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A population-based follow-up study on gallstone disease among type 2 diabetics in Kinmen,Taiwan

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World Journal of Gastroenterology 2006年第28期12卷 4536-4540页

作者： Tao-Hsin Tung Hsiao-Man Ho Hui-Chuan Shih Pesus Chou Jorn-Hon Liu Victor tk chen De-Chuan Chan Chi-Ming Liu cheng Hsin Rehabilitation Medical Center TaipeiTaiwan National Taipei College of Nursing TaipeiTaiwanChina Department of Mathematics and Science Education National Taipei Teachers CollegeTaipeiTaiwanChina Department of Nursing Kaohsiung Military General HospitalKaohsiungTaiwan I-Shou University KaohsiungTaiwanChina Community Medicine Research Center & Institute of Public Health National Yang-Ming UniversityTaipeiTaiwanChina cheng Hsin Rehabilitation Medical Center Faculty of Medicine School of MedicineNational Yang-Ming UniversityTaipeiTaiwanChina Cardinal Tien Hospital College of Medicine Fu-Jen Catholic University National Defence Medicine Center TaipeiTaiwanChina Division of General Surgery Tri-Service General HospitalNational Defense Medical CenterTaipeiTaiwanChina Community Medicine Research Center and Institute of Public Health National Yang-Ming UniversityTaipeiTaiwanChina

AIM： To assess the incidence of and risk factors for gallstone disease （GSD） among type 2 diabetics in Kinmen, Taiwan. METHODS： A screening program for GSD was performed by two specialists who employed real-time abdominal ultrasound to examine the abdominal region after patients had fasted for at least eight hours. Screening, which was conducted in 2001, involved 848 patients diagnosed with type 2 diabetes. After exclusion of 63 subjects with prevalent GSD, 377 participants without GSD were invited in 2002 for a second round of screening. A total of 281 （74.5%） subjects were re-examined. RESULTS： Among the 281 type 2 diabetics who had no GSD at the first screening, 10 had developed GSD by 2002. The incidence was 3.56% per year （95%CI： 1.78% per year-6.24% per year）. Using a Cox regression model, age （RR = 1.07, 95% CI： 1.00-1.14）, waist circumference （RR = 1.12, 95% CI： 1.01-1.29）, and ALT （RR = 1.13, 95%CI： 1.01-1.26） appeared to be significantly correlated with development of GSD. CONCLUSION： Older age is a known risk factor for the development of GSD. Our study shows that greater waist circumference and elevated ALT levels are also associated with the development of GSD among type 2 diabetics in Kinmen.

关键词： Type 2 diabetes Gallstone disease Incidence density Population-based study

Response of soil nutrients to terracing and environmental factors in the Loess Plateau of China

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Geography and Sustainability 2024年第2期5卷 230-240页

作者： Die chen Wei Wei Liding chen Bojun Ma Hao Li Department of Soil and Water Conservation Changjiang River Scientific Research InstituteWuhan 430010China State Key Laboratory of Urban and Regional Ecology Research Center for Eco-environmental SciencesChinese Academy of SciencesBeijing 100085China University of Chinese Academy of Sciences Beijing 100049China Research Center on Mountain Torrent&Geologic Disaster Prevention of Ministry of Water Resources Wuhan 430010China

Terracing is a widely adopted agricultural practice in mountainous regions around the world that aims to conserve soil and water *** nutrients play a crucial role in determining soil quality,particularly in landscapes prone to *** are influenced by factors such as land-use type,slope aspect,and *** this study,we sought to examine the impact of terracing on soil nutrients(soil organic content(SOC),total nitrogen(TN),nitrate-nitrogen(NO_(3)^(-)-N),ammonium nitrogen(NH_(4)^(+)-N),total phosphorus(TP),available phosphorus(AP),total potassium(tk),and available potassium(AK))and how they vary with environmental factors in the Chinese Loess *** the growing season,we collected 540 soil samples from the 0 to 100 cm soil layer across five major land-use types,different slope aspects,and varying ***,a meta-analysis of literature data further corroborated the effective accumulation of soil nutrients through terracing in the Loess *** findings are as follows:(1)Terraced fields,regardless of land-use type,showed a significant improvement in SOC and TN content.(2)Soil nutrient contents within terraced fields were predominantly higher on sunny slopes.(3)Terraces at lower altitudes are characterized by elevated SOC concentrations.(4)A meta-analysis of literature data pertaining to terracing and soil nutrients in this region confirmed the effective accumulation of soil nutri-ents through *** elucidated outcomes of this study offer a profound theoretical underpinning for the accurate planning and management of terraces,the scientific utilization of land resources,and the enhancement of land productivity.

