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Remodel the perifollicular microenvironment via Minoxidil-loaded microneedle patch and cold atmospheric plasma for treating androgenetic alopecia

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Nano Research 2024年第7期17卷 6411-6419页

作者： Hao chen Xianzhe Tang Yueye Huang chen chen Yuheng Yang Chaojie Hao Wenqi Xie Tingjing Huang Xiaofeng cheng Qingnan Xu Shicong Huang Zhi Ye Xucong Lin Zhaowei chen zhitong chen MOE Key Laboratory for Analytical Science of Food Safety and Biology and New Cornerstone Science LaboratoryCollege of ChemistryFuzhou UniversityFuzhou 350108China Institute of Biomedical and Health Engineering Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China Advanced Therapeutic Center National Innovation Center for Advanced Medical DevicesShenzhen 518000China Department of Chemistry University College LondonLondon WC1H 0AJUK Engineering Technology Research Center on Reagent and Instrument for Rapid Detection of Product Quality and Food Safety in Fujian Province College of ChemistryFuzhou UniversityFuzhou 350108China Key Laboratory of Biomedical Imaging Science and System Chinese Academy of SciencesShenzhen 518055China

Androgenetic alopecia(AGA)is a chronic and progressive form of hair loss characterized by vascular degeneration in the perifollicular microenvironment,leading to cell apoptosis and eventual loss of hair follicles(HFs).Traditional therapeutic formulations,such as Minoxidil(MXD)tincture,have limitations in reshaping the perifollicular microenvironment and exhibit limited ***,we report a multi-synergistic therapeutic platform for high-performance hair regeneration *** platform combines microneedle(MN)patches loaded with MXD-encapsulated nanostructured lipid carriers(MXD-NLC-MNs)and cold atmospheric plasma(CAP).The MNs’mechanical strength enables efficient transdermal delivery of MXD to the targeted dermal papilla cells,promoting cell ***,in collaboration with MXD,the mechanical stimulation exerted by MN application synergistically upregulates the expression of vascular endothelial growth factor,leading to ***,the transient microchannels in the skin created by MNs facilitate the transdermal delivery of CAPgenerated nitric oxide(NO)to the sites of HF lesions,whereby the synergistic interaction between MXD and NO boosts perifollicular ***,the perifollicular microenvironment can be effectively reshaped to accelerate hair regeneration in AGA murine *** multi-synergistic combination therapy strategy would hold great promise for effectively treating AGA and promoting hair regrowth.

关键词： nanomedicine androgenetic alopecia microneedle cold atmospheric plasma drug delivery

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Bacterial microcompartment-mimicking Pickering emulsion droplets for detoxification of chemical threats under sweet conditions

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Science China Chemistry 2024年第9期67卷 3039-3049页

作者： Xiao Xu Wenqi Xie Ting Wu chen chen Xiaoning chen Yuheng Yang Hao Lian Hao chen Xiaofeng cheng zhitong chen Guojun chen Chaoqun Liu Lanlan chen Yu He Zhaowei chen Bernard P.Binks Huanghao Yang New Cornerstone Science Laboratory MOE Key Laboratory for Analytical Science of Food Safety and BiologyCollege of ChemistryFuzhou UniversityFuzhou 350002China Institute of Biomedical and Health Engineering Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China Department of Biomedical Engineering and the Rosalind&Morris Goodman Cancer Research Institute McGill UniversityMontreal QC H3A 1A3Canada School of Pharmacy Henan UniversityKaifeng 475004China Department of Chemistry University of HullHull HU67RXUK

Chemical warfare agents represent a severe threat to mankind and their efficient decontamination is a global ***,traditional disposal strategies have limitations,including high energy consumption,use of aggressive reagents and generation of toxic ***,inspired by the compartmentalized architecture and detoxification mechanism of bacterial microcompartments,we constructed oil-in-water Pickering emulsion droplets stabilized by hydrogen-bonded organic framework immobilized cascade enzymes for decontaminating mustard gas simulant(2-chloroethyl ethyl sulfide,CEES)under sweet *** exemplified droplet systems were developed with two-enzyme(glucose oxidase/chloroperoxidase)and threeenzyme(invertase/glucose oxidase/chloroperoxidase)cascades,both achieving over 6-fold enhancement in decontamination efficiency compared with free enzymes and>99% selectivity towards non-toxic *** found that the favored mass transfer of sugars and CEES from their respective phases to approach the cascade enzymes located at the droplet surface and the facilitated substrate channeling between proximally immobilized enzymes were key factors in augmenting the decontamination *** importantly,the robustness of immobilized enzymes enabled easy reproduction of both the droplet formation and detoxification performance over 10 cycles,following long-term storage and in far-field locations.

