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Remodel the perifollicular microenvironment via Minoxidil-loaded microneedle patch and cold atmospheric plasma for treating androgenetic alopecia

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Nano Research 2024年第7期17卷 6411-6419页

作者： Hao chen Xianzhe Tang Yueye Huang chen chen Yuheng Yang Chaojie Hao Wenqi Xie Tingjing Huang Xiaofeng cheng Qingnan Xu Shicong Huang Zhi Ye Xucong Lin Zhaowei chen zhitong chen MOE Key Laboratory for Analytical Science of Food Safety and Biology and New Cornerstone Science LaboratoryCollege of ChemistryFuzhou UniversityFuzhou 350108China Institute of Biomedical and Health Engineering Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China Advanced Therapeutic Center National Innovation Center for Advanced Medical DevicesShenzhen 518000China Department of Chemistry University College LondonLondon WC1H 0AJUK Engineering Technology Research Center on Reagent and Instrument for Rapid Detection of Product Quality and Food Safety in Fujian Province College of ChemistryFuzhou UniversityFuzhou 350108China Key Laboratory of Biomedical Imaging Science and System Chinese Academy of SciencesShenzhen 518055China

Androgenetic alopecia(AGA)is a chronic and progressive form of hair loss characterized by vascular degeneration in the perifollicular microenvironment,leading to cell apoptosis and eventual loss of hair follicles(HFs).Traditional therapeutic formulations,such as Minoxidil(MXD)tincture,have limitations in reshaping the perifollicular microenvironment and exhibit limited ***,we report a multi-synergistic therapeutic platform for high-performance hair regeneration *** platform combines microneedle(MN)patches loaded with MXD-encapsulated nanostructured lipid carriers(MXD-NLC-MNs)and cold atmospheric plasma(CAP).The MNs’mechanical strength enables efficient transdermal delivery of MXD to the targeted dermal papilla cells,promoting cell ***,in collaboration with MXD,the mechanical stimulation exerted by MN application synergistically upregulates the expression of vascular endothelial growth factor,leading to ***,the transient microchannels in the skin created by MNs facilitate the transdermal delivery of CAPgenerated nitric oxide(NO)to the sites of HF lesions,whereby the synergistic interaction between MXD and NO boosts perifollicular ***,the perifollicular microenvironment can be effectively reshaped to accelerate hair regeneration in AGA murine *** multi-synergistic combination therapy strategy would hold great promise for effectively treating AGA and promoting hair regrowth.

关键词： nanomedicine androgenetic alopecia microneedle cold atmospheric plasma drug delivery

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Bacterial microcompartment-mimicking Pickering emulsion droplets for detoxification of chemical threats under sweet conditions

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Science China Chemistry 2024年第9期67卷 3039-3049页

作者： Xiao Xu Wenqi Xie Ting Wu chen chen Xiaoning chen Yuheng Yang Hao Lian Hao chen Xiaofeng cheng zhitong chen Guojun chen Chaoqun Liu Lanlan chen Yu He Zhaowei chen Bernard P.Binks Huanghao Yang New Cornerstone Science Laboratory MOE Key Laboratory for Analytical Science of Food Safety and BiologyCollege of ChemistryFuzhou UniversityFuzhou 350002China Institute of Biomedical and Health Engineering Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China Department of Biomedical Engineering and the Rosalind&Morris Goodman Cancer Research Institute McGill UniversityMontreal QC H3A 1A3Canada School of Pharmacy Henan UniversityKaifeng 475004China Department of Chemistry University of HullHull HU67RXUK

Chemical warfare agents represent a severe threat to mankind and their efficient decontamination is a global ***,traditional disposal strategies have limitations,including high energy consumption,use of aggressive reagents and generation of toxic ***,inspired by the compartmentalized architecture and detoxification mechanism of bacterial microcompartments,we constructed oil-in-water Pickering emulsion droplets stabilized by hydrogen-bonded organic framework immobilized cascade enzymes for decontaminating mustard gas simulant(2-chloroethyl ethyl sulfide,CEES)under sweet *** exemplified droplet systems were developed with two-enzyme(glucose oxidase/chloroperoxidase)and threeenzyme(invertase/glucose oxidase/chloroperoxidase)cascades,both achieving over 6-fold enhancement in decontamination efficiency compared with free enzymes and>99% selectivity towards non-toxic *** found that the favored mass transfer of sugars and CEES from their respective phases to approach the cascade enzymes located at the droplet surface and the facilitated substrate channeling between proximally immobilized enzymes were key factors in augmenting the decontamination *** importantly,the robustness of immobilized enzymes enabled easy reproduction of both the droplet formation and detoxification performance over 10 cycles,following long-term storage and in far-field locations.