关键词： Terrace Soil nutrients Land-use Slope aspect Altitude Loess Plateau

Unidirectional movement behavior of underwater bubbles on the wettability gradient mesh via asymmetrical bounce

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Science China Chemistry 2024年第8期67卷 2606-2613页

作者： Yuzhen Ning Zhihong Zhao Shuang Ben Qiang Li Cunming Yu Xudong Zhang Huawei chen Kesong Liu Lei Jiang School of Mechanical Engineering and Automation Beihang UniversityBeijing 100191China Key Laboratory of Bio-Inspired Smart Interfacial Science and Technology School of ChemistryBeihang UniversityBeijing 100191China Research Institute of Aero-Engine Beihang UniversityBeijing 100191China School of Materials Science and Engineering Shenyang Ligong UniversityShenyang 110159China Tianmushan Laboratory Hangzhou 310023China The Analysis Testing CenterBeihang UniversityBeijing 100191China

The impact of underwater bubbles on solid surfaces with a gradient wettability is important for fundamental science and technological applications. Despite progress in the translational motion of underwater bubbles on asymmetric surface, a fundamental dynamic understanding of asymmetrical bounce behavior of the underwater bubble needs to be further ***, we investigate asymmetrical bounce of underwater bubbles after impacting the wettability gradient copper mesh *** bounce of the underwater bubble on the wettability gradient mesh(WGM) surface is composed by asymmetrical spread in the spread process and asymmetrical recoil in the recoil process, which induce the unidirectional movement ***, effective bubble-size manipulation can be easily implemented due to different volumes of bubbles remaining at different locations of WGM surface. We envision that this work will provide a new understanding of asymmetrical bounce behavior of the underwater bubble on the wettability gradient surface, and propose a novel and feasible strategy for constructing the underwater bubble manipulation system.

关键词： asymmetrical bounce unidirectional movement behavior gradient wettability

Tumor-targeted metabolic inhibitor prodrug labelled with cyanine dyes enhances immunoprevention of lung cancer

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Acta Pharmaceutica Sinica B 2024年第2期14卷 751-764页

作者： Wen Li Jiali Huang chen Shen Weiye Jiang Xi Yang Jingxuan Huang Yueqing Gu Zhiyu Li Yi Ma Jinlei Bian State Key Laboratory of Natural Medicines China Pharmaceutical UniversityNanjing 210009China Department of Biomedical Engineering School of EngineeringChina Pharmaceutical UniversityNanjing 210009China Jiangsu Key Laboratory of Drug Design and Optimization Department of Medicinal ChemistrySchool of PharmacyChina Pharmaceutical UniversityNanjing 210009China

Recent progress in targeted metabolic therapy of cancer has been limited by the considerable toxicity associated with such *** address this challenge,we developed a smart theranostic prodrug system that combines a fluorophore and an anticancer drug,specifically 6-diazo-5-oxo-L-norleucine(DON),using a thioketal linkage(tk).This system enables imaging,chemotherapy,photodynamic therapy,and on-demand drug release upon radiation *** optimized prodrug,DON-tk-BM3,incorporating cyanine dyes as the fluorophore,displayed potent reactive oxygen species release and efficient tumor cell *** the parent drug DON,DON-tk-BM3 exhibited no toxicity toward normal ***,DON-tk-BM3 demonstrated high tumor accumulation and reduced side effects,including gastrointestinal toxicity,in *** study provides a practical strategy for designing prodrugs of metabolic inhibitors with significant toxicity stemming from their lack of tissue selectivity.

