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Association of Human Whole-blood NAD+Levels with Nabothian Cyst

Biomedical and Environmental Sciences 2024年第5期37卷 471-478页

作者： XU Ling WANG yue Xuan WANG Wei FAN xue chen xue yu ZHOU Tian yun LIU yu He yu Ye YANG Fan JU Zhen yu ZHOU Yong WANG Deng Liang Clinical Research Institute Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 200080China NHC Key Lab of Reproduction Regulation Shanghai Engineering Research Center of Reproductive Health Drugs and DevicesShanghai Institute for Biomedical and Pharmaceutical TechnologiesShanghai 200237China Department of Applied Statistics Johannes Kepler University LinzLinz 4040Austria Hematology Center Beijing Key Laboratory of Pediatric Hematology OncologyNational Key Discipline of Pediatrics(Capital Medical University)Key Laboratory of Major Diseases in ChildrenMinistry of EducationBeijing Children's HospitalCapital Medical UniversityNational Center for Children's HealthBeijing 100045China Department of Biostatistics School of Public HealthCheeloo College of MedicineShandong UniversityJinan 250012ShandongChina Clinical Medicine School of Basic MedicineShanghai Medical College Fudan UniversityShanghai 200032China Department of Biochemistry and Molecular Biology Hengyang Medical SchoolUniversity of South ChinaHengyang 421001HunanChina Administrative Office Total Quality Management OfficeTotal Quality Management InstituteShanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 200080China The First Affiliated Hospital of Jinan University Institute of Aging and Regenerative MedicineJinan UniversityJinan 510632GuangzhouChina Department of Scientific Research The First Affiliated Hospital of Huzhou UniversityHuzhou 313000ZhejiangChina Department of Neurosurgery Neurosurgery Research InstituteThe First Affiliated HospitalFujian Medical UniversityFuzhou 350005FujianChina Department of Neurosurgery Binhai Branch of National Regional Medical CenterThe First Affiliated HospitalFujian Medical UniversityFuzhou 350209FujianChina Fujian Provincial Institutes of Brain Disorders and Brain Sciences The First Affiliated HospitalFujian Medical UniversityFuzhou 350005FujianChina Fujian Provincial Clinical Research Center for Neurological

Objective Little is known about the association between whole-blood nicotinamide adenine dinucleotide(NAD^(+))levels and nabothian *** study aimed to assess the association between NAD^(+)levels and nabothian cysts in healthy Chinese *** Multivariate logistic regression analysis was performed to analyze the association between NAD^(+)levels and nabothian *** The mean age was 43.0±11.5 years,and the mean level of NAD^(+)was 31.3±5.3μmol/*** cysts occurred in 184(27.7%)participants,with single and multiple cysts in 100(15.0%)and84(12.6%)participants,*** total nabothian cyst prevalence gradually decreased from37.4%to 21.6%from Q1 to Q4 of NAD^(+)and the prevalence of single and multiple nabothian cysts also decreased across the NAD^(+)*** compared with the highest NAD^(+)quartile(≥34.4μmol/L),the adjusted odds ratios with 95%confidence interval of the NAD^(+)Q1 was 1.89(1.14–3.14)for total nabothian *** risk of total and single nabothian cysts linearly decreased with increasing NAD^(+)levels,while the risk of multiple nabothian cysts decreased more rapidly at NAD^(+)levels of 28.0 to35.0μmol/***:Low NAD^(+)levels were associated with an increased risk of total and multiple nabothian cysts.

关键词： Nicotinamide adenine dinucleotide Nabothian cyst Female Risk factor

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超早产儿解脲脲原体感染及定植状态的临床特征分析

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中国当代儿科杂志 2024年第8期26卷 811-816页

作者：王燕琼曾雅丽陈雪雨黄智峰杨传忠南方医科大学第一临床医学院深圳市妇幼保健院新生儿科广东深圳518000

目的探讨超早产儿解脲脲原体(Ureaplasma urealyticum,UU)感染及定植状态的临床特征及对支气管肺发育不良(bronchopulmonary dysplasia,BPD)的影响。方法选取2018年9月—2022年9月于深圳市妇幼保健院新生儿科住院的258例超早产儿进行回... 详细信息

目的探讨超早产儿解脲脲原体(Ureaplasma urealyticum,UU)感染及定植状态的临床特征及对支气管肺发育不良(bronchopulmonary dysplasia,BPD)的影响。方法选取2018年9月—2022年9月于深圳市妇幼保健院新生儿科住院的258例超早产儿进行回顾性分析。根据UU核酸检测结果以及UU感染和定植的评估标准,将研究对象分为UU阴性组(155例)、UU感染组(70例)、UU定植组(33例)。比较三组超早产儿的一般资料、主要及次要临床结局。结果与UU阴性组相比,UU感染组BPD的发生率升高(P0.05)。结论UU对早产儿BPD的影响与UU的致病状态密切相关(即感染或定植),UU感染的超早产儿BPD的发生率明显升高,总用氧时间及住院时长明显延长。UU定植的超早产儿BPD和中重度BPD的发生率无上升。

