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Revealing Tissue Heterogeneity and Spatial Dark Genes from Spatially Resolved Transcriptomics by Multiview Graph Networks

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Research 2024年第2期6卷 629-645页

作者： ying Li Yuejing Lu chen Kang Peiluan Li Luonan chen School of Mathematics and Statistics Henan University of Science and TechnologyLuoyang471023China Longmen Laboratory LuoyangHenan471003China Key Laboratory of Systems Biology Institute of Biochemistry and Cell BiologyCenter for Excellence in Molecular Cell ScienceChinese Academy of SciencesShanghai201100China Key Laboratory of Systems Health Science of Zhejang Province Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou310000China School of Life Science and Technology ShanghaiTech UniversityShanghai201100.China

Spatially resolved transcriptomics(SRT)is capable of comprehensively characterizing gene expression patterns and providing an unbiased image of spatial *** fully understand the organizational complexity and tumor immune escape mechanism,we propose stMGATF,a multiview graph attention fusion model that integrates gene expression,histological images,spatial location,and gene *** better extract information,stMGATF exploits SimCLRv2 for visual feature exaction and employs edge feature enhanced graph attention networks for the learning potential embedding of each view.A global attention mechanism is used to adaptively integrate 3 views to obtain low-dimensional *** to diverse SRT datasets,stMGATF is robust and outperforms other methods in detecting spatial domains and denoising data even with different resolutions and *** particular,stMGATF contributes to the elucidation of tissue heterogeneity and extraction of 3-dimensional expression ***,considering the associations between genes in tumors,stMGATF can identify the spatial dark genes ignored by traditional methods,which can be used to predict tumor-driving transcription factors and reveal tumor immune escape mechanisms,providing theoretical evidence for the development of new immunotherapeutic strategies.

关键词： Spatial integrate driving

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Quantitative Analysis of Frosting Characteristics on the Drip Tray of A Cryogenic Valve for LNG Ships

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China Ocean Engineering 2024年第4期38卷 572-585页

作者： BAI xu chen Guan-yu DU Yue xu Cao chen Jia-jing School of Naval Architecture&Ocean Engineering Jiangsu University of Science and TechnologyZhenjiang 212003China

Cryogenic valves play a crucial role in the production and transportation of liquefied natural gas(LNG),and are primarily responsible for efficiently controlling the inflow and outflow of LNG and regulating ***,due to their operation in low-temperature and high-humidity environments,crucial components such as drip trays are susceptible to frosting,which may lead to LNG leakage,thereby causing severe safety *** this study,the user-defined function(UDF)is employed to redevelop Fluent,which integrates the frost growth model with the Eulerian multiphase flow model,to conduct a quantitative analysis of frosting on drip trays of cryogenic *** effects of environmental parameters,such as wind speed,ambient temperature,air humidity,and cold surface temperature on the growth of the frost layer were *** study reveals a limiting wind speed between 1 m/s and 2 m/*** reaching this limit speed,the growth of the frost layer reaches its maximum,and further increases in the wind speed have no significant effect on the growth of the frost ***,the influence of the change in the flow field on droplet impingement and freezing during the growth of the frost layer is considered through the coupling method of the kinematic characteristics of water droplets and the collection coefficient of water *** study identifies the influence of different parameters on the droplet impact efficiency,leading to the modification of the frost layer on the drip tray.

关键词： LNG carrier drip tray frost effective impact coefficient

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Research on Sarcasm Detection Technology Based on Image-Text Fusion

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Computers, Materials & Continua 2024年第6期79卷 5225-5242页

作者： Xiaofang Jin Yuying Yang YinanWu ying xu School of Information and Communication Engineering Communication University of ChinaBeijing100024China Cable Television Technology Research Institute Academy of Broadcasting ScienceBeijing100053China

