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In situ photoelectric biosensing based on ultranarrowband near-infrared plasmonic hot electron photodetection

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Advanced Photonics 2024年第2期6卷 81-89页

作者： Xianghong nan Wenduo Lai Jie Peng Haiquan Wang Bojun chen Huifan He Zekang Mo Zikun Xia Ning Tan Zhong Liu Long Wen Dan Gao Qin chen Jinan University College of Physics & Optoelectronic Engineering Institute of Nanophotonics Guangdong Provincial Key Laboratory of Nanophotonic Manipulation Tsinghua University Shenzhen International Graduate School State Key Laboratory of Chemical Oncogenomics Jinan University College of Life Science and Technology

Narrowband photodetection is an important measurement technique for material analysis and sensing, for example, nondispersive infrared sensing technique. Both photoactive material engineering and nanophotonic filtering schemes have been explored to realize wavelength-selective photodetection,while most devices have a responsive bandwidth larger than 2% of the operating wavelength, limiting sensing performance. Near-infrared photodetection with a bandwidth of less than 0.2% of the operating wavelength was demonstrated experimentally in Au/Si Schottky nanojunctions. A minimum linewidth of photoelectric response down to 2.6 nm was obtained at a wavelength of 1550 nm by carefully tailing the absorptive and radiative loss in the nanostructures. Multiple functions were achieved on chip with the corrugated Au film, including narrowband resonance, light harvesting for sensing and photodetection, and electrodes for hot electron emission. Benefiting from such a unity integration with in situ photoelectric conversion of the optical sensing signal and the ultranarrowband resonance, self-contained on-chip biosensing via simple intensity interrogation was demonstrated with a limit of detection down to 0.0047%in concentration for glucose solution and 150 ng∕m L for rabbit IgG. Promising potential of this technique is expected for the applications in on-site sensing, spectroscopy, spectral imaging, etc.

关键词： Photodetectors Plasmonics Biosensing Optical gratings Gold Absorption spectrum Acoustooptic tunable filters Absorption Sensors In situ remote sensing

Cancer-educated neutrophils promote lung cancer progression via PARP-1-ALOX5-mediated MMP-9 expression

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Cancer Biology & Medicine 2024年第2期21卷 175-192页

作者： Lulu Han Yuxin chen nan Huang Xiaowan Zhou Yanfang Lv Huizhong Li Dafei Chai Junnian Zheng Gang Wang Cancer Institute Xuzhou Medical University209 Tongshan RoadXuzhou 221004China Center of Clinical Oncology The Affiliated Hospital of Xuzhou Medical University99 West Huaihai RoadXuzhou 221002China Jiangsu Center for the Collaboration and Innovation of Cancer Biotherapy Xuzhou Medical University209 Tongshan RoadXuzhou 221004China Department of Oncology Suzhou Xiangcheng People’s HospitalSuzhou 215131China

Objective:Neutrophils are one of the most predominant infiltrating leukocytes in lung cancer tissues and are associated with lung cancer *** neutrophils promote lung cancer progression,however,has not been ***:Kaplan–Meier plotter online analysis and tissue immunohistochemistry were used to determine the relationship between neutrophils and overall survival in lung cancer *** effect of neutrophils on lung cancer was determined using the Transwell migration assay,a proliferation assay,and a murine tumor *** knockdown was used to determine poly ADPribose polymerase(PARP)-1 function in lung cancer-educated *** blot analysis and gelatin zymography were used to demonstrate the correlation between PARP-1 and matrix metallopeptidase 9(MMP-9).Immunoprecipitation coupled to mass spectrometry(IP/MS)was used to identify the proteins interacting with ***-immunoprecipitation(Co-IP)was used to confirm that PARP-1 interacts with arachidonate 5-lipooxygenase(ALOX5).Neutrophil PARP-1 blockage by AG14361 rescued neutrophil-promoted lung cancer ***:An increased number of infiltrating neutrophils was negatively associated with overall survival in lung cancer patients(P<0.001).Neutrophil activation promoted lung cancer cell invasion,migration,and proliferation in vitro,and murine lung cancer growth in ***,PARP-1 was shown to be involved in lung cancer cell-induced neutrophil activation to increase MMP-9 expression through interacting and stabilizing ALOX5 by post-translational protein modification(PARylation).Blocking PARP-1 by gene knockdown or AG14361 significantly decreased ALOX5 expression and MMP-9 production,and eliminated neutrophil-mediated lung cancer cell invasion and in vivo tumor ***:We identified a novel mechanism by which PARP-1 mediates lung cancer cell-induced neutrophil activation and PARylates ALOX5 to regulate MMP-9 expression,which exacerbates lung cancer