关键词：解脲脲原体感染定植临床特征超早产儿

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Estimation of surface geometry on combustion characteristics of AP/HTPB propellant under rapid depressurization

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Defence Technology（防务技术） 2024年第3期33卷 546-558页

作者： Kaixuan chen Zhenwei Ye Xiaochun xue Yonggang yu School of Energy and Power Engineering Nanjing University of Science and TechnologyNanjing 210094JiangsuChina School of Science Hangzhou Dianzi UniversityHangzhou 310018ZhejiangChina

The 2D sandwich model serves as a potent tool in exploring the influence of surface geometry on the combustion attributes of Ammonium perchlorate/Hydroxyl-terminated polybutadiene(AP/HTPB)propellant under rapid pressure *** thickness of the sandwich propellant is derived from slicing the 3D random particle packing,an approach that enables a more effective examination of the micro-flame *** analysis of the predicted burning characteristics has been performed with experimental *** findings demonstrate a reasonable agreement,thereby validating the precision and soundness of the *** on the typical rapid depressurization environment of solid rocket motor(initial combustion pressure is 3 MPa and the maximum depressurization rate is 1000 MPa/s).A-type(a flatter surface),B-type(AP recesses from the combustion surface),and C-type(AP protrudes from the combustion surface)propellant combustion processes are numerically *** comparison of the evolution of gas-phase flame between 0.1 and 1 ms,it is discerned that the flame strength and form created by the three sandwich models differ significantly at the beginning stage of depressurization,with the flame structures gradually becoming harmonized over *** are drawn by comparison extinction times:the surface geometry plays a pivotal role in the combustion process,with AP protrusion favoring combustion the most.

关键词： AP/HTPB propellant BDP model Rapid pressure decay Burning surface geometry

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A Strong,Tough,and Self-Healing Strengthening Thioctic Acid-based Elastomer for Highly Reliable Flexible Strain Sensor

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Chinese Journal of Polymer Science 2024年第10期42卷 1610-1618,I0016页

作者： Xin-yu chen yu-Bing Fu xue-Ling Yan Lan Liu School of Materials Science and Engineering Key Lab of Guangdong Province for High Property and Functional Polymer MaterialsSouth China University of TechnologyGuangzhou510641China

Elastomers with high strength and toughness,excellent self-healing properties,and biocompatibility have broad application prospects in wearable electronics and other fields,but preparing it remains a *** this work,we propose a highly adaptable strategy by introducing the small molecule crosslinking agent of triethanolamine(TEA)to the poly(thioctic acid)(PTA)chains and preparing the PAx Ey elastomers using a simple synthesis *** strategy stabilizes the PTA chains by constructing multiple non-covalent cross-linked dynamic networks,endowing materials with excellent strength and toughness(tensile strength of 288 kPa,toughness of 278.2 kJ/m3),admirable self-healing properties(self-healing efficiency of 121.6%within 7 h at 70℃),and good *** PAx Ey elastomers can also be combined with MWNTs to become flexible strain sensors,which can be used to monitor human joint movements with high sensitivity,repeatable responses,and stability.

关键词： Thioctic acid Ion clusters Multiple dynamic networks Self-healing strengthening Flexible strain sensor

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Enhancing reversible hydrogen storage performance of 2LiBH_(4)–MgH_(2)via in-situ building heterogeneous nucleation sites

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Rare Metals 2024年第9期43卷 4367-4376页

作者： Wei chen Ya-Hui Sun Tian Xu xue-Bin yu Guang-Lin Xia Department of Materials Science Fudan UniversityShanghai 200433China

2LiBH_(4)-MgH_(2)composite is one of the most attractive reactive hydride composites with a theoretic hydrogen capacity of 10.8 wt%.However,the large nucleation restriction of MgB_(2)during the second step of dehydrogenation results in sluggish hydrogen storage kinetics and high operating temperature,which hinders its practical application as on-board hydrogen storage ***,Al3Ti doped Al nanoparticles(AT NPs)are prepared by a facile chemical reduction reaction to improve the hydrogen storage performance of 2LiBH_(4)-MgH_(2)*** the initial H_(2)desorption process,MgAlB_(4)and TiB_(2)that have identical crystal structure and low d-value mismatch with MgB_(2)resulting from the reaction between AT NPs and 2LiBH_(4)-MgH_(2)composite serve as effective nucleation sites for the formation of MgB_(2).As a result,the apparent activation energy of the two-step H_(2)desorption of AT NPs doped 2LiBH_(4)-MgH_(2)composite are notably decreased to(110.0±5.9)and(119.6±1.4)kJ·mol^(-1),which is 55.5 and 33.5 kJ·mol^(-1)lower than that of the undoped *** importantly,a reversible hydrogen storage capacity of 9.2 wt%after 10cycles of H_(2)desorption and adsorption could be achieved,corresponding to a capacity retention rate of 99%.The building of reactive bimetallic catalyst towards in situ formation of heterogeneous nucleation sites provides a new strategy for improving the hydrogen storage performance of reactive hydride composites.