关键词： Pickering emulsion biomimetics chemical warfare agent bacterial microcompartment biocatalysis

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KIF5B-mediated internalization of FMDV promotes virus infection

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Virologica Sinica 2024年第3期39卷 378-389页

作者： Wei Zhang Fan Yang Yang Yang Weijun Cao Wenhua Shao Jiali Wang Mengyao Huang zhitong chen Xiaoyi Zhao Weiwei Li Zixiang Zhu Haixue Zheng State Key Laboratory for Animal Disease Control and Prevention College of Veterinary MedicineLanzhou UniversityLanzhou Veterinary Research InstituteChinese Academy of Agricultural SciencesLanzhou 730000China Gansu Province Research Center for Basic Disciplines of Pathogen Biology Lanzhou 730046China

Foot-and-mouth disease(FMD)is a highly contagious and economically important disease,which is caused by the FMD virus(FMDV).Although the cell receptor for FMDV has been identified,the specific mechanism of FMDV internalization after infection remains *** this study,we found that kinesin family member 5B(KIF5B)plays a vital role during FMDV ***,we confirmed the interaction between KIF5B and FMDV structural protein VP1 by co-immunoprecipitation(Co-IP)and co-localization in FMDV-infected *** particular,the stalk[amino acids(aa)413–678]domain of KIF5B was indispensable for KIF5B-VP1 ***,overexpression of KIF5B dramatically enhanced FMDV replication;consistently,knockdown or knockout of KIF5B suppressed FMDV ***,we also demonstrated that KIF5B promotes the internalization of FMDV via regulating clathrin ***5B also promotes the transmission of viral particles to early and late endosomes during the early stages of *** conclusion,our results demonstrate that KIF5B promotes the internalization of FMDV via regulating clathrin uncoating and intracellular *** study may provide a new therapeutic target for developing FMDV antiviral drugs.

关键词： FMDV VP1 protein KIF5B Endosome Clathrin

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面向全型面精加工的整体叶盘铣磨组合加工技术研究

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航空制造技术 2024年第4期67卷 104-109,117页

作者：陈帅陈志同刘超柴晋峰刘成北京航空航天大学北京100191 中国航发南方工业有限公司株洲412002

整体叶盘由多个叶片呈圆周阵列布置在轮毂上,由于叶身型面为弱刚性零件,精加工时刀具磨损、颤振及让刀变形较为严重,影响了加工质量的进一步提高。提出一种面向全型面精加工的整体叶盘铣磨组合加工工艺,叶片型面采用磨削加工工艺,叶根... 详细信息

整体叶盘由多个叶片呈圆周阵列布置在轮毂上,由于叶身型面为弱刚性零件,精加工时刀具磨损、颤振及让刀变形较为严重,影响了加工质量的进一步提高。提出一种面向全型面精加工的整体叶盘铣磨组合加工工艺,叶片型面采用磨削加工工艺,叶根、流道区域采用铣削加工工艺,通过控制磨削与铣削刀轨重叠区域的接刀误差实现叶盘全型面加工。试验结果表明,铣磨组合加工工艺表现出较好的加工质量,接刀误差控制在0.01 mm以内,轮廓误差小于0.04 mm,并通过加工试验验证了多主轴阵列加工的可行性,在保证加工质量的同时可大幅度提升加工效率。

关键词：整体叶盘全型面加工磨削加工铣削加工多主轴

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Suppression of Surface Burn in Grinding of Titanium Alloy TC4 Using a Self-inhaling Internal Cooling Wheel

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Chinese Journal of Aeronautics 2011年第1期24卷 96-101页

作者： LI Xun chen zhitong chen Wuyi School of Mechanical Engineering and Automation Beijing University of Aeronautics and Astronautics Beijing 100191 China