关键词： Smart prodrug system Glutamineantagonists Immunotherapy Photodynamictherapy Reactive oxygen species Metabolicinhibitor Cyaninedye Non-small-cell lung cancer(NSCLC)

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双工位针刺机器人系统设计

纺织学报 2024年第7期45卷 204-212页

作者：李皎辛世纪陈利陈小明天津工业大学纺织科学与工程学院天津300387 天津工业大学先进纺织复合材料教育部重点实验室天津300387 天津工业大学机械工程学院天津300387

针对单工位针刺成型系统中人和机器无法高效协同生产,预制体生产效率较低;现有的直线型双工位针刺机器人设备需要2个外部回转轴带动双工位参与织物针刺,系统编程难度较高,且工位切换时需要占据的空间大的问题。提出一种混合切换双工位... 详细信息

针对单工位针刺成型系统中人和机器无法高效协同生产,预制体生产效率较低;现有的直线型双工位针刺机器人设备需要2个外部回转轴带动双工位参与织物针刺,系统编程难度较高,且工位切换时需要占据的空间大的问题。提出一种混合切换双工位针刺机器人系统,并开展了双工位针刺成形系统的机械结构设计、异型预制体模具和针刺工艺设计、控制系统设计、运动仿真以及预制体制备的实验验证。结果表明:系统成功实现了大尺寸异型曲面预制体的高效针刺成形,直线/旋转混合切换的双工位使得实现预制体的自动换装的同时又能保证系统空间占用量小;双工位中只有针刺工位上的外部回转轴与6关节机械臂联动,系统较为简单,编程方便;同时提高了数控回转工作台的承载力且将针刺末端执行器的布针数量增加至25针,满足了大尺寸预制体的针刺成形,并使得针刺成形效率直接提高2倍。本文系统可应用于批量化制备大尺寸异型曲面复材预制体。

关键词：双工位预制体机器人针刺技术异型曲面复合材料

A Survey Study on TPACK Framework for Normal Students of English Major in Ethnic Colleges and Universities:Empirical Analysis Based on Structural Equation Modeling

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Journal of Contemporary Educational Research 2024年第9期8卷 112-119页

作者： Qinxian chen Xuanxuan Zhong Xinyi Liu School of Foreign Languages Tibet UniversityLhasa 850000Xizang Autonomous RegionChina

With the continuous advancement of education informatization,Technological Pedagogical Content Knowledge(TPACK),as a new theoretical framework,provides a novel method for measuring teachers’informatization teaching *** study takes normal students of English majors from three ethnic universities as the research object,collects relevant data through questionnaires,and uses structural equation modeling to conduct data analysis and empirical research to investigate the differences in the TPACK levels of these students at different grades and the structural relationships among the elements in the TPACK *** technological pedagogical knowledge element of the TPACK structure was not obtained by exploratory factors analysis but through path analysis and structural equation modeling,the results show that the one-dimensional core knowledge of technological knowledge(tk),content knowledge(CK),and pedagogical knowledge(PK)have a positive effect on the two-dimensional interaction knowledge of technological content knowledge(TCK)and pedagogical content knowledge(PCK);furthermore,TCK and PCK have a positive effect on TPACK;and tk,CK,and PK indirectly affect TPACK through TCK and *** this basis,suggestions are provided to ethnic colleges and universities to develop the TPACK knowledge competence of normal students of English majors.

关键词： TPACK Ethnic colleges and universities Normal students of English major Structural equation modeling

我国青少年运动员接受反兴奋剂教育的影响因素研究

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广州体育学院学报 2024年第3期44卷 67-79页

作者：汪喆汪嘉琦陈佩杰王晨李成易陈淑琴上海体育科学研究所(上海市反兴奋剂中心) 上海200030 上海体育大学上海200090 上海市竞技体育训练管理中心上海202179

目的:探究当前影响我国青少年运动员接受反兴奋剂教育各种因素,为优化我国青少年运动员反兴奋剂教育提供理论参考依据。方法:基于自编的《青少年运动员反兴奋剂教育影响因素问卷》分析影响接受反兴奋剂教育各种因素,并探讨不同维度影响... 详细信息

目的:探究当前影响我国青少年运动员接受反兴奋剂教育各种因素,为优化我国青少年运动员反兴奋剂教育提供理论参考依据。方法:基于自编的《青少年运动员反兴奋剂教育影响因素问卷》分析影响接受反兴奋剂教育各种因素,并探讨不同维度影响因素之间的相互关系。结果:研究发现,趣味娱乐需求对于运动项目及训练年限、教育形式对于年龄、教育形式和竞技发展需求对于运动等级都存在非常显著性差异;同时,各个维度的各项指标拟合度较好,教育内容、他人的行为态度、竞技发展需求分别为认知维度、人际维度、动力维度中权重占比最大的二级影响因子;将认知维度作为调节变量时模型拟合度最高。结论:优化我国青少年运动员反兴奋剂教育应当以教育内容和教育形式为主线,遵循青少年运动员的身心发展规律,同时扩大教育范围,以达到期望的反兴奋剂教育效果。