关键词： Reversible hydrogen storage Reactive hydride composites Catalytic effects Heterogeneous nucleation

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A hybrid physics-informed data-driven neural network for CO_(2) storage in depleted shale reservoirs

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Petroleum Science 2024年第1期21卷 286-301页

作者： Yan-Wei Wang Zhen-xue Dai Gui-Sheng Wang Li chen yu-Zhou Xia yu-Hao Zhou College of Construction Engineering Jilin UniversityChangchun130026JilinChina Institute of Intelligent Simulation and Early Warning for Subsurface Environment Jilin UniversityChangchun130026JilinChina School of Energy Resources China University of GeosciencesBeijing100083China Department of Safety Environmental Protection and Quality ManagementShengli OilfieldSinopecDongying257000ShandongChina Key Laboratory of Thermo-Fluid Science and Engineering of MOE School of Energy and Power EngineeringXi'an Jiaotong UniversityXi'an710049ShaanxiChina College of Computer Science and Technology China University of Petroleum(East China)Qingdao266580ShandongChina Department of Physics University of FribourgFribourg1700Switzerland

To reduce CO_(2) emissions in response to global climate change,shale reservoirs could be ideal candidates for long-term carbon geo-sequestration involving multi-scale transport ***,most current CO_(2) sequestration models do not adequately consider multiple transport ***,the evaluation of CO_(2) storage processes usually involves laborious and time-consuming numerical simulations unsuitable for practical prediction and *** this paper,an integrated model involving gas diffusion,adsorption,dissolution,slip flow,and Darcy flow is proposed to accurately characterize CO_(2) storage in depleted shale reservoirs,supporting the establishment of a training *** this basis,a hybrid physics-informed data-driven neural network(HPDNN)is developed as a deep learning surrogate for prediction and *** incorporating multiple sources of scientific knowledge,the HPDNN can be configured with limited simulation resources,significantly accelerating the forward and inversion ***,the HPDNN can more intelligently predict injection performance,precisely perform reservoir parameter inversion,and reasonably evaluate the CO_(2) storage capacity under complicated *** validation and test results demonstrate that the HPDNN can ensure high accuracy and strong robustness across an extensive applicability range when dealing with field data with multiple noise *** study has tremendous potential to replace traditional modeling tools for predicting and making decisions about CO_(2) storage projects in depleted shale reservoirs.

关键词： Deep learning Physics-informed data-driven neural network Depleted shale reservoirs CO_(2)storage Transport mechanisms

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Palladium-Catalyzed[4+2]and[6+2]Dipolar Cycloadditions for the Construction of Benzo[d]isothiazole 1,1-Dioxide Fused 1,3-Oxazinanes and 1,3-Oxazocanes

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Chinese Journal of Chemistry 2024年第8期42卷 829-834页

作者： Lei chen Hongling Xie yu xue Zhengyu Han Jianwei Sun Hai Huang Jiangsu Key Laboratory of Advanced Catalytic Materials&Technology School of Petrochemical EngineeringChangzhou UniversityChangzhouJiangsu213164 China Department of Chemistry The Hong Kong University of Science and TechnologyClear Water BayKowloonHong Kong SARChina

Comprehensive Summary,The Pd-catalyzed dipolar cycloaddition represents a significant synthetic strategy for the construction of useful heterocyclic *** study developed the dipolar[4+2]and[6+2]cycloaddition reactions of benzo[d]isothiazole 1,1-dioxides(BDs)leading to the synthesis of BD-fused 1,3-oxazinane and 1,3-oxazocane derivatives,*** particular,the synthesis of BD-fused 1,3-oxazinanes demonstrated regio-and enantioselective characteristics,resulting in products with good yields,enantioselectivity and regioselectivity(if applicable).Furthermore,the[6+2]cycloaddition reaction developed in this work represented the first strategy for the synthesis of medium-sized ring compounds based on BDs.

