检索结果-南通市图书馆

Multiplicity of solutions for the semilinear subelliptic Dirichlet problem

在线全文

学校读者我要写书评

暂无评论

Science China Mathematics 2024年第3期67卷 475-504页

作者： Hua chen Hong-Ge chen Jin-Ning Li Xin Liao School of Mathematics and Statistics Wuhan UniversityWuhan 430072China Wuhan Institute of Physics and Mathematics Innovation Academy for Precision Measurement Science and TechnologyChinese Academy of SciencesWuhan 430071China

In this paper,we study.t.e semilinear subelliptic equation{−△Xu=f(x,u)+g(x,u)inΩ,u=0 on∂Ω,where△X=−∑m i=1 Xi∗Xi is the self-adjoint Hormander operator associated with the vector fields X=(X_(1),X_(2),...,X_(m))satisfying the Hormander's condition,f(x,u)∈C(Ω×R),g(x,u)is a Carathéodory function onΩ×R,andΩis an open bounded domain in R~n with smooth *** the perturbation from the symmetry method with the approaches involving the eigenvalue estimate and the Morse index in estimating the minimax values,we obtain two kinds of existence results for multiple weak solutions to the problem ***,we discuss the difference between the eigenvalue estimate approach and the Morse index approach in degenerate *** with the classical elliptic cases,both approaches here have their own strengths in the degenerate *** new phenomenon implies that the results in general degenerate cases would be quite different from the situations in classical elliptic cases.

关键词： degenerate elliptic equations Hormander operators perturbation method Morse index

Metabolic basis of solute carrier transporters in treatment of type 2 diabetes mellitus

在线全文

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2024年第2期14卷 437-454页

作者： Jiamei Le yilong chen Wei yang Ligong chen Jianping ye Shanghai Key Laboratory of Molecular Imaging Zhoupu HospitalShanghai University of Medicine and Health SciencesShanghai 201318China School of Health Science and Engineering University of Shanghai for Science and TechnologyShanghai 200093China Metabolic Disease Research Center Zhengzhou Central Hospital Affiliated to Zhengzhou UniversityZhengzhou 450007China School of Pharmaceutical Sciences Tsinghua UniversityBeijing 100084China Research Center for Basic Medicine Academy of Medical SciencesZhengzhou UniversityZhengzhou 450052China

Solute carriers(SLCs) constitute the largest superfamily of membrane transporter *** transporters, present in various SLC families, play a vital role in energy metabolism by facilitating the transport of diverse substances, including glucose, fatty acids, amino acids, nucleotides, and *** actively participate in the regulation of glucose metabolism at various steps, such as glucose uptake(e.g., SLC2A4/GLUt4), glucose reabsorption(e.g., SLC5A2/SGLt2), thermogenesis(e.g., SLC25A7/UCP-1), and AtP production(e.g., SLC25A4/ANt1 and SLC25A5/ANt2). the activities of these transporters contribute to the pathogenesis of type 2 diabetes mellitus(t2DM). Notably, SLC5A2 has emerged as a valid drug target for t2DM due to its role in renal glucose reabsorption, leading to groundbreaking advancements in diabetes drug discovery. Alongside SLC5A2, multiple families of SLC transporters involved in the regulation of glucose homeostasis hold potential applications for t2DM therapy. SLCs also impact drug metabolism of diabetic medicines through gene polymorphisms, such as rosiglitazone(SLCO1B1/OAtP1B1) and metformin(SLC22A1-3/OCt1-3 and SLC47A1, 2/MAtE1, 2). By consolidating insights into the biological activities and clinical relevance of SLC transporters in t2DM, this review offers a comprehensive update on their roles in controlling glucose metabolism as potential drug targets.