关键词： Pickering emulsion biomimetics chemical warfare agent bacterial microcompartment biocatalysis

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Plasma induced grain boundaries to boost electrochemical reduction of CO_(2)to formate

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Journal of Energy Chemistry 2024年第8期95卷 636-643,I0014页

作者： Guan Wang Shengtao Zhong Xiaoqian Xiong Jing Li Fangyuan Wang Li Huo Daoxiong Wu Xingqi Han zhitong Wang Qi chen Xinlong Tian Peilin Deng School of Marine Science and Engineering State Key Laboratory of Marine Resource Utilization in South China SeaHainan UniversityHaikou 570228HainanChina

Bismuth-based catalysts are highly promising for the electrochemical carbon dioxide reduction reaction(eCO_(2)RR)to formate ***,achieving high activity and selectivity towards formate and ensuring long-term stability remains *** work reports the oxygen plasma inducing strategy to construct the abundant grain boundaries of Bi/BiO_x on ultrathin two-dimensional Bi *** oxygen plasma-treated Bi nanosheet(OP-Bi)exhibits over 90%Faradaic efficiency(FE)for formate at a wide potential range from-0.5 to-1.1 V,and maintains a great stability catalytic performance without significant decay over 30 h in flow ***,membrane electrode assembly(MEA)device with OPBi as catalyst sustains the robust current density of 100 mA cm^(-2)over 50 h,maintaining a formate FE above 90%.In addition,rechargeable Zn-CO_(2)battery presents the peak power density of1.22 mW cm^(-2)with OP-Bi as bifunctional *** mechanism experiments demonstrate that the high-density grain boundaries of OP-Bi provide more exposed active sites,faster electron transfer capacity,and the stronger intrinsic activity of Bi *** situ spectroscopy and theo retical calculations further elucidate that the unsaturated Bi coordination atoms between the grain boundaries can effectively activate CO_(2)molecules through elongating the C-O bond,and reducing the formation energy barrier of the key intermediate(^(*)OCOH),thereby enhancing the catalytic performance of eCO_(2)RR to formate product.

关键词： CO_(2)electroreduction Bi nanosheet Grain boundary Unsaturation Bi atoms MEA device

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KIF5B-mediated internalization of FMDV promotes virus infection

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Virologica Sinica 2024年第3期39卷 378-389页

作者： Wei Zhang Fan Yang Yang Yang Weijun Cao Wenhua Shao Jiali Wang Mengyao Huang zhitong chen Xiaoyi Zhao Weiwei Li Zixiang Zhu Haixue Zheng State Key Laboratory for Animal Disease Control and Prevention College of Veterinary MedicineLanzhou UniversityLanzhou Veterinary Research InstituteChinese Academy of Agricultural SciencesLanzhou 730000China Gansu Province Research Center for Basic Disciplines of Pathogen Biology Lanzhou 730046China

Foot-and-mouth disease(FMD)is a highly contagious and economically important disease,which is caused by the FMD virus(FMDV).Although the cell receptor for FMDV has been identified,the specific mechanism of FMDV internalization after infection remains *** this study,we found that kinesin family member 5B(KIF5B)plays a vital role during FMDV ***,we confirmed the interaction between KIF5B and FMDV structural protein VP1 by co-immunoprecipitation(Co-IP)and co-localization in FMDV-infected *** particular,the stalk[amino acids(aa)413–678]domain of KIF5B was indispensable for KIF5B-VP1 ***,overexpression of KIF5B dramatically enhanced FMDV replication;consistently,knockdown or knockout of KIF5B suppressed FMDV ***,we also demonstrated that KIF5B promotes the internalization of FMDV via regulating clathrin ***5B also promotes the transmission of viral particles to early and late endosomes during the early stages of *** conclusion,our results demonstrate that KIF5B promotes the internalization of FMDV via regulating clathrin uncoating and intracellular *** study may provide a new therapeutic target for developing FMDV antiviral drugs.

关键词： FMDV VP1 protein KIF5B Endosome Clathrin

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Studies on the adaptability of Chamaecrista *** red earth in Fujian China

Studies on the adaptability of Chamaecrista *** red earth in...

