脓毒血症、慢性肾病、2型糖尿病、休克、脑梗死”入院,临床抽取血标本进行相关检查,导管血和静脉血需氧和厌氧培养均报阳,通过VITEK MS鉴定病原菌是巴斯德葡萄球菌,确定为巴斯德葡萄球菌引起的导管相关血流感染。临床经验性... 详细信息

1例患者因“脓毒血症、慢性肾病、2型糖尿病、休克、脑梗死”入院,临床抽取血标本进行相关检查,导管血和静脉血需氧和厌氧培养均报阳,通过VITEK MS鉴定病原菌是巴斯德葡萄球菌,确定为巴斯德葡萄球菌引起的导管相关血流感染。临床经验性使用哌拉西林抗感染治疗无效后,最终根据体外药敏试验改用万古霉素治疗,并拔除血管导管病情好转。巴斯德葡萄球菌目前在国内尚未有相关的病例报道,尽早明确病原学诊断和根据药敏试验结果调整治疗方案,对于该病例的有效治疗非常重要。

关键词：巴斯德葡萄球菌导管血流感染 CRBSI

静脉-动脉体外膜肺氧合时左心室及升主动脉血栓1例

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中国临床医学影像杂志 2024年第5期35卷 365-367页

作者：陈慧颖何亚峰马小静夏娟王黎钟锦珑武汉科技大学附属武汉亚洲心脏病医院超声科武汉市心血管影像临床医学研究中心武汉科技大学医学部医学院湖北武汉430022

病例男,52岁,因“突发胸痛、胸闷17天”就诊,外院冠脉造影示:冠状动脉左前降支远段血管夹层伴血管闭塞,既往无烟酒史和其它已知心血管危险因素。入院查体:呼吸20次/分,血压92/50 mmHg(1 mmHg≈0.133 kPa),心率126次/分,可见躯体肌颤,双... 详细信息

病例男,52岁,因“突发胸痛、胸闷17天”就诊,外院冠脉造影示:冠状动脉左前降支远段血管夹层伴血管闭塞,既往无烟酒史和其它已知心血管危险因素。入院查体:呼吸20次/分,血压92/50 mmHg(1 mmHg≈0.133 kPa),心率126次/分,可见躯体肌颤,双肺呼吸音清晰,未闻及罗音,各瓣膜听诊区未闻及杂音,余无特殊。辅助检查:心电图示:前壁及高侧壁ST段抬高。超声心动图示:心包腔中量积液和严重的左心室功能障碍(左心室射血分数为15%)。检验结果示:肌钙蛋白19.174 ng/mL,活化部分凝血活酶时间35.6 s,D-二聚体测定10.732μg/m,临床诊断提示急性心肌梗死伴心源性休克,考虑患者临床心功能差且有手术适应症,行房间隔造瘘术缓解心功能。

关键词：血栓形成心室主动脉超声心动描记术

Study on Seepage Characteristics of Composite Bucket Foundation Under Eccentric Load

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China Ocean Engineering 2021年第1期35卷 123-134页

作者： chen qing-shan ZHANG Pu-yang DING Hong-yan LE Cong-huan XU Yun-long State Key Laboratory of Hydraulic Engineering Simulation and Safety Tianjin UniversityTianjin 300072China Key Laboratory of Coast Civil Structure Safety(Tianjin University) Ministry of EducationTianjin 300072China

Under the effect of eccentric loads,when the suction pressure of the composite bucket foundation is leveled,the seepage failure is very easy to *** seepage failure occurrence causes the foundation to settle unevenly and impairs the bearing *** study uses ABAQUS finite element software to establish a composite bucket foundation model for finite element *** model simulates the seepage of the foundation penetrating process under eccentric load to reveal the induced seepage characteristics of the bucket *** most vulnerable position of seepage failure under the eccentric loading is *** suction formulas for different offset eccentric moment strategies are derived and compared with existing literature *** the derived formula is supplemented and corrected according to the pressure difference between adjacent *** can be drawn:(1)Under eccentric loads,the critical suction decreases about 7%−10%.(2)The pressure difference between adjacent cabins impacts significantly on the seepage field,and the critical suction,at most,can be reduced by 17.56%.(3)the offset strategies have little effect on the seepage *** and appropriate strategies can be selected to meet the requirement of leveling in engineering project.