关键词： Solute carriers(SLCs) Energ ymetabolism AtP production type 2 diabetes mellitus(t2DM) Glucose homeostasis Polymorphisms

Preparation of wood-based hydrogel membranes for efficient purification of complex wastewater using a reconstitution strategy

在线全文

学校读者我要写书评

暂无评论

Frontiers of Environmental Science & Engineering 2024年第7期18卷 59-72页

作者： Qian He Junkai Gao Zhongzhi chen yuanjing Ding Mengsheng Xia Pengtao Xu yan chen School of Naval Architecture and Maritime Zhejiang Ocean UniversityZhoushan 316022China Innotech Alberta P.0.Box 4000Hwy 16A&75 StreetVegrevilleAB T9C 1T4Canada

to avoid resource wastage and secondary environmental pollution,recycling and reusing waste wood powder is still a great ***,the poor viscosity and irregular pore size of wood powder limit its practical *** study,employed a green and convenient wood powder reconstitution strategy.t. achieve highly adhesive bonding and pore size control between wood powder particles,thus preparing a high-strength and super hydrophilic wood powder *** wood powder fibers were partially dissolved and regenerated to create a reconstituted wood powder hydrogel membrane,using waste wood powder as the raw *** wood powder reconstitution strategy offers advantages such as environmental friendliness,simplicity,cost-effectiveness,and strong ***,the materials exhibit excellent self-cleaning properties and *** by gravity.t.e membrane can purify oily wastewater and ***,the reconstitution strategy offers a new pathway for recycling wood powder.

关键词： Wood powder Reconstitution strategy Hydrogel membrane Recycling Wastewater

temperature-sensing array using the metal-to-insulator transition of Nd_(x)Sm_(1-x)NiO_(3)

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Minerals,Metallurgy and Materials 2024年第7期31卷 1694-1700页

作者： Fengbo yan Ziang Li Hao Zhang yuchen Cui Kaiqi Nie Nuofu chen Jikun chen School of Materials Science and Engineering University of Science and Technology BeijingBeijing 100083China School of Renewable Energy North China Electric Power UniversityBeijing 102206China Beijing Synchrotron Radiation Facility Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China

Rare-earth nickelates(RENiO_(3))show widely.t.nable metal-to-insulator transition(MIt)properties with ignorable variations in lattice constants and small latent heat across the critical temperature(tMIt).Particularly,it is worth noting that compared with the more commonly investigated vanadium oxides,the MIt of RENiO_(3)is less abrupt but usually across a wider range of *** sheds light on their alternative applications as negative temperature coefficient resistance(NtCR)thermistors with high sensitivity compared with the current NtCR thermistors,other than their expected use as critical temperature resistance *** this work,we demonstrate the NtCR thermistor functionality for using the adjustable MIt of Nd_(x)Sm_(1-x)NiO_(3)within 200–400 K,which displays larger magnitudes of NtCR(e.g.,more than 7%/K)that is unattainable in traditional NtCR thermistor *** temperature dependence of resistance(R–t)shows sharp variation during the MIt of Nd_(x)Sm_(1-x)NiO_(3)with no hy.t.resis via decreasing the Nd content(e.g.,x≤0.8),and such a R–t tendency can be linearized by introducing an optimum parallel *** sensitive range of temperature can be further extended to 210–360 K by combining a series of Nd_(x)Sm_(1-x)NiO_(3)with eight rare-earth co-occupation ratios as an array,with a high magnitude of NtCR(e.g.,7%–14%/K)covering the entire range of temperatures.

关键词： rare-earth nickelates metal-to-insulator transition correlated oxides perovskites

Remodel the perifollicular microenvironment via Minoxidil-loaded microneedle patch and cold atmospheric plasma for treating androgenetic alopecia

在线全文

学校读者我要写书评

暂无评论

Nano Research 2024年第7期17卷 6411-6419页

作者： Hao chen Xianzhe tang yueye Huang chen chen yuheng yang Chaojie Hao Wenqi Xie tingjing Huang Xiaofeng cheng Qingnan Xu Shicong Huang Zhi ye Xucong Lin Zhaowei chen Zhitong chen MOE Key Laboratory for Analytical Science of Food Safety and Biology and New Cornerstone Science LaboratoryCollege of ChemistryFuzhou UniversityFuzhou 350108China Institute of Biomedical and Health Engineering Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China Advanced therapeutic Center National Innovation Center for Advanced Medical DevicesShenzhen 518000China Department of Chemistry University College LondonLondon WC1H 0AJUK Engineering technology Research Center on Reagent and Instrument for Rapid Detection of Product Quality and Food Safety in Fujian Province College of ChemistryFuzhou UniversityFuzhou 350108China Key Laboratory of Biomedical Imaging Science and Sy.t.m Chinese Academy of SciencesShenzhen 518055China

