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Regulation and function of cyclic nucleotide phosphodiesterases in pathological vascular remodeling

中国药理学与毒理学杂志 2017年第5期31卷 456-457页

作者： yan chen Aab Cardiovascular Research Institute University of Rochester

Pathological vascular remodeling is characterized by thickening or thinning of the vessel wall through altering cellular and non-cellular components,which associates with various blood circulation disorders in brain,heart,lung,and peripheral vasculatures. Pathological vascular remodeling occurs in response to a variety of vascular insults such as mechanical(angioplasty or stenting) or biological(lipids,diabetes,smoking,or virus) injuries. It is a polygenic process involving multiple cell types in the vessel wall or circulation,including endothelial cells(ECs),smooth muscle cells(SMCs),fibroblasts,leukocytes,and platelets. One of hallmarks is the transition of vascular smooth muscle cells(SMCs)from a differentiated/quiescent contractile phenotype to a myofibroblast-like dedifferentiated/active so-called synthetic phenotype. Synthetic SMCs are proliferatory,migratory,secretory and inflammatory,playing key roles in the pathogenesis of vascular remodeling. In the normal vessel,ECs synthesize and secrete biological substances such as prostacyclins(PGI_2) and nitric oxide(NO) that not only function as vasodilators but also inhibit SMC phenotype transition and other properties associated with the synthetic phenotype. Cyclic nucleotides cAMP and cGMP are primary mediators of PGI_2 and NO,respectively,and play critical roles in control vascular structural integrity and function. Cyclic nucleotides are controlled by selective activation or inhibition of distinct cyclic nucleotide phosphodiesterase(PDE) isozymes catalyzing the degradation reaction. To date,more than 60 different PDE isoenzymes derived from 22 genes are identified and grouped into 11 broad families(PDE1-PDE11). PDEs are expressed in a cell/tissue-specific manner and only a few enzymes are expressed in any single cell type. Through systematic assessment of the expression levels of all known PDE isoforms in contractile versus synthetic SMCs,we found that the expression levels of a number of PDE are significantly

关键词： phosphodiesterases smooth muscle cells vascular remodeling

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Effect of oxygen content on dielectric characteristics of Cr-doped LaTiO_(x)

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Chinese Physics B 2018年第5期27卷 492-499页

作者： Ming Ma yan chen Yi-Min Cui School of Aeronautic Science and Engineering Beihang UniversityBeijing 100191China School of Physics Beihang UniversityBeijing 100191China

The ceramics La_(0.85)Cr_(0.15)TiO_(x)and La_(0.7)Cr_(0.3)TiO_(x)are prepared by conventional solid-state reaction *** dielectric properties of Cr-doped La TiO_(x)as a function of frequency(0.1 k Hz≤f≤1 MHz)and temperature(77 K≤T≤360 K)are *** blocks are then annealed in a flowing O2 or Ar/H_(2)to convert their oxygen content and the tests mentioned above are *** highly oxygenated samples exhibit extremely high low-frequency dielectric constants at room temperature(~10^(6)).The results show that the oxygen stoichiometry could significantly influence the dielectric properties of Cr-doped LaTiO_(x).

关键词： oxygen content dielectric characteristics LaTiO_(x)

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A study of flames with millimeter-wave radiation

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Defence Technology（防务技术） 2020年第4期16卷 876-882页

作者： Jing-ran Xu Ru Peng chen-guang Zhu Xiao Xie chen-guang yan Department of Applied Chemistry School of Chemical EngineeringNanjing University of Science and TechnologyNanjingJiangsuChina

It is a valuable issue to explore whether a flame can radiate microwaves,in spite of the electric field formed in the *** herein is an experimental study on a series of flames with millimeterwave radiation in the combustion of pyrotechnic *** pyrotechnic films were composed of ultrafine red phosphorus(P),sodium nitrate(NaNO_3),Polyvinyl Alcohol(PVA) and some additives such as chopped carbon fibers(CFs) and aluminized glass fibers(GFs).The combustion temperatures and millimeter-wave radiation signals of the flames were measured,the millimeter-wave emissivity and spectral radiant exitance were calculated to describe the millimeter-wave radiation *** results demonstrate that the flame of the pyrotechnic films based on P/NaNO_3/CFs can radiate millimeter waves,and different materials and their proportion have a great effect on the millimeter-wave radiation intensity.

