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Synthesis and characterization of novel ternary deep eutectic solvents

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Chinese Chemical Letters 2014年第1期25卷 104-106页

作者： Yu-Ting Liu yan-An chen yan-Jun Xing Key Laboratory of Science & Technology of Eco-Textile (Donghua University) Ministry of Education College of Chemistry Chemical Engineering and BiotechnologyDonghua University

A series of room-temperature ternary deep eutectic solvents （TDESs） were prepared from imidazolium halides, zinc halides and amides. The [BMIM]Cl-ZnCl2-acetamide （1：1：1） system shows the lowest freezing point （-60℃） and lowest density in the series. The viscosity and conductivity of TDESs have an exponential relationship with temperature and can be fitted by Arrhenius equation.

关键词： Ternary deep eutectic solvents Room-temperature Synthesis Physical properties

Effects of Δ-Isobars on Neutron Stars

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Communications in Theoretical Physics 2008年第5期49卷 1283-1286页

作者： chen yan-Jun GUO Hua Center for Astrophysics University of Science and Technology of China Hefei 230026 China Department of Technical Physics Peking University Beijing 100871 China

We have investigated the possibility of the presence of the deltas in neutron star matter and their effects on neutron stars. Δ-meson couplings of the theoretical predictions are only restricted in a region where the deltas can be present and even a first-order phase transition may take place, making the EOS sorer and the maximum mass of neutron stars smaller. The presence of the deltas leads to the rapid decrease of neutrino mean free paths.

关键词： neutron star matter neutron star Δ-isobars

PDCD6 Promotes Hepatocellular Carcinoma Cell Proliferation and Metastasis through the AKT/GSK3β/β-catenin Pathway

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Biomedical and Environmental Sciences 2023年第3期36卷 241-252页

作者： WEN Shi Yuan LIU yan Tong WEI Bing yan MA Jie Qiong chen yan yan College of Basic Medical Sciences Shanxi Medical UniversityTaiyuan 030000ShanxiChina School of Life Science and Technology ShanghaiTech UniversityShanghai 201210China Shanxi Key Laboratory of Experimental Animals and Animal Models for Human Diseases Laboratory Animal CenterShanxi Medical UniversityTaiyuan 030000ShanxiChina School of Medicine Jiangsu UniversityZhenjiang 212001JiangsuChina

Objective Programmed cell death 6(PDCD6), a Ca~(2+)-binding protein, has been reported to be aberrantly expressed in all kinds of tumors. The aim of this study was to explore the role and mechanism of PDCD6 in hepatocellular carcinomas(HCCs).Methods The expression levels of PDCD6 in liver cancer patients and HCC cell lines were analyzed using bioinformatics and Western blotting. Cell viability and metastasis were determined by methylthiazol tetrazolium(MTT) and transwell assays, respectively. And Western blotting was used to test related biomarkers and molecular pathway factors in HCC cell lines. LY294002, a PI3K inhibitor inhibiting AKT, was used to suppress the AKT/GSK3β/β-catenin pathway to help evaluate the role of this pathway in the HCC carcinogenesis associated with *** The analysis of The Cancer Genome Atlas Database suggested that high PDCD6 expression levels were relevant to liver cancer progression. This was consistent with our finding of higher levels of PDCD6 expression in HCC cell lines than in normal hepatocyte cell lines. The results of MTT, transwell migration, and Western blotting assays revealed that overexpression of PDCD6 positively regulated HCC cell proliferation, migration, and invasion. Conversely, the upregulation of PDCD6 expression in the presence of an AKT inhibitor inhibited HCC cell proliferation, migration, and invasion. In addition, PDCD6promoted HCC cell migration and invasion by epithelial-mesenchymal transition. The mechanistic investigation proved that PDCD6 acted as a tumor promoter in HCC through the AKT/GSK3β/β-catenin pathway, increasing the expression of transcription factors and cellular proliferation and *** PDCD6 has a tumor stimulative role in HCC mediated by AKT/GSK3β/β-catenin signaling and might be a potential target for HCC progression.

关键词： PDCD6 Hepatocellular carcinoma Proliferation Metastasis

Polyphyllin D induces G2/M Cell Cycle Arrest via Dysfunction of Cholesterol Biosynthesis in Liver Cancer Cells

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Biomedical and Environmental Sciences 2023年第1期36卷 94-98页

作者： chen yan yan REN Cai Fang WEN Shi Yuan School of Medicine Jiangsu UniversityZhenjiang 212003JiangsuChina College of Basic Medical Sciences ShanxiMedical UniversityTaiyuan 030000ShanxiChina

Liver cancer is a frequently occurring malignancy with a poor prognosis and a high mortality rate and is the second leading cause of cancer-related deaths[1]. Many chemotherapeutic drugs are extensively used to treat liver cancer, such as doxorubicin and cisplatin. However, these drugs have shown poor treatment effects in clinical trials because of acquired resistance and the high heterogeneity of liver cancer[2]. Therefore.