Based on analysis of surface average temperature and burn degree, this article obtains the threshold temperature of surface burn in grinding titanium alloy with cup wheels. Meanwhile, the impact of the burn degree on the metallographic structure of workpiece surface and metallurgical phase transformations is investigated. In order to reduce the grinding temperature and improve the grinding efficiency, a self-inhaling structure cup segmented wheel is developed to generate internal cooling effect. The internal cooling technology is compared with traditional cooling conditions in the grinding experiments on TC4 （Ti-6Al-4V）. The results indicate that the self-inhaling internal cooling wheel can reduce the grinding surface temperature by 30% or more, and the grinding efficiency doubles. Utilizing water-based semi-synthetic coolant, the segmented wheel with the self-inhaling structure can further reduce the grinding temperature by about 50%.

关键词： grinding temperature measurement surface burn internal cooling self-inhaling

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Tool Positioning Algorithm Based on Smooth Tool Paths for 5-axis Machining of Sculptured Surfaces

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Chinese Journal of Mechanical Engineering 2011年第5期24卷 851-858页

作者： XU Rufeng chen zhitong chen Wuyi School of Mechanical Engineering and Automation Beihang University Beijing 100191 China

The current research of the 5-axis tool positioning algorithm mainly focuses on searching the local optimal tool position without gouging and interference at a cutter contact（CC） point,while not considering the smoothness and continuity of a whole tool *** the surface curvature varies significantly,a local abrupt change of tool paths will *** abrupt change has a great influence on surface machining *** order to keep generated tool paths smooth and continuous,a five-axis tool positioning algorithm based on smooth tool paths is ***,the inclination angle,the tilt angle and offset distance of the tool at a CC point are used as design variables,and the machining strip width is used as an objective function,an optimization model of a local tool positioning algorithm is thus ***,a vector equation of tool path is derived by using the above optimization *** analyzing the equation,the main factors affecting the tool path quality are ***,a new tool position optimization model is established,and the detailed process of tool position optimization is also *** experiment is conducted to machine an aircraft turbine blade by using the proposed algorithm on a 5-axis blade grinding machine,and the machined blade surface is measured with a coordinate measuring machine（CMM）.Experimental and measured results show that the proposed algorithm can ensure tool paths are smooth and continuous,improve the tool path quality,avoid the local abrupt change of tool paths,and enhance machining quality and machining efficiency of sculptured surfaces.

关键词： tool position tool path smooth five-axis sculptured surfaces machining

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基于反向分段加工的整体叶盘变形控制技术研究

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航空制造技术 2024年第12期67卷 28-35页

作者：杨滨涛刘明柏廷越陈帅吴禹鹏陈志同中国航发贵州黎阳航空动力有限公司贵阳550014 北京航空航天大学北京100191

针对航空发动机整体叶盘精加工过程中易产生颤振和加工变形的难题,开展了整体叶盘变形控制技术研究,设计出一种基于反向分段加工的光固化辅助支撑夹具。首先依据工件分段刚性化原则说明反向分段加工对于减少工件加工变形的有效性。其次... 详细信息

针对航空发动机整体叶盘精加工过程中易产生颤振和加工变形的难题,开展了整体叶盘变形控制技术研究,设计出一种基于反向分段加工的光固化辅助支撑夹具。首先依据工件分段刚性化原则说明反向分段加工对于减少工件加工变形的有效性。其次设计了包括压紧块、仿形块、固定板在内的三段式叶盘加工辅助支撑夹具,通过光敏树脂填充仿形块与叶片之间的缝隙,为整体叶盘的加工提供良好支撑。并对夹具支撑性能进行了测试,验证了夹具的可靠性。最后,采用叶盘模拟件进行了反向分段加工验证试验,结果表明,所设计的夹具减小了叶盘截面线加工误差,最大让刀变形量由0.1 mm下降到了0.05 mm,验证了光固化辅助夹具对整体叶盘加工具有较好的变形控制作用。

关键词：整体叶盘变形控制反向分段加工辅助支撑光敏树脂

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原发性阴茎恶性黑色素瘤1例报告

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中华泌尿外科杂志 2024年第8期45卷 633-634页