The emergence of new media in various fields has continuously strengthened the social aspect of social *** tend to express emotions in social interactions,and many people even use satire,metaphors,and other techniques to express some negative emotions,it is necessary to detect sarcasm in social comment *** sarcasm,the more reference data modalities used,the better the experimental *** paper conducts research on sarcasm detection technology based on image-text fusion *** effectively utilize the features of each modality,a feature reconstruction output algorithm is *** algorithm is based on the attention mechanism,learns the low-rank features of another modality through cross-modality,the eigenvectors are reconstructed for the corresponding modality through weighted *** only the image modality in the dataset is used,the preprocessed data has outstanding performance in reconstructing the output model,with an accuracy rate of 87.6%.When using only the text modality data in the dataset,the reconstructed output model is optimal,with an accuracy rate of 85.2%.To improve feature fusion between modalities for effective classification,a weight adaptive learning algorithm is *** algorithm uses a neural network combined with an attention mechanism to calculate the attention weight of each modality to achieve weight adaptive learning purposes,with an accuracy rate of 87.9%.Extensive experiments on a benchmark dataset demonstrate the superiority of our proposed model.

关键词： Sentiment analysis sarcasm detection feature fusion feature reconstruction

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Effects of dimethyl ether and ethanol additions on soot transition in ethylene counterflow diffusion flames

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Science China(Technological Sciences) 2024年第4期67卷 1094-1112页

作者： GUO LinGe ying YaoYao chen chen ZHAO xuan LIU Dong MIIT Key Laboratory of Thermal Control of Electronic Equipment School of Energy and Power EngineeringNanjing University of Science and TechnologyNanjing 210094China Advanced Combustion Laboratory School of Energy and Power EngineeringNanjing University of Science and TechnologyNanjing 210094China

This paper investigates the effect of blending dimethyl ether(DME)and ethanol on the soot transition periods in ethylene counterflow diffusion flames by using a novel optical diagnostic *** soot critical transition point in different conditions is identified experimentally and *** kinds of flames are carried out to gain the soot critical transition point in counterflow diffusion flames by changing oxygen fraction(Xo)and changing volume flow rates of fuel and oxidizer(Qv).The red-green-blue(RGB)ratio method is used to precisely identify the soot critical transition point,and chemical kinetic simulations are performed to analyze the detailed reaction *** results show that compared to the ethylene flame,the soot critical transition point occurs at a higher Xoand a lower Qvwhen DME or ethanol is *** addition of DME and ethanol can inhibit soot formation,due to the degree of soot formation reaction being lower than the degree of the oxidation reaction in the blending flames.

关键词： optical diagnosis sooting tendency counterflow diffusion flame dimethyl ether ethanol

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Covalency competition induced selective bond breakage and surface reconstruction in manganese cobaltite towards enhanced electrochemical charge storage

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Green Energy & Environment 2024年第5期9卷 909-918页

作者： Peng Gao Pei Tang ying Mo Peitao Xiao Wang Zhou Shi chen Hongliang Dong Ziwei Li Chaohe xu Jilei Liu College of Materials Science and Engineering Hunan Joint International Laboratory of Advanced Materials and Technology for Clean EnergyHunan Province Key Laboratory for Advanced Carbon Materials and Applied TechnologyHunan UniversityChangshaHunan410082China Department of Materials Science and Engineering National University of Defense TechnologyChangshaHunan410073China Joint Key Laboratory of the Ministry of Education Institute of Applied Physics and Materials EngineeringUniversity of MacaoAvenida da UniversidadeTaipaMacao999078China Center for High Pressure Science and Technology Advanced Research PudongShanghai201203China College of Aerospace Engineering Chongqing UniversityChongqing400044China

Manganese cobaltite(MnCo_(2)_(4))is a promising electrode material because of its attractive redox chemistry and excellent charge storage *** previous work demonstrated that the octahedrally-coordinated Mn are prone to react with the hydroxyl ions in alkaline electrolyte upon electrochemical cycling and separates on the surface of spinel to reconstruct into d-MnO_(2) nanosheets irreversibly,thus results in a change of the reaction mechanism with Kþion ***,the low capacity has greatly limited its practical ***,we found that the tetrahedrally-coordinated Co_(2) þions were leached when MnCo_(2)_(4) was equilibrated in 1 mol L^(-1) HCl solution,leading to the formation of layered CoOOH on MnCo_(2)_(4) surface which is originated from the covalency competition induced selective breakage of the CoT–O bond in CoT–O–CoO and subsequent rearrangement of free Co_(6) *** as-formed CoOOH is stable upon cycling in alkaline electrolyte,exhibits conversion reaction mechanism with facile proton diffusion and is free of massive structural evolution,thus enables utilization of the bulk electrode material and realizes enhanced speciﬁc capacity as well as facilitated charge transfer and ion *** general,our work not only offers a feasible approach to deliberate modiﬁcation of MnCo_(2)_(4)'s surface structure,but also provides an in-depth understanding of its charge storage mechanism,which enables rational design of the spinel oxides with promising charge storage properties.