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中国—澳大利亚可持续性草地管理研讨会

作者： Huang Yibin~1 Ying Zhaoyang~1 chen zhitong~1 Li Yanchun~1 and Weng Boqi~1 1 Agricultural Ecology Institute Fujian Academy of Agricultural Science/Fujian Engineering and Technology Research Centre for Hilly Prataculture Fuzhou Fujian Province 350013 China

＜正＞Aimed at the problems of lacking leguminous forage source for developing prataculture and ecological restoration in the red earth region in Southern China,40 strains of Chamaecrista spp. have been introduced from Australia to screen their ecological adaptability in Fujian *** RAPD analysis by using 16 random primers showed that,all the tested strains of Chamaecrista spp. could be divided into 5 *** result was in accord with its genetic characters,but was inconsistent with the clustering analysis result of their adaptability *** experiment results of their ecological adaptability showed that,biomass yield of 30 strains,overwintering ability of 9 strains and seedling growth of 7 strains were better than that of present demonstrative strain （Chamaecrista rotundifolia CPI34721）.The clustering analysis results by using 14 evaluating indices showed that,40 tested strains of Chamaecrista *** be divided into 8 typical groups,among which 35 strains were concentrated in four types of group（A～D）.The investigation results on the individual and population growing characters of different clustering groups were as *** strains in groupA（Chamaecrista nictitans ATF2217 etc.） were erective type,mid-early maturing, high seed yield,high biomass and low regenerating capacity,which were suitable to be utilised by single harvesting *** strains in group B（Chamaecrista rotundifolia CPI92985 and CPI34721 etc.） were semi-creeping type,mid-early maturing,high biomass,rich nutrient components andstrong regenerating capacity under fertilising condition,which were suitable to be intercropped in orchard or comprehensively *** strains in group C（Chamaecrista rotundifolia ATF2228 etc.） were creeping type,strong overwintering capacity,early maturing with low biomass production, which were suitable to be intercropped in tea *** strains in group D（Chamaecrista rotundifolia CPI86134 etc.） were nearly erective type and late maturing,bot

关键词： Forage:Chamaecrista spp. C.rotundifolia C.nictitans red soil,plant selection

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Profile of *** chen

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Science China(Life Sciences) 2024年第10期67卷 2062-2063页

作者： chen, Songlin Yellow Sea Fisheries Res Inst Qingdao Peoples R China

For decades,*** has been engaged in fish germplasm preservation,sex control and research focusing on molecular breeding for disease *** discovered the first sex-specific molecular marker of fish(chen et al.,2007),deciphered the first fish genome(Chinese tongue sole)in China,revealed the sex determination mechanism in fish(chen et al.,2014),and created molecular sex control *** also discovered the molecular mechanism of metamorphosis in flatfish(Shao et al.,2017)and developed China's first fish disease-resistant breeding gene chip,“YUXIN No.1”.

关键词： technology breeding

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Effect of Reclamation on the Groundwater-Lake Water Interaction in chen Lake

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Journal of Earth Science 2024年第3期35卷 1083-1086页

作者： Kun Lei Teng Ma Liuzhu chen Zhenxing Li Yu chen School of Environmental Studies State Key Laboratory of Biogeology and Environmental GeologyChina University of GeosciencesWuhan 430078China

0 INTRODUCTION To relieve the short supply of suitable land for residing,cultivating,and commerce,it is accepted to reclaim land from lakes,river estuaries,and coastal regions in many countries(Mancini et al.,2020).The large-scale reclamation activities have an irreversible effect on the mico-geomorphology and hydrodynamic system of seasonally flooded areas(Zhang et al.,2019;Yu et al.,2018).For example,coastal regions reclaimed extended the groundwater flow paths,as well as created groundwater level rise,resulting in water-logging in the reclaimed area(Hu et al.,2008).Similar changes in groundwater flow systems may alter groundwater-lake water interactions,and it can ultimately affect the water cycle in the lake ***,such detailed studies are presently *** addition,natural exchanges between the lake and groundwater systems can be strongly affected by physical hydrological processes(Javadzadeh et al.,2020),chemical properties(Kamtchueng et al.,2015),and bioto behavior(Hancock et al.,2005).