关键词： Combustion Flame Pyrotechnics Millimeter-wave radiation

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RALF22 promotes plant immunity and amplifies the Pep3 immune signal

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Journal of Integrative Plant Biology 2023年第11期65卷 2519-2534页

作者： Yu-Han He Song-Yu chen Xing-yan chen You-Ping Xu yan Liang Xin-Zhong Cai Key Laboratory of Biology of Crop Pathogens and Insects of Zhejiang Province Institute of BiotechnologyCollege of Agriculture and BiotechnologyZhejiang University866 Yu Hang Tang RoadHangzhou 310058China Centre of Analysis and Measurement Zhejiang University866 Yu Hang Tang RoadHangzhou 310058China Hainan Institute Zhejiang UniversitySanya 572025China

Rapid alkalinization factors(RALFs)in plants have been reported to dampen pathogenassociated molecular pattern(PAMP)-triggered immunity via suppressing PAMP-induced complex formation between the pattern recognition receptor(PRR)and its co-receptor ***,the direct and positive role of RALFs in plant immunity remains largely ***,we report the direct and positive roles of a typical RALF,RALF22,in plant ***22alone directly elicited a variety of typical immune responses and triggered resistance against the devastating necrotrophic fungal pathogen Sclerotinia sclerotiorum in a FERONIA(FER)-dependent ***(LRE)-like glycosylphosphatidylinositol(GPI)-anchored protein 1(LLG1)and NADPH oxidase RBOHD were required for RALF22-elicited reactive oxygen species(ROS)*** mutation of cysteines conserved in the C terminus of RALFs abolished,while the constitutive formation of two disulfide bridges between these cysteines promoted the RALF22-elicited ROS production and resistance against ***,demonstrating the requirement of these cysteines in the functions of RALF22 in plant ***,RALF22 amplified the Pep3-induced immune signal by dramatically increasing the abundance of PROPEP3 transcript and *** with RALF22 induced resistance against *** in Brassica crop ***,our results reveal that RALF22 triggers immune responses and augments the Pep3-induced immune signal in a FER-dependent manner,and exhibits the potential to be exploited as an immune elicitor in crop protection.

关键词： RALF22 FER reactive oxygen species Pep3 plant immunity Sclerotinia sclerotiorum

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Regularities of the Band Structures for the Even-Even Rare-Earth Nuclei

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Chinese Physics Letters 1995年第7期12卷 385-388页

作者： ZHAO Yumin chen yan ZONG Hongshi Department of Physics Nanjing UniversityNanjing 210008

The parametrizations,VNP and VNP/Vpair,are extracted empirically from nuclear binding *** systematics in the VNP and VNP/Vpairchemes,together with elegant regularities of the excitation energies for the ground,β and ... 详细信息

关键词： Regular Rare Even

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Leaching Behavior and Mechanism of Cement Solidified Heavy Metal Pb in Acid Medium

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Journal of Wuhan University of Technology(Materials Science) 2015年第4期30卷 781-786页

作者：周明凯王彩萍 chen yan chen Xiao State Key Laboratory of Silicate Materials for Architectures Wuhan University of Technology

The relationship between Pb leaching concentration and the solution＇s pH with time was analyzed when cement in its solidified form was leached in an acid medium. The effects of the particle size of the solidified form, the cement adding method, and the hydration degree on Pb solidification were also investigated. The experimental results indicate that cement is quickly dissolved and hydrated in the acid medium, forming a C-S-H gel or silicic acid sol with good adsorption. When cement-Pb solidified form is leached in an acetate solution, the hydrated product erodes with time, so the Pb concentration increases slightly in the beginning. Then, some of the Pb ions are absorbed by the newly generated silicic acid sol, C-S-H. Others produce Pb（OH）2 precipitation for secondary solidification, leading to a gradual decrease in the Pb concentration in a leaching time of more than two hours. Moreover, the particle size of the solidified form has important effects on the Pb dissolution. When the amount of added cement is low, with a pH of less than 9.5, the solidification affects the sequence of the original cement powder, the cement hydrated powder, and the cement- Pb solidified form. When the added amount of cement increases with a pH of more than 11, the effect of adding methods on solidification decreases, and the solidified form is a little better than others.

关键词： cement acid medium heavy metal leaching behavior

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Impurity- and magnetic-field-induced quasiparticle states in chiral p-wave superconductors

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Frontiers of physics 2017年第5期12卷 63-70页

作者： Yao-Wu Guo Wei Li yan chen Department of Physics and State Key Laboratory of Surface Physics Fudan University Shanghai 200333 China State Key Laboratory of Functional Materials for Inforrnatics and Shanghai Center for Superconductivity Shanghai Institute of Microsystem and Information Technology Chinese Academy of Sciences Shanghai 200050 China CAS Center for Excellence in Superconducting Electronics Shanghai 200050 China Collaborative Innovation Center of Advanced Microstructures Nanjing 210093 China

Both impurity- and magnetic-field-induced quasiparticle states in chiral p-wave superconductors are investigated theoretically by solving the Bogoliubov-de Gennes equations self-consistently. At the strong scattering limit, we find that a universal state bound to the impurity can be induced for both a single nonmagnetic impurity and a single magnetic impurity. Furthermore, we find that different chiral order parameters and the corresponding supercurrents have uniform distributions around linear impurities. Calculations of the local density of states in the presence of an external magnetic field show that the intensity peak of the zero-energy Majorana mode in the vortex core can be enhanced dramatically by tuning the strength of the external magnetic field or pairing interaction.