关键词： Manganese cobaltite Tetrahedrally-coordinated Co^(2+)leaching Selective bond breakage Surface reconstruction Charge storage mechanisms

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Design and fabrication of Nd-Fe-B magnet with excellent thermal stability

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Journal of Rare Earths 2024年第5期42卷 980-986,I0006页

作者： Rui Han Shengzhi Dong Dong Li Dongmin Zhang Hongsheng chen Jiyuan xu George CHadjipanayis Zhuolin Li ying Zhang Wei Li Division of Functional Materials Research Central Iron and Steel Research InstituteBeijing100081China Department of Physics and Astronomy Sharp Lab University of DelawareNewarkDE19716USA Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing100190China

A novel Nd-Fe-B type permanent magnet with excellent thermal stability was designed by Co replacing Fe in the main phase and the grain boundary *** remanence and coercivity temperature coefficient reach 0.058%/℃and 0.465%/℃in the te mperature range from 25 to 100℃,which are much lower than those of commercial Nd-Fe-B *** enhanced Curie temperature is obtained for the novel magnet due to the Co substitution,which significantly improves the operating *** microstructure result reveals that an amorphous phase exists in the intergranular grains which is probably responsible for the deterioration of intrinsic *** work can provide a reference for the design and optimization of components of sintered Nd-Fe-B magnets with excellent thermal stability.

关键词： Thermal stability Remanence temperature coefficient Operating temperature Atomic substitution Rare earths

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Analytical computation of magnetic field in coil-dominated superconducting quadrupole magnets based on racetrack coils

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Nuclear Science and Techniques 2024年第4期35卷 119-135页

作者： Chuang Shen ying-Shun Zhu Fu-San chen China Spallation Neutron Source Institute of High Energy PhysicsChinese Academy of Sciences1 Zhongziyuan RoadDongguan 523000China Institute of High Energy Physics Chinese Academy of Sciences19B Yuquan RoadBeijing 100049China University of Chinese Academy of Sciences Beijing 100049China

Currently,three types of superconducting quadrupole magnets are used in particle accelerators:cos 2θ,CCT,and ***,all three coil configurations have complex spatial geometries,which make magnet manufacturing and strain-sensitive superconductor applications *** with the three existing quadrupole coils,the racetrack quadrupole coil has a simple shape and manufacturing process,but there have been few theoretical *** this paper,the two-dimensional and three-dimensional analytical expressions for the magnetic field in coil-dominated racetrack superconducting quadrupole magnets are *** analytical expressions of the field harmonics and gradient are fully resolved and depend only on the geometric parameters of the coil and current ***,a genetic algorithm is applied to obtain a solution for the coil geometry parameters with field harmonics on the order of 10^(-4).Finally,considering the practical engineering needs of the accelerator interaction region,electromagnetic design examples of racetrack quadrupole magnets with high gradients,large apertures,and small apertures are described,and the application prospects of racetrack quadrupole coils are analyzed.