关键词： Cycloaddition 1,3-Oxazinanes 1,3-Oxazocanes Medium-ring compounds Stereochemistry N-Heterocycles Sulfonamides Enantioselectivity Asymmetricsynthesis

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p-d Orbital Hybridization Engineered Single-Atom Catalyst for Electrocatalytic Ammonia Synthesis

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Energy & Environmental Materials 2024年第2期7卷 119-125页

作者： Jingkun yu xue Yong Siyu Lu Green Catalysis Center and College of ChemistryZhengzhou UniversityZhengzhou 450001China Department of Chemistry University of SheffieldSheffieldS37HFUK

The rational design of metal single-atom catalysts(SACs)for electrochemical nitrogen reduction reaction(NRR)is ***-dimensional metal-organic frameworks(2DMOFs)is a unique class of promising *** to now,the roles of individual metals,coordination atoms,and their synergy effect on the electroanalytic performance remain ***,in this work,a series of 2DMOFs with different metals and coordinating atoms are systematically investigated as electrocatalysts for ammonia synthesis using density functional theory *** a specific metal,a proper metal-intermediate atoms p-d orbital hybridization interaction strength is found to be a key indicator for their NRR catalytic *** hybridization interaction strength can be quantitatively described with the p-/d-band center energy difference(Δd-p),which is found to be a sufficient descriptor for both the p-d hybridization strength and the NRR *** maximum free energy change(ΔG_(max))andΔd-p have a volcanic relationship with OsC_(4)(Se)_(4)located at the apex of the volcanic curve,showing the best NRR *** asymmetrical coordination environment could regulate the band structure subtly in terms of band overlap and *** work may shed new light on the application of orbital engineering in electrocatalytic NRR activity and especially promotes the rational design for SACs.

关键词： first-principle calculations Nitrogen reduction p-d orbital hybridization single-atom catalysts

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Cardiac regeneration: Pre-existing cardiomyocyte as the hub of novel signaling pathway

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Genes & Diseases 2024年第2期11卷 747-759页

作者： Tao Wang Xinzhe chen Kai Wang Jie Ju xue yu Wanpeng yu Cuiyun Liu Yin Wang Institute for Translational Medicine The Affiliated Hospital of Qingdao UniversityCollege of MedicineQingdao UniversityQingdaoShandong 266023China College of Medicine Qingdao UniversityQingdaoShandong 266023China

In the mammalian heart,cardiomyocytes are forced to withdraw from the cell cycle shortly after birth,limiting the ability of the heart to regenerate and *** development of multimodal regulation of cardiac proliferation has verified that pre-existing cardiomyocyte proliferation is an essential driver of cardiac *** the continuous development of genetic lineage tracking technology,it has been revealed that cell cycle activity produces polyploid cardiomyocytes during the embryonic,juvenile,and adult stages of cardiogenesis,but newly formed mononucleated diploid cardiomyocytes also elevated sporadically during myocardial *** implied that adult cardiomyocytes have a weak regenerative capacity under the condition of ischemia injury,which offers hope for the clinical treatment of myocardial ***,the regeneration frequency and source of cardiomyocytes are still low,and the mechanism of regulating cardiomyocyte proliferation remains further *** is noteworthy to explore what force triggers endogenous cardiomyocyte proliferation and heart ***,we focused on summarizing the recent research progress of emerging endogenous key modulators and crosstalk with other signaling pathways and furnished valuable insights into the internal mechanism of heart *** addition,myocardial transcription factors,non-coding RNAs,cyclins,and cell cycle-dependent kinases are involved in the multimodal regulation of pre-existing cardiomyocyte ***,awakening the myocardial proliferation endogenous modulator and regeneration pathways may be the final battlefield for the regenerative therapy of cardiovascular diseases.

关键词： Cardiac regeneration Cell cycle re-enter Myocardial infarction Pre-existing cardiomyocyte proliferation Regenerative therapy of cardiovascular diseases

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Very long wave infrared quantum dot photodetector up to 18μm

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Light(Science & Applications) 2024年第4期13卷 772-782页

作者： Xiaomeng xue Qun Hao Menglu chen School of Optics and Photonics Beijing Institute of TechnologyBeijing 100081China. Westlake Institute for Optoelectronics FuyangHangzhou 311421China. Physics Department Changchun University of Science and TechnologyChangchun 130022China

Colloidal quantum dots(CQDs)are of interest for optoelectronic devices because of the possibility of high-throughput solution processing and the wide energy gap tunability from ultraviolet to infrared *** may question about the upper limit on the CQD wavelength *** date,although the CQD absorption already reaches terahertz,the practical photodetection wavelength is limited within mid-wave *** figure out challenges on CQD photoresponse in longer wavelength,would reveal the ultimate property on these ***’s more,it motivates interest in bottom-up infrared photodetection with less than 10%cost compared with epitaxial growth semiconductor *** this work,developing a re-growth method and ionic doping modification,we demonstrate photodetection up to 18μm wavelength on HgTe *** liquid nitrogen temperature,the responsivity reaches 0.3 A/W and 0.13 A/W,with specific detectivity 6.6×108 Jones and 2.3×109 Jones for 18μm and 10μm CQD photoconductors,*** work is a step toward answering the general question on the CQD photodetection wavelength limitation.

关键词： quantum wave ultraviolet

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