关键词： Lung cancer neutrophils PARP-1 ALOX5 MMP-9

MOF-derived 1D CGO Cathode for Efficient Solid Oxide Electrolysis Cells

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Chemical Research in Chinese Universities 2024年第4期40卷 737-746页

作者： TIAN Jiayu SUN Qi LIU Pei DAI Jiuyi CAI Yezheng XU Miao YE Tian-nan chen Jie-Sheng Frontiers Science Center for Transformative Molecules School of Chemistry and Chemical EngineeringShanghai Jiao Tong UniversityShanghai200240P.R.China Zhangjiang Institute for Advanced Study Shanghai Jiao Tong UniversityShanghai200240P.R.China State Key Laboratory of Space Power-sources Shanghai Institute of Space Power-sourcesShanghai200245P.R.China

Solid oxide electrolysis cells(SOECs)provide a promising way for converting renewable energy into chemical ***,NiO/CGO(nickel-gadolinium doped ceria)cermet has shown its excellent properties in ionic and electronic conductivity under reducing ***,we developed a novel 1D NiO/CGO cathode through a cerium metal-organic framework(MOF)derived *** cathode’s 1D nanostructure integrated with a microchannel scaffold facilitates enhanced mass transport,providing vertically aligned pathways for CO_(2)and H_(2)O ***,the 1D framework increases the number of interfacial sites and reduces ion diffusion distances,thereby simplifying electron/ion ***,this advanced cathode achieved a significant breakthrough in SOEC performance,maintaining efficient CO_(2)and H_(2)O electrolysis at an extraordinary current density of 1.41 A/cm^(2)at 1.5 V and excellent stability over 24 h at 850℃.The enhanced performance of this newly developed cathode not only achieves a remarkable 100%improvement compared to those of NiO/CGO cathodes with varying geometrical configurations but also surpasses those of commercial NiO/CGO catalysts by an outstanding 40%when tested under identical *** development of the 1D NiO/CGO enhances the efficiency and durability of ceramic cathodes for CO_(2)and H_(2)O co-electrolysis in SOECs and improves the scalability and effectiveness of SOECs in renewable energy applications.

关键词： Cerium metal-organic framework One-dimensional structure Gadolinium doped ceria CO_(2)activation co-Electrolysis

Distribution and Formation Causes of PM_(2.5) and O_(3) Double High Pollution Events in China during 2013–20

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Advances in Atmospheric Sciences 2024年第6期41卷 1235-1250,I0004-I0021页

作者： Zhixuan TONG Yingying YAN Shaofei KONG Jintai LIN nan chen Bo ZHU Jing MA Tianliang ZHAO Shihua QI Department of Atmospheric Science School of Environmental SciencesChina University of GeosciencesWuhan 430074China State Key Laboratory of Atmospheric Boundary Layer Physics and Atmospheric Chemistry Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China Research Centre for Complex Air Pollution of Hubei Province Wuhan 430074China Laboratory for Climate and Ocean–Atmosphere Studies Department of Atmospheric and Oceanic SciencesSchool of PhysicsPeking UniversityBeijing 100871China Eco-Environmental Monitoring Centre of Hubei Province Wuhan 430074China Key Laboratory of Atmospheric Chemistry China Meteorological AdministrationBeijing 100081China School of Atmospheric Physics Nanjing University of Information Science and TechnologyNanjing 210044China State Key Laboratory of Biogeology and Environmental Geology China University of GeosciencesWuhan 430074China