关键词： Superconducting quadrupole magnet Racetrack coil Multipole field Genetic algorithm Magnetic design

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Controllable chemical redox reactions to couple microbial degradation for organic contaminated sites remediation:A review

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Journal of Environmental Sciences 2024年第5期139卷 428-445页

作者： Bin chen Jiang xu Lizhong Zhu College of Environmental and Resource Sciences Zhejiang UniversityHangzhou 310058China Zhejiang Provincial Key Laboratory of Organic Pollution Process and Control Zhejiang UniversityHangzhou 310058China Zhejiang Agriculture&Forest University Lin'an 311300China

Global environmental concern over organic contaminated sites has been progressively conspicuous during the process of urbanization and industrial *** traditional physical or chemical remediation technologies may significantly destroy the soil structure and function,coupling moderate chemical degradation with microbial remediation becomes a potential way for the green,economic,and efficient remediation of contaminated ***,this work systematically elucidates why and how to couple chemical technology with microbial remediation,mainly focused on the controllable redox reactions of organic *** rational design of materials structure,selective generation of reactive oxygen species,and estimation of degradation pathway are described for chemical ***,current progress on efficient and selective reductions of organic contaminants(i.e.,dechlorination,defluorination,-NO_(2) reduction)is *** with the microbial remediation of contaminated sites,several consideration factors of how to couple chemical and microbial remediation are proposed based on both fundamental and practical points of *** review will advance the understanding and development of chemical-microbial coupled remediation for organic contaminated sites.

关键词： Soil remediation Groundwater remediation Rational design Reactive species Environmental nanotechnology

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Designing gradient nanograined dual-phase structure in duplex stainless steel for superior strength-ductility synergy

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Journal of Materials Science & Technology 2024年第3期170卷 122-128页

作者： Songsong xu ying Han Jiapeng Sun Guoqing Zu Mingkun Jiang Weiwei Zhu xu Ran Key Laboratory of Advanced Structural Materials Ministry of EducationChangchun University of TechnologyChangchun 130012China School of Materials Science and Engineering Changchun University of TechnologyChangchun 130012China Provincial Key Laboratory of Advanced Materials Processing and Application for Rail Transit Changchun University of TechnologyChangchun 130012China College of Mechanics and Materials Hohai UniversityNanjing 211100China

Similar to other metallic materials,duplex stainless steel dramatically loses its advantage of high ductility as they are ***,we produce a gradient nanograined dual-phase structure in the 2101 duplex stainless steel,thus facilitating a superior strength-ductility synergy:a yield strength of 1009.5 MPa being two times higher than that of the as-received sample,a total elongation of 23.4%and a uniform elongation of 5.9%.This novel structure is produced through a processing route of ultrasonic severe surface rolling and annealing,which realizes a superposition of gradient nanostructure and lamellar dual-phase structure with austenite and *** the tension deformation of gradi-ent nanograined dual-phase structured duplex stainless steel,a significant accumulation of geometrically necessary dislocations *** dislocations are formed to accommodate the deformation incompat-ibility caused by the layer-by-layer difference in strength and hardness of individual phase domains,as well as the inherent difference in properties between the austenite and ferrite *** results in a stronger hetero-deformation induced strengthening and hardening significantly contributing to superior mechanical *** study provides a new avenue to develop advanced steels with high strength and ductility.

关键词： Gradient structure Duplex stainless steel Synergetic strengthening Strength Ductility

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A froth velocity measurement method based on improved U-Net++semantic segmentation in flotation process

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International Journal of Minerals,Metallurgy and Materials 2024年第8期31卷 1816-1827页

作者： Yiwei chen Degang xu Kun Wan School of Automation Central South UniversityChangsha 410083China

During flotation,the features of the froth image are highly correlated with the concentrate grade and the corresponding working *** static features such as color and size of the bubbles and the dynamic features such as velocity have obvious differences between different working *** extraction of these features is typically relied on the outcomes of image segmentation at the froth edge,making the segmentation of froth image the basis for studying its visual ***,the absence of scientifically reliable training data with label and the necessity to manually construct dataset and label make the study difficult in the mineral *** solve this problem,this paper constructs a tungsten concentrate froth image dataset,and proposes a data augmentation network based on Conditional Generative Adversarial Nets(cGAN)and a U-Net++-based edge segmentation *** performance of this algorithm is also evaluated and contrasted with other algorithms in this *** the results of semantic segmentation,a phase-correlationbased velocity extraction method is finally suggested.

关键词： froth flotation froth segmentation froth image data augmentation velocity extraction image features

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