关键词： composite bucket foundation eccentric load seepage failure critical suction

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k玻色子q相干态的反聚束效应(英文)

高能物理与核物理 2002年第6期26卷 576-581页

作者：汪仲清石油大学应用物理系山东东营257061

研究了q变形湮没算符高次幂 (akq,k≥ 3 )本征态的反聚束效应 ,并就k =3的情况用数值计算方法研究了q变形参数对该效应的影响 .结果表明 ,当q变形相干态中谐振子的强度x=|z| 2 在某些区间内取值时 ,akq 的本征态将呈现反聚束效应 ,并且... 详细信息

研究了q变形湮没算符高次幂 (akq,k≥ 3 )本征态的反聚束效应 ,并就k =3的情况用数值计算方法研究了q变形参数对该效应的影响 .结果表明 ,当q变形相干态中谐振子的强度x=|z| 2 在某些区间内取值时 ,akq 的本征态将呈现反聚束效应 ,并且这一效应明显地受到q参数的影响 .当参数q取定时 ,随着q变形光场强度的变大 ,该光场的光子数涨落在经典 (或量子 )和量子 (或经典 )特性之间交替地变化 .

关键词： κ玻色子 q相干态 q变形本征态反聚束效应量子光学湮没算符高次幂谐振子

An experimental study on RH vacuum chamber with a weir

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Journal of Iron and Steel Research International 2023年第10期30卷 1929-1938页

作者： qing He Tong-lu Yao Liu Liu Xiang-chen Li Bing Ni Long-fei Li Metallurgical Technology Research Department Central Iron and Steel Research Institute Co.Ltd.Beijing 100081China

A new Ruhrstahl-Heraeus(RH)equipment with a weir added to the vacuum chamber was designed to help improve refining efficiency of low-carbon steel *** flow characteristics of the new RH equipment and a traditional RH equipment were evaluated and compared through water modeling experiments and an optimized calculation *** the water experiments,the mixing time,the residence time and the circulation flow rates were measured,and the flow simulating molten steel in the vacuum was *** results show that the decarburization efficiency in the new RH equipment is much *** mixing time is equal to or less than that of the latter when the gas flow rate is higher than 2.33 m^(3)/*** proportion of the piston flow increases by at least 40%,and the proportion of the well-mixed flow decreases from greater than 40%to less than 20%.The effective flow rate of the new RH equipment increases greatly in the piston flow zone and the total lag flow zone based on the residence time distribution *** conclusion,when a weir is added to a RH vacuum chamber,the effective circulation flow increases significantly,and the decarburization rate KC of molten steel at low-carbon stage is improved.

关键词： Ruhrstahl-Heraeus Weir Water modeling Residence time distribution Decarburization

镜下前交叉韧带重建联合固定平台单髁置换术的早中期临床疗效观察

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生物骨科材料与临床研究 2024年第2期21卷 38-42页

作者：曾伟清肖子鹏唐刚健柴晟钟健陈炜坚吕青车小乔广西中医药大学附属桂林市中医医院骨科广西桂林541002

目的探讨单髁置换手术(unicompartmental knee arthroplasty, UKA)联合前交叉韧带重建手术(anterior cruciate ligament reconstruction, ACLR)对单间室膝骨关节炎(unicompartmental knee osteoarthritis, UKOA)合并前交叉韧带缺失(anterior cruciate ligament deficient, ACLD)患者的早期临床疗效结果。方法选取2018年1月至2022年6月广西中医药大学附属桂林市中医医院采用同期UKA联合ACLR治疗的UKOA合并ACLD的12例患者进行回顾性研究。评估术前和末次随访的VAS、IKDC、Lysholm评分,并随访观察并发症及翻修的发生情况。结果所有患者随访6~55个月,平均随访(24.58±10.48)个月。所有患者的平均住院时间为(13.67±6.20)d,平均出血量为(43.33±39.44)mL,平均切口长度为(9.25±0.43)cm。末次随访时的VAS评分较术前明显降低(P<0.05);Lysholm评分平均为(67.17±22.96)分、IKDC评分平均为(59.87±8.77)分,分别较术前平均(51.33±14.99)分、(48.95±13.68)分明显提高(P<0.05)。结论早中期的临床数据显示,同时进行ACLR联合UKA对UKOA合并ACLD手术治疗的临床疗效显著,可有效改善患者的膝关节不稳定和内侧间室疼痛,提高患者本体感觉,患者并发症发生率较低,值得临床推广应用,但应严格把握手术的适应证。