作者：陈峙橦黄龙陈小彬周晓峰陈爽程文龙陈国俊青海大学附属医院泌尿外科西宁810000 青海大学附属医院肝胆胰外科西宁810000 青海大学附属医院病理科西宁810000

本文报道青海大学附属医院收治的1例阴茎原发性恶性黑色素瘤患者,56岁,因发现阴茎肿物1个月入院。查体:尿道外口下方近系带处可见大小约1.5cm×2.0cm不规则菜花样肿物,表面覆盖黄色坏死组织,触痛阳性;左、右侧腹股沟区可触及数枚包块,... 详细信息

本文报道青海大学附属医院收治的1例阴茎原发性恶性黑色素瘤患者,56岁,因发现阴茎肿物1个月入院。查体:尿道外口下方近系带处可见大小约1.5cm×2.0cm不规则菜花样肿物,表面覆盖黄色坏死组织,触痛阳性;左、右侧腹股沟区可触及数枚包块,触痛阳性。实验室检查未见异常。头、胸部、腹部、盆腔CT检查未见明显异常。阴茎肿物活检病理提示恶性黑色素瘤。右侧腹股沟区淋巴结穿刺活检病理结果考虑局部炎症反应。结合患者病史、查体、影像学检查和淋巴结穿刺结果诊断为原发性阴茎恶性黑色素瘤。行阴茎部分切除术,术后病理诊断为恶性黑色素侵犯表皮伴溃疡。术后随访9个月无局部复发和转移。

关键词：黑色素瘤原发性阴茎恶性黑色瘤手术免疫组化

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An approach for machining distortion measurements and evaluation of thin-walled blades with small datum

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Chinese Journal of Aeronautics 2016年第6期29卷 1806-1814页

作者： Yu Jianhua chen zhitong Jiang Zepeng School of Mechanical Engineering and Automation Beihang UniversityBeijing 100083China AVIC Commercial Aircraft Engine Manufacturing Co. Ltd.Shanghai 201306China Co-Innovation Center for Advanced Aero-Engine Beijing 100083China

Inspection techniques for aero-engine blades are a hot topic in industry. Since these blades have a sculptured surface and a small datum, measurement results may deviate from an actual position. There are few proper approaches compensating for non-uniform distribution errors that are within specified tolerance ranges. This study aimed to develop a meshing structure measuring approach for the distortion of blades via non-contact optical 3D scanning. A rough measurement and a registration procedure are initially adopted to rectify the coordinate system of a blade, which avoids the initial coordinate system errors caused by the small datum. A measurement path with meshing structure is then unfolded on the blade surface. For non-uniform distribution errors, the meshing structure measurement is more visual and clear than the traditional constant height curves method. All measuring points take only 7 min to complete, and the distribution of error is directly and accurately presented by the meshing structure. This study provides a basis for future research on distortion control and error compensation.

关键词： Free surface Machining distortion Optical testing Thin-walled workpiece Turbine blades

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Design and experimental study of a micro-groove grinding wheel with spray cooling effect

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Chinese Journal of Aeronautics 2014年第2期27卷 407-412页

作者： Shi Chaofeng Li Xun chen zhitong School of Mechanical Engineering and Automation Beihang University China Precision Engineering Institute for Aircraft Industry

The effectiveness of grinding fluid supply has a crucial impact on grinding quality and efficiency in high speed grinding. In order to improve the cooling and lubrication, through in-depth research of self-inhaling internal cooling method and intermittent grinding mechanism, a new spray cooling method used in high speed grinding is proposed. By referring to the structure of bowl- shaped dispersion disk, the grinding wheel matrix with atomization ability is designed; through studying heat transfer of droplet collision and the influence of micro-groove on the boiling heat transfer, grinding segment with micro-groove is designed to enhance the heat flux of coolant and achieve maximum heat transfer between droplets and grinding contact zone. High-speed grinding experiments on GH4169 with the developed grinding wheel are carried out. The results show that with the micro-groove grinding wheel just 5.4% of pump outlet flow rate and 0.5% of spindle energy is needed to reduce the grinding temperature to 200℃, which means the developed grinding wheel makes cooling high efficient and low energy consuming.

关键词： Cooling Droplet Grinding Micro grooveSpray cooling

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