Androgenetic alopecia(AGA)is a chronic and progressive form of hair loss characterized by vascular degeneration in the perifollicular microenvironment,leading to cell apoptosis and eventual loss of hair follicles(HFs).traditional therapeutic formulations,such as Minoxidil(MXD)tincture,have limitations in reshaping the perifollicular microenvironment and exhibit limited ***,we report a multi-synergistic therapeutic platform for high-performance hair regeneration *** platform combines microneedle(MN)patches loaded with MXD-encapsulated nanostructured lipid carriers(MXD-NLC-MNs)and cold atmospheric plasma(CAP).the MNs’mechanical strength enables efficient transdermal delivery of MXD to the targeted dermal papilla cells,promoting cell ***,in collaboration with MXD,the mechanical stimulation exerted by MN application synergistically upregulates the expression of vascular endothelial growth factor,leading to ***,the transient microchannels in the skin created by MNs facilitate the transdermal delivery of CAPgenerated nitric oxide(NO)to the sites of HF lesions,whereby.t.e synergistic interaction between MXD and NO boosts perifollicular ***,the perifollicular microenvironment can be effectively reshaped to accelerate hair regeneration in AGA murine *** multi-synergistic combination therapy strategy would hold great promise for effectively.t.eating AGA and promoting hair regrowth.

关键词： nanomedicine androgenetic alopecia microneedle cold atmospheric plasma drug delivery

Comparison of CWSI and t_(s)-t_(a)-VIs in moisture monitoring of dryland crops(sorghum and maize)based on UAV remote sensing

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Integrative Agriculture 2024年第7期23卷 2458-2475页

作者： Hui chen Hongxing chen Song Zhang Shengxi chen Fulang Cen Quanzhi Zhao Xiaoyun Huang tengbing He Zhenran Gao College of Agriculture Guizhou UniversityGuiyang 550025China Institute of New Rural Development Guizhou UniversityGuiyang 550025China Institute of Rice Industry.t.chnology Research College of Agricultural SciencesGuizhou UniversityGuiyang 550025China

Monitoring agricultural drought using remote sensing data is crucial for precision irrigation in modern *** unmanned aerial vehicle(UAV)remote sensing,we explored the applicability of an empirical crop water stress index(CWSI)based on canopy.t.mperature and three-dimensional drought indices(tDDI)constructed from surface temperature(t_(s)),air temperature(t_(a))and five vegetation indices(VIs)for monitoring the moisture status of dryland *** machine learning algorithms(random forest regression(RFR),support vector regression,and partial least squares regression)were used to compare the performance of the drought indices for vegetation moisture content(VMC)estimation in sorghum and *** main results of the study were as follows:(1)Comparative analysis of the drought indices revealed that t_(s)-t_(a)-normalized difference vegetation index(tDDIn)and t_(s)-t_(a)-enhanced vegetation index(tDDIe)were more strongly correlated with VMC compared with the other *** indices exhibited varying sensitivities to VMC under different irrigation regimes;the strongest correlation observed was for the tDDIe index with maize under the fully irrigated treatment(r=-0.93).(2)Regarding spatial and temporal characteristics,the tDDIn,tDDIe and CWSI indices showed minimal differences Over the experimental period,with coefficients of variation were 0.25,0.18 and 0.24,*** three indices were capable of effectively characterizing the moisture distribution in dryland maize and sorghum crops,but the tDDI indices more accurately monitored the spatial distribution of crop moisture after a rainfall or irrigation event.(3)For prediction of the moisture content of single crops,RFR models based on tDDIn and tDDIe estimated VMC most accurately(R^(2)>0.7),and the tDDIn-based model predicted VMC with the highest accuracy when considering multiple-crop samples,with R^(2)and RMSE of 0.62 and 14.26%,***,tDDI proved more effective than the CWSI in e

关键词： maize sorghum t_(s)-t_(a)-VIs CWSI UAV machine learning crop moisture monitoring