关键词： nonmagnetic/magnetic impurity chiral p-wave superconductor vortex state Majorana mode

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Microvesicles as Emerging Biomarkers and Therapeutic Targets in Cardiometabolic Diseases

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Genomics, Proteomics & Bioinformatics 2018年第1期16卷 50-62页

作者： yan chen Guangping Li Ming-Lin Liu Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease Department of Cardiology Tianjin Institute of Cardiology Second Hospital of Tianjin Medical University Tianjin 300211 China Section of Endocrinology Diabetes and Metabolism Department of Medicine Temple University School of Medicine Philadelphia PA 19140 USA Department of Dermatology Perelman School of Medicine University of Pennsylvania Philadelphia PA 19140 USA Philadelphia VA Medical Center Philadelphia PA 19140 USA

Microvesicles （MVs, also known as microparticles） are small vesicles that originate from plasma membrane of almost all eukaryotic cells during apoptosis or activation. MVs can serve as extracellular vehicles to transport bioactive molecules from their parental cells to recipient target cells, thereby serving as novel mediators for intercellular communication. Importantly, more and more evidence indicates that MVs could play important roles in early pathogenesis and subsequent progression of cardiovascular and metabolic diseases. Elevated plasma concentrations of MVs, originating from red blood cells, leukocytes, platelets, or other organs and tissues, have been reported in various cardiometabolic diseases. Circulating MVs could serve as potential biomarkers for disease diagnosis or therapeutic monitoring. In this review, we summarized recently- published studies in the field and discussed the role of MVs in the pathogenesis of cardiometabolic diseases. The emerging values of MVs that serve as biomarker for non-invasive diagnosis and prog- nosis, as well as their roles as novel therapeutic targets in cardiometabolic diseases, were also described.

关键词： Mierovesicle Microparticle Exosome Cardiometabolie disease Biomarker

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Syntheses and Crystal Structures of Five Sr^(Ⅱ)-Ln^(Ⅲ)(Ln=Nd,Pr,Er) Heterometallic Coordination Polymers

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Chinese Journal of Structural Chemistry 2013年第12期32卷 1859-1867页

作者： CAO yan-Yuan chen yan-Mei LIU Wei LI Ya-Hong Key Laboratory of Organic Synthesis of Jiangsu Province College of ChemistryChemical Engineering and Materials ScienceSoochow University

Five novel SrⅡ-LnⅢ heterometallic coordination polymers based on pyridine-2,6- dicarboxylic acid （H2pda） and imidazole （im）, namely, [LnSr（pda）3（H2O）5]-Him·C2H5OH·3H2O （Ln = Nd （1）; Pr （2））, [Ln2Sr（pda）6（H2O）5]-4Him·C2H5OH·5H2O （Ln = Nd （3）; Pr （4））, and [ErSr（pda）3（H2O）4].Him-3.5H2O （5）, have been prepared and structurally characterized. X-ray crystallographic analyses revealed that these complexes display three varieties of l-D chain structures. Several types of hydrogen bonding interactions are found for 1-5, which connect the 1 -D chain structures to form 2-D suoramolecular networks.

关键词： heterometallic coordination polymers strontium lanthanide crystal structure

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Heterogeneous signals in plant–biotic interactions and their applications

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Science China(Life Sciences) 2019年第12期62卷 1707-1709页

作者： Fang-yan chen Xiao-Ya chen Ying-Bo Mao Chinese Academy of Sciences (CAS) Key Laboratory of Insect Developmental and Evolutionary Biology CAS Center for Excellence in Molecular Plant Sciences/Shanghai Institute of Plant Physiology and Ecology University of CAS Chinese Academy of Sciences

Plants have to overcome different types of environment stress including various insect and pathogen attacks during their life *** long-term evolution,plants have developed sophisticated systems to recognize different biotic attacks and initiate an integrated defense network for *** the other hand,pathogens and insects have devised multiple strategies to adapt to their host *** the past three decades,substantial progress has been made toward improving the understanding of plant-biotic *** increasing number of active molecules have been identified that not only have functions within an organism but also act as heterogeneous regulators that can migrate across interacting individuals(Kan et al.,2017;Qian et al.,2017).The discovery of new heterogeneous regulators and their mechanisms of migration across interacting organisms is potentially helpful in the development of novel strategies to protect crop plants from biotic threats.

关键词： plant overcome migrate

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