关键词： groundwater coastal logging

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Meridional deflection of global eddy propagation derived from tandem altimetry: Mechanism and implication

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Science China Earth Sciences 2024年第3期67卷 811-825页

作者： Ge chen Xiaoyan chen Frontiers Science Center for Deep Ocean Multispheres and Earth System School of Marine TechnologyOcean University of ChinaQindao 266100China Laboratory for Regional Oceanography and Numerical Modeling Laoshan LaboratoryQindao 266237China

A common view on meridional deflection of eddy propagation is poleward for cyclones and equatorward for anticyclones. This widely accepted polarity-sensitive pattern has been increasingly undermined given that it is systematically violated on both zonal and regional scales as recently reported. Here, we approach the problem by exploring these violations in terms of eddy effects of spatiotemporal geostrophy, thermal fading, and flow dragging, yielding the following main conclusions.(1) The polarity-dependent deflection discrepancy is a pseudo feature resulting from a biased fit to the normalized eddy tracks which are spatially asymmetric(though azimuthally symmetric) between the two signs;Instead, the primary pattern of eddy deflection appears to be geographically correlated and polarity independent.(2) Geostrophic adjustment plays a critical role in defining the meridional movement of an eddy. Specifically, a consistent poleward(equatorward) trajectory bending of spatially(temporally) ageostrophic eddies is observed irrespective of their polarity.(3) The mechanism of eddy deflection is also determined by its zonal propagation direction. Westward propagating eddies are substantially affected by thermal fading, while opposite ones by flow dragging. A realistic and comprehensive understanding of eddy deflection mechanisms serves as a significant contribution to the prediction of eddy trajectory, and the protection of ocean environment.

关键词： Mesoscale eddies Eddy propagation Eddy meridional deflection Satellite observation Geostrophic adjustment

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A refined representation method of the particle size distribution curve based on grading entropy

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Particuology 2024年第5期88卷 302-311页

作者： Xing Li Qun chen Zhaozhao Liu cheng Zhou chen Wang chen chen State Key Laboratory of Hydraulics and Mountain River Engineering College of Water Resource and HydropowerSichuan UniversityChengdu610065China

The particle size distribution(PSD)curve is an important expression of the basic properties of the *** characteristic parameters such as median particle size D_(50),effective particle size D_(10),and some combinations of characteristic parameters can only represent some points of the PSD curve,failing to represent all information of the PSD *** this paper,a fraction characteristic parameter F that could reflect the fraction size variation of the PSD curve was introduced based on grading *** a new presentation method of the A-B-F three parameters was proposed for a refined representation of the PSD *** was found that the newly constructed model not only better represents the differences in the width of PSD curves but also has a higher sensitivity than the A-B two-parameter model proposed by Lő*** PSD curves with similar distributions,the new presentation method has a higher degree of discrimination than that of the D_(50)-C_(u)-C_(c) three-parameter or the four-parameter combination G_(c) proposed by ***,the application of this new method in describing the spatial nonuniformity distribution of depositions and predicting the soil hydraulic conductivity was *** research results can provide a reference for the refined representation of PSD curves.

关键词： Grading entropy Particle size distribution curve Refined representation

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Track correlation algorithm based on CNN-LSTM for swarm targets

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Journal of Systems Engineering and Electronics 2024年第2期35卷 417-429页

作者： chen Jinyang WANG Xuhua chen Xian Research Institute for National Defense Engineering Academy of Military SciencesLuoyang 471023China Information Engineering University Zhengzhou 450001China School of Computer Science and Technology Xidian UniversityXi’an 710071China

The rapid development of unmanned aerial vehicle(UAV) swarm, a new type of aerial threat target, has brought great pressure to the air defense early warning system. At present, most of the track correlation algorithms only use part of the target location, speed, and other information for *** this paper, the artificial neural network method is used to establish the corresponding intelligent track correlation model and method according to the characteristics of swarm ***, a route correlation method based on convolutional neural networks (CNN) and long short-term memory (LSTM)Neural network is designed. In this model, the CNN is used to extract the formation characteristics of UAV swarm and the spatial position characteristics of single UAV track in the formation,while the LSTM is used to extract the time characteristics of UAV swarm. Experimental results show that compared with the traditional algorithms, the algorithm based on CNN-LSTM neural network can make full use of multiple feature information of the target, and has better robustness and accuracy for swarm targets.

关键词： track correlation correlation accuracy rate swarm target convolutional neural network(CNN) long short-term memory(LSTM)neural network

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