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Characterization of a New HIV-1 Circulating Recombinant Form CRF142_BC—Yunnan,China,2015 and 2021

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China CDC weekly 2024年第42期6卷 1080-1085页

作者： Min chen Huichao chen Shouxiong Lei Jie Dai yanling Ma Manhong Jia Yunnan Provincial Key Laboratory of Public Health and Biosafety&Health Laboratory Center Yunnan Center for Disease Control and PreventionKunming CityYunnan ProvinceChina Institute for AIDS/STD Control and Prevention Yunnan Center for Disease Control and PreventionKunming CityYunnan ProvinceChina Division for AIDS/STD Control and Prevention Zhaotong Center for Disease Control and PreventionZhaotong CityYunnan ProvinceChina Yunnan Provincial Key Laboratory of Public Health and Biosafety&Institute for AIDS/STD Control and Prevention Yunnan Center for Disease Control and PreventionKunming CityYunnan ProvinceChina

What is already known about this topic?Recombinant strains dominate the human immunodeficiency virus 1(HIV-1)epidemic in *** Province was the first region in China to report HIV-1 infections in *** long-term HIV-1 epidemic led to the generation of various recombinant *** the 47 circulating recombinant forms(CRFs)reported in China,more than 20 were first identified in Yunnan *** is added by this report?This study reported a previously unrecognized HIV-1 CRF(CRF142_BC)characterized by the insertion of four short subtype B fragments into the subtype C ***142_BC was estimated to have emerged in the mid-1990s,close to the time of the emergence of most known CRF_BCs in *** are the implications for public health practice?The discovery of new CRFs will provide a basis for HIV-1 molecular tracing and intervention *** addition,HIV-1 recombination can alter viral biological *** study of HIV-1 gene variants needs to be intensified.

关键词： properties. China. intensified

Cell Mechanics Regulates the Dynamic Anisotropic Remodeling of Fibril Matrix at Large Scale

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Research 2024年第3期2023卷 401-415页

作者： Mingxing Ouyang yanling Hu Weihui chen Hui Li Yingbo Ji Linshuo Qiu Linlin Zhu Baohua Ji Bing Bu Linhong Deng Institute of Biomedical Engineering and Health Sciences School of Medical and Health Engineering and School of PharmacyChangzhou UniversityChangzhou213164China Institute of Biomechanics and Applications Department of Engineering MechanicsZhejang UniversityHangzhou310027China.

Living tissues often have anisotropic and heterogeneous organizations, in which developmental processes are coordinated by cells and extracellular matrix modeling. Cells have the capability of modeling matrix in long distance;however, the biophysical mechanism is largely unknown. We investigated the dynamic remodeling of collagen I (COL) fibril matrix by cell contraction with designed patterns of cell clusters. By considering cell dynamic contractions, our molecular dynamics simulations predicted the anisotropic patterns of the observed COL bundling in experiments with various geometrical patterns without spatial limitation. The pattern of COL bundling was closely related to the dynamic remodeling of fibril under cell active contraction. We showed that cell cytoskeletal integrity (actin filaments and microtubules), actomyosin contractions, and endoplasmic reticulum calcium channels acting as force generations and transductions were essential for fiber bundling inductions, and membrane mechanosensory components integrin and Piezo played critical roles as well. This study revealed the underlying mechanisms of the cell mechanics-induced matrix remodeling in large scales and the associated cellular mechanism and should provide important guidelines for tissue engineering in potential biomedical applications.

关键词： contraction Dynamic Matrix

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江西省不同土地利用方式的碳排放效应

气象与减灾研究 2024年第2期47卷 121-128页

作者：戴芳筠占明锦桂晗亮李柏贞周媛陈燕玲唐春燕江西省生态气象中心江西南昌330096 南昌国家气候观象台江西南昌330043 江西信息应用职业技术学院江西南昌330000 中山大学地理科学与规划学院广东广州510275

基于1995—2020年卫星遥感数据,对中国江西省土地利用类型的年际变化进行了解译,结合能源消费数据,采用碳排放系数法估算全省的碳排放量和吸收量,利用碳足迹和碳生态承载力方法评估区域内的碳排放效应。研究表明:1)江西省1995—2020年... 详细信息

基于1995—2020年卫星遥感数据,对中国江西省土地利用类型的年际变化进行了解译,结合能源消费数据,采用碳排放系数法估算全省的碳排放量和吸收量,利用碳足迹和碳生态承载力方法评估区域内的碳排放效应。研究表明:1)江西省1995—2020年土地利用变化类型中除城乡建设用地面积显著增加,其他用地类型变化幅度较小;2)江西省净碳排放量呈显著增长趋势,研究末期较研究初期增长近3倍,城乡建设用地面积每增加1 km^(2)就会增加1.308 t的碳源,而每增加1 km^(2)的林地仅会增加0.006 t的碳汇,江西中部及南部地区净碳排量少于北部地区;3)江西省碳足迹增长迅速,碳生态承载力变化缓慢,导致生态赤字明显增加,江西南部及中部地区生态赤字效应略轻于北部地区。