Fine particulate matter(PM_(2.5))and ozone(O_(3))double high pollution(DHP)events have occurred frequently over China in recent years,but their causes are not completely *** this study,the spatiotemporal distribution of DHP events in China during 2013–20 is *** synoptic types affecting DHP events are identified with the Lamb–Jenkinson circulation classification *** meteorological and chemical causes of DHP events controlled by the main synoptic types are further *** show that DHP events(1655 in total for China during 2013–20)mainly occur over the North China Plain,Yangtze River Delta,Pearl River Delta,Sichuan Basin,and Central *** occurrence frequency increases by 5.1%during 2013–15,and then decreases by 56.1%during 2015–*** main circulation types of DHP events are“cyclone”and“anticyclone”,accounting for over 40%of all DHP events over five main polluted regions in China,followed by southerly or easterly flat airflow types,like“southeast”,“southwest”,and“east”.Compared with non-DHP events,DHP events are characterized by static or weak wind,high temperature(20.9℃ versus 23.1℃)and low humidity(70.0%versus 64.9%).The diurnal cycles of meteorological conditions cause PM_(2.5)(0300–1200 LST,Local Standard Time=UTC+8 hours)and O_(3)(1500–2100 LST)to exceed the national standards at different periods of the DHP *** pollutant conversion indices further indicate the rapid secondary conversions during DHP events,and thus the concentrations of NO_(2),SO_(2) and volatile organic compounds decrease by 13.1%,4.7%and 4.4%,*** results of this study can be informative for future decisions on the management of DHP events.

关键词： double high pollution events PM_(2.5) ozone spatiotemporal distribution meteorological causes chemical composition characteristics

Engineering a high-barrier d-f single-molecule magnet centered with hexagonal bipyramidal Dy(Ⅲ)unit

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Science China Chemistry 2024年第10期67卷 3291-3298页

作者： Wei Deng Chan-Ying Yao Yan-Cong chen Ying-Qian Zhou Shan-nan Du Jun-Liang Liu Ming-Liang Tong Key Laboratory of Bioinorganic and Synthetic Chemistry of Ministry of Education School of ChemistryInstitute of Green Chemistry and Molecular EngineeringGuangdong Basic Research Center of Excellence for Functional Molecular EngineeringSun Yat-sen UniversityGuangzhou 510006China

In the pursuit of high-performance single-molecule magnets(SMMs),incorporating intramolecular magnetic coupling emerges as a pivotal *** these,d-f SMMs have garnered significant attention due to their remarkable versatility,which lies in their ability to tune coordination environments and facilely substitute metal ***,achieving performance-centric d-f SMMs through the synergistic interplay between highly anisotropic f ions and d-f magnetic interactions remains a formidable *** mononuclear hexagonal bipyramidal(D_(6h))Dy^(Ⅲ)SMMs have been successfully isolated,the exploration of d-f SMMs featuring D_(6h)-lanthanide metal centers remains uncharted *** this study,we employed planar bipodal ligands in conjunction with“staple-like”axial phenoxide ligands to synthesize the first hexagonal bipyramidal d-f ***,this compound exhibits alternating-current magnetic susceptibilities peaking up to 68 K with an energy barrier surpassing 1,200 K,thus establishing a new benchmark within the heterometallic d-f SMM landscape inclusive of complexes with diamagnetic d metals and paramagnetic f ***,the ferromagnetic interaction at the d-f sites engenders oscillating relaxation times contingent on the magnetic field—a characteristic distinct from mononuclear *** findings shed light on a deliberate design approach for d-f SMMs,emphasizing the cooperative utilization of high-barrier lanthanide modules alongside d ions through magnetic *** synergy significantly enhances and diversifies the magnetic dynamics of these intriguing molecular systems.

关键词： single-molecule magnets magnetic coupling crystal engineering hexagonal bipyramid energy barrier

Thermal conductivity of iron under the Earth’s inner core pressure

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Chinese Physics B 2024年第10期33卷 343-348页

作者： Cui-E Hu Mu-Xin Jiao Xue-nan Yang Zhao-Yi Zeng Jun chen College of Physics and Electronic Engineering Chongqing Normal UniversityChongqing 400047China Laboratory of Computational Physics Institute of Applied Physics and Computational MathematicsBeijing 100088China Center for Applied Physics and Technology Peking UniversityBeijing 100071China

The thermal conductivity ofε-iron at high pressure and high temperature is a key parameter to constrain the dynamics and thermal evolution of the Earth’s *** this work,we use first-principles calculations to study the Hugoniot sound velocity and the thermal transport properties ofε-*** total thermal conductivity considering lattice vibration is 200 W/mK at the Earth’s inner core *** suppressed anharmonic interactions can significantly enhance the lattice thermal conductivity under high pressure,and the contribution of the lattice thermal conductivity should not be ignored under the Earth’s core conditions.