关键词：青少年运动员反兴奋剂教育影响因素交互关系

整合技术的英语学科教学知识(TPACK)对线上教学效果影响的调查研究

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甘肃高师学报 2024年第3期29卷 119-125页

作者：陈伟甘肃中医药大学定西校区人文教学部甘肃定西743000

随着TPACK教学理论应用到线上教育,其对线上教学效果的影响成了学界的关注点之一。该研究基于D高校“雨课堂”线上教学实践,收集问卷数据和访谈资料,分析高校英语教师的TPACK水平对线上教学效果的影响状况。问卷数据分析表明:高校英语教... 详细信息

随着TPACK教学理论应用到线上教育,其对线上教学效果的影响成了学界的关注点之一。该研究基于D高校“雨课堂”线上教学实践,收集问卷数据和访谈资料,分析高校英语教师的TPACK水平对线上教学效果的影响状况。问卷数据分析表明:高校英语教师TPACK各元素知识水平由高到低依次为CK>PK>tk>TCK>PCK>TPK>TPACK;教师TPACK水平与线上教学效果呈正相关(p<0.01);教师的PCK对教学内容影响最显著,TPK对教学设计影响最显著,TPACK对教学支持影响最显著;访谈也证实了影响线上教学效果的主要有PCK、TPK和TPACK三个元素。依据TPACK教学理论,提出如下建议:探究教师TPACK发展机制,提高教师综合教学技能;应用支架式互动教学,增加朋辈互动;依托技术优势,提高学生的教学参与度。

关键词：高校英语教师 TPACK 线上教学教学效果远程教学

青少年腰椎间盘突出症的影响因素分析及列线图模型建立

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海军军医大学学报 2024年第6期45卷 708-716页

作者：刘青山陈滢刘延何大为海军军医大学(第二军医大学)研究生院上海200433 中国人民解放军联勤保障部队北戴河康复疗养中心秦皇岛066199 海军军医大学(第二军医大学)第一附属医院脊柱外科上海200433

目的分析青少年腰椎间盘突出症(ALDH)的危险因素并制定风险量化评估工具。方法对2010年8月至2021年8月海军军医大学(第二军医大学)第一附属医院75例ALDH青少年患者(病例组)和有腰痛但无ALDH的青少年患者(对照组)的临床资料及影像学资料... 详细信息

目的分析青少年腰椎间盘突出症(ALDH)的危险因素并制定风险量化评估工具。方法对2010年8月至2021年8月海军军医大学(第二军医大学)第一附属医院75例ALDH青少年患者(病例组)和有腰痛但无ALDH的青少年患者(对照组)的临床资料及影像学资料进行回顾性分析。两组患者均按照7∶3的比例随机分为训练集与验证集,比较训练集病例组与对照组年龄、性别、BMI、职业、腰部外伤史、吸烟史、腰骶移行锥(LSTV)、髂嵴长度与腰5横突长度比值(ICL/L_(5)TP)、小关节突不对称性(FT)、胸椎后凸角(tk)、腰椎前凸角(LL)、骶骨倾斜角(SS)、骨盆入射角(PI)。采用logistic回归模型分析ALDH风险的独立影响因素,并通过R 4.1.3软件绘制量化评估ALDH风险的列线图。分别利用训练集与验证集数据对列线图模型进行内部验证与外部验证,通过ROC曲线、C指数、校准曲线及决策曲线分析列线图模型的价值。结果训练集中病例组和对照组之间性别、BMI、职业、腰部外伤史、吸烟史、LSTV、ICL/L_(5)TP、FT、LL、SS差异均有统计学意义(均P<0.05);多因素logistic回归模型分析表明腰部外伤史、吸烟史、BMI、ICL/L_(5)TP、FT、LL是ALDH患病风险的独立影响因素(均P<0.05),基于这6个因素建立列线图模型。在训练集与验证集中,该列线图模型对ALDH风险的预测价值较高(AUC值分别为0.980、0.969),且有较高的准确度(C指数分别为0.71、0.76)、校准度(P=0.562、0.985)和临床收益。结论腰部外伤史、吸烟史、BMI、ICL/L_(5)TP、FT、LL与ALDH风险密切相关,基于这6个因素构建的列线图能用于量化评估ALDH的患病风险。

关键词：青少年腰椎间盘突出症危险因素评估列线图量化工具