关键词： drugs Liver cancer

Complete Moment Convergence for Sequence of Identically Distributed φ-mixing Random Variables

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Acta Mathematica Sinica,English Series 2010年第4期26卷 679-690页

作者： Ping yan chen Ding cheng WANG Department of Mathematics Ji'nan University Guangzhou 510630 P. R. China Center of Financial Mathematics MSI Australian National UniversityCanberra Act 0200 Australia School of Applied Mathematics University of Electronic Science and Technology of China Chengdu 610054 P. R. China

In the paper we extend and generalize some results of complete moment convergence results （or the refinement of complete convergence） obtained by Chow [On the rate of moment complete convergence of sample sums and extremes. Bull. Inst. Math. Academia Sinica, 16, 177-201 （1988）] and Li ＆ Spataru [Refinement of convergence rates for tail probabilities. J. Theor. Probab., 18, 933-947 （2005）] to sequences of identically distributed φ-mixing random variables.

关键词： complete convergence complete moment convergence φ-mixing

Convergence Rates for Probabilities of Moderate Deviations for Moving Average Processes

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Acta Mathematica Sinica,English Series 2008年第4期24卷 611-622页

作者： Ping yan chen Ding cheng WANG Department of Mathematics Jinan University Guangzhou 510630 P. R. China Center of Financial Mathematics MSI Australian National University Canberra Act 0200 Australia School of Applied Mathematics University of Electronic Science and Technology of ChinaChengdu 610054 P. R. China

The present paper first shows that, without any dependent structure assumptions for a sequence of random variables, the refined results of the complete convergence for the sequence is equivalent to the corresponding complete moment convergence of the sequence. Then this paper investigates the convergence rates and refined convergence rates （or complete moment convergence） for probabilities of moderate deviations of moving average processes. The results in this paper extend and generalize some well-known results.

关键词： complete convergence complete moment convergence moderate deviation law of the iterated logarithm invariance principle moving average process

轻度认知障碍老人与认知正常老人在不同单双任务下姿势控制能力的差异性

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中国组织工程研究 2025年第8期29卷 1643-1649页

作者：张雨馨于聪张翠丁建军陈岩山东体育学院山东省济南市250102 山东省体育科学研究中心山东省济南市250102 山东体育学院运动与健康学院山东省济南市250102

背景:老年人由于轻度认知障碍而引起姿势控制能力下降,导致跌倒风险增高。双任务是在接近真实生活场景下评估认知与姿势控制能力关系的主要研究范式,站立时足底压力中心位移样本熵可代表姿势控制的复杂程度。目的:基于压力中心位移样本... 详细信息

背景:老年人由于轻度认知障碍而引起姿势控制能力下降,导致跌倒风险增高。双任务是在接近真实生活场景下评估认知与姿势控制能力关系的主要研究范式,站立时足底压力中心位移样本熵可代表姿势控制的复杂程度。目的:基于压力中心位移样本熵分析轻度认知障碍老年人与认知正常老年人在姿势控制-空间工作记忆任务中姿势稳定性特征及控制策略的差异,探究认知功能损伤对站立姿势控制能力影响。方法:筛选出符合条件的16名轻度认知障碍老年人和17名认知正常老年人为研究对象,老年人分别完成5种测试任务,包括空间工作记忆、双脚平衡站立、Romberg站立、双脚平衡站立-空间工作记忆双任务、Romberg站立-空间工作记忆双任务,每个任务有效完成3次。使用Kistler三维测力台采集足底压力中心数据,测试指标包括认知行为学指标(认知得分与反应时长)、动力学指标(压力中心位移及样本熵)。结果与结论:①轻度认知障碍老年人在执行空间工作记忆任务时认知得分最大、反应时间最短,双脚平衡站立-空间工作记忆双任务居中,Romberg站立-空间工作记忆双任务认知得分最小、反应时长最长,任务间比较差异均有显著性意义(P0.05);在两种双任务下,与认知正常老年人相比,轻度认知障碍老年人的认知得分更小、反应时长更长(P<0.05),同时轻度认知障碍老年人压力中心前后、内外方向位移更大,压力中心前后、内外方向位移样本熵值更小(P<0.05);④结果表明:与认知正常老年人相比,轻度认知障碍老年人在执行双任务时姿势控制复杂度降低,系统适应性较差,自动调控能力下降,更容易受到空间工作记忆干扰,跌倒风险增大。

关键词：轻度认知障碍老年人空间工作记忆姿势控制双任务样本熵

Weighted Endpoint Estimates for Maximal Commutators Associated with the Sections

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Acta Mathematica Sinica,English Series 2010年第8期26卷 1463-1474页

作者： Jie cheng chen yan Dan ZHANG Department of Mathematics Zhejiang University Hangzhou 310027 P. R. China

We prove endpoint estimates for maximal commutators for a class of singular integral operators related to the real analysis of the Monge Ampere equation.

关键词： Weighted inequalities maximal commutators Monge-Ampere equation the sharp maximal function

Complete and Complete Moment Convergence for Weighted Sums of Widely Orthant Dependent Random Variables

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Acta Mathematica Sinica,English Series 2014年第9期30卷 1539-1548页

作者： De Hua QIU Ping yan chen School of Mathematics and Statistics Guangdong University of Finance & Economics Department of Mathematics Jinan University

In this paper, we establish a complete convergence result and a complete moment convergence result for weighted sums of widely orthant dependent random variables under mild conditions. As corollaries, the corresponding results for weighted sums of extended negatively orthant dependent random variables are also obtained, which generalize and improve the related known works in the literature.

关键词： Widely orthant dependent random variables extended negatively orthant dependent random variables complete convergence complete moment convergence