关键词：单髁置换手术前交叉韧带重建术单间室膝骨关节炎关节镜

Seasonal variations of organic carbon and nitrogen in the upper basins of Yangtze and Yellow Rivers

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Journal of Mountain Science 2017年第8期14卷 1577-1590页

作者： LI Xiang-ying DING Yong-jian HAN Tian-ding XU Jian-zhong KANG Shi-chang WU qing-bai Mika Sillanp?? YU zhong-bo YU Cong-rong College of Hydrology and Water Resources/State Key Laboratory of Hydrology-Water Resources and Hydraulic Engineering Hohai University State Key Laboratory of Cryospheric Sciences Northwest Institute of Eco-Environment and ResourcesChinese Academy of Sciences University of Chinese Academy of Sciences State Key Laboratory of Frozen Soil Engineering Northwest Institute of Eco-Environment and ResourcesChinese Academy of Sciences Laboratory of Green Chemistry School of Engineering ScienceLappeenranta University of Technology Department of Civil and Environmental Engineering Florida International University

The profound impacts exerted by climate warming on the Tibetan Plateau have been documented extensively, but the biogeochemical responses remain poorly understood. This study was aimed at seasonal variations of total organic carbon(TOC) and total organic nitrogen(TON) in stream water at two gauging sections(TTH, ZMD) in the upper basin of Yangtze River(UBYA) and at fourgauging sections(HHY, JM, JG, TNH) in the upper basin of Yellow River(UBYE) in 2013. Results showed that concentrations of TON exhibit higher values in spring and winter and lower values in summer. TOC exhibits higher concentrations in spring or early summer and lower concentrations in autumn or winter. Seasonal variations of TOC and TON fluxes are dominated by water flux. In total, the UBYE and UBYA delivers 55,435 tons C of organic carbon and 9,872 tons N of organic nitrogen to downstream ecosystems in 2013. Although the combined flux ofTOC from UBYA and UBYE is far lower than those from large rivers, their combined yields is higher than, or comparable with, those from some large rivers(e.g. Nile, Orange, Columbia), implying that organic carbon from the Tibetan Plateau may exert a potentially influence on regional and/or global carbon cycles in future warming climate.

关键词： Seasonal variation Total organic carbon(TOC) Total organic nitrogen(TON) Yangtze River Yellow River

Dual activation and C-C coupling on single atom catalyst for CO_(2) photoreduction

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npj Computational Materials 2023年第1期9卷 110-117页

作者： u-li Sun Cun-biao Lin Wei Zhang qing chen Wen-xian chen Xiao-nian Li Gui-lin Zhuang H-PSI Computational Chemistry Lab Institute of Industrial CatalysisState Key Laboratory Breeding Base of Green-Chemical Synthesis TechnologyCollege of Chemical EngineeringZhejiang University of TechnologyHangzhou 310032PR China Surface Lab 10 Institute of PhysicsChinese Academy of SciencesBeijingPR China

An excellent single-atomic photocatalyst,Ti@C_(4)N_(3),is theoretically found to effectively convert CO_(2) to C_(2)H_(6) by density functional theory(DFT)calculations and non-adiabatic molecular dynamics(NAMD)*** Ti@C_(4)N_(3) photocatalyst has remarkable stability both thermally,chemically,and ***,it has strong absorption properties(λ=327.77 and 529.61 nm),suitable band positions,and a long photogenerated electron lifetime(τ_(e)=38.21 ps),allowing photogenerated electrons to migrate to the ***,the high-valence active site effectively activates two CO_(2) through dual activation:Under light irradiation,the weakly adsorbed CO_(2) undergoes photo-induced activation by the photoelectron of conduction band minimum(CBM);without light,the high Lewis acidity of the Ti site induces CO_(2) activation through back-donatingπ-*** simulation results uncovered that dual activation of CO_(2) is attributed to the thermal and photonic ***,two activated CO_(2) species under light easily couple to form oxalate with the barrier of 0.19 eV,and further reduced to C_(2)H_(6) with a low activation energy of 1.09 eV.

关键词： activation catalyst coupling