Long-time Asymptotics for the Reverse Space-time Nonlocal Hirota Equation with Decaying Initial Value Problem:without Solitons

在线全文

学校读者我要写书评

暂无评论

Acta Mathematicae Applicatae Sinica 2024年第3期40卷 708-727页

作者： Wei-qi PENG yong chen School of Mathematical Sciences East China Normal UniversityShanghai 200241China College of Mathematics and Sy.t.ms Science Shandong University of Science and TechnologyQingdao 266590China

In this work,we mainly consider the Cauchy problem for the reverse space-time nonlocal Hirota equation with the initial data rapidly decaying in the solitonless *** from the Lax pair,we first construct the basis Riemann-Hilbert problem for the reverse space-time nonlocal Hirota ***,using the approach of Deift-Zhou nonlinear steepest descent,the explicit long-time asymptotics for the reverse space-time nonlocal Hirota is *** the reverse space-time nonlocal Hirota equation,since the symmetries of its scattering matrix are different with the local Hirota equation,the v(λ_(i))(i=0,1)would like to be imaginary,which results in theδ_(λi)^(0)contains an increasing t(±Imv(λ_(i)))/2,and then the asymptotic behavior for nonlocal Hirota equation becomes differently.

关键词： Riemann-Hilbert problem reverse space-time nonlocal Hirota equation long-time asymptotics nonlinear steepest descent method

Control of chiral-optical activities by magnetic field based on the transformation of achiral binary cry.t.ls into chiral ternary cry.t.ls

在线全文

学校读者我要写书评

暂无评论

Science China Chemistry 2024年第7期67卷 2300-2305页

作者： Zhiyan chen yan Lv Wei Qin College of Physics Qingdao UniversityQingdao 266071China School of Physics State Key Laboratory of Crystal MaterialsShandong UniversityJinan 250100China Shandong Linuo Photovoltaic Hi-tech Co. Ltd.Jinan 250100China

Multicomponent self-assembled chiral sy.t.ms have attracted great attention due to their promising application in the area of spin-photonics and *** this work,through introducing an achiral third component into an achiral binary cry.t.l,a chiral organic ternary cry.t.l is fabricated,where both pronounced chiral-optical coupling and magnetic field dependence of chiral-optical activities are *** transformation of achiral structure into chiral structure generates a significant effect on the polarized state of light and the electron spin resonance ***,the coupling between circularly polarized photon and spin is observed in chiral ternary cry.t.l with pronounced chiral orbit,where obvious magnetic field-transmissivity loop is ***,temperature could increase the magnitude of lattice parameters to lead to a larger helix radius to increase the chiral orbit ***,this work indicates that the further exploration of photon-chiral orbit-spin interactions in organic chiral ternary cry.t.ls is promising.

关键词： organic chiral ternary cry.t.ls chiral orbit chiral-optical activities magnetic field

同方期刊数据库

GMAt:A Graph Modeling Method for Group Preference Prediction

在线全文

学校读者我要写书评

暂无评论

Journal of Sy.t.ms Science and Sy.t.ms Engineering 2024年第4期33卷 475-493页

作者： Xiangyu Li Xunhua Guo Guoqing chen International Business School Jinan UniversityZhuhai519070China School of Economics and Management Tsinghua UniversityBeijing100084China

Preference prediction is the building block of personalized services,and its implementation at the group level helps enterprises identify.t.eir target customers *** methods for preference prediction mainly focus on behavioral interactions to extract the associations between groups and products,ignoring the importance of other auxiliary records(e.g.,online reviews and social tags)in association *** paper proposes a novel method named GMAt for group preference prediction,aiming to collectively detect the sophisticated association patterns from user generated content(UGC)and behavioral *** doing so,we construct a tripartite graph to collaborate these two types of data,and design a deep-learning algorithm with mutual attention module for generating the contextualized representations of groups and *** experiments on two real-world datasets show that GMAt is superior to other baselines in terms of group preference ***,GMAt is able to improve prediction accuracy compared with its different variants,further verifying the proposed method’s effectiveness on association pattern detection.

关键词： Group preference UGC tripartite graph deep learning