关键词：土地利用碳排放系数碳源/汇碳排放效应江西省

Congenital bifurcation of tympanic segment of facial nerve

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Chinese Medical Journal 2014年第9期127卷 1788-1790页

作者： Wang Danni Zhao Shouqin Zhao yanling chen Shubin Yang Lin Department of Otolaryngology Head and Neck Surgery Beijing Tongren Hospital Capital Medical University Key Laboratory of Otolaryngology Head and Neck Surgery (Capital Medical University) Ministry of Education Beijing 100730 China

Congenital aural atresia is usually associated with facial nerve （the seventh cranial nerve,CN7） anomalies with an incidence rate of 60%-75%.These anomalies include facial nerve displacement,facial nerve component overlying the oval window,bony canal dehiscence,and bifurcation,which increase the risk of surgical facial nerve *** all these anomalies,congenital bifurcation of the tympanic segment of facial nerve is the most confusing situation that significantly increases the surgical risk during hearing reconstruction.

关键词： congenital aural atresia facial nerve

Potential value of detection of minimal residual disease in colorectal cancer following radical resection

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Chinese Journal of Cancer Research 2024年第4期36卷 442-454页

作者： Wenji Pu Fang chen Yuan Tang yanling Qu Yunzhu Han Jiandong Zha Jing Jin Fengming Kong Medical Department of Shenzhen University/General Hospital of Shenzhen University/Academy of Clinical Medicine of Shenzhen University Shenzhen 518055China Department of Clinical Oncology the University of Hong Kong-Shenzhen HospitalShenzhen 518053China Department of Radiotherapy National Cancer Center/National Cancer Clinical Medical Research Center/Shenzhen HospitalCancer Hospital of Peking Union Medical CollegeChinese Academy of Medical SciencesShenzhen 518116China

Although there has been significant advancement in the identification and management of colorectal cancer(CRC)in recent years,there is still room for improvement in the current standard treatment *** area of concern is the lack of reliable tumor markers to predict treatment efficacy and guide tailored *** to its dynamic,effective,and non-invasive benefits over tissue biopsy,the detection of minimal or molecular residual lesions(MRD)based on circulating tumor DNA(ctDNA)is beneficial to the clinical development of drugs for patients with CRC after radical treatment,as well as for continuous monitoring of tumor recurrence and malignancy molecular gene *** detection of ctDNA can currently be used to guide individual postoperative auxiliary treatment decisions(upgrade or downgrade treatment)in CRC,stratify the risk of clinical recurrence more precisely,and predict the risk of recurrence in advance of imaging examination,according to a large number of observational or prospective clinical *** increasing clarity comes the possibility of selecting a regimen of treatment based on postoperative ctDNA,which also improves the accuracy of clinical recurrence risk assessment for ***,it is anticipated that the identification of ctDNA would alter the current framework for dealing with CRC and lead to individualized,stratified precision therapy;however,additional confirmation will require subsequent high-quality,prospective,large-scale randomized controlled *** article will provide an overview of the definition and clinical significance of MRD,the primary indications and technological challenges for MRD detection,along with the advancement in clinical research about ctDNA detection following radical resection of the CRC.

关键词： Colorectal cancer minimal residual disease circulating tumor DNA prognosis recurrence biomarkers

Multifunctional cellular carbon foams derived from chitosan toward self-cleaning, thermal insulation, and highly efficient microwave absorption properties

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Nano Research 2024年第3期17卷 927-938页

作者： Beibei Zhan yanling Hao Xiaosi Qi Yunpeng Qu Junfei Ding Jing-liang Yang Xiu Gong Yanli chen Qiong Peng Wei Zhong College of Physics Guizhou Province Key Laboratory for Photoelectrics Technology and ApplicationGuizhou UniversityGuiyang 550025China Minzu Normal University of Xingyi Xingyi 562400China National Laboratory of Solid State Microstructures and Jiangsu Provincial Laboratory for NanoTechnology Nanjing UniversityNanjing 210093China

To adapt the practical demand,designing and constructing the multifunctional microwave absorbers(MAs)is the key future direction of research and ***,effective integrating the multiple functions into a single material remains a huge ***,cellular carbon foams(CCFs)with different porous structures were elaborately designed and fabricated in high efficiency through a facile continuous freeze-drying and carbonization processes using a sustainable biomass chitosan as the *** obtained results revealed that the thermal treated temperature and g-C_(3)N_(4) amount played a great impact on the carbonization degrees,pore sizes,and morphologies of CCFs,which led to their tunable electromagnetic(EM)parameters,improved conduction loss,and polarization loss *** to the special cellular structure,the designed CCFs samples simultaneously displayed the strong absorption capabilities,broad absorption bandwidths,and thin matching ***,the as-prepared CCFs exhibited the strong hydrophobicity and good thermal insulation,endowing its attractive functions of self-cleaning and thermal ***,our findings not only presented a facile approach to produce different porous structures of CCFs,but also provided an effective strategy to develop multifunctional high-performance MAs on basis of three-dimensional CCFs.