关键词： thermal conductivity first-principles high pressure and high temperature

Sporadic gastrinoma with refractory benign esophageal stricture:A case report

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World Journal of Clinical Cases 2024年第7期12卷 1284-1289页

作者： Qian-nan chen Bing-Qing Bai Yan Xu Qiao Mei Xiao-Chang Liu Department of Gastroenterology First Affiliated Hospital of Anhui Medical UniversityHefei 230001Anhui ProvinceChina

BACKGROUND Gastrinoma is characterized by an excessive release of gastrin,leading to hypersecretion of gastric acid,subsequently resulting in recurrent peptic ulcers,chronic diarrhea,and even esophageal *** case report aims to improve awareness and facilitate early diagnosis and treatment of gastrinoma by presenting a rare case of gastrinoma with refractory benign esophageal stricture(RBES).Additionally,it highlights the persistent challenges that gastroenterologists encounter in managing *** SUMMARY This case demonstrates a patient with gastrinoma who developed RBES and complete esophageal obstruction despite management with maximal acid suppressive therapy,multiple endoscopic bougie dilations and endoscopic incisional therapy(EIT).CONCLUSION It is essential to diagnose gastrinoma as early as possible,as inadequately controlled acid secretion over an extended period increases the risk of developing severe esophageal *** patients with esophageal strictures causing complete luminal obstruction,blind reopening EIT presents challenges and carries a high risk of perforation.

关键词： Gastrinoma Zollinger-Ellison syndrome Neuroendocrine neoplasm Chronic diarrhea Refractory benign esophageal stricture Case report

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景深的艺术效果分析

湛江师范学院学报 2009年第4期30卷 130-132页

作者：陈友南湛江师范学院实验教学管理处广东湛江524048

景深的控制是摄影技术中重要的艺术造型手段之一,景深的深浅是由光圈、焦距和拍摄的距离来决定。景深的调整可以突出拍摄的主体,丰富画面内涵,增加画面的艺术效果。

关键词：摄影技术景深艺术效果

Enhancing alkaline water oxidation with NiFe alloy-encapsulated nitrogen-doped vertical graphene array

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nano Research 2024年第6期17卷 4790-4796页

作者： Jue nan Beirong Ye Xun He chen Li Wanli Zhang Qian Liu Luming Li Wei Chu Xuping Sun Yongqi Zhang School of Integrated Circuit Science and Engineering University of Electronic Science and Technology of ChinaChengdu 611731China Institute of Fundamental and Frontier Science University of Electronic Science and Technology of ChinaChengdu 611731China Institute for Advanced Study Chengdu UniversityChengdu 610106China College of Chemistry Chemical Engineering and Materials ScienceShandong Normal UniversityJinan 250014China

Advancing efficient and affordable electrocatalysts to boost the oxygen evolution reaction(OER)is pivotal for sustainable green hydrogen ***,we propose the fabrication of nickel-iron alloy nanoparticles-encapsulated on N-doped vertically aligned graphene array on carbon cloth(NiFe@NVG/CC)as a highly active three-dimensional(3D)catalyst electrode for *** 1 M KOH,such NiFe@NVG/CC demonstrates outstanding catalytic performance,necessitating merely overpotential of 245 mV for achieving a current density of 10 mA·cm^(−2),a remarkably low Tafel slope of 36.2 mV·dec^(−1).Furthermore,density functional theory calculations validate that the incorporate of N species into graphene can reinforce the electrocatalytic activity though reducing the reaction energy barrier during the conversion of*O to*OOH *** outstanding performance and structural benefits of NiFe@NVG/CC offer valuable insights for the development of innovative and efficient electrocatalysts for water oxidation.

关键词： NiFe alloy N-doped vertical graphene array electrocatalyst oxygen evolution reaction density functional theory