关键词： multifunctional microwave absorbers carbon foams cellular structure self-cleaning thermal insulation

Dempster Shafer distance-based multi-classifier fusion method for pig cough recognition

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International Journal of Agricultural and Biological Engineering 2024年第4期17卷 245-254页

作者： Weizheng Shen Xipeng Wang yanling Yin Nan Ji Baisheng Dai Shengli Kou chen Liang School of Electrical Engineering and Information Northeast Agricultural UniversityHarbin 150030China Heilongjiang Agricultural Technology Extension Station Harbin 150036China

High precision pig cough recognition and low computational cost is of great importance for the realization of early warning of pig respiratory *** researchers have improved the recognition rate of pig cough sounds to a certain extent from feature selection and feature fusion ***,there is still a margin for the improvement in the accuracy and complexity of existing ***,it is challenging to further enhance the precision of a single ***,this study proposed a multi-classifier fusion strategy based on Dempster Shafer distance(DS-distance)algorithm to increase the classification *** the engineering implementation,the machine learning with low computational complexity for fusion was ***,three metrics of accuracy and diversity between classifiers were defined,including overall accuracy(OA),double fault(DF),and overall accuracy and double fault(OADF),for selecting the base ***,a two-step base classifier selection approach based on these metrics was proposed to make an optimized selection of features and ***,the proposed DS-distance algorithm was used to fuse the selected base classifiers to create a *** sound data collected in the pig barn verified the proposed *** experimental results revealed that the overall recognition accuracy of the proposed method could reach 98.76%,which was better than the existing *** study has achieved a high recognition accuracy through ensembled machine learning with low computational *** proposed method provided an efficient way for the quick establishment of high precision pig cough recognition model in practice.

关键词： pig cough recognition classifier fusion classifier selection Dempster Shafer fusion distance fusion

具有α-葡萄糖苷酶抑制活性的益生乳酸菌筛选

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农业机械学报 2020年第11期51卷 349-356页

作者：曾珠陈艳玲陈尚武西南大学蚕桑纺织与生物质科学学院重庆400715 农业农村部蚕桑生物学与遗传育种重点实验室重庆400715 中国农业大学食品科学与营养工程学院北京100083

利用α-葡萄糖苷酶抑制剂体外筛选模型,分析了来源于传统乳制品的10株乳杆菌对猪小肠提取的α-葡萄糖苷酶的抑制活性;对这些菌株的基本益生特性,包括对人工模拟胃肠液的耐受性及对肠上皮细胞的粘附性等进行了评价;最后,通过Caco2细胞建... 详细信息

利用α-葡萄糖苷酶抑制剂体外筛选模型,分析了来源于传统乳制品的10株乳杆菌对猪小肠提取的α-葡萄糖苷酶的抑制活性;对这些菌株的基本益生特性,包括对人工模拟胃肠液的耐受性及对肠上皮细胞的粘附性等进行了评价;最后,通过Caco2细胞建立的Transwell模型分析了乳杆菌对人肠道α-葡萄糖苷酶活性及其基因表达的影响。结果表明,这10株乳杆菌对猪小肠提取的α-葡萄糖苷酶均具有不同程度的抑制作用;乳杆菌的α-葡萄糖苷酶抑制活性在菌株生长的对数期或稳定期达到高峰,随后出现下降的趋势;结合菌株的基本益生特性评价发现,有3株具有较高抑制活性的乳杆菌能够耐受人工模拟的胃肠液,并具有较强的黏附肠上皮细胞HT-29的能力;由Transwell模型发现,乳杆菌能同时抑制α-葡萄糖苷酶的活性及基因表达量。研究表明,筛选出的3株乳杆菌(副干酪乳杆菌L14和Z3-11以及植物乳杆菌NL42)均具有较高的α-葡萄糖苷酶抑制活性和较好的益生特性,可作为潜在的辅助降血糖的益生菌株。

关键词：乳酸菌 α-葡萄糖苷酶益生菌抑制活性

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福建省普通话水平测试后受测者语言态度调查

语言文字应用 2014年第3期 59-68页

作者：陈燕玲泉州师范学院文学与传播学院福建泉州362000

文章以泉州市为调查核心点,辐射福建省的福州、南平、龙岩、三明、宁德等区域,就福建省普通话水平测试后受测者的态度(包括对测试的认知、语言情感、语言行为倾向等)展开调查。调查数据显示,普通话水平测试提升了普通话的影响力,提高了... 详细信息

文章以泉州市为调查核心点,辐射福建省的福州、南平、龙岩、三明、宁德等区域,就福建省普通话水平测试后受测者的态度(包括对测试的认知、语言情感、语言行为倾向等)展开调查。调查数据显示,普通话水平测试提升了普通话的影响力,提高了受测者对普通话的认同感,在一定程度上影响了受测者的语言行为倾向,较好地促进了普通话的推广与普及。但是,仅靠测试还不能长期、有效地影响受测者的语言行为倾向,测试效果的巩固还需要后续举措;普通话的推广与方言的使用关系也需要进一步引导、理顺,相关部门还应该着力促进国家语言生态的和谐发展。

关键词：普通话水平测试福建省语言态度